• 제목/요약/키워드: Herbal combination

검색결과 486건 처리시간 0.028초

고지방식이로 비만이 유도된 C57BL/6 마우스에서 Metformin과 황금추출물의 병용 투여 시 비만관련 지표에 미치는 영향 (The Effect of Scutellariae Radix Combined with Metformin on Obesity-Relating Biomarker in High Fat Fed C57BL/6 Mice)

  • 장세주;왕경화;최한석;진영원;김호준
    • 한방비만학회지
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    • 제17권1호
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    • pp.20-28
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    • 2017
  • Objectives: The purpose of this study was to investigate anti-obesity effect of Scutellariae Radix extract combined with metformin. Methods: Male C57BL/6 mice, 4 weeks of age, were used to set high-fat diet induced obesity model. They were grouped NOR (normal control), HFD (high fat diet control), MET (metformin, 100 mg/kg/day), MH2 (metformin 50 mg/kg/day+Scutellariae Radix 200 mg/kg/day), and HG4 (Scutellariae Radix 400 mg/kg/day). MET, MH2, and HG4 were orally administered for 10 weeks. Body weight was measured every week. Fasting blood glucose, triglyceride, total cholesterol (TC), high density lipoprotein, glutamic oxaloacetic transaminase (GOT), and glutamic-pyruvic transaminase (GPT) were measured before sacrifice. Oral glucose tolerance test (OGTT) was also performed. Organ weight and internal fat weight were measured after sacrifice. Results: MH2 group showed a reduction of body weight when compared with HFD group. MH2 group showed stable blood level control which was calculated areas under the curves by OGTT. TC, GOT, GPT level, internal fat, and organ weight in MH2 group reduced. Conclusions: The combined treatment of Scutellariae Radix and Metformin has impact on treating obesity. Further studies are needed to evaluate the effect of Metformin and herbal medicine combination therapy.

한방치료와 인지행동치료를 병행한 공황장애 환자 1례에 대한 임상적 고찰 (A Case of Combination Therapy of Cognitive - Behavioral Therapy and Oriental Medical Treatment On Panic Disorder)

  • 정효창;성우용;김진원;정병주;장하정
    • 동의신경정신과학회지
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    • 제15권2호
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    • pp.211-219
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    • 2004
  • 상기 환자는 $4{\sim}5$년 발한 공황장애로 로컬 정신과에서 1년간 po. med 하시다 별무 호전하시고, 입원 3일전 증세 심하여 본원의 한방치료를 받은 환자로, DSM-4에 의거하면 광장공포증을 동반한 공황장애 환자로 한방적으로는 신음양구허(腎陰陽俱虛)에 간울화화(肝鬱化火)를 겸하였다고 하겠다. 지원탕(志遠湯)을 투여하고, 변증에 따라 자침하며, 주관법(走罐法)을 시행하고, 더불어 인지행동치료를 병행하여 PDSS상 21점이 13점으로 감소하는 좋은 결과를 내어 이를 보고하는 바이다. 하지만 관찰 기간이 그리 길지 않았고, 한방치료와 인지행동치료를 함께 시행함으로써 이상의 치료들 중 어떤 치료가 어느 정도의 효과를 내었는지 그 정도를 측정할 수 없으며, 측정절차도 환자의 주관적인 증상의 호소에 의존하여 객관성이 다소 결여되었다. 이를 보완하기 위해 공황장애에 대한 한방치료, 인지행동치료, 그리고 두 가지를 병행한 치료를 각각 시행한 후 효과를 후위분석연구를 통해 검증한다면 한방치료와 인지행동치료가 각각 어느 부분에 어느 정도의 치료효과를 발생시켰는지 검증할 수 있을 것이다. 이를 위한 향후 객관적이고 지속적인 연구가 필요하리라 사료된다.

