• Herbal Formula Science
• /
• v.25 no.1
• /
• pp.11-28
• /
• 2017

Objectives : The contents of aconitine in aconiti radix lateralis preparata, purified hot water extract of Aconiti Radix lateralis preparata, and purified hot water extract of Sambutang-P that contains Aconiti Radix lateralis preparata was analyzed to compare toxicity. Toxicity of Sambutang-P that contains Aconiti Radix lateralis preparata was assessed with a single oral toxicity test on 6-week-old male and female Sprague-Dawley rats. Methods : 1. The contents of aconitine in Aconiti Radix lateralis preparata, purified hot water extract of Aconiti Radix lateralis preparata, and purified hot water extract of Sambutang-P that contains Aconiti Radix lateralis preparata was analyzed using the purity test according to the "Korean Herbal Pharmacopoeia". 2. 2,000mg/kg was injected for the single oral toxicity test of purified hot water extract of Sambutang-P that contains Aconiti Radix lateralis preparata, and the test was done for a test group (injection) and a control group, each with 5 male and 5 female rats. For 14 days after injection, rats were observed for general symptoms and changes in weight. Afterwards, blood biochemical test, autopsy, and histophathological exam of the liver was conducted. Results : 1. The contents of aconitine was 0.0785% for Aconiti Radix lateralis preparata, 0.1510% for purified hot water extract of Aconiti Radix lateralis preparata, and 0.1248% for purified hot water extract of Sambutang-P that contains Aconiti Radix lateralis preparata. 2. There was no death of either male or female rats in both the control group and the test group (injection of 2,000mg/kg). 3. No unusual symptom was observed in both the control group and the test group (injection of 2,000mg/kg). 4. No significant change in weight was observed for both male and female rats in the test group (2,000mg/kg). 5. The histopathological exam of ALT, AST, ALP, GGT and LDH showed no significant changes for both male and female rats in the test group (2,000mg/kg). 6. According to the autopsy results, no visible abnormality of organs or tissues was found in both the control group and the test group (2,000mg/kg). 7. According to the histopathological exam of the liver, the effect of the injected material was not observed for either male or female rats in the test group (2,000mg/kg). Conclusions : The contents of aconitine in Aconiti Radix lateralis preparata was lower for decoction of Sambutang-P with ginseng radix alba than for decoction of only Aconiti Radix lateralis preparata. This suggests that ginseng radix alba can dilute toxicity of Aconiti Radix lateralis preparata. As for a single oral toxicity test of Sambutang-P that contains Aconiti Radix lateralis preparata, no abnormal reaction was observed even when the injection amount far exceeded a toxic dose or a lethal dose. Thus, it is deemed that using Sambutang-P at a clinically prescribed dose would not lead to hepatoxicity.

• Journal of Korean Medical classics
• /
• v.28 no.1
• /
• pp.97-110
• /
• 2015

Objectives : Usually medical terminology of oriental mecidine has a multiple meaning. But concept of Shanghan(傷寒) should be simple, because Shanghanlun(傷寒論) is a clinical guideline book. So I researched to suggest many concept of Shanghan, which are suitable for each chapter of Shanghanlun. Methods : I enumerated provisions including Shnaghan from the original texts of Gangpyeong-Shanghanlun(康平傷寒論). And I translated and reviewed them. Results : 1. Shanghan of Preface(序文) means a disease of high fatality. 2. Shanghan of Shanghanrye(傷寒例) means diseases due to physical damage of cold weather. 3. Shanghan of Diagnosis of Daeyang Disease(辨大陽病) - Neck stiffness(痙), Dampness(濕), Sun stroke(暍) means certain disease names accompanying fever, chill. 4. Shanghan used in Diagnosis of Diseases is a premise of many provisions of Shanghanlun. And Shanghan is made up of finished fever, expected fever, chill, body pain, loss of appetite, image of tension. Conclusions : We can use a appropriate translation on Shanghan of each chapter of Gangpyeong-Sanghanlun. Especially Shanghan used in "Diagnosis of Diseases" should have more accurate meaning.

