• Korean Chemical Engineering Research
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• v.58 no.1
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• pp.106-112
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• 2020

Analyzing vitamin D levels is important for monitoring health conditions because vitamin D deficiency is associated with various diseases such as rickets, osteomalacia, cardiovascular disorders and some cancers. However, vitamin D concentration in the blood is very low with optimal level of 75 nmol/L, making quantitative analysis difficult. The objective of this study was to develop a highly sensitive analysis method for vitamin D using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-MS). 25-hydroxyvitamin D (25(OH)D), which has been used as an indicator of vitamin D metabolites in human biofluids was chemically derivatized using a secosteroid signal enhancing tag (SecoSET) with powerful dienophile and permanent positive charge. The SecoSET-derivatized 25(OH)D provided good linearity (R² > 0.99) and sensitivity (limit of quantitation: 11.3 fmol). Chemical derivatization of deuterated 25-hydroxyvitamin D₃ (d₆-25(OH)D3) with SecoSET enabled absolute quantitative analysis using MALDI-MS. The highly sensitive method could be successfully applied into monitoring of quantitative changes of bioactive vitamin D metabolites after treatment with ketoconazole to inhibit 1α-hydroxylase reaction related to vitamin D metabolism in human breast cancer cells. Taken together, we developed a MALDI-MS-based platform that could quantitatively analyze vitamin D metabolites from cell products, blood and other biofluids. This platform may be applied to monitor various diseases associated with vitamin D deficiency such as rickets, osteomalacia and breast cancer.

• The Journal of the Korea Contents Association
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• v.13 no.4
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• pp.8-16
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• 2013

Active studies are under way on telemedicine and medical support based on mobile devices in order to vitalize U-Healthcare. Especially when the medical law is revised to allow a remote prescription system, studies on a mobile prescription system will rapidly increase. And yet since mobile apps have less compatibility due to the nature of mobile platform, there is a restriction that they have to be redeveloped to be compatible with the platform. To compensate this problem, this study designs a mobile web prescription interface by using HLTML5, the standard language of mobile web development and jQuery Mobile, a JavaScript Library. It also adds a feature of converting to a form of standard protocol HL7-based messages to share data with existing hospital information system. This interface makes it possible to be interlocked with the existing hospital information system through the transmission of the HL7 messages. The advantage of the proposed system is that it can be used in various environments since it is independent of mobile platforms and compatible with general computers.

• Journal of Periodontal and Implant Science
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• v.50 no.4
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• pp.209-225
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• 2020

Purpose: Marginal bone loss (MBL) is an important clinical issue in implant therapy. One feature that has been cited as a contributing factor to this bone loss is peri-implant mucosal thickness. Therefore, in this report, we conducted a systematic review of the literature comparing bone remodeling around implants placed in areas with thick (≥2-mm) vs. thin (<2-mm) mucosa. Methods: A PICO question was defined. Manual and electronic searches were performed of the MEDLINE/PubMed and Cochrane Oral Health Group databases. The inclusion criteria were prospective studies that documented soft tissue thickness with direct intraoperative measurements and that included at least 1 year of follow-up. When possible, a meta-analysis was performed for both the overall and subgroup analyses. Results: Thirteen papers fulfilled the inclusion criteria. A meta-analysis of 7 randomized clinical trials was conducted. Significantly less bone loss was found around implants with thick mucosa than around those with thin mucosa (difference, -0.53 mm; P<0.0001). Subgroups were analyzed regarding the apico-coronal positioning, the use of platform-matched vs. platform-switched (PS) connections, and the use of cement-retained vs. screw-retained prostheses. In these analyses, thick mucosa was found to be associated with significantly less MBL than thin mucosa (P<0.0001). Among non-matching (PS) connections and screw-retained prostheses, bone levels were not affected by mucosal thickness. Conclusions: Soft tissue thickness was found to be correlated with MBL except in cases of PS connections used on implants with thin tissues and screw-retained prostheses. Mucosal thickness did not affect implant survival or the occurrence of biological or aesthetic complications.