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척수공동증을 동반한 경추통 환자에 대한 치험 2례 보고 (Case Reports on Neck Pain with Cervical Syringomyelia Patients Treated by Korean Medical Therapy)

  • 유형진;김민균;이동현;박주언;이현호;정성현
    • 척추신경추나의학회지
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    • 제10권1호
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    • pp.107-116
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    • 2015
  • Objectives : The purpose of these clinical cases is to evaluate the effectiveness of Korean medical therapy on neck pain with cervical syringomyelia Methods : These are case reports on 2 patients admitted to Daejeon jaseng Hospital of Korean Medicine with neck pain and diagnosis of cervical syringomyelia by Cervical spine Magnetic Resonance Imaging, were observed during hospitalization. They were analyzed according to pain and Cervical spine Range of Motion. All patients received a combination of treatments including Acupunture, Chuna, Pharmacopunture, Herbal medication. Pain scales(Number Rating Scale, Neck Disability Index) and Cervical spine Range of Motion were used during hospitalization. Results : After 3 weeks for these patients, Cervical spine Number Rating Scales decreased from 7 to 3 and from 9 to 4 respectively. And Trapezius muscle Number Rating Scales decreased from 7 to 3 and from 2 to 1 respectively. Also Cervical spine Range of Motion improved to the normal. Conclusions : Korean medical therapy might be effective in reducing pain and improving range of motion for patients with neck pain. And we hope this study further confirmed the effectiveness of Korean medical therapy on neck pain with cervical syringomyelia.

Change in Adiponectin and Oxidative Stress after Modifiable Lifestyle Interventions in Breast Cancer Cases

  • Karimi, Niloofar;Roshan, Valiollah Dabidi
    • Asian Pacific Journal of Cancer Prevention
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    • 제14권5호
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    • pp.2845-2850
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    • 2013
  • Background: Breast cancer is one of the most frequent diseases in women today. Little information exists on modifiable lifestyle factors including effects of ginger supplements (as an anti-oxidant and anti-inflammatory herbal) and water-based exercise on biomarkers related to oxidative stress such as malondialdehyde (MDA), nitric oxide (NO) and glutathione peroxidase (GPx) and adiponectin in obese women with breast cancer. The aim of this study was to determine the single and concomitant effect of 6-wks water-based exercise and oral ginger supplement on the aforesaid markers in obese women with breast cancer. Materials and Methods: Forty women diagnosed with breast cancer ($48{\pm}5.4$ years, $76{\pm}9$ kg, fat mass $41.8{\pm}4%$), volunteered to participate in the study. Subjects were randomly assigned into four groups; placebo, water-based exercise, ginger supplement and water-based exercise+ginger supplement groups. Subjects in the ginger supplement group and the water-based exercise+ginger supplement group orally received 4 capsules (each capsule contained 750 mg), 7 days a week for 6 weeks. The water-based exercise program featured progressive increase in intensity and time, ranging from 50% to 75% of heart rate reserve, in a pool with 15 meters width, 4 times a week for 6 weeks. Fasting blood samples were collected at pre-test and post-test time points. Results: The ginger supplementation and or the water-base exercise resulted in an increase of adiponectin, NO and GPx and reduction MDA, as compared to pre-test values. However, the combined intervention (water-base exercise and ginger supplement) group showed significantly a far better effect on the biomarkers related to oxidative stress and adiponectin levels, as compared to the waterbase exercise or ginger supplement alone groups and the age-matched placebo group. Conclusions: Our results revealed that water-base exercise is a non-drug therapeutic strategy to reduce systemic stress in obese women suffering from breast cancer. Further, ginger supplementation alone or in combination with training, also play an important role in the pathogenesis of oxidative stress in obese women diagnosed with breast cancer.

운동, 알코올, 약물 등 복합적 요인으로 유발된 횡문근융해증 환자 치험 1례 (A Case Report of Rhabdomyolysis Induced by a Combination of Exercise, Alcohol, and Medication)

  • 진준수;이희정;민백기;공원호;서호석;김진원
    • 대한한방내과학회지
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    • 제39권5호
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    • pp.904-913
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    • 2018
  • Rhabdomyolysis is a syndrome that evokes either myopathy or cola-colored urine with elevated creatine kinase and myoglobin levels. The most common complication of rhabdomyolysis is acute renal failure (ARF). A large quantity of fluid must be injected promptly the first time symptoms appear, whereas sequela of symptoms has remained in the long run. In this report, a 58-year-woman was diagnosed with ARF due to rhabdomyolysis induced by exercise, alcohol, and medication. A treatment of acupuncture and herbal medicines was carried out for over 2 months. To evaluate the condition of the patient's lower limb, a short form of the McGill Pain Questionnaire, Visual Analogue Scale (VAS), European Quality of Life-5 Dimensions (EQ-5D), and Manual Muscle Test (MMT) points were used. As a result, clinical symptoms and quality of life improved noticeably after treatment with Korean medicine. This suggests that Korean medicine has an effect on rhabdomyolysis.

