• Asian Pacific Journal of Cancer Prevention
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• 제16권16호
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• pp.7071-7076
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• 2015

Epidermal growth factor receptor (EGFR) is one of the targeted molecular markers in many cancers including lung malignancies. Gefitinib and erlotinib are two available therapeutics that act as specific inhibitors of tyrosine kinase (TK) domains. We performed a case-control study with formalin-fixed paraffin-embedded tissue blocks (FFPE) from tissue biopsies of 167 non-small cell lung carcinoma (NSCLC) patients and 167 healthy controls. The tissue biopsies were studied for mutations in exons 18-21 of the EGFR gene. This study was performed using PCR followed by DNA sequencing. We identified 63 mutations in 33 men and 30 women. Mutations were detected in exon 19 (delE746-A750, delE746-T751, delL747-E749, delL747-P753, delL747-T751) in 32 patients, exon 20 (S786I, T790M) in 16, and exon 21 (L858R) in 15. No mutations were observed in exon 18. The 63 patients with EFGR mutations were considered for upfront therapy with oral tyrosine kinase inhibitor (TKI) drugs and have responded well to therapy over the last 15 months. The control patients had no mutations in any of the exons studied. The advent of EGFR TKI therapy has provided a powerful new treatment modality for patients diagnosed with NSCLC. The study emphasizes the frequency of EGFR mutations in NSCLC patients and its role as an important predictive marker for response to oral TKI in the south Indian population.

• Asian Pacific Journal of Cancer Prevention
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• 제13권4호
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• pp.1247-1251
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• 2012

Background: Helicobacter pylori is an important gastrointestinal pathogen related to the development of not only atrophic gastritis and peptic ulcer, but also gastric cancer. Human leukocyte antigens (HLA) may play particular roles in host immune responses to bacterial antigens. This study aimed to investigate the association between HLA-DQA1 and DQB1 genotypes and haplotypes vs H. pylori infection in an Indonesian population. Methods: We selected 294 healthy participants in Mataram, Lombok Island, Indonesia. H. pylori infection was determined by urea breath test (UBT). We analyzed HLA-DQA1 and DQB1 genotypes by PCR-RFLP and constructed haplotypes of HLA-DQA1 and DQB1 genes. Multiple comparisons were conducted according to the Bonferroni method. Results: The H. pylori infection rate was 11.2% in this Indonesian population. The DQB1*0401 genotype was noted to be associated with a high risk of H. pylori infection, compared with the DQB1*0301 genotype. None of the HLA-DQA1 or DQB1 haplotypes were related to the risk of H. pylori infection. Conclusions: The study suggests that HLADQB1 genes play important roles in H. pylori infection, but there was no statistically significant association between HLA-DQA1 or DQB1 haplotypes and H.pylori infection in our Lombok Indonesian population.

• Journal of Preventive Medicine and Public Health
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• 제49권4호
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• pp.249-251
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• 2016

Objectives: Nail salon owners in New York City (NYC) are required to provide their workers with gloves and it is their responsibility to maintain healthy, safe working spaces for their employees. The purpose of this study was to determine the frequency with which nail salon workers wear protective gloves. Methods: A Freedom of Information Law request was submitted to New York Department of State's Division of Licensing Services for a full list of nail salons in Manhattan, NYC. A sample population of 800 nail salons was identified and a simple random sample (without replacement) of 30% (n=240) was selected using a random number generator. Researchers visited each nail salon from October to December of 2015, posing as a potential customer to determine if nail salon workers were wearing gloves. Results: Among the 169 salons in which one or more workers was observed providng services, a total of 562 workers were observed. For 149 salons, in which one or more worker was observed providing services, none of the workers were wearing gloves. In contrast, in six of the salons observed, in which one or more workers was providing services, all of the workers (1 in 2 sites, 2 in 1 site, 3 in 2 sites, and 4 in 1 site) were wearing gloves. Almost three-quarters of the total number of workers observed (n=415, 73.8%) were not wearing gloves. Conclusions: The findings of this study indicate that, despite recent media attention and legislation, the majority of nail salon workers we observed were not wearing protective gloves when providing services.

• 한국주거학회:학술대회논문집
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• 한국주거학회 2009년도 추계학술발표대회 논문집
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• pp.109-112
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• 2009

Various environmental problems due to the rapid industralization and urbanization have been worsened as much as to threaten the environmental restitution of globe and become a critical international issue. Korean government presented the green growth as a new state vision for 60 years afterwards and is making efforts to solve the environmental problems. Daegu metropolitan city has faced various environmental problems including overpopulation of cities, traffic pollution, household wastes and green zone problem because of urbanization for the last decades. As such urbanism continues, the quality of residential environment is rapidly deteriorating and the intensive use of land leads to increase of building area raising the temperature of cities. Therefore there have been demands for the healthy, pleasant and satisfying residential environment and the improvement of residential environment and such recognition rises from society in full measure. Nevertheless the current residential complex concentrates only on raising the efficiency of land use. Related laws in the past(Daegu Metropolitan City, Urban Planning Municipal Ordinance as of October 10, 2003) tried to prepare a standard to segmentalize the building-to-land ratio, floor area ratio and regulations of number of floors vertically, but currently it is abolished and the regulations are becoming eased. The purpose of this study was to analyze the characteristics of the floating wind before and after the vertical segmentation of residential areas(Daegu Metropolitan City, Urban Planning Municipal Ordinance as of October 10, 2003) by using KLAM_21, a model that enables analysing and predicting the flow and generation of clod wind, and to present a plan to improve the quality of residential areas afterwards when developing building lot and re-developing housing areas.

