• International journal of advanced smart convergence
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• 제9권1호
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• pp.90-97
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• 2020

Oncolytic viruses are characterized by their ability to selectively kill cancer cells, and thus they have potential for application as novel anticancer agents. Despite an increase in the number of studies on methodologies involving oncolytic viruses, bioinformatic studies generating useful data are lacking. We constructed a database for oncolytic virus research (the oncolytic virus database, OVDB) by integrating scattered genetic information on oncolytic viruses and proposed a systematic means of using the biological data in the database. Our database provides data on 14 oncolytic viral strains and other types of viruses for comparative analysis. We constructed the OVDB using the basic local alignment search tool, and therefore can provides genetic information on highly homologous oncolytic viruses. This study contributes to facilitate systematic bioinformatics research, providing valuable data for development of oncolytic virus-based anticancer therapies.

• Structural Engineering and Mechanics
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• 제31권5호
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• pp.527-544
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• 2009

In this study, the periodic seismic performance evaluation scheme is proposed using a structural health monitoring system in terms of seismic fragility. An instrumented highway bridge is used to demonstrate the evaluation procedure involving (1) measuring ambient vibration of a bridge under general vehicle loadings, (2) identifying modal parameters from the measured acceleration data by applying output-only modal identification method, (3) updating a preliminary finite element model (obtained from structural design drawings) with the identified modal parameters using real-coded genetic algorithm, (4) analyzing nonlinear response time histories of the structure under earthquake excitations, and finally (5) developing fragility curves represented by a log-normal distribution function using maximum likelihood estimation. It is found that the seismic fragility of a highway bridge can be updated using extracted modal parameters and can also be monitored further by utilizing the instrumented structural health monitoring system.

• 한국콘텐츠학회논문지
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• 제17권5호
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• pp.423-429
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• 2017

급격한 고령화 사회로 다양한 노인문제가 나타나고 있다. 특히, 노인건강의 문제는 사회-경제적 부담으로 작용되고 있다. 이러한 노인건강증진을 위한 방안으로 ICT기술과 결합된 다양한 콘텐츠 개발과 실생활 적용을 통해 많은 노인들이 쉽고 편리하게 활용할 수 있는 방안이 모색되어져야 한다. 우리나라의 경우 지난 2010년 이후 스마트 폰의 보급과 사용을 통해 다양한 연령층의 건강 증진 혹은 유지를 위한 다양한 콘텐츠가 제공되고 있으나, 노인을 위한 콘텐츠는 그 양과 질이 매우 빈약하다. 따라서 본 연구는 ICT기반 노인건강증진을 위한 콘텐츠 개발의 일환으로 신체움직임을 통한 무용을 활용하고자 하는 것이다. 본 연구의 방법은 국내 학회지 및 학위논문(석, 박사)의 연구주제, 연구기간을 바탕으로 하고 노인복지 관련 선행연구동향, ICT기반의 노인관련 선행연구동향, 노인을 위한 무용프로그램에 대한 선행연구동향을 분석하였고 이를 바탕으로 무용콘텐츠 개발과 활용방안에 대해 제시하고자 하였다.

• 여성건강간호학회지
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• 제27권3호
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• pp.243-255
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• 2021

Purpose: This study aimed to develop a lifestyle modification (LSM) mobile application based on the Android operating system for overweight and obese breast cancer survivors (BCS) in Korea and evaluate its usability. Methods: The content analysis, design, development, implementation, and evaluation of the LSM intervention mobile application for overweight and obese BCS was conducted by identifying survivors' needs, searching the literature, and reviewing existing mobile applications. The survey was conducted from June 1 to December 28, 2020 at Jeonju, Korea. Results: The mobile application for BCS included dietary and exercise information, weight logs, as well as distress and daily achievement check. It also included information and videos on the prevention of breast cancer recurrence and used a communication bulletin board. Expert and user usability evaluation of its content and functions confirmed that it was appropriate and satisfactory for overweight and obese BCS. Conclusion: This LSM mobile application developed for overweight and obese BCS was found to be appropriate for use. It can be applied for further study of effectiveness on improving their health and maintaining a healthy lifestyle, to ultimately improve quality of life.

• 한국학교보건학회지
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• 제31권2호
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• pp.98-107
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• 2018

Purpose: The purpose of this study was to develop an instrument for measuring sexual values of college students. Methods: The data were collected from 308 university students for three months from March 15th to June 15th, 2016. The development of the scale was done in the following order: development of preliminary items; verification of content validity and reliability; factor analysis; and criterion validity of final items. Results: We developed a questionnaire using a five-point Likert-type scale in a self-report form containing 18 items. From the factor analysis, 18 items in three factors were finalized. The 18 items included 3 sub-scales: Cognitive (5 items); Affective (4 items); and Behavioral (9 items). The internal consistency was acceptable (Cronbach's ${\alpha}=.88$). In this study, sexual values were significantly correlated with self-concept (r=.344, p<.001). Conclusion: The results of this study will be useful not only for evaluating sexual values of college students but also for obtaining basic data for sex education. However, we need further studies in order to use the scale in practice and research.

