• Korean Journal of Pharmacognosy
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• v.43 no.3
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• pp.231-238
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• 2012

Menthae herba (MH) extracts exhibit anti-inflammatory effects. The purpose of this study was to determine whether the anti-inflammatory effects of MH extracts vary according to the cultivation regions. We performed a comparative analysis of MH extracts by evaluating the production of inflammatory mediators in RAW 264.7 murine macrophage cells and HaCaT human keratinocyte cells. MH extracts obtained from different cultivation regions in Korea and China significantly reduced the production of nitric oxide (NO), prostaglandin $E_2$ ($PGE_2$), and tumor necrosis factor-${\alpha}$ (TNF-${\alpha}$) in RAW 264.7 cells stimulated with lipopolysaccharide (LPS). No differences in these inhibitory activities were observed between MH extracts. In HaCaT cells stimulated with TNF-${\alpha}$ and interferon-${\gamma}$ (IFN-${\gamma}$), MH extracts did not inhibit the production of macrophage-derived chemokine (MDC/CCL22), but most extracts reduced the production of the regulated on activation normal T-cell expression and secreted (RANTES/CCL5). We used clustering tree analysis of the MH extracts according to the chromatographic pattern and anti-inflammatory potency of MH extracts. We observed differences in the chromatographic pattern of MH extracts but no difference in anti-inflammatory potency. Our findings suggest that MH extracts from different regions do not show any differences in their pharmacological potency in that MH extracts are used as therapeutic agents to treat inflammatory disorders.

• Journal of the Korean Wood Science and Technology
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• v.50 no.6
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• pp.448-457
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• 2022

Yersinia enterocolitica, which causes yersiniosis, is a bacterium that produces biofilms effectively. The inhibition of biofilm formation provides a method for preventing infections with Y. enterocolitica. In this study, the inhibitory activity of Y. enterocolitica biofilm formation was investigated in a library of 140 edible plant methanol extracts including forest products. It was identified that the biofilm formation could be inhibited by 12 extracts of plants, Agastachis Herba, Agrimoniae Herba, Diospyros kaki leaves, Elsholtziae Herba, Ginkgonis Semen, Lycopi Herba, Melonis Pedicellus, Menthae Herba, Mori Radicis Cortex, Polygoni Multiflori Radix, Prunellae Spica, and Schizonepetae Spica. After changing the solvent to ethanol and water, the greatest inhibition of biofilm formation was produced by a 50% ethanol extract of Polygoni Multiflori Radix. A method to effectively prevent yersiniosis can be developed using the edible plant extracts identified in this study.

• Korean Journal of Pharmacognosy
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• v.37 no.1 s.144
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• pp.48-52
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• 2006

Advanced glycation end products (AGEs) are largely involved in the pathogenesis of diabetic complications. As part of our ongoing project directed toward the discovery of preventive and/or delay agents for diabetic complications from natural sources, 92 Korean traditional herbal medicines have been investigated with an in vitro evaluation system using AGEs inhibitory activity. Of these, 17 herbal medicines exhibited a significant inhibitory activity against AGEs formation. Particularly, 9 herbal medicines, i.e., Cinnamomi Cortex, Artemisiae Argyi Herba, Ammoni Tsao-ko Fructus, Menthae Herba, Amomi Semen, Polygoni Avicularis Herba, Lycopi Herba, Salviae Radix, and Nelumbinis Semen showed more potent inhibitory activity (2-4 fold) than the positive control aminoguanidine.

