• Journal of the Korea Academia-Industrial cooperation Society
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• v.19 no.12
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• pp.765-773
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• 2018

The purpose of this study was to investigate the effect of Healing Beat on autonomic balance, heart rate, and anxiety in healthy adults exposed to stressors. Data were collected from 64 healthy volunteers who volunteered after responded to a recruitment announcement at D City University and analyzed using descriptive statistics, the X2-test, the t-test, and repeated measures of ANOVA. Results showed that both experimental and control general characteristics and variables were homogeneous. Significant intergroup differences were obtained for autonomic balance (F = 6.151, p <.001), heart rate (F = 5.455, p <.001), and anxiety (t = -7.633, p <.001). These results indicate Healing Beat is effective at relieving anxiety in stressful situations, and that Healing Beat can be used to relieve stress in many clinical situations or daily life when individuals are exposed to various stressors.

• Proceedings of the Korean Institute of Building Construction Conference
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• 2022.11a
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• pp.241-242
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• 2022

Recently, related studies on the application of bacterial spores to self-healing concrete have been widely reported. Using the self-healing method of bacterial spores as a kind of pro-environment, the green method is very attractive, but because the living environment of bacterial spores is relatively harsh, it is necessary to have a way to separate the living environment of bacterial spores from the harsh external environment, And release bacterial spores when needed. Therefore, capsules are widely used in self-healing concrete. To enhance the self-healing effect, the capsules need to be evenly distributed in the concrete. Furthermore, we develop a CIP-based smart capsule with controllability. We determined the magnetic force of each capsule by mixing CIP in resin, then mass-fabricating the capsules for self-healing by a microfluidic method, and by measuring the kinetic distance of the capsules containing different amounts of cip under the action of a magnetic field strength. The results show that with the increase of the amount of cip, the active distance of the capsule also increases. When the cip is 8wt%, the active distance reaches 1.75cm. We believe this research can provide momentum for the development of self-healing capsule applications.

• Journal of the Korean Recycled Construction Resources Institute
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• v.8 no.1
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• pp.134-142
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• 2020

In this study, in order to evaluate the self-healing performance of cement composites the self-healing test method and the analysis method were suggested by applying constant water head permeability test, chloride migration test and repeated bending test. The method of making a cracked specimen and controlling crack width are also proposed. Constant head water permeability test can evaluate the healing performance by using the decreasing rate of water flow passing through the crack zone of a specimen. Furthermore, the equivalent crack width can be used to intuitively investigate the healing effect with healing period. The chloride migration test can evaluate the healing rate by the decreasing rate of the diffusion coefficient obtained by ASTM C 1202. Mechanical healing performance can be evaluated using ISR and IDR estimated from load vs. CMOD relationship graph obtained through the repeated bending test. Finally, the applicability of proposed self-healing evaluation methods was examined by testing mortar specimens with or without self-healing agents.

• The Journal of the Korea Contents Association
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• v.15 no.4
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• pp.114-121
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• 2015

This study aims to reveal the educational effect and healing action of senior dance by approaching the experiential awareness of the social workers in phenomenological ways. The social workers who participated in the study are 7 social workers at Institute of Social Welfare of the Elderly Welfare in 2014 selected from ARTE Culture and Arts Culture and Arts Education Support Project as beneficiary organizations in the field of dance education. The materials and data of this study have been collected through 1 to 1 in-dept interviews with them. As a result, social welfare workers were recognizing senior dance education as emotional, recognizable, mental, social art activities rather than simple physical activities. And the senior citizens stimulate individual positive emotions and cognitive and have given feedback on and on. So, snowball effect that satisfactory feel of our lives get increased occurs. Finally, senior dance education provided at welfare institutions can be considered healing art activity to improve quality of life gradually through continuous interaction among individuals and communities.

• Archives of Plastic Surgery
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• v.35 no.2
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• pp.115-120
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• 2008

