• Asian Pacific Journal of Cancer Prevention
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• 제13권7호
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• pp.3471-3476
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• 2012

Background and Objective: Histone deacetylase (HDAC) inhibitors represent a promising class of potential anticancer agents for treatment of human malignancies. In this study, we investigated the effect of trichostatin A (TSA), one such HDAC inhibitor, in combination with docetaxel (TXT), a cytotoxic chemotherapy agent or erlotinib, a novel molecular target therapy drug, on lung cancer A549 cells. Methods: A549 cells were treated with TXT, erlotinib alone or in combination with TSA, respectively. Cell viability, apoptosis, and cell cycle distribution were evaluated using MTT (3- (4, 5-dimethylthiazol-2-yl) -2, 5-diphenyltetrazolium bromide) assay, Hochst33258 staining and flow cytometry. Moreover, immunofluorescent staining and Western blot analysis were employed to examine alterations of ${\alpha}$-tubulin, heat shock protein 90 (hsp90), epidermal growth factor receptor (EGFR), and caspase-3 in response to the different exogenous stimuli. Results: Compared with single-agent treatment, co-treatment of A549 cells with TSA/TXT or TSA/erlotinib synergistically inhibited cell proliferation, induced apoptosis, and caused cell cycle delay at the $G_2/M$ transition. Treatment with TSA/TXT or TSA/erlotinib led to a significant increase of cleaved caspase-3 expression, also resulting in elevated acetylation of ${\alpha}$-tubulin or hsp90 and decreased expression of EGFR, which was negatively associated with the level of acetylated hsp90. Conclusions: Synergistic anti-tumor effects are observed between TXT or erlotinib and TSA on lung cancer cells. Such combinations may provide a more effective strategy for treating human lung cancer.

• Composites Research
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• 제15권1호
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• pp.32-40
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• 2002

가압주조법을 이용하여 전자 패키징용 고부피분율 $SiC_p/Al$ 금속복합재료를 제조하였다. $SiC_p$ 예비성형체를 제조하기 위하여 예비성형체 금형을 고안하였으며, $Al_2O_{3f}$섬유 보강재를 $SiC_p$ 입자 보강재의 1/10비율로 첨가하고, 무기 성형제($SiO_2$)를 0.8% 이하로 사용하여 49~70 vol.% 의 예비성형체 제작에 성공하였다. 제조된 고부피분율 예비성형체로 금속용탕을 원활히 침투시키기 위해 온도, 가압력 등의 제조조건을 정하였으며, 이러한 새로이 고안된 금형조건을 FEM 열전도 해석에 도입하여 금속복합재료 제조시 몰드 내부에서 발생하는 온도변화를 분석하였다. 제조된 금속복합재료에 대해서는 충격특성 및 열팽창계수 특성평가를 실시하였다. 본 연구를 통해 제조된 금속복합재료의 충격흡수 에너지는 0.2~0.3J, 열팽창계수는 $8~10ppm/^{\circ}C$, 밀도는 $2.9~3.0g/cm^3$로 나타나 패기징 재료로서 적합한 특징을 가진 복합재료가 성공적으로 개발되었음을 확인하였다.

• 대한기계학회논문집A
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• 제36권2호
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• pp.217-221
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• 2012

노트북용 액정 모듈 내부의 광학 시트(Optical Sheet) 변형에 기인한 시인성 품질 불량을 개선하기 위한 기초 연구의 일환으로 변형 유발의 요인인 온도 및 습도의 영향을 분석할 수 있는 측정 시스템이 필요하였다. 액정 모듈 내부에는 0.5mm 미만의 미세한 공기 층이 존재하는데, 이 공간으로 외부의 습한 공기가 내부로 확산되는 것으로 추정된다. 이러한 현상을 규명하기 위하여 초소형 온도 및 습도 센서를 실장한 초박형 센서 PCB 를 액정 모듈 내부에 삽입하여 실시간으로 온/습도 변화를 측정 및 분석하였으며, 향후 변형 거동 시뮬레이션 및 구조 설계 시 필요한 기초 데이터로 활용하고자 한다.