• Asian Pacific Journal of Cancer Prevention
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• 제17권sup3호
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• pp.161-166
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• 2016

Iranian women are at high risk of low compliance with repeat mammography due to a lack of awareness about breast cancer, negative previous experiences, cultural beliefs, and no regular visits to a physician. Thus research is needed to explore factors associated with repeated mammography participation. Applying the concept of perceived risk as the guiding model, this study aimed to test the fit and strength of the relationship between perceived risk and physician recommendation in explaining repeat mammography. A total of 601 women, aged 50 years and older referred to mammography centers in region 6, were recruited via a convenience sampling method. Using path analysis, family history of breast cancer and other types of cancer were modeled as antecedent perceived risk, and physician recommendation and knowledge were modeled as an antecedent of the number of mammography visits. The model explained 49% of the variance in repeat mammography. The two factors of physician recommendation and breast self-examination had significant direct effects (P < 0.05) on repeat mammography. Perceived risk, knowledge, and family history of breast cancer had significant indirect effects on repeat mammography through physician recommendation. The results of this study provide a background for further research and interventions not only on Iranian women but also on similar cultural groups and immigrants who have been neglected to date in the mammography literature.

• 한국산업보건학회지
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• 제28권1호
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• pp.1-17
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• 2018

Objectives: This research is part of a study to be conducted over five years starting from 2017 by the Ministry of Environment on the development of technologies to evaluate the impact of chemical accidents on the human body. Methods: For this research, a five-stage specific study method was developed. Results: In brief, the developed health risk assessment method can be summarized as follows. First, a health risk assessment system was built based on the guidelines set forth by the USA NRC/NAS. Second, based on the disease manifestation theory, the health risk assessment method was divided into 1) a carcinogenic health risk assessment method focused on all carcinogens except non-genotoxic carcinogens and 2) a non-carcinogenic health risk assessment method focused on noncarcinogens including non-genotoxic carcinogens. Third, the detailed contents of the health risk assessment method were developed in four stages(hazard identification, dose-response assessment, exposure assessment, and risk determination) through theoretical consideration of the assessment of the level of health risk related to chemical exposure. Finally, a health risk assessment methodology, classified into stages to address acute, subacute/subchronic, and chronic conditions was developed after considering the physicochemical behavior of hazardous chemicals upon implementation of countermeasures after a chemical accident. Conclusions: A method to evaluate the health risks related to toxic chemicals generated by chemical accidents was developed. This study was performed with the purpose of developing a mathematical health risk assessment method to evaluate the health effects of exposure to hazardous chemicals upon implementation of emergency countermeasures after chemical accidents.

• 한국산업보건학회지
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• 제22권2호
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• pp.164-173
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• 2012

Objectives: Epichlorohydrin is a material that has been predicted to have high volatility and strong toxicity and is used normally in working area. Therefore, the hazardous and dangerous level and the foreign management system about epichlorohydrin should be invested at home and abroad and through hazard assessment for occupational environment measurement and exposure status of industrial workers in domestic working area. Methods: To assess risk and to suggest Development and Adoption to prevent health damage of workers owing to the epichlorohydrin exposure, the hazardousness and dangerousness of epichlorohydrin and its practical examples and regulation level for domestic and abroad health impairment are researched on the base of various references. Results: The epichlorohydrin caused skin and mucus membrane irritation, respiratory paralysis, kidney and live damage under the influence of acute toxicity and in animal study, it was confirmed as a doubtful carcinogenic substance to trigger reducement of sperm number and reproduction ability, abnormal spermatogenesis, mutagen, increase of forestomach epithelium and occurrence of papilloma and so on, as well as it induced stimulus asthma and allergic contact dermatitis for exposure workers. Conclusions: Epichlorohydrin was found to occur allergic contact dermatitis, carcinogenesis doubt and reproduction toxicity and was verified as a material which would be established reinforcement of management level to care health of handlers, such as denotement dangerousness of skin absorption.

• 한국보건간호학회지
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• 제27권2호
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• pp.241-253
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• 2013

Purpose: We performed an ethnographic analysis on health-related behavioral patterns of male college students enrolled in a weight-control program. Methods: The participants in this study were 12 obese male college students and one member of the health program staff. Data, collected through interviews and participatory observations during fieldwork, were analyzed using text analysis and taxonomic methods. Results: Patterns of health behavior were categorized into one of two types: the type with a willingness and motivation toward improving health (including a positive management of diseases and lifestyle) or the type concerned with social development and competence (including the application of strategic relationships and a self-conscious inclination toward appearance). Conclusion: The concepts of body and health in sociocultural contexts lead to weight-control practices. These results strongly indicate that providers of dieting programs for young adults need to understand the physical and psychological concerns of their students. Moreover, another implication from our results is that health-related interventions should be designed according to specific aspects of its participants.

• 한국축산식품학회지
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• 제36권5호
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• pp.577-582
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• 2016

Despite several issues in relation to human health, beef is still a most popular meat product among large section of society due to the presence of high quality protein and other nutrients. The current paper reviews numerous studies that provide nutritional profiles and health implications of high marbled beef consumption. In relation to lipid content of beef, intramuscular fat contains high level of PUFA and MUFA compared to other beef fat. Level and composition of intramuscular fat varies depending on breed and feeding regime. Literature suggests that the marbling is more complex than the development of subcutaneous fat and marbling not only provides good fatty acids but also contributes to the higher eating quality of beef. Finally, the current work emphasize that meat plays a pivotal role in nutritious diets, high quality marbled beef is not only of excellent eating quality but also contain more beneficial fatty acids.