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Effect of Polyopes lancifolia Extract on Oxidative Stress in Human Umbilical Vein Endothelial Cells Induced by High Glucose

  • Min, Seong Won;Han, Ji Sook
    • Preventive Nutrition and Food Science
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    • v.18 no.1
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    • pp.38-44
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    • 2013
  • The protective effect of Polyopes lancifolia extract on high glucose-induced oxidative stress was investigated using human umbilical vein endothelial cells (HUVECs). High concentration of glucose (30 mM) treatment induced HUVECs cell death, but Polyopes lancifolia extract, at concentrations of 25, 50, and $100{\mu}g/mL$, protected cells from high glucose-induced damage. Furthermore, thiobarbituric acid reactive substances, intracellular reactive oxygen species, and nitric oxide levels increased by high glucose treatment were effectively decreased by treatment with Polyopes lancifolia extract in a dose-dependent manner. Also, Polyopes lancifolia extract treatment reduced the overexpressions of inducible nitric oxide synthase, cyclooxygenase-2, and nuclear factor-kappa B proteins activation that was induced by high glucose in HUVECs. These results indicate that Polyopes lancifolia extract is a potential therapeutic material that will reduce the damage caused by high glucose-induced-oxidative stress associated with diabetes.

An experimental study on the fragility factor of high strength concrete (고강도 콘크리트의 취도계수에 관한 실험적 연구)

  • Kim, Hui-Doo;Yang, Seong-Hwan
    • Proceedings of the Korean Institute of Building Construction Conference
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    • 2014.05a
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    • pp.148-149
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    • 2014
  • In modern society, population overcrowding and concentration of facilities are happened because of the concentration on to city. So this phenomenon demands improvement of material's performance, technical development of structure analysis and design and improvement of constructing ability .High strength concrete has some merits. High strengthening makes the cross section reduced, and that cause decrease of structure weight. And using high durable and superplasticizer promote liquidity, thus high quality concrete can be produced. Because of these advantages, this study is for showing validity of using it by compression/tensile strength experiment. As this experiment's result, when concrete become stronger, interface intensity coefficient between cement and aggregate is different and they don't adhere to each other. So there is brittle failure. Fragility factor also steadily increase with strong concrete, it tells high strength concrete has problem. Therefore the sources used in high strength concrete like cement and aggregate must have great quality. So the source's performance must be supervised well because their quality decides performance criteria.

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Creep Properties of Ultra High Strength Concrete at High Temperature under Loading (재하와 가열을 받은 초고강도 콘크리트의 크리프 특성)

  • Lee, Young-Wook;Kim, Gyu-Yong;Choe, Gyeong-Cheol;Yoon, Min-Ho;Kim, Hong-Seop;Lee, Jun
    • Proceedings of the Korean Institute of Building Construction Conference
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    • 2014.05a
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    • pp.286-287
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    • 2014
  • Performance degradation of Ultra High Strength Concrete occurs more than that of normal strength concrete at high temperature. Thus, strain of concrete subjected to high temperature and loading is one of the core assessment items for evaluating performance of structures. Therefore, in this study, creep of ultra high strength concrete subjected to various temperature conditions and 25%, 40% loading was evaluated. As the results, Creep strain increased with increase of temperature and loading. Creep strain of concrete at high temperature is influenced by loading.

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A High Performance Three-Phase Telecom Supply Incorporating a HF Switched Mode Rectifier with a Phase Shifted PWM Controller

  • Shahani, Arushi;Singh, Bhim;Bhuvaneshwari, G.
    • Journal of Power Electronics
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    • v.10 no.3
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    • pp.219-227
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    • 2010
  • Telecom supplies need to conform to low Total Harmonic Distortion (THD) and high Power Factor (PF) as per IEC 61000-3-2 and IEEE 519-1992 standards. These high rating power supplies use a three phase utility in which low THD and high PF are realized via various passive and active wave shaping schemes. In this paper, a new design for three phase telecom power supplies is presented with circuit parameter values optimized for high performance in terms of a low THD, high PF, low ripple and high line and load regulation using a suitable combination of various strategies. The performance of the power supply is validated by extensive simulations.

Pressure and Temperature Control and HPHT Diamond Synthesis Using FB25 Type Belt Apparatus

  • Fukunaga, O.;Ko, Y.S.;Ohashi, N.
    • The Korean Journal of Ceramics
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    • v.4 no.1
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    • pp.5-8
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    • 1998
  • Flat belt(FB) type high pressure apparatus has been succesfully utilized in various high pressure experimental stations in Korea and Japan to conduct HPHT (high pressure and high temperature) diamond synthesis. Present paper discusses pressure calibration of FB apparatus at high temperature to establish P-T condition of diamond synthesis. We also present some examples of controling P-T condition through careful experimental set-up of the high pressure sample cells. Finally we discuss reproducibility of pressure and temperature condition of the HPHT diamond synthesis.