• 대한상한금궤의학회지
• /
• v.10 no.1
• /
• pp.125-132
• /
• 2018

Objective : The purpose of this study is to review a case of hypertension. The patient was 41 years, a male. We stabilized blood pressure after administration of Daehuanghuanglianxiexin-tang. In this paper, we review the interpretation of Shanghanlun by analyzing the patient's progress, diagnosis, treatment. Methods : Blood pressure changes have been monitored during the period. Additionally, We have observed the patients' compliance and accompanied symptom by the timeline analysis. Results : According to Shanghanlun disease pattern identification diagnostic system, Wediagnosed a Greater yang disease. The patient was treated with Daehuanghuanglianxiexin-tang for 2 months. Daehuanghuanglianxiexin-tang was able to control blood pressure to under 120mmhg / 80mmhg. During the treatment period, the accompanied symptom Stiffness and pain in posterior neck has improved, patient's compliance was good, and symptoms improved without significant complication Conclusions : Taking of the Daehuanghuanglianxiexin-tang makes patient's blood pressure controlled to safe and stable range and eases the discomfort of posterior neck pain.

• 대한상한금궤의학회지
• /
• v.10 no.1
• /
• pp.1-13
• /
• 2018

Objectives : Purpose of this study is to suggest a diagnostic definition of Chest bind(結胸) in GangpyeongShnghanlun 15 letters provision. Methods : Using The Etymology Dictionary of Chinese Characters, we interpreted the meaning of Chest bind(結胸) and symptoms on 134th provision of Shanghanlun. Results : The meaning of Chest bind is endurance of worries. Symptoms on 134th provision can be interpreted as follows. Worrywart person whose behavior is dilatory, who suffer from an inferiority complex, feel pressure on chest, feel heavy with worries, unstable, talkative, suffer from a feeling of anger, think himself as fallen into a trap, feel always nervous and is stubborn can be in a situation of Chest bind. Conclusions : Chest bind is one of the Names of disease in Shanghanlun. The Name of disease has its own meaning that can be used as diagnostic evidence. Further studies are needed to verify a hypothesis of diagnostic definition of Chest bind.

• 대한상한금궤의학회지
• /
• v.12 no.1
• /
• pp.171-182
• /
• 2020

Objective : The purpose of this study is to report the improvement in a patient who had Tourette syndrome treated with Hoeyeoksan based on Shanghanlun provisions. Methods: The symptoms of the patient were checked on days 14, 34, 62, 82, 103, and 119 after administration of Hoeyeoksan. Tourette syndrome was evaluated using Yale Global Tic Severity Scale (YGTSS), and oversleep and constipation were evaluated using visual analog scale (VAS). In addition, new clinical implications for the interpretation of Shanghanlun provision 318 were reviewed. Results: Daily tics occurred ten times a day for 14 days after the initial diagnosis but decreased to eight times a day after 34 days, six times a day after 62 days, five times a day after 82 days, twice a day after 103 days, and once a day after 119 days after administration of Hoeyeoksan. Oversleep and constipation improved together with Tourette syndrome. Conclusions: In this study, we observed that Hoeyeoksan had a therapeutic effect by improving the chief complaint of the patient. Hence, the interpretation of Shanghanlun provision 318 must include a patient's behavioral and sleep patterns as predisposing factors of Tourette syndrome.

• 대한상한금궤의학회지
• /
• v.13 no.1
• /
• pp.165-178
• /
• 2021

Objective: This study aimed to report the improvement of a patient with chronic insomnia who was treated with Baekho-tang based on the Shanghanlun disease pattern identification diagnostic system (DPIDS). Methods: The patient's symptoms were checked on days 19, 37, and 52 after taking Baekho-tang. Chronic insomnia was evaluated by the degree of insomnia, hours spent asleep, and the number of times the patient woke up during the night, which were all assessed by a visual analog scale (VAS) with the Leeds Sleep Evaluation Questionnaire. In addition, new clinical implications for the interpretation of the 350th Shanghanlun provision were reviewed. Results: After administering Baekho-tang for 52 days, based on the 350th Shanghanlun provision according to the DPIDS, the VAS score decreased from 10 to 1. Conclusions: The patient recovered from chronic insomnia. This case report suggests that the words "滑," "厥," and "裏" in the 350th provision of Shanghanlun mean physical and psychological causes of insomnia. In addition, Baekho-tang had a therapeutic effect in improving the chief complaint of the patient. Therefore, the interpretation of the 350th Shanghanlun provision requires a new definition that includes the patient's lifestyle, family conflict, and past history of the patient as a cause of chronic insomnia.