보양환오탕에 의한 비특이적 세포독성 T 세포 활성 증강 (Promotion of Nonspecific Cytotoxic T Lymphocyte Activity by Bo-yang-hwan-oh-tang)

  • 하종천;김영현;우원홍;남상윤
    • 생약학회지
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    • 제32권3호통권126호
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    • pp.226-232
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    • 2001
  • To explore the possible cancer therapeutic application of "Bo-yang-hwan-oh-tang" (BH), a herbal medicinal recipe used for improvement of blood stasis, we have examined its direct cytotoxicity against tumor cell, and induction of cytotoxic activity of lymphocytes. Water extract of BH alone did not exhibit direct cytotoxicity to Yac-1 target cells even with high concentrations (10 mg/ml). By exposure for 3 days, BH did not induce any nonspecific cytotoxic activity of mouse spleen cells, either, when assessed in a 4 hr $^{51}Cr-release$ assay. However, when BH was added during CD3 stimulation of non-adherent spleen cells, non-specific CTL activity was markedly promoted in a dose dependent manner. In contrast, BH did not alter activated NK cell activity following IL-2 stimulation. These data suggest that BH does not induce but upregulates non-specific CTL effecter function and that activated NK cell does not respond to BH. For elucidation of the mechanism underlying this function of BH, time kinetic study for IL-2 production using ELISA was undertaken. IL-2 production following CD3 stimulation was significantly augmented and higher level of IL-2 is sustained over 3 days in the culture medium by BH treatment. Moreover, addition of exogenous IL-2 during CD3 stimulation resulted in a similar level of cytotoxicity between control and BH-treated culture. These data indicate that the BH-mediated upregulation of non-specific CTL activity is contributed by augmentation of IL-2 production. Our data imply the possible application of BH for combination therapy of cancer with non-specific activator.

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REM 수면 행동 장애의 치료에 대한 중의학 및 Kampo의 연구 경향 (Recent Reports in Treatment for REM Sleep Behavior Disorder in Traditional Chinese Medicine and Kampo in Japan)

  • 최윤희;정진형;김보경
    • 동의신경정신과학회지
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    • 제24권4호
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    • pp.343-352
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    • 2013
  • Objectives: This study was performed to review the research trends in treatment for REM sleep behavior disorder (RBD) in Traditional Chinese Medicine (TCM) and Kampo in Japan. Methods: We searched articles in CNKI (China National Knowledge Infrastructure) under the key words, "RBD", and Chinese words related with it in Traditional Chinese Medicine, Traditional Chinese Medicinal Herbs and Combination of Traditional Chinese Medicine With Western Medicine' field, and also in CiNii (Citation Information by NII); we also searched articles in Kampo Square in Japan under the key words, "RBD" and Japanese words related with it. We found 10 papers, and then selected 6 of them except the non-clinical and unrelated studies. We then analyzed their way of diagnosis, treatments, study type and etc.. Results: 6 studies were divided into 4 case reports, one control study, and one literature review study. All of the studies reported that Herbal medicine for RBD was effective as much as Western medicine like clonazepam and paroxetine. However, the quality and the quantity of these clinical studies were not enough. Conclusions: It seems that the researches for RBD have gradually been performed in TCM and Kampo. We hope that our study can activate/push forward clinical research for this disorder in Korean traditional medicine.

방풍통성산(防風通聖散)의 문헌(文獻) 및 형상의학적(形象醫學的) 고찰(考察) (Documentational Study and Observation from the View of Hyungsang Medicine on Bangpungtongseong-san)

  • 석민희;김준홍;이용태
    • 동의생리병리학회지
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    • 제22권1호
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    • pp.51-59
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    • 2008
  • The following conclusions were obtained from the studies on Bangpuntongseongsan both from the documents and Hyungsang medicine. Bangpungtongseong-san was created by Yu Wan-so to relieve both interior and exterior of disease from the pathogenic fire, and it cures wind syndrome and dry syndrome. Bangpungtongseong-san is of light herbal combination and it works in the upper part of the body and is mainly applied to skin disease. Perspiration without harming the exterior and purgation without hurting the interior shows that it is not a severe prescription belonging to meditation therapy. It is mostly used for curing the disease of internal heat caused by over drinking and consuming heavy food, and it has special relationship with Yangmyung meridian. It is mentioned in the chapters of spirit, head, face, eye, ear, nose, throat, skin, hair, prescription, wind, dryness, fire, internal damage, epidemic infectious disease, carbuncle and cellulitis, ulceration, and pediatrics of ${\ulcorner}$Donguibogam${\lrcorner}$. It is usually applied to those who belong to Yangmyung type of the six meridian types or wind type, who has excessive heat, people with red complexion, reddened nose, pimples over the face and nose, coarse heel, loss of hair due to wind-heat, and to those who tend to have dandruff. Through examination over the cases treated with Hyungsan medicine, Bangpungtongseong-san was found efficacious in bloodshot eyes, brandy nose, loss of hair, various skin problems, tetanus, acute alcoholism, paralysis of hand and foot, deafness, and tinnitus.