• The Journal of Korean Medical History
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• v.24 no.2
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• pp.117-123
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• 2011

Objectives : To quantitatively analyze the academic characteristics of Yuhagan and Idongwon and compare it to existing qualitative analysis. Methods : The prescriptions listed in Somunsunmyungronbang and Nansilbijang were entered into a database. Commonly used combination of medical herbs were researched throughout the literature. Results : In Nansilbijang, among the combinations of 8 medical herbs, Glycyrrhizae Radix, Cimicifugae Rhizoma, Bupleuri Radix, Ginseng Radix, Citri Pericarpium, Atractyodis Rhizoma, Astragali Radix, Phellodendri Cortex combination was used 11 times out of the 277 prescriptions. In Somunsunmyungronbang, combinations of 7 medical herbs: (Glycyrrhizae Radix, Platycodi Radix, Rhei Radix et Rhizoma, Menthae Herba, Atractylodis Rhizoma Alba, Gypsum Fibrosum, Forsythiae Fructus), (Glycyrrhizae Radix, Angelicae gigantis Radix, Paeniae Radix Alba, Atractylodis Rhizoma Alba, Gypsum Fibrosum, Cnidii Rhizoma, Scutellariae Radix), (Glycyrrhizae Radix, Platycodi Radix, Angelicae gigantis Radix, Rhei Radix et Rhizoma, Atractylodis Rhizoma Alba, Gypsum Fibrosum, Schizonepete Herba) were each used 7 times out of the 350 prescriptions. Conclusions : Nansilbijang shows more prescriptions applying Cimicifugae Rhizoma, Bupleuri Radix, Ginseng Radix, Citri Pericarpium, Atractyodis Rhizoma, Astragali Radix, Phellodendri Cortex. Prescriptions aimed to tonify ql with Ginseng Radix and Astragali Radix, to upraise the middle qi with Bupleuri Radix and Cimicifugae Rhizoma, and to regulate qi with Citri Pericarpium and Atractyodis Rhizoma were common. Somunsunmyungronbang preferred the use of Angelicae gigantis Radix, Platycodi Radix, Rhel Radix et Rhizoma, Gypsum Fibrosum, Schizonepete Herba, Forsythiae Fructus and Menthae Herba so its focus was on the aggressive management of febrile diseases.

• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• v.12 no.1
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• pp.295-312
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• 1999

A literature study on the nasal stuffiness, the results are as follows. 1. The pathogenic factors nasal stuffiness are wind-cold, cold, fire-heat, heart & lung disease, deficiency of lung-energy and spleen & stomach disease caused by internal damage. 2. The method on the external treatment of nasal stuffiness are obstructive method, blowing method and pouring method, obstructive method used many. 3. The method on the internal treatment of nasal stuffiness are diaphoretic therapy, clearing away heat & toxic materials and warming the lung & invigorating the spleen. 4. You-taek-tong-gue-tang is used in nasal stuffness. 5. Herba Asari, Radix Angelicae Dahuricae, Flos Magnaliae, Fructus Xanthii, Rhizama Acori Graminei, Herba Menthae, Zanthoxyli Fructus and Spina Gleditsiae are used in nasal stuffness.

• Journal of Haehwa Medicine
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• v.8 no.2
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• pp.171-189
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• 2000

By Literatural studying on migraine, The results were obtained as fallow : 1. A different name on migraine were called hemicrania(頭偏痛, 邊頭痛, 偏頭風). 2. In the cause of a disease in migraine, the cases were clasified into the fallowing kind : internal cause were a decline in energy and blood(氣血具虛), external cause were outside evil(外邪) in wind cold heat wetness(風寒暑濕), non internal, external cause were exhaustion. The right side migraine were concerned phlegm heat, the right side migraine were concerned wind decline in blood. 3. Migraine is appeared on the side, For the reason, liver function in excess of normal limits(肝陽上亢), a sudden of liver fire(肝火) is becomeed of invasion upon soyangkuong(少陽經) in internal external cause 4. Usage method of medicines is appeared that order underclothes theraphy(內服法), to pump out in nose theraphy, to join head theraphy(頭點法), heating smoke theraphy(熏煙法) 5. CNIDII RHIZOMA(川芎) is in mostly general use for migraine, in that order LEDEBOURIELLAE RADIX(防風) ANGELICAE DAHURICAE RADIX(白芷) ASARI HERBA CUM RADICE(細辛) NOTOPTERYGII RHIZOMA(羌活) GLYCYRRHIZAE RADIX(甘草) CHRYSANTHEMI FLOS(菊花) BUPLEURI RADIX(柴胡) SCUTELLARIAE RADIX(黃芩) ANGELICAE GIGANTIS RADIX(當歸) GYPSUM FIBROSUM(石膏) MENTHAE HERBA(薄荷) GLYCYRRHIZAE RADIX(炙甘草) VITICIS FRUCTUS(蔓荊子), nature is in mostly general hot warm(辛溫), bitter cold(苦寒), guikuong(歸經) is in mostly general liver gall kuong(肝膽經), efficacy is in mostly general to remove wind pain (祛風止痛) and to down fire(瀉火).

