A case of osteochondritis dissecans of the talus improved by Shanghanlun Gamchobuja-tang

『상한론(傷寒論)』 감초부자탕(甘草附子湯)으로 호전된 거골 박리성 골연골염 증례 1례

  • Jae-young Choi (Namdaemun Sehwa Korean medicine clinic) ;
  • Sung-jun Lee (Korean Medical Association of Clinical Sanghan-Geumgwe) ;
  • Soong-in Lee (Dept. of Herbal Formula Science, College of Korean Medicine, Dogshin University)
  • 최재영 (남대문세화한의원) ;
  • 이성준 (대한상한금궤의학회) ;
  • 이숭인 (동신대학교 한의과대학 방제학교실)
  • Received : 2023.11.05
  • Accepted : 2023.12.29
  • Published : 2023.12.31

Abstract

Objective: This is the result of a study on patients with osteochondritis dissecans (OCD) of the talus whose pain was improved by Gamchobuja-tang (GBT). Methods: The patient took GBT for 46 days. We observed the progress of symptoms, patient compliances and side effects. Quality of life related to pain was quantified through the SF-36 and AQoL-6D questionnaires. The degree of pain in the talus and ankle areas was quantified using VAS and observed through the symptoms and frequency complained of by the patient. Results: According to the DPIDS, the patient was diagnosed with the 175 provision in Taeyangbing chestbind (大陽病 結胸). As a result, SF-36 score increased from 36 points to 74 points, and the AQoL-6D score increased from 74 points to 104 points. The visual analogue scale (VAS) of ankle pain lowered from 9 to 2. The number of days with VAS levels 1 also increased. Conclusions: Gamchobuja-tang is effective in reducing pain in the talus area caused by osteochondritis dissecans..

Keywords

Acknowledgement

이 성과는 정부(과학기술정보통신부)의 재원으로 한국연구재단의 지원을 받아 수행된 연구임(No. 2021R1A2C1009604).

References

  1. The korean orthopaedic association. Orthopaedics. Seoul:Choishineuihaksa 2020;2:1366-9,1960. 
  2. SH Hahn, BK Yang, SR Yi, SW Chung, DH Lee, CH Lee. Treatment of osteochondritis dissecans of the talus. J of korean society of foot surg. 2002;6(2):190-4. 
  3. HIRA bigdata open portal. Medical practice statistics [Cited 2023 Aug 20] https://opendata.hira.or.kr/op/opc/olapDiag BhvInfoTab1.do.
  4. BK Lee. Oriental Medicine Diagnostics. Seoul. Sungbosa 2000;5:202-4. 
  5. SH Jeong, GH Roh, KS Kang, SK Moon, KH Joh, HS Bae. Case of treating the paresthesia suggested from peripheral neuropathy. J Korean oriental med. 2000;22(1):242-7. 
  6. CW Choi. A case of treating the paresthesia suggested from peripheral neuropathy. Korean J orient.int med. 2009;30(3):648-55. 
  7. WY Cho, JY Jung, SH Chung. A study of bi-jeung in the mid-chosun dynasty: Based on the seungjeongwon ilgi. Journal of korean medicine rehabilitation. 2015; 25(2):111-8.  https://doi.org/10.18325/JKMR.2015.25.2.111
  8. Kosinski M, Keller SD, Hatoum HT, Kong SX, Ware Jr JE. The SF-36 Health Survey as a generic outcome measure in clinical trials of patients with osteoarthritis and rheumatoid arthritis: tests of data quality, scaling assumptions and score reliability. Med Care. 1999;37(5 Suppl):MS10-22. 
  9. Pollard B, Johnston M, Dixon D. Exploring differential item functioning in the SF-36 by demographic, clinical, psychological and social factors in an osteoarthritis population. BMC Musculoskeletal Disorders. 2013;14:346. 
  10. Stausholm MB, Naterstad IF, Joensen J, Lopes-Martins RAB, Saebo H, Lund H, et al. Efficacy of low-level laser therapy on pain and disability in knee osteoarthritis: systematic review and meta-analysis of randomised placebo-controlled trials. BMJ Open, 2019;9(10):e031142. 
  11. JE Ware , KK Snow , M Kosinski , B Gandek . SF-36 Health Survey: Manual and Inter- pretation Guide. New England Medical Center, Boston MA, 1993. 
  12. MM Al Mahrouqi, DA MacDonald, B V icenzino, MD Smith. Quality of life, function and disability in individuals with chronic ankle symptoms: across-sectional online survey. Journal of Foot and Ankle Research. 2020;13:67-76.  https://doi.org/10.1186/s13047-020-00432-w
  13. Lee SI, Cho HR. Comparison of Shanghanlun. Seoul:KMediACs publishing house. 2015:39,104,173,218. 
  14. GB Jang. Korean translation Gyeongagjeonseo. Seoul Iljungsa. 1992;2:71. 
  15. Naver chinese letter dictionary. 濕. [Cited 2023 Aug 20] Available from: URL: https://hanja.dict.naver.com/#/entry/ccko/ec39285705264bde955fa1852d351fbf. 
  16. Ha YS. hanjaeowonsajeon. 3 publication. 2014:483. 
  17. Choi JY. Effects of Kamchobujatang((甘草附子湯) on Papain-Induced Osteoarthritis in Mice. Dept. of Oriental Medicine Graduate School Daejeon University.2012. 
  18. Choi JS, Jung SH, Seo IB, Kim SJ. Effects of Gamchobuja-tang on the Adjuvant-induced Arthritis in Rats. The Society of Korean Medicine Rehabilitation. 2012;22(2):105-18. 
  19. Li N, Zhou T, Wu F, Zhao Q. Pharmacokinetic mechanisms underlying the detoxification effect of Glycyrrhizae Radix et Rhizoma (Gancao): drug metabolizing enzymes, transporters, and beyond. Expert Opinion on Drug Metabolism & Toxicology. 2019;15(2):167-77.  https://doi.org/10.1080/17425255.2019.1563595
  20. Fu Y, Zou YF, Lei FY , Wangensteen H. Aconitum carmichaelii Debeaux: A systematic review on traditional use, and the chemical structures and pharmacological properties of polysaccharides and phenolic compounds in the roots. Journal of Ethnopharmacology. 2022;291:115148. 
  21. Zhu B, Zhang QL , Hua JW, Cheng WL, Qin LP. The traditional uses, phytochemistry, and pharmacology of Atractylodes macrocephala Koidz.: A review. Journal of Ethnopharmacology. 2018;226:143-67.  https://doi.org/10.1016/j.jep.2018.08.023
  22. Zhang C, Fan L, Fan S, Wang J, Luo, Tang Y, Chen Z, Yu L. Cinnamomum cassia Presl: A Review of Its Traditional Uses, Phytochemistry, Pharmacology and Toxicology. Molecules. 2019;24(19):3473.