• Nutrition Research and Practice
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• 제4권4호
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• pp.339-344
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• 2010

The objective of this study was to measure anthropometric and haemoglobin level and nutrient intake of expecting women in the third trimester of pregnancy and to relate the birth weight of neonates as outcome of pregnancy. A cross sectional study was performed in Zahedan City. Two hospitals situated in the city were selected based on their approval and cooperation. Five hundred healthy pregnant women in the age group 16-40 years were selected for this study. Findings showed that the mean height, weight, fundal height, and haemoglobin of pregnant women were 156.4 cm, 62.6 kg, 34.2 cm, and 11.1g/dl respectively. Nutrient intake was computed based on 24 hour recall method. The results showed that, the mean intake of energy was 1802 Kcal/day. The intake of protein, calcium, iron, zinc and magnesium were 70.7 g, 544.0 mg, 16.1 mg, 10.6 mg and 266.0 mg respectively. Percentage adequacy of nutrient intakes with reference to RDA recommendation showed 95% and 80% of subjects had sufficient RDA intakes, while energy, calcium, iron and zinc intake considered as insufficient. The mean birth weight of neonates was 3.0 kg and 13% of neonates showed low birth weight. Maternal height, weight, fundal height and haemoglobin level were significantly correlated with birth weight of neonates. Energy, protein and calcium intakes in the third trimester were significantly correlated with birth weight of neonates. Using the binary logistic regression analysis fundal height, haemoglobin level and energy intake of pregnant women were considered as predictor factors of birth weight of neonates.

• Journal of Nutrition and Health
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• 제19권6호
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• pp.355-362
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• 1986

The purpose of this study was to estimate the urinary excretion of sodium cho\ulcornerloride of adolescent in Jeon Bug. Korea and to evaluate the correlation of sodium chloride excretion by sex and area. The subjects were 261 healthy persons of 16 years old ( male 131. fermale 130) which were randomly choosen from different areas (city, farming area and fishing area). The urinary sodium chloride excretion in 24hrs were evaluated. which were cal\ulcornerculated from the analysis of urine sample gathered for 12hrs. The results were as follows; 1) The urinary excretion of sodium chloride by the group of male and female in 24hrs were 388.0$\pm$191.4mEq(22.68$\pm$l1.19gm) and 303.6\ulcorner138.0mEq(l7.75$\pm$8.07gm) reo spectively. 2) The urinary excretion of sodium chloride by the group of male was higher than by the group of female. 3) The urinary excretion of sodium chloride by the group of city, farming area and fishing area in 24hrs. were 256.2$\pm$96.8mEq(14.97$\pm$5.66 gm), 433.2$\pm$188.6 mEq (25.32$\pm$l1.62gm) and 356.0$\pm$169.8mEq (20.81$\pm$.92gm) respectively. 4) The urinary excretion of sodium chloride by the farming area group and the fishing area group were higher than the city group. Hence the daily urinary excretion of sodium chloride by adolescent of 16years old was estimated to be 20.21$\pm$9.63gm.

• 한국생활과학회지
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• 제19권6호
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• pp.1083-1094
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• 2010

The purpose of this study is to provide a fundamental research data that is necessary in an education of dietary life so that the students have sound dietary life through a right food purchase after investigating perception of children's dietary habit and activity, food labelling, and nutrition labelling for 400 students of the 5 and 6th grades. The result of the study are as followings. In terms of perception questions over food labelling, on the whole, "know it little bit" was the highest. Girls and country was higher than boys and city. A list of item that is important in contents of food labelling were period of circulation, data of manufacturing, price, used ingredient, origin of product, nutrition contain labelling, manufacturer, quantity in contents(quantity, the number). A meaningful difference was shown in gender(p<.05) and area(p<.01). In 30 perception questions over nutrition labelling, "know it little bit" was the most, and girls and country were higher than boys and city. In ascertaining nutrition labelling at the time of purchasing the food, "look often" was the most. Girls and city were higher than boys and Gun in average but no difference was statistically shown in knowledge mark in utilization and perception of nutrition labelling. The response rate in girls(p<.01) and country(p<.05) was higher in a question of "if nutrition labelling is displayed, nutriment that is harmful for our body will be eaten less" and girls' response rate was higher in the question of "being educated for my health". Therefore, practice centered nutrition education is necessary to purchase the food after ascertaining food nutrition labelling out of an attitude in habitually purchasing the processed food. The students develop comprehensible food nutrition labelling the direction to emphasizing nutrition educational labelling and recognizing that the healthy nutriment is contained without conventional and food safety centered labelling should be changed.