• Journal of Sasang Constitutional Medicine
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• v.23 no.2
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• pp.184-193
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• 2011

1. Objectives: This paper investigates the origin, the progressive changes and the constructive principles of Yangkyuksanhwa-tang (凉膈散火湯). 2. Methods: Yangkyuksanhwa-tang and other related prescriptions were analyzed in terms of their pathological indications, based on previous literature including "Donguisusebowon Chobongwon (東醫壽世保元 草本卷)", "Donguisusebowon Gabobon (東醫壽世保元 甲午本)", "Donguisusebowon Sinchukbon (東醫壽世保元 辛丑本)" and "Dongmuyugo (東武遺稿)". 3. Results and Conclusion: 1) The Yangkyuksanhwa-tang most likely originates from Sodokeum, Yangkyuksan, Baekho-tang and Indongdeung. 2) Sodoksanhwa-tang introduced in "Donguisusebowon Chobongwon (東醫壽世保元 草本卷)" progressively transformed into Chungyangsanghwa-tang ("Donguisusebowon Gabobon (東醫壽世保元 甲午本)") and ultimately into Yangkyuksanhwa-tang ("Donguisusebowon Sinchukbon (東醫壽世保元 辛丑本)"), a prescription appropriate for usage in the Sangso symptomatology (上消證). 3) Yangkyuksanhwa-tang is composed of 9 herbs. Of these, Schixonepetae herba(荊芥), Ledebouriellae Radix(防風), Forsythiae fructus(連翹), Menthae Herba(薄荷), Gardeniae fructus(梔子) scatter the Hwa-qi(火氣), and Rehmanniae Radix(生地黃), Gypsum fibrosum(石膏), Anemarrhenae(知母) put off the Stomach-heat(胃熱), whereas Lonicerae caulis(忍冬藤) support the prevention of carbunculosis(癰疽).

• Toxicological Research
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• v.21 no.3
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• pp.255-261
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• 2005

Gami-Samhwang-San, a herbal prescription for obesity treatment, is composed of seven crude herbs such as Rehmanniae Radix Preparata, Ephedrae Herba, Scutellariae Radix, Acori Gramineri Rhizoma, Polygalae Radix, Typhae Pollen, Armeniacae Semen, Menthae Herba. In this study, marker substances in n-butanol fraction (SH-21-B) from Gami-Samhwang-San were analyzed by high performance liquid chromatography (HPLC) and acute toxicity of standardized SH-21-B was evaluated by good laboratory practices (GLP) guideline of Korea Food and Drug Administration. Therefore we confirmed that there were baicalin of 15.92%, amygdalin of 6.57% and ephedrine of 2.49% in SH-21-B. SH-21-B was administered in rats at dose of 0 mg/kg, 2,000 mg/kg, and 5,000mg/kg. Clinical signs of both sexes of rats were observed daily for 14 days after single oral administration. Two female rats one administered at 2,000 mg/kg and the other administered at 5,000 mg/kg, died, but no dead animal was observed among male rats. Therefore $LD_{50}$ in the female rat is observed to be 8,710 mg/kg, and MLD (Minimun Lethal Dose) of the male rat is observed to be more than 5,000 mg/kg.