Purpose: Oncostatin M(OSM) is a multifunctional cytokine that belongs to the interleukin(IL)-6 family. Although there have been a number of studies that focused on the role and mechanism of OSM in various organs and tissues, there are few reports on its effect on wound healing. The final purpose of this project is to evaluate the effect of OSM on wound healing. This pilot study was designed to investigate the effect of OSM on proliferation and matrix synthesis of human dermal fibroblasts, which are the major components of the wound healing. Methods: Excess skin that was obtained from patients who underwent skin grafts, was used for this study. From this material, fibroblasts were isolated and cultured. The cultured fibroblasts were treated with one of four concentrations of OSM. The OSM concentrations used were 0, 50, 100, and 200 ng/ml, respectively. After the OSM treatment, cell proliferation was determined by the MTT assay, collagen synthesis by the C1CP method, GAG levels by the Blyscan Dye method. The parameter levels of each group were compared. Results: OSM treatment increased all the components tested in the study. In particular, cell proliferation, GAG synthesis demonstrated statistically significant increases(p<0.05 in the Mann-Whitney U-test). The highest increase in all the components was obtained at a 100 ng/ml concentration of OSM.Conclusion: The results of the present study indicate that OSM stimulates proliferation and matrix synthesis of human dermal fibroblast and the optimal concentration for wound healing is 100 ng/mL.

• Journal of People, Plants, and Environment
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• v.22 no.6
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• pp.691-698
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• 2019

This study is to examine the effect of improving the forest therapy program for adolescents using forest healing resources (focused on improving index of greenness for adolescents). The participants were 30 students from in the control group that participated in the 2018 program, and 51 students in experimental group that participated in the improved program in 2019. The questionnaire, developed by Korea Forest Welfare Institute, was comprised of items on general matters, index of greenness, restorative environment, positive emotion, negative emotion, facial expression and psychological assessment. The control group had 30 and the experimental group had 49 valid copies of the questionnaires. As a result of the paired sample t-test for each group, the control group showed a significant increase in all categories except restorative environment. In the experimental group, all categories significantly improved to a higher level (p <.01). An independent sample t-test (one-tailed test) was performed to test the effect of the forest therapy program with improved index of greenness. As a result, the index of greenness increased by 0.73 points(t=2.555, p <.01) and restorative environment by 1.01 points (t=2.567, p <.01), showing statistical significance. Negative emotion increased by 0.04 points (t=0.183, p >.05), which was not significant. On the other hand, positive emotion decreased by 0.42 points (t=-1.918, p <.05), facial expression by 0.57 points (t=-1.775, p <.05), and psychological assessment by 0.29 points (t=-0.981, p >.05), showing significance in positive emotion and facial expression. However, all the decreased items showed significant improvements between the pretest and posttest scores of the experimental group.

• Archives of Plastic Surgery
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• v.38 no.6
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• pp.733-739
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• 2011

Purpose: Cellulose is a natural substance from plants or bacteria. It is known that bacterial synthesized cellulose has an effect of wound healing. The aim of this study is to show the effect of bacterial synthesized cellulose from citrus on wound healing. Methods: Three full-thickness skin defects were made on the back of Sprague-Dawley rats. Three wounds were treated by vaseline gauze (Group V), Algisite $M^{(R)}$ (Group A) and bacterial synthesized cellulose from citrus (Group C) was used for dressing on skin defect on rats. We analyzed the gross, histological and biochemistry finding. Results: Group C showed more decrease of wound size compared to Group V (33% versus 7.2%) after 14 days. The histologic findings revealed Group C and Group A preceed the process of wound healing rather than Group V (More rapid collagen deposition and neovascularization and reduced inflammation). Also, the expressions of vascular endothelial growth factor (VEGF) and transforming growth factor (TGF)-${\beta}1$ were increased in the Group C and Group A compared with the Group V in 7 days. VEGF and TGF-${\beta}1$ expression were decreased in the Group C and Group A in 14 days, however Group V was not decreased at 14 day because of delayed wound healing process. Conclusion: Bacterial synthesized cellulose from citrus affects wound healing by reducing the inflammatory stage. And stimulates wound contracture by the deposition of extracellular matrix, thus preventing the formation of chronic wounds.

• Journal of Korean Medicine Rehabilitation
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• v.26 no.2
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• pp.29-50
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• 2016

