• 한국정보통신학회논문지
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• 제16권7호
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• pp.1397-1405
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• 2012

협력통신용 MAC 프로토콜은 주파수 자원이 한정된 무선통신망에서 프레임 전송속도를 증가시키는데 매우 중요한 역할을 담당한다. 본 논문에서는 협력통신용 MAC 프로토콜 기법에서 매우 중요한 협력노드를 선정하는 방법에 대하여 연구를 수행하였으며, 선행연구로서 기존에 제안된 도움노드 선정기법들을 컴퓨터 모의실험을 통해 성능평가를 직접 수행하여 성능결과를 서로 비교하였고, 각 기법의 장단점을 분석하였다. 성능평가 척도로는 시스템 처리량을 사용하였으며, 각 통신노드는 IEEE 802.11b 무선 랜 프로토콜을 사용하여 주어진 통신영역 내에서 자유롭게 이동하는 random way point 이동성 모델을 사용하였다.

• Biomolecules & Therapeutics
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• 제27권5호
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• pp.466-473
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• 2019

Angelica gigas has been used as a Korean traditional medicine for pain relief and gynecological health. Although the extracts are reported to have an anti-inflammatory property, the bioactive compounds of the herbal plant and the effect on T cell responses are unclear. In this study, we identified decursinol angelate (DA) as an immunomodulatory ingredient of A. gigas and demonstrated its suppressive effect on type 17 helper T (Th17) cell responses. Helper T cell culture experiments revealed that DA impeded the differentiation of Th17 cells and IL-17 production without affecting the survival and proliferation of CD4 T cells. By using a dextran sodium sulfate (DSS)-induced colitis model, we determined the therapeutic potential of DA for the treatment of ulcerative colitis. DA treatment attenuated the severity of colitis including a reduction in weight loss, colon shortening, and protection from colonic tissue damage induced by DSS administration. Intriguingly, Th17 cells concurrently with neutrophils in the colitis tissues were significantly decreased by the DA treatment. Overall, our experimental evidence reveals for the first time that DA is an anti-inflammatory compound to modulate inflammatory T cells, and suggests DA as a potential therapeutic agent to manage inflammatory conditions associated with Th17 cell responses.

• BMB Reports
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• 제56권3호
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• pp.140-144
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• 2023

While CD8⁺ cytotoxic T cells have long been considered the primary effector in controlling tumors, the involvement of CD4⁺ "helper" T cells in anti-tumor immunity has been underappreciated. The investigations of intra-tumoral T cells, fueled by the recent advances in genomic technologies, have led to a rethinking of the indirect role of CD4⁺ T cells that have traditionally been described as a "helper". Accumulating evidence from preclinical and clinical studies indicates that CD4⁺ T cells can acquire intrinsic cytotoxic properties and directly kill various types of tumor cells in a major histocompatibility complex class II (MHC-II)-dependent manner, as opposed to the indirect "helper" function, thus underscoring a potentially critical contribution of CD4⁺ cytotoxic T cells to immune responses against a wide range of tumor types. Here, we discuss the biological properties of anti-tumor CD4⁺ T cells with cytotoxic capability and highlight the emerging observations suggesting their more significant role in anti-tumor immunity than previously appreciated.

• KSII Transactions on Internet and Information Systems (TIIS)
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• 제7권11호
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• pp.2636-2656
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• 2013

To improve the cooperative efficiency of node cooperation and multiple access performance for multihop wireless networks, a priority-differentiated cooperative medium access control protocol with contention resolution (CRP-CMAC) is proposed. In the protocol, the helper selection process is divided into the priority differentiation phase and the contention resolution phase for the helpers with the same priority. A higher priority helper can choose an earlier minislot in the priority differentiation phase to send a busy tone. As a result, the protocol promptly selects all the highest priority helpers. The contention resolution phase of the same priority helpers consists of k round contention resolution procedures. The helpers that had sent the first busy tone and are now sending the longest busy tone can continue to the next round, and then the other helpers that sense the busy tone withdraw from the contention. Therefore, it can select the unique best helper from the highest priority helpers with high probability. A packet piggyback mechanism is also adopted to make the high data rate helper with packet to send transmit its data packets to its recipient without reservation. It can significantly decrease the reservation overhead and effectively improve the cooperation efficiency and channel utilization. Simulation results show that the maximum throughput of CRP-CMAC is 74%, 36.1% and 15% higher than those of the 802.11 DCF, CoopMACA and 2rcMAC protocols in a wireless local area network (WLAN) environment, and 82.6%, 37.6% and 46.3% higher in an ad hoc network environment, respectively.

• 사물인터넷융복합논문지
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• 제2권1호
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• pp.41-48
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• 2016

논문에서는 python 언어를 학습하고자 하는 학생을 위한 학습 도우미 'PyStudy'를 개발하였다. 'PyStudy'는 콘솔창, 학습창, 학습 진도창, 파이썬 도움말, 학습콘텐츠로 구성되어 있다. 학생은 통상적인 통합개발환경(IDE) 기능과 학습콘텐츠들을 학습창을 통해 이용할 수 있다. 학습도중 모르는 것이 있을 경우 파이썬 도움말을 이용해 빠르게 찾을 수 있다. 학생의 학습관리는 학습 진도창을 통해 이루어진다. PyStudy는 파이썬 언어에 대한 효율적 학습환경을 제공하며, 이를 통해 파이썬 기반 고급 프로그래밍 교육에 적용할 수 있다.

