• 한국지역사회생활과학회지
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• 제17권4호
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• pp.29-38
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• 2006

The present study proposed to develop a Hanji hat that can protect the body from UV rays and be preferred by consumers. For this purpose, using Hanji dyed by ginkgo leaf extract, we manufactured Hats in 12 designs. The UV blocking rate was determined by putting the hats on a mannequin and measuring the quantity of UV rays penetrating through the hat. In addition, preference for each design was surveyed, and the hat most suitable for the purpose was selected. The results of this study are as follows. 1. The UV blocking rate of the manufactured Hanji hats was over 92% for UVA and 97% for UVB in all of the 12 hats. 2. Among the 12 designs, the UV blocking rate for UVA was highest in 'Design(b)' and 'Design(1)' $(P\leq0.05)$, and the UV blocking rate for UVB was identical in all the designs except 'Design(i)' and 'Design(g)' $(P\leq0.01)$. 3. The effect of UV blocking was highest on the nape of the neck; next, on the brow, the cheeks, the nose and the chin in that order. 4. According to the result of the survey of preference, simple designs such as 'Design(a), (b)' and 'Design(9)' were preferred. In addition, it was found that the design would affect the purchase of a hat marked with a UV blocking index (68%). 5. Based on the results of this research as presented above, 'Design(b)', which showed a high UV blocking effect and was highly preferred, was selected as the most suitable hat for the purpose of this research.

• Nutrition Research and Practice
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• 제17권1호
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• pp.13-31
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• 2023

BACKGROUND/OBJECTIVES: Epigenetic regulation by nutrients can influence the development of specific diseases. This study sought to examine the effect of individual nutrients and nutrient families in the context of preventing chronic metabolic diseases via epigenetic regulation. The inhibition of lipid accumulation and inflammation by nutrients including proteins, lipids, vitamins, and minerals were observed, and histone acetylation by histone acetyltransferase (HAT) was measured. Correlative analyses were also performed. MATERIALS/METHODS: Nutrients were selected according to information from the Korean Ministry of Food and Drug Safety. Selected nutrient functionalities, including the attenuation of fatty acid-induced lipid accumulation and lipopolysaccharide-mediated acute inflammation were evaluated in mouse macrophage Raw264.7 and mouse hepatocyte AML-12 cells. Effects of the selected nutrients on in vitro HAT inhibition were also evaluated. RESULTS: Nitric oxide (NO) production correlated with HAT activity, which was regulated by the amino acids group, suggesting that amino acids potentially contribute to the attenuation of NO production via the inhibition of HAT activity. Unsaturated fatty acids tended to attenuate inflammation by inhibiting NO production, which may be attributable to the inhibition of in vitro HAT activity. In contrast to water-soluble vitamins, the lipid-soluble vitamins significantly decreased NO production. Water- and lipid-soluble vitamins both exhibited significant inhibitory activities against HAT. In addition, calcium and manganese significantly inhibited lipid accumulation, NO production, and HAT activity. CONCLUSIONS: Several candidate nutrients and their family members may have roles in the prevention of diseases, including hepatic steatosis and inflammation-related diseases (i.e., nonalcoholic steatohepatitis) via epigenetic regulation. Further studies are warranted to determine which specific amino acids, unsaturated fatty acids and lipid-soluble vitamins or specific minerals influence the development of steatosis and inflammatory-related diseases.

• Food Science and Biotechnology
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• 제16권3호
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• pp.457-462
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• 2007

Histone acetyltransferase (HAT) is a family of enzymes that regulate histone acetylation. Dysfunction of HAT plays a critical role in the development of cancer. Here we have screened the various plant extracts to find out the potent HAT inhibitors. The bellflower (Platycodon grandiflorum) root have exhibited approximately 30% of the inhibitory effects on HAT activity, especially p300 and CBP (CREB-binding protein) at the concentration of $100\;{\mu}g/mL$. The cell viability was decreased approximately 52% in LNCaP cell for 48 hr incubation. Furthermore, mRNA level of 3 androgen receptor target genes, PSA, NKX3.1, and TSC22 were decreased with bellflower root extract treatment ($100\;{\mu}g/mL$) in the presence of androgen. In ChIP assay, the acetylation of histone H3 and H4 in PSA promoter region was dramatically repressed by bellflower root treatment, but not TR target gene, Dl. Therefore, the potent HAT inhibitory effect of bellflower root led to the decreased transcription of AR target genes and prostate cancer cell growth with the repression of histone hyperacetylation.

• 대한임베디드공학회논문지
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• 제9권1호
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• pp.11-16
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• 2014

When it comes to develop flight simulator, HAT (Height Above Terrain) is required to provide altitude information to the pilot who learns how to control an airplane in landing and takeoff situation. However, there might be inconsistent problem between real terrain and simulation information since current implementation of HAT simply depends on center of gravity point on the airplane. To overcome mentioned problem, in this paper, we propose how to obtain more accurate altitude information than existing scheme by making use of HAT and HOT (Height Of Terrain) information of landing equipments according to movement of the airplane. Moreover, we demonstrate the accuracy of the proposed scheme through new flight simulator developed through OSG(OpenSceneGraph) by taking example of terrain information for domestic airport.