• Physical Therapy Korea
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• v.4 no.3
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• pp.34-44
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• 1997

The purpose of this study was to compare the balance ability at different foot angle with KAT 2000 (Breg, Inc., Vista, CA. 1994). Forty-nine (male 24, female 25) normal subjects participated in this study. All subjects were assessed under two conditions. One was eye-opened condition and the other one was eye-closed one in 3 psi surface condition. All subjects were tested at different foot angle that were toe-in $25^{\circ}$, $45^{\circ}$, toe-out $25^{\circ}$ and $45^{\circ}$. The subject attempted to keep the platform as stable as possible with eyes closed and with eyes opened for every 20 seconds. The starting position was that subject crossed their arms across chest and flexed knees slightly. The results of each test were showed by a score on screen, which meant balance index. The se collected data were analyzed by using oneway ANOVA, Scheffe test, and t-test. The results of this study were as follows: 1. When the foot angle were changed, balance index was the lowest in toes-out $25^{\circ}$ condition and greatest with toes-in $45^{\circ}$ with eyes opened and with eyes closed. There were statistically significant difference with eyes opened and with eyes closed (p<0.05). 2. There was statistically significant difference in balance index according to visual condition and the balance index tested with eyes closed was higher than with eyes closed(p<0.05). 3. There was statistically significant difference in balance index by gender(p<0.05).

• Journal of the Korean Society of Safety
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• v.35 no.5
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• pp.1-8
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• 2020

Mobile elevating work platforms (MEWPs) consist of a work platform, extending structure, and chassis, and are used to move persons to working positions. MEWPs are useful but are composed of pieces of equipment, and accidents do occur owing to equipment defects. Among these defects, accidents caused by the fracture of bolts fixed to the extension structure and swing system are increasing. This paper presents a failure analysis of the fixing bolts of MEWP. Standard procedure for failure analysis was employed in this investigation. Visual inspection, chemical analysis, tensile strength measurement, microstructural characterization, fractography analysis by Optical Microscope(OM) and Scanning Electron Microscopy(SEM), and finite element analysis (FEA) were used to analyze the failure of the fixing bolts. Using this failure analysis approach, we found the root cause of failure and proposed a means for solving this type of failure in the future. First, the chemical composition of the fixing bolt is obtained by a spectroscopy chemical analysis method, which determined that the chemical composition matched the required standard. The tensile test showed that the tensile and yield strengths were within the required capacity. The stress analysis was carried out at five different boom angles, and it was determined that the fixing bolt of MEWP can withstand the loads at all the boom angles. The outcomes of the fatigue analysis revealed that the fixing bolt fails before reaching the design requirements. The results of the fatigue analysis showed primarily that the failure of the fixing bolt was due to fatigue. A visual inspection of the fractured section of the fixing bolt also confirmed the fatigue failure. We propose a method to prevent failure of the fixing bolt of the MEWP from four different standpoints: the manufacturer, safety certification authority, safety inspection agency, and owner.

• The Journal of The Korea Institute of Intelligent Transport Systems
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• v.20 no.5
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• pp.172-185
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• 2021

As the era of autonomous driving approaches, it is expected to have a significant impact on our lives. When autonomous driving cars emerge, it is necessary to develop an index that can evaluate autonomous driving cars as it enhance the productive value of the car by reducing the burden on the driver. This study analyzed how the autonomous driving era affects commuting time and commuting time satisfaction among office goers using a car in Gyeonggi-do. First, a nonlinear relationship (V) was derived for the commuting time and commuting time satisfaction. Here, the factors affecting commuting time satisfaction were analyzed through a binomial logistic model, centered on the sample belonging to the nonlinear section (70 minutes or more for commuting time), which is likely to be affected by the autonomous driving era. The analysis results show that the variables affected by the autonomous driving era were health, sleeping hours, working hours, and leisure time. Since the emergence of autonomous driving cars is highly likely to improve the influencing variables, long-distance commuters are likely to feel higher commuting time satisfaction.

