• 사상체질의학회지
• /
• 제20권2호
• /
• pp.85-97
• /
• 2008

1. Objectives The purpose of this study is to investigate the anti-aging and anti-oxidant effects of Hyeongbangjiwhang-tang decoction(HGD) in SD rats. 2. Methods This experiment was used the tissue of kidney, bladder and spleen cells of 6, 52 and 68 weeks old SD rats. Each age group was again divided into three groups. One group, as normal group, was not-treated cells, another group, as control group, was saline-treated cells, and the last group, as experimental group, was HG-treated cells. After culture for 48 hours, each groups measured the level of SOD, GSH, MDA and NO in the tissue of kidney, bladder and spleen cells. 3. Results and Conclusions The activity of SOD were significantly increased in kidney cell of 68 w-HGD group, bladder cell of 52 w-HGD group and in spleen cell of 52,68 w-HGD group compared with those of the control groups. The level of GSH were significantly increased in bladder cell of 52w-HGD group and in spleen cell of 68w-HGD group compared with those of the control groups. The level of MDA were significantly decreased in bladder cell of 68 w-HGD group and in spleen cell of 68w-HGD group compared with those of the control groups. The level of NO were significantly decreased in kidney cell of 68 w-HGD group, bladder cell of 52, 68w-HGD groups, and in spleen cell of 68w-HGD group compared with those of the control groups. These results suggest that HGD(Hyeongbangjiwhang-tang) has anti-oxidant effects in aged rats.

• 한국식품위생안전성학회지
• /
• 제20권1호
• /
• pp.69-72
• /
• 2005

이 연구는 글루코만난과 유청칼슘의 혼합물이 $1\%$-Cholesterol을 식이한 후 혈청콜레스테롤에 미치는 영향과 $70\%$-Sucrose를 식이한 후 혈당에 미치는 영향을 알아보았다. $1\%$-Cholesterol을 식이한 쥐를 일반식이군(ND) 비교하였으며, 고콜레스테롤식이군(HCD)에 글루코만난식이군(HCDG)과 글루코만난과 유청칼슘군식이군(HCDGW)으로 나누어 관찰하였다. 또한 $70\%$-Sucroe를 식이한 쥐를 일반식이군(ND) 비교하였으며, 고혈당식이군(HGD)에 글루코만 난식이군(HGDG)과 글루코만난과 유청칼슘군식이군(HCDGW)으로 나누어 관찰하였다. 이를 비교 조사한 결과를 요약하면 다음과 같다. 1. 혈청콜레스테롤수치는 HCD>HCDG>HCDGW>ND의 순서로 감소하였다. 2. HCD의 혈청콜레스테롤증가량에 비하여HCDC는 약 $23.84\%$ HCDCW는 약 $42.38\%$ 감소하였다. 3. 혈당수치는 HGD>HGDG>HGDGW>ND의 순서로 감소하였다. 4. HGD의 혈당증가량에 비하여 HGDG는 약 $6.63\%$ HGDGW는 약$36.14\%$ 감소하였다.

• Asian Pacific Journal of Cancer Prevention
• /
• 제16권14호
• /
• pp.5875-5881
• /
• 2015

Cholangiocarcinoma (CCA) is a rare but highly fatal cancer for which the molecular mechanisms and diagnostic markers are obscure. We therefore investigated the kinetic expression of isocitrate dehydrogenase-1 (IDH1), isocitrate dehydrogenase-2 (IDH2) and homogentisate 1,2-dioxygenase (HGD) during the tumorigenesis of O. viverrini infection-associated CCA in an animal model, and confirmed down-regulation of expression in human cases of opisthorchiasis-associated CCA through real time PCR. Kinetic expression of HGD, IDH1 and IDH2 in the animal model of O. viverrini infection-induced CCA was correlated with human CCA cases. In the animal model, expression of HGD was decreased at all time points (p<0.01) and expression of both IDH1 and IDH2 was decreased in the CCA group. In human cases, expression of HGD, IDH1 and IDH2 was decreased more than 2 fold in 55 cases (70.5%), 25 cases (32.1%) and 24 cases (30.8%) respectively. The present study suggests that reduction of HGD, IDH1 and IDH2 may be involve in cholangiocarcinoma genesis and may be useful for molecular diagnosis.

• 생명과학회지
• /
• 제24권11호
• /
• pp.1168-1173
• /
• 2014

HGD (homogentisate1,2-dioxygenase)유전자는 소의 1번 염색체에 존재하며, tyrosine과 phenylalanine의 이화 작용을 돕는 효소 중 하나로 알려져 있다. 또한 소에서 도체중과 등심단면적에 영향을 주는 유전자로 보고된 바 있다. 본 연구는 한우 집단을 대상으로 HGD유전자내 변이지역을 탐색하고, 경제형질과의 연관성을 분석하기 위하여 실시하였다. 총 14개의 Exon지역을 바탕으로 변이지역을 탐색한 결과, 10개의 SNPs를 확인하였고, 이 중 genotype의 Frequency (MAF>0.1)를 고려하여 6개의 SNPs (G34256T, G34257C, T34284C, T42333G, T42348C, T42468C)를 발굴하여 경제형질과의 연관성을 분석하였다. 그 결과 G34256T에서 근내지방도와 유의적인 연관성이 확인되었고, G34257C에서 등심단면적과 근내지방도에서 유의적인 연관성이 확인되었다. 따라서 본 연구 결과에서 확인된 HGD 유전자의 SNP유전자형은 한우선발 및 개량을 위한 분자육종의 기초 자료로 이용할 수 있을 것으로 사료된다.