• 대한기계학회논문집B
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• 제38권4호
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• pp.347-355
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• 2014

전자장치들의 소형화 및 박형화가 됨에 따라 전자장치의 수명과 직결되는 열적문제가 중요해지고 있다. 열적문제를 해결하기위해 열확산과 단열을 통한 열적 안정성 연구가 필요하다. 허니컴 샌드위치 평판은 이방성의 열전도계수를 갖는다. 허니컴 샌드위치 평판이 적용된 시스템에 대해 온도분포와 열변형을 해석하기 위하여 열 및 탄성 물성치가 필요하다. 본 연구에서는 허니컴 코어의 크기, 두께 그리고 구성된 재료에 따라 허니컴 샌드위치 평판의 물성치가 변하기 때문에 허니컴 샌드위치 평판의 열전도계수, 열팽창계수, 탄성계수, 전단탄성계수, 푸아송비와 같은 열 및 탄성 물성치를 예측하였다.

• 대한한의학원전학회지
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• 제31권3호
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• pp.33-58
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• 2018

Objectives : Literatures related to Bianque are studied to discover the path of development and the impact of Bianque school's pulse diagnosis system. Methods : Texts regarding Bianque were searched in history books such as Shiji and Zhanguoce, and medical texts such as the medical books of Mawangdui Han Tomb, Huangdineijng, Maijing, and Qianjinyifang to understand how the Bianque school's pulse diagnosis system was developed. Results : 1. Bianque school's pulse diagnosis system was used to inspect the distribution pattern of blood vessels and discover the location of the disease including the palpatation realm such as only hard or only fall. 2. The system of inspection was created when the diagnosis method that uses the color of the pulse by using the color of blood vessels was added to the diagnostic method of pulse condition. 3. Adding the concept of pulse to the visual information that derives from pulse condition becomes pulsation. This is a diagnostic method that falls under the realm of palpation, and it was used to discover the location of disease. 4. The qi of pulse is motor that induces pulse, and this concept is used in order to understand how normal and abnormal pulsations appear, and to treat the circulation disorder of qi and blood. 5. Cubit skin examination is a method that comprehensively take into account the upper arm skin's cold and heat, slippery and roughness, and relax and tension state. This method was used together with other diagnostic methods. As described above, it seems that the diagnostic method with blood vessels used by Bianque school seems to have developed from Bianque's special inspection ability to the stage where it uses palpation, and then to the stage of cubit skin examination which uses both palpation and inspection.

• 한국항해항만학회지
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• 제26권4호
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• pp.435-440
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• 2002

잔류응력이 판의 파괴 특성에 미치는 영향의 정량적 평가를 위하여, 균열이 존재하는 CT(Compact Tension) 시편에 가스 토오치 (gas torch)를 이용한 국부 가열을 실시하여 인위적인 잔류응력을 생성시키고, 열탄소성 유한요소해석을 통하여 생성된 잔류응력장을 평가하였으며, 잔류응력이 존재하는 시편과 잔류응력이 존재하지 않는 시편에 대한 파괴인성 실험을 실시하여 이들의 결과를 파괴저항 선도 상에서 비교, 분석함으로써 압축 잔류응력이 파괴 특성에 미치는 영향을 정량화하였다.

• 한국항공우주학회지
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• 제38권12호
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• pp.1202-1208
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• 2010

추진제가 배출되는 동안 발사체 추진제탱크의 압력을 유지하기 위해 필요한 가압가스의 요구량을 예측하는 것은 가압시스템의 설계를 위해 반드시 필요하다. 추진제탱크로 유입되는 가압가스의 온도는 가압가스의 요구량에 가장 큰 영향을 미치는 요소로서, 저장탱크의 무게, 열교환기의 크기 등 가압시스템의 개발에 있어 중요한 설계기준이 된다. 이에 극저온 추진제탱크 내에 저장된 추진제를 가압하여 배출하는 실험을 수행하였고, 가압가스 온도 조건에 따른 가압가스 요구량과 얼리지 온도분포를 측정하였다. 그 결과 가압가스의 온도가 높을수록 요구량 자체는 감소하였지만, 이상적인 가압가스 요구량 대비 실제 필요량의 비율은 증가하였다.

