• 한국응용과학기술학회지
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• 제35권2호
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• pp.389-398
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• 2018

본 연구는 노루궁뎅이버섯 균사체로 발효시킨 엄나무 추출물의 항산화 및 항아밀로이드 활성을 알아보고자 하였다. 항산화 활성은 2,2-diphenyl-1-picrylhydrazyl(DPPH) radical, 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid)(ABTS) radical 소거 측정법을 사용하여 관찰하였다. 엄나무추출물(KP), 노루궁뎅이버섯 균사체 추출물(HE), 엄나무 발효물(KP-HE)에서 모두 라디칼 소거활성이 관찰되었다. 그러나 KP-HE가 KP와 HE에 비해서 더 높은 소거 활성을 갖는 것으로 관찰되었다. KP-HE는 peroxyl radical에 의한 DNA의 산화적 손상을 억제하였다. 알츠하이머병 (Alzheimer's disease: AD)과 관련 있는 $A{\beta}_{1-42}$의 응집에 KP, HE, KP-HE가 어떤 영향을 미치는 지를 알아보았다. KP와 HE는 $A{\beta}_{1-42}$의 응집에 거의 영향을 미치지 않았고 KP-HE는 $A{\beta}_{1-42}$의 응집을 효과적으로 억제하였다. 또한 $A{\beta}_{1-42}$에 의한 신경세포 사멸에 엄나무 발효물을 $300{\mu}g/mL$ 농도로 전 처리한 세포생존율은 20.3% 높게 증가되었다. 또한 엄나무 발효물을 $50{\mu}g/mL$ 농도로 처리했을 경우 세포 내 ROS의 축적이 유의적으로 감소되었다. 결론적으로 본 연구에서 관찰된 결과들을 통해 엄나무 발효물은 항산화 및 항아밀로이드 활성을 가지는 것으로 확인되었다. 따라서 엄나무 발효물은 알츠하이머병과 같은 퇴행성 뇌질환을 예방할 수 있는 식품소재로 이용될 수 있을 것으로 사료된다.

• 대한수학회보
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• 제57권3호
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• pp.583-595
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• 2020

Let HE_I, HE_II, HE_III and HE_IV be the first, second, third and fourth type Loo-Keng Hua domain respectively, 𝜑 a holomorphic self-map of HE_I, HE_II, HE_III, or HE_IV and u ∈ H(𝓜) the space of all holomorphic functions on 𝓜 ∈ {HE_I, HE_II, HE_III, HE_IV}. In this paper, motivated by the well known Hua's matrix inequality, first some inequalities for the points in the Bers-type spaces of the Loo-Keng Hua domains are obtained, and then the boundedness and compactness of the weighted composition operators W_𝜑,u : f ↦ u · f ◦ 𝜑 on Bers-type spaces of these domains are characterized.

• 한국응용과학기술학회지
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• 제35권1호
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• pp.194-204
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• 2018

본 연구는 신경퇴행성질환과 밀접한 관련이 있는 neurofilament-L(NF-L)의 산화적 손상에 엄나무 발효물이 미치는 영향을 알아보고자 하였다. 용액 상에서 peroxyl radical을 생성하는 AAPH를 처리하여 NFL의 산화적 변형을 유도하고 엄나무 추출물(KP), 노루궁뎅이버섯 균사체 추출물(HE), 엄나무 발효물(KP-HE)을 각각 처리하여 어떤 영향을 미치는 지를 알아보고자 하였다. KP와 HE는 peroxyl radical에 의한 NF-L의 산화적 손상을 막지 못했으나 KP-HE는 NF-L의 변형을 효과적으로 억제하였다. KP-HE는 peroxyl radical에 의한 NF-L 변형에서 나타나는 dityrosine 형성을 효과적으로 억제하였고 peroxyl radical 소거활성도 증가시켰다. 파킨슨병 환자에서 발견되는 신경독성물질인 tetrahydropapaveroline(THP)에 의한 NFL의 변형에 KP, HE, KP-HE가 미치는 영향을 관찰하였다. 그 결과 KP-HE는 KP와 HE에 비해서 THP에 의한 NF-L의 변형을 효과적으로 억제하는 것으로 관찰되었다. 또한 KP-HE는 THP에 의한 NF-L 변형에서 나타나는 dityrosine 형성도 효과적으로 억제하였고 THP에 의해 유도되는 활성산소 생성도 현저히 감소시켰다. 이와 같은 결과들은 KP-HE가 활성산소와 신경독성물질에 의한 산화적 스트레스로부터 세포를 보호해 줄 수 있을 것으로 사료되었다. 그러므로 엄나무 발효물은 신경퇴행성질환을 예방할 수 있는 식품소재로 이용될 수 있을 것으로 사료된다.