• Journal of the Korea Institute of Construction Safety
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• v.2 no.1
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• pp.9-15
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• 2019

Despite the efforts for enhancing the safety record, construction industry has been suffered from higher fatalities than other industries. The poor record of safety in construction industry means that there is a clear need for an effective countermeasure. As mentioned in previous studies, it is important to identify the type of activities or risks that are likely to cause accidents and to develop appropriate safety measures. Considering the large number of accident cases on the temporary installations including work platforms and work passages, the temporary installations should be managed first. To support it, this study aims to analyze falling accident cases on construction working platforms and passages which can lead to develop proper safety measures. Through the analysis of 1663 accident cases in the perspective of cost, progress, activity, and type of workers, this study identifies how the recent accidents occur and what is the cause of the accident occurrence. The identified causes of accident occurrence will help us to improve current construction safety.

• Food Engineering Progress
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• v.21 no.1
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• pp.12-21
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• 2017

Foods are becoming more customized and consumers demand food that provides great taste and appearance and that improves health. Food three-dimensional (3D)-printing technology has a great potential to manufacture food products with customized shape, texture, color, flavor, and even nutrition. Food materials for 3D-printing do not rely on the concentration of the manufacturing processes of a product in a single step, but it is associated with the design of food with textures and potentially enhanced nutritional value. The potential uses of food 3D-printing can be forecasted through the three following levels of industry: consumer-produced foods, small-scale food production, and industrial scale food production. Consumer-produced foods would be made in the kitchen, a traditional setting using a nontraditional tool. Small-scale food production would include shops, restaurants, bakeries, and other institutions which produce food for tens to thousands of individuals. Industrial scale production would be for the mass consumer market of hundreds of thousands of consumers. For this reason, food 3D-printing could make an impact on food for personalized nutrition, on-demand food fabrication, food processing technologies, and process design in food industry in the future. This article review on food materials for 3D-printing, rheology control of food, 3D-printing system for food fabrication, 3D-printing based on molecular cuisine, 3D-printing mobile platform for customized food, and future trends in the food market.

• Journal of Platform Technology
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• v.9 no.3
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• pp.36-43
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• 2021

Stroke disease is one of the leading causes of death worldwide, and in particular, it is the most important causative disease that causes disability in the elderly. Since stroke disease often causes death or serious disability, active primary prevention and early detection of prognostic symptoms are very important. In particular, it is necessary to detect and accurately predict stroke prognostic symptoms in daily life and prompt diagnosis and treatment by medical staff. In recent studies, image analysis such as computed tomography (CT) or magnetic resonance imaging (MRI) is mostly used as a methodology for predicting prognostic symptoms in stroke patients. However, this approach has limitations in terms of long test time and high cost. In this paper, we experimented with clinical data on how stroke disease affects foot pressure in elderly in walking. Experiments have shown that there is a significant difference in * p < .05 in 12 cells between the stroke elderly and the normal elderly during walking. As a result, it is significant that we found a significant difference in the gait patterns in daily life of the stroke elderly and the normal elderly.

• The Journal of the Convergence on Culture Technology
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• v.7 no.3
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• pp.571-576
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• 2021

This study was carried out to overcome the problems of the existing fitness business and to build a fitness system that can meet the increased demand in the Corona situation. As a platform technology for non-face-to-face fitness edutainment service, it is a next-generation fitness exercise device that can use various body parts and synchronize network-type information. By synchronizing the exercise information of the fitness equipment, it was composed of learning contents through MR-based avatars. A quantified result was derived from examining the applicability of the customized evaluation system through momentum analysis with A.I analysis applying the LSTM-based algorithm according to the cumulative exercise effect of the user. It is a motion capture and 3D visualization fitness program for the application of systematic exercise techniques through academic experts, and it is judged that it will contribute to the improvement of the user's fitness knowledge and exercise ability.