• Journal of Advanced Marine Engineering and Technology
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• 제11권3호
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• pp.45-52
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• 1987

Generally the factors affected largely by the cold cracking sensitivity of the weld are the quantity of the diffusible hydrogen, the brittleness and hardness of the bond area and the tensile restraint stress. These factors have relation each other, and if we can reduce one of these factors, it becomes instrumental to the root cracks prevention of weld. This study deals with the gravity type-underwater-welding of KR Grade A-3 marine steel plate using E4303 welding electrode in order to compare wet-underwater-welding with in-air- welding, resulting in obtaining the tensile restraint characteristics, the hardness distribution, the quantity of diffusible hydrogen and the macro- and micro-crack properties in both underwater and in-air welds. The main results obtained are as follows: 1) The quantity of diffusible hydrogen measured for 48 hours is about 18cc/100g-weld-metal for the in-air-weld of one pass and about 48cc/100g-weld-metal for the underwater-weld of one pass which is about 3 times penetration of diffusible hydrogen compairing with the case of the in-air-weld. However, it was experimentally confirmed that, by the multi-pass welding of 2 to 5 passes, the diffusible hydrogen in the underwater weld metal can be reduced as much as 27 to 49%. 2) The hardness of the weld metal indicates the highest value in the heat affected zones of underwater weld for more rapid cooling rate, resulting in the higher sensitivity of cold cracking. So, it is desirable to soften the higher hardness in the HAZ by tempering effect such as the multi-pass welding in the underwater welding. 3) At the bond vicinity of the underwater weld HAZ, micro cracks were found as resulted by both more rapid cooling rate and more diffusible hydrogen and also by the stress corrosion cracking under the tensile restraint stress in the underwater. But this could be prevented by the tempering effect of the following weld bead such as the multi-pass welding.

• 대한기계학회논문집B
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• 제28권12호
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• pp.1557-1566
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• 2004

A flame extinction phenomenon is a typical unsteady process in combustion. Flame extinction is characterized by various physical phenomena, such as convection, diffusion, and the production of heat and mass. Flame extinction can be achieved by either increasing the strain rate or curvature, by diluting an inert gas or inhibitor, or by increasing the thermal or radiant energy loss. Though the extinction is an inherently transient process, steady and quasi-steady approaches have been used as useful tools for understanding the flame extinction phenomenon. Recently, unsteady characteristics of flames have been studied by many researchers, and various attempts have been made to understand unsteady flame behavior, by using various extinction processes. Representative parameters for describing flame, such as flame temperature, important species related to reactions, and chemi-luminescence of the flame have been used as criterions of flame extinction. In these works, verification of each parameter and establishing the proper criterions of the extinction has been very important. In this study, a time-dependent flame temperature and an OH radical concentration were measured using optical methods, and the instantaneous change of the flame luminosity was also measured using a high-speed ICCD (HICCD) camera. We compare the unsteady extinction points obtained by three different methods, and we discuss transient characteristics of maximum flame temperature and OH radical distribution near the extinction limit.

• 한국재료학회지
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• 제25권2호
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• pp.95-99
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• 2015

$NiAl_2O_4$ nanoparticle was synthesized by a reverse micelle processing for inorganic pigment. $Ni(NO_3)_2{\cdot}6H_2O$ and $Al(NO_3)_3{\cdot}9H_2O$ were used for the precursor in order to synthesize $NiAl_2O_4$ nanoparticles. The aqueous solution, which consisted of a mixing molar ratio of Ni/Al, was 1:2 and heat treated at $800{\sim}1100^{\circ}C$ for 2h. The average size and distribution of synthesized $NiAl_2O_4$ powders are in the range of 10-20 nm and narrow, respectively. The average size of the synthesized $NiAl_2O_4$ powders increased with an increasing water-to-surfactant molar ratio and heating temperature. The crystallinity of synthesized $NiAl_2O_4$ powder increased with an increasing heating temperature. The synthesized $NiAl_2O_4$ powders were characterized by X-ray diffraction analysis(XRD), a field emission scanning electron microscopy(FE-SEM), and a color spectrophotometer. The properties of synthesized powders were affected as a function such as a molar ratio and heating temperature. Results indicate that synthesis using a reverse miclle processing is a favorable process to obtain $NiAl_2O_4$ spinels at low temperatures. The procedure performed suggests that this new synthesis route for producing these oxides has the advantage of being fast and simple. Colorimetric coordinates indicate that the pigments obtained exhibit blue colors.