• 대한상한금궤의학회지
• /
• v.14 no.1
• /
• pp.81-93
• /
• 2022

Objective : This study reports on the case of a patient with irritable bowel syndrome (IBS) diagnosed by the Shanghanlun disease pattern identification diagnostic system (DPIDS). We tried to verify the therapeutic effects of Soseunggi-tang (SSGT) administration and pathological character. Methods : The patient was administered SSGT for 31 days. We observed the progression of symptoms, patient compliance, and the presence of side effects. The progression of IBS was evaluated based the on Gastrointestinal Symptom Rating Scale (GSRS). Abdominal pain, flatus, visual findings, and patient statements were also assessed. Results : According to the DPIDS, the patient was diagnosed with Yangmingbing (陽明病). As a result, his GSRS score dropped from 15 to 5, the visual analog scale (VAS) score for abdominal pain lowered from 9 to 4, and the VAS score for flatus decreased from 8 to 4. The stool type changed from diarrhea to a loose stool form. Conclusions : SSGT showed therapeutic effects on the patient diagnosed with IBS and Yangmingbing.

• 대한상한금궤의학회지
• /
• v.15 no.1
• /
• pp.161-182
• /
• 2023

Objective: This is the result of a study on patients with osteochondritis dissecans (OCD) of the talus whose pain was improved by Gamchobuja-tang (GBT). Methods: The patient took GBT for 46 days. We observed the progress of symptoms, patient compliances and side effects. Quality of life related to pain was quantified through the SF-36 and AQoL-6D questionnaires. The degree of pain in the talus and ankle areas was quantified using VAS and observed through the symptoms and frequency complained of by the patient. Results: According to the DPIDS, the patient was diagnosed with the 175 provision in Taeyangbing chestbind (大陽病 結胸). As a result, SF-36 score increased from 36 points to 74 points, and the AQoL-6D score increased from 74 points to 104 points. The visual analogue scale (VAS) of ankle pain lowered from 9 to 2. The number of days with VAS levels 1 also increased. Conclusions: Gamchobuja-tang is effective in reducing pain in the talus area caused by osteochondritis dissecans..

• 대한상한금궤의학회지
• /
• v.15 no.1
• /
• pp.183-196
• /
• 2023

Objective : This study reports a case of chronic Bartholin's cyst treated with Sosiho-tang and suggests a modifying method. Methods : We reviewed a 41-year-old female patient with fatigue accompanied by chronic Bartholin's cyst. Symptomatic changes were checked on every visit using SF-12 (Short-form-12 health survey) and VAS (Visual analogue scale). The 104^th provision in Shanghanlun was compared with diagnosis and process analysis. Results : The modified Sosiho-tang removed Scutellariae Radix and used Phlomidis Radix of the same weight. The exacerbation factors were characterized with excessive activity (大), Edema and swelling of the foot (滿), Feeling tired in morning (朝) in 104th provision. After 45 days modified Sosiho-tang and 15 days Sosiho-tang, SF-12 and VAS ameliorated. No adverse effects was observed to the last follow-up visit. Conclusions : Modified sisiho-tang and Sosiho-tang were effective to the patient. Clinical application of 104^th provision of Shanghanlun can consider excessive activity, edema, and morning fatigue.

• Korean Journal of Pharmacognosy
• /
• v.38 no.1
• /
• pp.50-55
• /
• 2007

This study was designed to investigate the effects KH-204 on erectile dysfunction in hyperlipidemic rat. KH-204 has been evaluated antihyperlipidemic and antierectile dysfunction effects on experimental hyperlipidemic rats induced by high fat diet. After oral administration of the water extract KH-204 (50, 100, 200, 300 mg/kg) to hyperlipidemic rats for 8 weeks, the variables including body weight, total cholesterol, HDL and LDL levels in serum, the expression of eNOS and nNOS in penis were measured. And erectile function was determined by measurement of intracavernosal pressure (ICP) and maximal arterial pressure (MAP) after electrical stimulation of the cavernosal nerve. Oral administration of KH-204 significantly inhibited the increases of serum total cholesterol and LDL-cholesterol levels and the decreased of serum HDL-cholesterol levels in hyperlipidemic rats induced by high fat diet. The penile expression level of the two enzyme (eNOS, nNOS) were increased significantly after oral administration of the KH-204 50 mg/kg. Erectile function after 10 volts stimulation was significantly decreased in the hyperlipidemic rat compared with the normal rat, but increased in KH-204 group compared with hyperlipidemic group. These results suggest that KH-204 is effective for erectile dysfunction in hyperlipidemia.