• 대한기계학회논문집A
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• 제25권1호
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• pp.98-105
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• 2001

The fundamental and widely used spot welded sections of automobiles (hat and double hat-shaped section members) absorb most of the energy in a front-end collision. The sections were tested on axial static(10mm/min) and quasi-static(1000mm/min) loads. Based on these test results, specimens with various thickness, shape and spot weld pitch on the flange have been tested with impact velocity(7.19m/sec) the same as a real life car clash. Characteristics of collapse have been reviewed and a structure of optimal energy absorbing capacity is suggested.

• 한국추진공학회지
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• 제23권5호
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• pp.53-59
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• 2019

고체연료는 추진제 연소 시 산화제와 반응하여 추진제 성능을 증가시키는 역할을 한다. 대표적인 고체연료는 Al, RDX, HMX 등이 있다. 이들 물질은 연소 시 수분과 만나 흰색 연기를 발생시키고, 일산화탄소, 이산화탄소, 메탄가스 등의 환경유해 물질을 다량 발생시킨다. 이러한 문제를 해결하기 위해 본 연구에서는 고체 연료로 사용 가능한 고질소 에너지 물질인 hydrazinium 5-aminotetrazolate(HAT)를 제조하였다. 분광분석(NMR)을 통해 HAT의 구조를 분석하였으며, DSC를 이용하여 열특성 분석을 하였다. 또한, EXPLO5 프로그램을 이용하여 비추력, 가스발생량 등을 계산하였다.

• Journal of the Korean Statistical Society
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• 제7권2호
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• pp.101-104
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• 1978

This paper considers the problem of estimating $\hat{\beta}$ in the case errors occur in observing the values of q-variables $X_1, X_2, ..., X_q$. The approximated estimator $\hat{\beta}(e)$ is obtained and its expected value, bias and covariance matrix are studied.

• 대한수학회보
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• 제57권3호
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• pp.649-660
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• 2020

This paper proves a new regularity criterion for solutions to the Cauchy problem of the 3D Boussinesq equations via one directional derivative of the horizontal component of the velocity field (i.e., (∂_iu₁; ∂_ju₂; 0) where i, j ∈ {1, 2, 3}) in the framework of the anisotropic Lebesgue spaces. More precisely, for 0 < T < ∞, if $$\large{\normalsize\displaystyle\smashmargin{2}{\int\nolimits_o}^T}({\HUGE\left\|{\small{\parallel}{\partial}_iu_1(t){\parallel}_{L^{\alpha}_{x_i}}}\right\|}{\small^{\gamma}_{L^{\beta}_{x_{\hat{i}}x_{\bar{i}}}}+}{\HUGE\left\|{\small{\parallel}{\partial}_iu_2(t){\parallel}_{L^{\alpha}_{x_j}}}\right\|}{\small^{\gamma}_{L^{\beta}_{x_{\hat{i}}x_{\bar{i}}}}})dt<{{\infty}},$$ where ${\frac{2}{{\gamma}}}+{\frac{1}{{\alpha}}}+{\frac{2}{{\beta}}}=m{\in}[1,{\frac{3}{2}})$ and ${\frac{3}{m}}{\leq}{\alpha}{\leq}{\beta}<{\frac{1}{m-1}}$, then the corresponding solution (u, θ) to the 3D Boussinesq equations is regular on [0, T]. Here, (i, ${\hat{i}}$, ${\tilde{i}}$) and (j, ${\hat{j}}$, ${\tilde{j}}$) belong to the permutation group on the set 𝕊₃ := {1, 2, 3}. This result reveals that the horizontal component of the velocity field plays a dominant role in regularity theory of the Boussinesq equations.

• Tribology and Lubricants
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• 제11권5호
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• pp.150-155
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• 1995

In order to analyze the thermal effects of the rotor models, the finite element technique was used in this study. The length of the hat was investigated as a design parameter. At the start of each brake application the disk surface temperature rapidly increases to a maximum value and then decays due to external cooling and thermal conduction to the hat. The calculated results indicate that the long length of the hat shows the minimum deformation in axial direction, which is related to the thermal problems, coned wear, vibration and noise.

• 품질경영학회지
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• 제26권1호
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• pp.88-98
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• 1998

Process capability indices are used to determine whether a production process is capable of producing items within a specified tolerance. Using conditional distribution, we study some process capability indices ${\hat{C}}_{Gp}$, ${\hat{C}}_{Gpk}$, ${\hat{C}}_{Gpm}$ under conjugate prior distribution. We consider some process capability indices with Gibbs sampling method. Also, we examine some small sample properties related to these estimaters by some simulations.