• Restorative Dentistry and Endodontics
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• 제22권1호
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• pp.374-387
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• 1997

The purpose of this study was to examine the distribution of lymphocyte populations in normal, reversibly inflamed and irreversibly inflamed human dental pulp tissues using flow cytometry. Flow cytometry, with specific antibody and fluorochrome reagent allows us to know cellular properties of hematolymphoid cells by measuring fluorescence of stained cells. Before extirpation of pulps in routine endodontic treatment, the clinical diagnosis were performed by symptom. The extirpated pulp tissues were divided into normal pulp group (N=5), reversible pulpit is group(N=10) and irreversible pulpitis group(N=7). The specimen was placed into RPMI 1640 medium, minced into small pieces, and then digested in medium with collagenase. The cell suspension was resuspended in PBS for monoclonal antibody staining of T lymhocytes(CD3+), B lymphocytes (CD19+), T helper cell (CD4+) and T supressor cell (CD8+). The percentages of cells were counted by FACStar(BD) flow cytometer. Following results were obtained; 1. In the most normal and inflamed pulps, the percentages of T lymphocyte, B lymphocytes, T helper cell and T suppressor/cytotoxic cell were less than 1 % in total counted pulpal cells. 2. The higher percentages of T, B, T helper and T suppressor cells were observed in irreversible pulpitis group as compared with the normal pulp and reversible pulpitis group but the differences between groups were not statistically significant (p>0.05). 3. The percentages of T helper cells (CD4 + cells) were greater than that of T suppressor/cytotoxic cells (CD8 + cells) in the inflamed pulps.

• 한국통신학회논문지
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• 제40권10호
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• pp.1947-1957
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• 2015

Content Centric Networking은 많은 연구자들이 관심을 가지고 연구되고 있는 미래 인터넷 중의 하나이다. 가상 네트워크 환경을 지원한 빠른 네트워크의 성장은 폭넓은 서비스를 가능하게 하였고 네트워크가 발달할수록 원거리 고 대역폭에서의 성능 또한 중요한 이슈가 되었다. 원거리 규모의 테스트 환경에서는 원거리의 특성으로 인하여 데이터 전송 지연이 발생할 수 있고 CCN 노드 간에는 혼잡 또는 낮은 연결 속도로 인하여 데이터 전송이 일어날 수 있다. 본 논문에서는 이러한 네트워크 환경에서 CCN-Helper 프로토콜을 제안함으로써 시뮬레이터를 통한 성능 테스트와 국제적으로 연동된 네트워크 테스트베드에서 이기종 머신 간의 데이터 전송 평가를 CCN-Helper 프로토콜을 통하여 검증해 보고자 한다. 국제 연동 네트워크 테스트 환경은 국내의 KREONET과 벨기에의 iLab.t 네트워크를 사용하였다.

• Molecules and Cells
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• 제38권3호
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• pp.195-201
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• 2015

Antibodies are powerful defense tools against pathogens but may cause autoimmune diseases when erroneously directed toward self-antigens. Thus, antibody producing cells are carefully selected, refined, and expanded in a highly regulated microenvironment (germinal center) in the peripheral lymphoid organs. A subset of T cells termed T follicular helper cells (Tfh) play a central role in instructing B cells to form a repertoire of antibody producing cells that provide life-long supply of high affinity, pathogenspecific antibodies. Therefore, understanding how Tfh cells arise and how they facilitate B cell selection and differentiation during germinal center reaction is critical to improve vaccines and better treat autoimmune diseases. In this review, I will summarise recent findings on molecular and cellular mechanisms underlying Tfh generation and function with an emphasis on T cell costimulation.

• Journal of Communications and Networks
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• 제15권3호
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• pp.252-257
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• 2013

To alleviate the damage caused by key exposures, Dodis et al. introduced the notion of key-insulated security where secret keys are periodically updated by using a physically insulated helper key. To decrease the risk of helper key exposures, Hanaoka et al. advocated parallel key-insulated mechanism where distinct helpers are independently used in key updates. In this paper, we propose the first parallel key-insulated signature scheme which is provably secure without resorting to the random oracle methodology. Our scheme not only allows frequent key updating, but also does not increase the risk of helper key exposures.

• 대한기계학회:학술대회논문집
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• 대한기계학회 2001년도 춘계학술대회논문집B
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• pp.325-329
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• 2001

This paper addresses a control architecture for the hospital service robot, SmartHelper. With a sensing-reasoning-acting paradigm, the deliberation takes place at planning layer while the reaction is dealt through the parallel execution of operations. Hence, the system presents both a hierarchical and an heterarchical decomposition, being able to show a predictable response while keeping rapid reactivity to the dynamic environment. The deliberative controller accomplishes four functions which are path generation, selection of navigation way, command and monitoring. The reactive controller uses fuzzy and potential field method for robot navigation. Through simulation under a virtual environment IGRIP, the effectiveness of the control architecture is verified.