• 한국토양환경학회지
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• 제4권2호
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• pp.185-192
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• 1999

천안시의 토양 환경을 종합적으로 평가하기 위하여 각 지역별(농경지 3개소, 공단지역 3개소, 도심지 2개소, 하천주변 3개소, 매립지 주변 3개소)로 13개 항목에 관한 오염도 조사를 실시하였다. 각 측정 항목마다 토양오염 우려기준에 못 미치는 오염도를 보였다. 토양의 산성화는 농경지에서 심한 것으로 나타났으며, 특히 고속도로 주변의 농경지는 자동차 배기가스에 의한 산성 강하물의 영향으로 의심되는 산성화가 진행되는 것으로 나타났다. 또한, 밭 지역의 산성화가 심화되어서 토양 측정망의 채취지점 추가가 요구되었다. 중금속 6종과 기타 유기득성물질은 모두 토양오염 우려기준에 못 미치는 값을 나타냈다. 유류성분인 BTEX성분 역시 우려기준에 못 미치는 값을 보였으며, TPH는 BTEX보다 광범위한 오염도를 보였다. 오염물질에 의한 토양의 상태를 종합적으로 판단할 수 있도록 고안된 토양오염지표(SPI, Soil Pollution Index)를 이용하여 천안시의 토양오염도를 평가하였다. 토양오염점수(SPC, Soil Pollution Score)에 의해 산출된 토양오염 등급은 모두 1 등급으로 판명되어 천안시의 토양은 비교적 건전한 것으로 나타났다.

• 가족자원경영과 정책
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• 제19권4호
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• pp.1-17
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• 2015

This study is aimed to discover the deciding factors in senior employment programs for improving the quality of life for the elderly. The dependent variable used in this study was the quality of elderly persons. Personal and familial characteristics, and the community involvement of the elderly were used as independent variables in a Multiple Regression analysis. First, the most influential factor encouraging the elderly to participate in a senior employment promotion program was previous experience of senior employment programs. Second, health condition, residence in city areas, experience of volunteer work, and knowledge of senior employment programs had positive effects on the continuous participation of the elderly men and women. However, living arrangements had an effect solely on elderly men, and home ownership and participation in economic activities had effects solely on elderly women. Third, the life quality of the elderly was affected differently by sex. Health condition had the greatest effect on male elderly persons, whereas, the effective variable, the composition of the family had the most effect on female elderly persons. Thus, active campaigns through various mass media and information sessions are needed to promote participation in senior employment programs, according to the above mentioned deciding factors. In particular infrastructure providing the elderly with more volunteer work opportunity needs to be built for baby boomers to improve their quality of life. In addition, diversified senior employment programs are needed. Because the elderly living in city areas are more willing to participate in senior employment programs, specialized programs suitable for the elderly in city areas are needed. The government should also prepare programs that help the elderly stay healthy while they are working.

• 한국환경복원기술학회지
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• 제23권6호
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• pp.1-14
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• 2020

Under the 「National Land Planning and Utilization Act」, Development Restriction Zones(DRZ) is one of the designated use district where the Minister of Land, Infrastructure and Transport deems it necessary to control urban development in order to prevent urban sprawl and conurbation and ensure a healthy living environment for citizens by conserving the natural environment surrounding metropolitan cities. DRZ was first designated around the Seoul Metropolitan city in 1971, and had been expanded to the 14 metropolitan areas across the country since 1977. The designated areas were accounted for about 5.4% of the total national land and its importance was demonstrated by contributing to control urban sprawl, curbing real estate speculation, and providing green space to citizens. However, DRZ has been repeatedly relaxed its regulations and allowed development under government. As a result, much of the green areas was damaged and several cities were merged and extended(conurbation). In particular, deregulation implemented for the purpose of securing land as part of national projects and local outstanding business(i.g. constructions of national rental housing, industrial complex, and international stadium) have caused continuous environmental damage around the metropolitan cities. In addition, the habitat fragmentation is in serious situation. Thus, the systematic plans for managing DRZ are necessary, since it is concerned that urban environment become deteriorate in the mid- to long-term. This study aims to continuously protect the urban environment from lifting DRZ. Therefore, firstly, we examined the environmental status through analyzing DRZ Management Plan which shall be drawn up by the Special Metropolitan City Mayor, the Metropolitan City Mayor or the Mayer/Do governor having jurisdiction, every five years to collectively manage DRZ. Secondly, we investigated the actual condition in DRZ based on the case study of Management Plan in Metropolitan areas(i.e. Seoul Metropolis, Gyeonggi-do, and Incheon Metropolis). Finally, we suggested the seven feasible improved political plan for managing DRZ.