• Journal of the Korean Society of Food Science and Nutrition
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• v.36 no.11
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• pp.1436-1443
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• 2007

This study was conducted to investigate the shelf-life and quality of Takju added with Glycyrrhiza uralensis (GU), Menthae herba(MH), Schizandra chinensis(SC), and chitosan (C) during storage at $10^{\circ}C$ for 12 days. The viable cell and yeast cell numbers of the Takju treated with Schizandra chinensis powder (SCP) and C were moderately reduced compared with those of the standard. The SC and C Takju were shown to have the lowest oxidations. For turbidity, the SC and C Takju were the most stabilized. Among the treatments, sugar content, pH, and acidity showed no significant differences during storage. However, the lightness, yellowness, and redness value of all the samples were higher than those of the standard. In the sensory evaluation, the standard, SCP, and C scored comparatively higher than the other samples at 0 day. On the other hand, SC and C, GU+MH, and C scored higher after 9 days. From these results, treating Takju with SCP, GU, MH, SC, and C resulted in improvements with regards to its preservation and development of quality.

• Journal of Physiology & Pathology in Korean Medicine
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• v.19 no.3
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• pp.710-715
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• 2005

This research was to investigate inhibitory activity of Sasang medicines on Obesity. 56 kind of herb medicines to powder, abstract add 100 times methanol. Examine inhibitory effect against lipase activity in vitro. It was compared Xenical(Orlistat) with 56 kind of herb medicines. Inhibitory effect against lipase activity of Xenical as a standard was 93.3%. It is Inhibitory effect against lipase activity of Taeyangin herb medicine. (Fructus Pruni Tomentosae 77.7% Cortex Acanthopanacis73.5%, Fructus Chaenomelis73.1%, rice bran on a mallet head68.1%, Semen Fagopyri 48.1%, Radix Vitis 31.5%) It is Inhibitory effect against lipase activity of Soyangin herb medicine. (Radix Saposhnikoviae 91.5%, Semen Plantaginis 90.4%, Semen Trichosanthis 89.2%, Herba Schizonepetae 85.7%, Radix Euphorbiae Kansui 76.1%, Rhizoma Anemarrhenae 76.0%, Cortex Phellodendri 75.1%, Herba Menthae 74.8%, Radix Angelicae Pubescentis 61.2%, Rhizoma Alismatis 62.6%, Poria 60.9%, Rhizoma Notopterygii 22.5%, Radix Peucedani 18.2%, Caulis Akebiae 17.7%) It is Inhibitory effect against lipase activity of Taeeumin herb medicine. (Herba Spirodelae 91.4%, Radix Polygalae 88.3%, Arillus Longanae 84.3%, Radix Platycodi 81.7%, Semen Zizyphi Spinosae 80.2%, Spina Gleditsiae 79.7%, Herba Ephedrae 75.3%, Semen Raphani 73.1%, Rhizoma Cimicifugae 73.0%, Rhizoma Acori Graminei 71.8%, Flos Chrysanthemi71.0%, Radix et Rhizoma Rhei 68.4%, Vermiculus Holotrichia 59.9%, Radix Puerariae 55.3%, Fructus Schizandrae 53.4% Semen Coicis 50.6%, Semen Biotae 47.5%, Semen Nelumbinis 46.7%, Radix Angelicae Dahuricae 45.1%, Semen Castaneae 44.4%, Rhizoma Ligustici 34.5%, Tuber Liriopis 16.4%, Radix Scutellariae4.2%) It is Inhibitory effect against lipase activity of Soeumin herb medicine. (Pericarpium Arecae89.9%, Rhizoma Alpiniae Officinarum 89.5%, Radix Polygoni Multiflori81.2%, Rhizoma Cyperi 79.0%, Cortex Magnoliae 72.8%, Radix Aucklandiae 72.0%, Rhizoma Zingiberis 71.9%, Pericarpium Citri Reticulatae Viride 71.3%, Radix Cynanchi Wilfordi 57.7% Rhizoma Pinelliae 36.7%, Fructus Alpiniae Oxyphyllae 35.8% Fructus Aurantii Immaturus 17.5%, Pericarpium Citri 16.1%) Therefore, Radix Saposhnikoviae(91.5) and Herba Spirodelae(91.4%) were the most effective medicice of 56 kind of medicines.