• Asian Pacific Journal of Cancer Prevention
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• 제13권9호
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• pp.4695-4698
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• 2012

Objective: To analyze differential diagnostic accuracy of urinary human epidydimis secretory protein 4 (HE4) in patients with ovarian tumors. Materials and methods: In the case-control study 23 patients with ovarian cancer, 37 patients with benign ovarian tumors and 18 women in the control group were included. Serum CA125 values and urinary concentrations of HE4were assessed quantitatively. Urinary creatinine concentrations and glomerular filtration rate were also determined and used to calculate ratios to HE4. Results: Higher urinary HE4 concentrations were observed in patients with late stage ovarian cancer (p=0.001) and also in patients with early stage ovarian cancer when compared to patients with benign ovarian tumors (p=0.044). On analysis where all ovarian cancer patients were included, higher diagnostic accuracy was observed with calculated ratio of HE4 to glomerular filtration rate (GFR) to unchanged urinary HE4 concentrations -AUC 0.861 vs. 0.858. When discriminatory accuracy was calculated for urinary HE4/GFR ratio and unchanged urinary HE4 concentrations, the last demonstrated a higher area under the curve - 0.701 vs. 0.602. The urinary HE4/creatinine ratio had lower discriminatory characteristics than unchanged concentrations of urinary HE4. However, HE4 serum concentration was more accurate for discrimination of patients with benign and malignant ovarian tumors when compared to urinary HE4 and CA125 in sera (AUCs were 0.868 for serum HE4 and 0.856 and 0.653 for urinary HE4 and CA125, respectively). Conclusions: Ovarian cancer patients have higher urinary concentrations of human epidydimis secretory protein 4 than patients with benign ovarian tumors. Urinary HE4 has comparable discriminatory accuracy with serum HE4 for benign and malignant ovarian tumors and can be recommended as a non-invasive ovarian cancer risk assessment method.

• 전기학회논문지P
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• 제67권4호
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• pp.214-220
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• 2018

Light sources induced by gas discharge using rare gases have been widely used in the thin film deposition, the surface modification and the polymer etching. A dielectric barrier discharge (DBD) has been developed in order to consistently emit light and control the wavelength of the emission light. However, much research on the characteristics of the movement of discharge particles is required to improve the efficiency of the light lamp and the life-time of the light apparatus in detail. In this paper, we developed a He DBD discharge simulation tool and investigated the characteristics of discharge particles which were electrons, two positive ions ($He^+$, $He_2^+$) and 5 excited particles ($He^*(1S)$, $He^*(3S)$, $He^*$, $He^{**}$, $He^{***}$). The discharge currents showed the transition from pulse mode to continuous mode with the increase of power. With the accumulated charges on the barrier walls, the discharge current was rapidly increased and caused oscillation of the discharge voltage. As the gas pressure increased, $He_2^+$ and $He^*(3S)$ became the dominant activated particles. The input power was mostly consumed by electrons and $He_2^+$ ion. And the change curve showed that power consumption by electrons increased more with gas pressure than with source voltage or frequency.

• Nuclear Engineering and Technology
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• 제23권4호
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• pp.420-425
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• 1991

SNU 1.5-MV 직렬형 반데그라프 가속기의 헬륨음이온원으로서 Rb 전하교환기를 제작하였다. 교환기의 최적운전조건을 결정하기 위해 특성실험을 수행하였다. Duoplasmatron 이온원에서 인출된 1~10 keV 에너지의 첼륨양이온빔을 Rb 증기속에 통과시킴으로써 2 단계 전하교환반응, 즉 $He^{+}\;+\;Rb\;{\rightarrow}\;He^{\circ\ast}\;+\;Rb^{+}\;과\;He^{\circ\ast}\;+\;Rb\;{\rightarrow}\;He^{-}\;+\;Rb^{+}$에 의해 헬륨음이온을 얻었다 실험결과로부터 헬륨음이온의 최대생성률이 헬륨양이온에너지가 7 keV일때 얻어짐을 알 수 있었다. Oven과 Canal의 최적온도는 각각 $370^{\circ}C{\;}와\;95^{\circ}C$로 결정되었다. 최적동작조건하에서 최대 헬륨음이온 생성률은 $2.42\pm002\;%$이었다. 본 전하교환기는 헬륨음이온생성에 효과적인 장치임이 입증되었다.