Objectives There is few Korean medicinal studies about post-operation wound healing despite much effort for minimizing wound or post-op scar. The aim of this study is to evaluate the wound healing effect of Gyejibokryeong-hwan (Guizhifuling-wan, GBH) after skin suture. Methods < In vitro > We observed anti-oxidative and anti-inflammatory effect by using lipopolysaccharide (LPS)-treated RAW 264.7 cells. For anti-oxidation, we mesured the total amount of polyphenol, flavonoid, DPPH scavenging ability, ABTS scavenging ability and the value of ROS production, and for anti-inflammation, we mesured the amount of NO and pro-inflammatory cytokines ($TNF-{\alpha}$, $IL-1{\beta}$, IL-6). < In vivo > Thirty SD rats were divided into five equal groups (n=6, one normal, two controls and two experimentals). All groups except normal group were made a scar (around $1{\times}4cm^2$) in the back by the depth of the fascia and then sutured by a thread and needle. Normal group rats received no treatment at all. Control group rats were fed distilled water, and positive control group rats were percutaneously applied terramycin once in 2 days. GBH 200 group rats were orally medicated GBH 200 mg/kg, and GBH 400 group rats were orally medicated GBH 400 mg/kg per day for two weeks. We analyzed the blood samples (WBC, neutrophil, lymphocyte, monocyte, eosinophil), and the serums (TIMP-1, MMP-2, MMP-2. $PGE_2$, $TGF-{\beta}$, VEGF), and examined the wounded skin tissue histopathologically. Results < in vitro > 1. DPPH and ABTS scavenging activity was increased concentration-dependantly, and ROS production was significantly increased in GBH treated cells ($100{\mu}g/ml$). Therefore in this study, Gyejibokryeong-hwan appears to have the anti-oxidative. 2. NO production was significantly reduced in GBH treated cells ($100{\mu}g/ml$), and $IL-1{\beta}$ production was significantly reduced in GBH treated cells ($1{\mu}g/ml$). But, $TNF-{\alpha}$ and IL-6 did not show uneffective action. Therefore in this study, Gyejibokryeong-hwan did not show any significant effect on anti-inflammatory process. < in vivo > 1. Monocyte and neutrophil was significantly increased in GBH (200, 400) groups. WBC, lymphocyte and eosinophil did not show significant change. 2. TIMP-1, MMP-2, VEGF were significantly increased in GBH 400 group, $PGE_2$ was significantly reduced in GBH 400 group. $TGF-{\beta}$ was significantly increased in GBH (200, 400) groups, and MMP-9 was increased concentration-dependantly in GBH groups, but there was no significance. 3. In histopathological examinations, collagen was significantly increased and keratin was significantly decreased in GBH (200, 400) groups. Conclusions According to in vitro experiment, GBH appears to have the anti-oxidative effect and in vivo experiment, GBH stimulate the wound healing process hematologically and histopathologically. In conclusion, the results suggest that GBH promotes wound healing after skin suture.

• Journal of the Korean Academy of Clinical Electrophysiology
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• v.1 no.1
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• pp.87-100
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• 2003

The present studies have been designed to evaluate the effect of acute wound healing that frequency and intensity of pulsed ultrasound application in diabetic rat. Mild diabetes mellitus was induced in rat with 45 mg/kg streptozotocin. The results were analyzed and summarized as follows: 1. The rate of wound length on ultrasonic capacity in $1.0\;W/cm^2$ $SATA_i$ group was more significantly decreased than $0.5\;W/cm^2$ $SATA_i$ group. 2. In the histological change, the $1.0\;W/cm^2$ $SATA_i$ application group was more effective than $0.5\;W/cm^2$ $SATA_i$ group, decrease of inflammatory cell was significantly in several groups. From the conclusions above, in this study application of 3 MHz pulsed ultrasound in acute wound healing, $1.0\;W/cm^2$ $SATA_i$ capacity can be an effective way of promotion wound healing than $0.5\;W/cm^2$ $SATA_i$ capacity in diabetic rat.

• Journal of Veterinary Clinics
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• v.17 no.1
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• pp.62-69
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• 2000

The effects of vaselin, silver sulfadiazine and propolis on healing of full-thickness skin defects were evaluated in rabbits. Two wounds measuring 2{times}2cm$ were created bilaterally (4 wounds/rabbit) on the dorsolateral aspect of the trunk of 17 Ne Zealand white. Wound treatments were evenly distributed 4 sites, using a Latin square design. Treatments evaluated were: vaselin(group A), silver sulfadiazine(group B), 5% propolis (group C) and 10% propolis(group D). On days 3, 7 and 14, mean percentage of wound in group A, B, and C. On days 21 and 28, mean percentage of wound contraction in group D were significantly higher than those of groups B and C, but were not higher than that of group A. Microscopically fibersis and epithelialization were noticed on days 14 and 28 after wounding in all group. Rates of fibrosis of collagen fiber and epithelialization of groups C and D were exceeded those of groups A and B. All wounds in all group achieved 100% healing during the 28-day study period. Results indicate that use of propolis as would ointment on full-thickness skin wounds in rabbits increase rate of healing.