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Optimal Design of a High Speed Carbon Composite Air Spindle (고속 공기 주축부를 위한 복합재료 주축의 최적 설계)

  • Bang, Gyeong-Geun;Lee, Dae-Gil
    • Transactions of the Korean Society of Mechanical Engineers A
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    • v.25 no.11
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    • pp.1767-1776
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    • 2001
  • For the stable operation of high speed air spindle, the low rotational inertia and high damping ratio of spindle shafts as well as high fundamental natural frequency are indispensable. Conventional steel spindles are net appropriate for very high speed operation because of their high rotational inertia and low damping ratio. In this study, a high speed spindle composed of carbon fiber epoxy composite shaft and steel flange was designed for maximum critical speed considering minimum static deflection and radial expansion due to bending load and centrifugal force during high speed relation. The stacking angle and the stacking thickness of the composite shaft and the adhesive bonding length of the 7teel flange were selected through vibrational analysis considering static and thermal loads due to temperature rise.

Optimization of high-speed machining process using constrained R-T characteristic curve (절삭률-공구수명 특성 곡선을 이용한 고속가공 공정의 최적화에 관한 연구)

  • 최용철;김동우;장윤상;조명우;허영무
    • Proceedings of the Korean Society of Machine Tool Engineers Conference
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    • 2003.10a
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    • pp.100-105
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    • 2003
  • With the recent development of machining technology, high speed machining process is widely used for-the mold and difficult-to -cut-materials machining since it allows achieving high productivity and surface quality. However, during the high speed machining process, high cutting speed and feed rate can cause abrupt tool life decrease due to rapid rising of the cutting tool temperature. Such situation may cause increase of machining cost. Thus, in this study, developed optimization algorithm is applied to determine optimal machining variables for multiple high speed machining. The R-T characteristic curve for machining economics problems with a linear-lorarithmic tool life model is determined by applying sensitivity analysis. finally, a series of high speed machining experiments are performed to determine the desired optimal machining variables, and the results are analyzed.

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A Study on Appropriate Driving Speed for High-Speed Trains Running the Conventional Line (기존선을 통과하는 고속차량의 적절한 주행속도에 관한 연구)

  • Ham, Young Sam
    • Journal of the Korean Society for Precision Engineering
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    • v.31 no.9
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    • pp.773-776
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    • 2014
  • KTX (Korea Train eXpress) is the first high-speed train operated in Korea and its highest speed reaches 300 km/h. Korean high-speed trains are mostly operated on the railroads exclusively designed for high-speed trains, but the sections of Seoul~Gwangmyeong, nearby of Daejeon station and Dongdaegu are operated on the existing tracks having the speed less than 150 km/h. With this paper, we'd like to analyze the lateral force that occurs between the wheels and the rail when high-speed trains were operated on the existing track section to suggest an appropriate driving speed for high-speed trains. As the rigid wheel base of the high-speed train is 3m which is about 50% longer than normal vehicles, it works as an advantage for high-speed driving. However, as the lateral force becomes higher than normal vehicles when driving on curves, plans to reduce wear-outs on the wheels are required.

A Study on Transition of Dimension Error and Surface Precision in High Speed Machining of Al-alloy (Al 합금의 고속가공에서 치수오차와 표면정도 추이고찰)

  • 정문섭
    • Journal of the Korean Society of Manufacturing Technology Engineers
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    • v.9 no.3
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    • pp.96-102
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    • 2000
  • High speed machining aims to raise the productivity and efficiency by making more precise and higher value-added products than any other machining method by means of the high speediness of spindle and feed drive system. The purpose of this study is to investigate the effects of the run-out of endmill on the dimension precision of workpiece and to obtain the fundamental data on high speed machining which is available by machining the side of Al-alloy with solid carbide endmills in high speed machining center and by measuring dimensions and surface roughness. From the results of experimentation following are obtained ; if spindle speed is ultra high in conditions that radial depth of cut and feed per tooth are very small highly precise and accurate products are to be made efficiently with high feed rate. and so we can raise productivity.

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A Study on the Design of the New Structural SOI Smart Power Device with High Switching Speed and Voltage Characteristics (새로운 구조의 고속-고내압 SOI Smart Power 소자 설계에 관한 연구)

  • Won, Myoung-Kyu;Koo, Yong-Seo;An, Chul
    • Proceedings of the IEEK Conference
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    • 1999.06a
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    • pp.239-242
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    • 1999
  • In this paper, we report the process/device design of high-speed, high-voltage SOI smart power IC for mobile communication system, high-speed HDD system and the electronic control system of automobiles. The high voltage LDMOS with 70V breakdown voltage under 0.8${\mu}{\textrm}{m}$ design rule, the high voltage bipolar with 40V breakdown voltage for analog signal processing, the high speed bipolar with cut-off frequency over 20㎓ and LDD NMOS for high density were proposed and simulated on a single chip by the simulator DIOS and DESSIS. And we extracted the process/device parameters of the simulated devices.

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