• 한국동물학회지
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• 제32권1호
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• pp.1-8
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• 1989

Pieris rapae의 휴면 유도 및 타파기작을 알아보기 위하여 비휴면기 유충과 휴면중인 번데기에 20-HE과 JH을 처리하여 변화를 관찰하는 한편, 체내의 각 호르몬의 농도도 측정하여 보았다. 비휴면기의 종령유충초기에 20-HE과 JH을 주입한 결과 어느 경우에도 휴면이 유도되지 않았다. Pre-diapausing 종령 유충에서는 20-HE 농도가 매우 낮았으며, 비휴면기용 2일의 20-HE peak가 휴면기에서는 나타나지 않았다. JH-I의 농도는 두 시기에 있어 뚜려한 차이가 없었다. 휴면중인 번데기의 초기와 말기에 20-HE, JH-I, JH-III을 주입한 결과 0.1-0.5 $\mu$g의 20-HE에 의해 휴면이 타파되었으나, JH-I과 JH-III에 의한 휴면 타파는 일어나지 않았다. 위의 결과로 배추흰나비의 휴면은 20-HE 농도가 저하됨으로 인해 유도되며, 휴면이 진행되는 동안 20-HE 농도가 점진적으로 증가하여 휴면이 타파되는 것으로 생각된다.

• 한국가정과교육학회지
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• 제8권1호
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• pp.33-49
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• 1996

The objectives of this study were (1) to determine the preferences for three home economics curriculum Models(Concept-based curriculum Model, Competency-based curriculum Model, and Practical Problem-based curriculum Model) of Korean home economics(HE) teachers and HE teacher educators, (2) to determine the difference between HE teachers and HE teacher educators according to purposes of HE, focus of learning, organization of HE subject matter, focus of HE curriculum, focus of HE content, HE knowledge, main questions addressed through HE curriculum, teaching strategies, students’progress, and systems of action, and (3) to determine the relationships between preferences for three curriculum Models and personal and professional characteristics of HE teachers. Respondents in this study were 225 HE teachers and 35 HE teacher educators. The survey method was used in this descriptive study. The survey method was used in this descriptive study. The overall curriculum Model preference of each teacher respondent was determined by counting number of times a given Model among 10 identified variables. The data were analyzed by using Chi-square to compare the differences between the two groups. To determine the relationships between preferences for three curriculum Models and personal and professional characteristics of HE teachers, coefficient of contingency tables was used. Both of HE teacher group(79.4%) and HE teacher educator group(67.6%) preferred the practical problem-based curriculum Model the most. There was a difference between the two groups on preferences for the curriculum Models related to systems of action. No significant difference emerged when Chi-square was applied to determine difference between the two groups on overall preferences for three HE curriculum Model. The chi square values between preferences for three curriculum Model and level of school, type of school were statistically significant. Each contingency coefficient for level of school(middle school and high school) and form of school(private and public school) was 27, which means there is a low association between the preferences and level of school and the preferences and form of school.

• 한방안이비인후피부과학회지
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• 제19권2호
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• pp.192-201
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• 2006

Objectives : Recently, He-Ne laser has been used for clinical purpose. We study the medical basis of He-Ne laser therapy and We make a proposal concerning the clinical application of using He-Ne laser in Medicine. Methods : We have selected data related to He-Ne laser therapy and study how to use He-Ne laser in clinic. Results : In biology, He-Ne laser therapy has been effects of an improve in skin regeneration an improve in peripheral and central nerve regeneration an improve in muscle regeneration, an anti-inflammation an alleviation of pain and a bone repair. In oriental medicine, He-Ne laser has been used to laser acupuncture and laser oriental physical treatment. In clinic, He-Ne laser have been used to care several parts like as facial palsy, facial spasm, trigeminal neuropathy, rhinitis and tinnitus. Recently, there is argument that He-Ne laser therapy is suitable to medical insurance. Conclusions : Laser therapy in oriental medicine is widespread and We can apply He-Ne laser to facial palsy, facial spasm, trigeminal neuropathy, rhinitis, tinnitus by using laser acupuncture or laser oriental physical treatment. Till now the whole mechanisms are not fully understood, so we hope to study these mechanisms actively and make suitable to medical insurance device in the near future.

• 안보군사학연구
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• 통권4호
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• pp.211-240
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• 2006

King Taejo, Wang Gun had succeeded in bringing order out of chaos of the Later Three Kingdoms and establishing a new unified dynasty, Koryo. Why can he gain the victory against the king of Later Baekje, GyunHwon? What is the his leadership? These are his leadership. (1) He had the peserverance. in 927 Wang Gun had broken by Gyun Hwon's army at Gong San. Nevertheless He didn't dissapoint and trained troops for battle steadily. Therefore in 930 he gained a great victory against Gyun Hwon at An Dong. (2) He use the command rights justically. (3)His soldiers are obedient to his orders involuntarily. (4) He always cooperateed with other’s commanders. (5)He efforted to gain victory without battle. (6)He had a high and great plan. (7) He took advantage of land configuration. (8) He made the enemy to fall into internal disarray. With these leadership, Wang Gun unified Later Three Kingdoms. Regarding himself as the success or to Goguryo, he pursued a policy of expansion to the north. Therefore he extended his borders to Chongchon River. At the same time he broke the chains of the bone-rank system which had shackled Shil1a's society.