• Journal of mucopolysaccharidosis and rare diseases
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• v.2 no.1
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• pp.19-22
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• 2016

Purpose: Mucolipidosis type II (ML II), also known as I-cell disease is an autosomal recessive inherited disorder of lysosomal enzyme transport caused by a deficiency of the uridine diphosphate (UDP)-N-acetylglucosamine:lysosomal enzyme N-acetylglucosamine-1-phosphotransferase (GlcNAc-phosphotransferase). Clinical manifestations are skeletal abnormalities, mental retardation, cardiac disease, and respiratory complications. A severely and rapidity progressive clinical course leads to death before 10 years of age. Methods/Results: In this study we diagnosed three cases of prenatal ML II in two different at-risk families. We compared two procedures -biochemical analysis and molecular analysis - for the prenatal diagnosis of ML II. Both methods require an invasive procedure to obtain specimens for the diagnosis. Biochemical analysis requires obtaining cell cultures from amniotic fluid for more than two weeks, and would result in a late diagnosis at 19 to 22 weeks of gestation. Molecular genetic testing by direct sequence analysis is usually possible when mutations are confirmed in the proband. Molecular analysis has an advantage in that it can be performed during the first-trimester. Conclusion: Molecular diagnosis is a preferable method when a prompt decision is necessary.

• The Korean Journal of Health Service Management
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• v.13 no.4
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• pp.33-44
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• 2019

Objectives: This study aimed to analyze the papers on nursing in the KJHSM (Korean Journal of Health Service Management) (2007-2018), to identify the research trends and to help the future development of nursing research. Methods: The data collection was carried out from September 1, 2019 to September 30, 2019. The 78 copies of the original text were provided by the KSHSM website, DBpia, and NDSL (National Digital Science Library) electronic database. Results: Forty-seven studies had a non-experimental design, with most having a descriptive research design (89.3%). The most common participants were nurses (55.7%) and nursing college students (26.1%). A questionnaire was the most commonly used research tools (96.2%) and data collection methods (95.0%). The major keywords were the terms included in the environmental domain among the meta-paradigms of nursing (43.6%). Conclusions: In order to expand the quantity and quality of nursing science in the KSHSM, efforts are needed to improve the quality of research participants, research tools, and sampling methods.

• Journal of Microbiology and Biotechnology
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• v.21 no.10
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• pp.1069-1072
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• 2011

A real-time PCR assay method was established to monitor Leuconostoc spp. populations via specific amplification of the dextransucrase gene. Quantification of L. mesenteroides B-512F using both genomic DNA and cell suspensions yielded a log-linear correlation spanning approximately 5 log units. By using this method, monitoring changes of Leuconostoc spp. during sauerkraut fermentation was successfully accomplished with accuracy after inoculation of starter and sugars (sucrose and maltose).

• Safety and Health at Work
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• v.11 no.4
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• pp.491-499
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• 2020

Background: Assembly lines work is frequently associated to work-related upper limb musculoskeletal disorders. The related disability and absenteeism make it important to implement efficient health surveillance systems. The main objective of this study was to identify self-reported variables that can determine work-related upper limb musculoskeletal symptoms-discomfort/pain-during a 6-month follow-up. Methods: This was a prospective study with a 6-month follow-up period, performed in an assembly line. Upper limb musculoskeletal discomfort/pain was assessed through the presence of self-reported symptoms. Uni- and multivariate logistic regression analyses were used to evaluate which self-reported variables were associated to upper limb symptoms after 6 months at the present and to upper limbs symptoms in the past month. Results: Of the 200 workers at baseline, 145 replied to the survey after 6 months. For both outcomes, "having upper limb symptoms during the previous 6 months" and "education" were possible predictors. Conclusion: Our results suggest that having previous upper limb symptoms was related to its maintenance after 6 months, sustaining it as a specific determinant. It can be a hypothesis that this population had mainly workers with chronic symptoms, although our results give only limited support to self-reported indicators as determinants for upper limb symptoms. Nevertheless, the development of an efficient health surveillance system for high demanding jobs should implicate self-reported indicators, but also clinical and work conditions assessment should be accounted on the future.

• The Korean Journal of Community Living Science
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• v.17 no.4
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• pp.67-80
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• 2006

This study conducted research on the actual state of community-oriented services for elderly rural inhabitants and their desire related to them to develop a local community service network model suitable to the characteristics of rural longevity villages. The research was conducted on 906 elderly people over 65 living in 20 rural longevity villages through questionnaires assessing filming and economy, economic activity, health care, learning and leisure activities as well as asking their wants and needs relative to local community services. As a result, it was found rural elderly people showed a high desire for local community services such as health, transportation and economy activity. In addition, they were mainly cultivating farm products as their economic activity and showed a high demand in the future as well. Most were found to take a walk in the healthcare field and showed a high demand for health examinations, health education, health consulting, hot spring bathing and basking in the woods. Respecting learning, social and leisure activities, they were mostly found to watch TV and do house chores, and showed a high desire for village environment repair, traditional farm music, visiting and tourism. With the above results, it is expected that the desire of rural elderly for such services can be satisfied, and the development of a local community service network model suitable to the characteristic of a local community is recommended.