Capsaicin 약침(藥鍼)이 흰쥐의 급성(急性) 염좌(捻挫)에 마치는 효과 (Capsaicin Pharmacopuncture Modulates Ankle Sprain Induced Pain in Rats)

  • 박상연;최윤영;전인숙;구성태;김경식;손인철;김재효
    • Korean Journal of Acupuncture
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    • 제23권2호
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    • pp.113-123
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    • 2006
  • Objectives: Pharmacopuncture which is a combination of acupuncture and herbal medicine helps to prevent and treat the diseases and symptoms including various pains. However, little was known about the therapeutic effects and its mechanisms on acute pain, although pharmacopuncture has been used frequently in acupuncture clinics. Acupuncture is known for producing analgesia for persistent ankle sprain pain in human. Furthermore, it also produces analgesia in a rat model of ankle sprain pain. Methods: To illuminate the underlying mechanisms of capsaicin pharmacopuncture-induced analgesia, weight bearing force (WBF) was observed on the acute ankle sprained rat model. Ankle sprain was induced in the rat by manually hyper-extending ligaments of the right ankle. Capsaicin pharmacopuncture was applied to SI6 (Yanglo) on the left forelimb (contralateral to the sprained ankle). Results: In behavioral test, capsaicin pharmacopuncture produced marked analgesic effects on acute ankle sprained animals as measured by WBF of the affected limb similar to manual acupuncture. Capsaicin pharmacopuncture was also suppressed by serotonin (5-HT) receptor antagonist methysergide (2 mg/kg, Lp.), but not by opioids receptor antagonist naltrexone (10 mg/kg, Lp.) and alpha adrenoceptor antagonist phentolamine (5 mg/kg, Lp.). Conclusion: The data suggest that capsaicin pharmacopuncture-induced analgesia is accomplished by activating the descending serotonergic inhibitory systems.

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한방 안과에 내원하여 안저 검사를 시행한 환자 463명에 대한 후향적 연구 보고 (The Retrospective Study of 463 Patients who had Funduscopy Examination at Korean Medicine Ophthalmology)

  • 이마음;정미래;김철윤;권강;서형식
    • 한방안이비인후피부과학회지
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    • 제33권2호
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    • pp.1-11
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    • 2020
  • Objectives : The purpose of this study was to analyze and report status of Korean Medicine Ophthalmology patients who did funduscopy examination. Through this, we hope that the development of our diagnosis and treatment. Methods : From June 1, 2010 to May 31, 2019, Based on the electronic medical records of patients who had funduscopy examination at Korean Medicine Ophthalmology, Busan University Korean Medicine Hospital, the gender, age, visiting motives and paths, diagnosis, examination number of years, other eye examinations and treatments method were summarized and analyzed. Results : 463 patients were able to check the electronic medical records. They were 283 females and 180 males. The mean age of the patients was 51.5 years and elderly patients who 50s and 60s were 49.3% of whole patients. The most common motives for Korean Medicine Ophthalmology visitation was 'combination treatment with other department in Korean Medicine Hospital'. Outer eye diseases were 283 cases, inner eye diseases were 198 cases. Dry eye syndrome, asthenopia, visual discomfort, conjunctivitis, and eye discomfort were most common in the outer eye diseases. Cataracts, Vitreous floater, Macular Degeneration, Glaucoma and Ocular Pain were most common in the inner eye disease. The most common parts of outer eye diseases were Conjunctival, lacrimal gland, paralytic, corneal, eyelid and front uveal, scleral disease and then in inner eye diseases parts, Retinal, lens, vitreous, glaucoma, optic nerve, behind uveal, choroid disease were most common. The number of funduscopy examination was ups and downs. Herbal medicine was the most common used. Conclusions : The funduscopy examination is essential for diagnosis and treatment of eye disease. We hope that the use of fundus examination and other ophthalmologic examination will be expanded soon in Korean Medicine Ophthalmology.