• 응용통계연구
• /
• 제5권1호
• /
• pp.1-8
• /
• 1992

Partitioned matrices를 이용해, v = 2.2.2인 경우의 Hierarchical Group Divisible (HGD) design의 해를 역행렬을 이용하지 아니하고 구하는 방법을 제시하였다.

• 대한기계학회논문집A
• /
• 제33권10호
• /
• pp.1108-1118
• /
• 2009

A Very High Temperature Gas Cooled Reactor (VHTR) has been selected as a high energy heat source of the order of $950^{\circ}C$ for nuclear hydrogen generation, which can produce hydrogen from water or natural gas. A primary hot gas duct (HGD) as a coaxial double-tube type cross vessel is a key component connecting a reactor pressure vessel and an intermediate heat exchanger in the VHTR. In this study, a structural sizing methodology for the primary HGD of the VHTR is suggested in order to modulate a flow-induced vibration (FIV). And as an example, a structural sizing of the horizontal HGD with a coaxial double-tube structure was carried out using the suggested method. These activities include a decision of the geometric dimensions, a selection of the material, and an evaluation of the strength of the coaxial double-tube type cross vessel components. Also in order to compare the FIV characteristics of the proposed design cases, a fluid-structure interaction (FSI) analysis was carried out using the ADINA code.

• Journal of Electrical Engineering and Technology
• /
• 제9권6호
• /
• pp.2070-2078
• /
• 2014

In this work, the frequency response of gate-all-around (GAA) Ge/GaAs heterojunction tunneling field-effect transistor (TFET) with hetero-gate-dielectric (HGD) and pnpn channel doping profile has been analysed by technology computer-aided design (TCAD) device-circuit mixed-mode simulations, with comparison studies among ppn, pnpn, and HGD pnpn TFET devices. By recursive tracing of voltage transfer curves (VTCs) of a common-source (CS) amplifier based on the HGD pnpn TFET, the operation point (Q-point) was obtained at $V_{DS}=1V$, where the maximum available output swing was acquired without waveform distortion. The slope of VTC of the amplifier was 9.21 V/V (19.4 dB), which mainly resulted from the ponderable direct-current (DC) characteristics of HGD pnpn TFET. Along with the DC performances, frequency response with a small-signal voltage of 10 mV has been closely investigated in terms of voltage gain ($A_v$), unit-gain frequency ($f_{unity}$), and cut-off frequency ($f_T$). The Ge/GaAs HGD pnpn TFET demonstrated $A_v=19.4dB$, $f_{unity}=10THz$, $f_T=0.487$ THz and $f_{max}=18THz$.

• 대한기계학회:학술대회논문집
• /
• 대한기계학회 2007년도 춘계학술대회A
• /
• pp.296-299
• /
• 2007

KAERI is in the process of carrying out the Nuclear Hydrogen Development and Demonstration (NHDD) Program. The indirect cycle gas cooled reactors that produce heat at temperatures in the order of $950^{\circ}C$ are being considered in the NHDD program. For the indirect gas cooled reactors, the intermediate hear exchanger (IHX) and hot gas duct (HGD) are the main components. For the NHDD program we are in the process of establishing a conceptual design of the IHX and HGD. The pre-conceptual design activities in this study dealt with a preliminary design of the IHX and the HGD including strength and thermal expansion evaluation of the main components.

• 대한기계학회:학술대회논문집
• /
• 대한기계학회 2008년도 추계학술대회A
• /
• pp.717-724
• /
• 2008

Very High Temperature Gas Cooled Reactor (VHTR) has been selected as a high energy heat source for nuclear hydrogen generation, which can produce hydrogen from water or natural gas. A primary hot gas duct (HGD) as a coaxial double-tube type cross vessel is a key component connecting the reactor pressure vessel and the intermediate heat exchanger for the VHTR. In this study, structural sizing methodology for the primary HGD with a coaxial double-tube of the VHTR that produces heat at temperatures in the order of $950^{\circ}C$ was suggested and a structural pre-sizing of it was carried out as an example.

• Journal of Genetic Medicine
• /
• 제15권1호
• /
• pp.17-19
• /
• 2018

Alkaptonuria (AKU, OMIM: 203500) is a rare autosomal recessive disorder of tyrosine metabolism due to a defect of enzyme activity, homogentisate 1,2-dioxygenase (HGD). The patients with AKU initially presented with dark urine discoloration, and ochronosis and arthritis develop after third decades of life. With advances of Internet resources, web-based health seekers for rare disease are increasing. Here, we report the case of an 18-year-old boy with AKU who visited our center due to dark black urine based on self-diagnosis via web searching of this rare condition. Compound heterozygous mutations in HGD gene, IVS5+3A>C and IVS12+6T>C were identified and both of mutations were detected in his parents. Our case illustrates the utility of publicly available Internet resources for diagnosis of rare disease.