• Journal of Computing Science and Engineering
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• v.5 no.3
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• pp.246-256
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• 2011

Due to the increasingly aging population, there is a rising demand for assistive living technologies for the elderly to ensure their health and well-being. The elderly are mostly chronic patients who require frequent check-ups of multiple vital signs, some of which (e.g., blood pressure and blood glucose) vary greatly according to the daily activities that the elderly are involved in. Therefore, the development of novel wearable intelligent systems to effectively monitor the vital signs continuously over a 24 hour period is in some cases crucial for understanding the progression of chronic symptoms in the elderly. In this paper, recent development of Wearable Intelligent Systems for e-Health (WISEs) is reviewed, including breakthrough technologies and technical challenges that remain to be solved. A novel application of wearable technologies for transient cardiovascular monitoring during water drinking is also reported. In particular, our latest results found that heart rate increased by 9 bpm (P < 0.001) and pulse transit time was reduced by 5 ms (P < 0.001), indicating a possible rise in blood pressure, during swallowing. In addition to monitoring physiological conditions during daily activities, it is anticipated that WISEs will have a number of other potentially viable applications, including the real-time risk prediction of sudden cardiovascular events and deaths.

• International Journal of Oral Biology
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• v.48 no.4
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• pp.33-44
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• 2023

In this review, the regulatory mechanisms of autophagy were described, and its interaction with apoptosis was identified. The role of autophagy in embryogenesis, tooth development, and cell differentiation were also investigated. Autophagy is regulated by various autophagy-related genes and those related to stress response. Highly active autophagy occurrences have been reported during cell differentiation before implantation after fertilization. Autophagy is involved in energy generation and supplies nutrients during early birth, essential to compensate for their deficient supply from the placenta. The contribution of autophagy during tooth development, such as the shape of the crown and root formation, ivory, and homeostasis in cells, was also observed. Genes control autophagy, and studying the role of autophagy in cell differentiation and development was useful for understanding human aging, illness, and health. In the future, the role of specific mechanisms in the development and differentiation of autophagy may increase the understanding of the pathological mechanisms of disease and development processes and is expected to reduce the treatment of various diseases by modulating the autophagic phenomenon.

• Journal of East-West Nursing Research
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• v.8 no.1
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• pp.103-112
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• 2003

This paper focused on providing the groundwork for the development of proper nursing interventions to enhance the quality of life for the elderly by identifying the factors that may affect their health beliefs and behaviors. A survey was conducted on a group of people aged between 60 and 86 years residing in S and K cities from January to March of 2003, who agreed to participate in the research. Data was collected using instruments measuring health beliefs and health behaviors, and was analyzed by using SPSS. The results of this study are as follow. 1) Those in the group were aged between60 and 86 years, and the average age was 66.94 years old. Most of them were living together with their spouses. From the survey, 83.5% replied "above average" on the question regarding their current health condition, whereas, 46.0% mentioned that they had some sort of diseases. 2) Overall average score of the health belief was 516.05, with a mean $3.71{\pm}4.07$. This indicates that the studied group held a high level of health belief, which affects their attitude and intention to lead a healthy life by placing the present life under control in harmony with nature. 3) Overall average score of the health behaviors was 392.24 with a mean $2.82{\pm}.52$. For health purposes, the behaviors that the elderly people were taking were mostly static ones requiring a low level of activity. The analysis showed that they generally were involved in self-trained, individualized health care. Thus, the elderly place a higher priority on regular dietary behaviors than on physical activity. 4) The correlation between health belief, a cognitive aspect on health, and health behaviors, a behavioral aspect showed a very high linear relationship (r=.520, p<.000). Consequently, it is found that those who have higher cognitive health belief are involved in higher level of behavioral health practice. These findings concluded that the Korean elderly have good health beliefs, well controlling their minds and being harmonious with nature. Health behaviors that they are engaged in are mostly static, requiring low level activity, while they place higher priority on regular dietary habits and conducting self-trained individualized health care. Important factor affecting their health beliefs and health behaviors was found to be their health practice. Since higher health belief is highly related with good health behaviors, development of health activity programs is in need as a means for an efficient health improvement, where motivating environment may be established to enhance the health belief of the elderly and to satisfy individual values.

• International Journal of Knowledge Content Development & Technology
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• v.7 no.1
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• pp.101-120
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• 2017

Healthcare professionals have edited many health questions (HQs) and their answers for healthcare consumers on the Internet. The HQs provide both readable and reliable health information, and hence retrieval of those HQs that are relevant to a given question is essential for health education and promotion through the Internet. However, retrieval of relevant HQs needs to be based on the recognition of the intention of each HQ, which is difficult to be done by predefining syntactic and semantic rules. We thus model the intention recognition problem as a text classification problem, and develop two techniques to improve a learning-based text classifier for the problem. The two techniques improve the classifier by location-based and area-based feature weightings, respectively. Experimental results show that, the two techniques can work together to significantly improve a Support Vector Machine classifier in both the recognition of HQ intentions and the retrieval of relevant HQs.

• Korean Journal of Adult Nursing
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• v.27 no.2
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• pp.198-210
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• 2015

Purpose: This study was to develop a health promotion program for marriage immigrant women and to evaluate its efficacy. Methods: The health promotion program was comprised of eight 100-minute weekly sessions. Each session included understanding of health responsibility, nutrition, physical activity, interpersonal relations, stress management, and self actualization. The research was conducted under the principles of nonequivalent control group pretest-post test design. The outcome variables were health promoting behavior, health status, acculturation, self efficacy, and perceived barrier. The participants were 15 immigrant women in the experimental group and 16 in the control group. Data was analyzed using ${\chi}^2$ test, Fisher's exact test, Mann Whitney U-test and Wilcoxon signed rank test. Results: There was a significant improvement in health promoting behaviors (U=-3.08, p=.002), left shoulder flexibility (U=-3.02, p=.003), right shoulder flexibility (U=-3.02, p=.003), low back flexibility (U=-3.37, p=.001), social health status (U=-3.38 p=.001) and subjective health status (U=-2.17 p=.030) in the experimental group compared to the control group. Conclusion: The health promotion program for marriage immigrant women was an effective intervention for improving health promoting behavior, physical health status, social health, and subjective health status. Therefore, the developed health promotion program needs to be applied to married immigrant women in other kinds nursing care settings in future research.