• 약학회지
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• 제36권6호
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• pp.518-528
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• 1992

To determine the optimal conformation of sulfonylureas, the correlation between conformation and hypoglycemic activity of the two sulfonylureas of tolbutamide and chlorpropamide as hypoglycemic agent was studied using an empirical potential function (ECEPP/2) and the hydration shell model in the unhydrated and hydrated states. The conformational energy was minimized from several starting conformations with possible torsion angles in each molecule. The conformational entropy change of each conformation was computed using a harmonic approximation. To understand the hydration effect on the conformation of the molecules in aqueous solution, the contribution of water-accessible volume of each group or atom in the lowest-free-energy conformation was calculated and compared each other. From comparison of the computed lowest-free-energy conformations of two sulfonylureas, it could be suggested that the hydration of sulfonylurea moiety is related to increase the hypoglycemic activity. From the calculation results, it was known that the conformational entropy is the major contribution to stabilize the low-free-energy conformations of two sulfonylureas in unhydrated state. Whereas, in hydrated state, the hydration free energy largely contributes to the total free energies of low-free-energy conformations of tolbutamide and conformational entropy contributes to stabilize the low-free-energy conformations of chlorpropamide. The torsion angles from phenyl ring to urea moiety of the low-free-energy conformations of the two sulfonylureas were shown the nearly regular trend. On the basis of these results, the conformation exhibiting the optimal hypoglycemic activity of sulfonylureas and the binding direction to pancreatic receptor site A could be predicted. Also, according to the side chain lengthening of urea moiety, tolbutamide showed various conformational change. Therefore, steric effect may be important factor in the interaction between sulfonylureas and the putative pancreatic receptor.

• 한국항공우주학회지
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• 제30권4호
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• pp.28-37
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• 2002

음향불안정을 억제하는 수동제어기구중 하나인 음향공의 음향학적 효과를 파악하기 위해, 음향공이 장착된 로켓엔진 연소실의 음향장 특성을 수치해석적으로 조사하였다. 음향공 모델로서 Helmholtz 형태의 공명기가 채택되었고, 조화해석을 통해 주로 음향공에 의해 야기되는 음향학적 효과를 관찰하였다. 음향공의 음속을 조정하여 동조주파수를 변화시켜가면서 가진음원에 대한 연소실의 음향진동 응답을 구하고, 제1접선방향 음향모드의 감쇠인자를 구하였다. 동조주파수가 제1접선방향 음향모드의 공진주파수에 접근함에 따라 모드분할 현상이 나타났고, 이로인해 음향공을 본래의 제1접선방향 음향모드에 동조시키더라도 음향감쇠효과가 저하됨을 알았다. 모드분할 현상과 분할된 각 모드의 감쇠인자 및 음향 에너지 분포를 고려하였으며, 이를 토대로 효과적인 감쇠를 위해서는, 억제하고자 하는 음향모드로부터 모드분할 현상이 나타나지 않으면서 그 음향모드의 감쇠효과를 극대화하도록 음향공을 동조시키는 것이 바람직함을 알 수 있었다.

• 물과 미래
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• 제15권3호
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• pp.23-36
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• 1982

The stochastic variations and structures of time series data on water quality were examined by employing the techniques of autocorrelation function, variance spectrum, Fourier series, autoregressive model and ARIMA model. These time series included hourly and daily observation on DO, turbidity, conductivity pH and water temperature. The measurement was made by automatic recording instrument at Noryangjin and Dook-do located in the downstream part of Han River during 1975 and 1976. Hourly water quality time series varied with the dominant 24-hour periodicity, and the 12-hour periodicity was also observed. An important factor affecting 24-hour periodic variation of DO is believed to be photosynthesis by algae. These phenomena might be attributable to periodic discharges of municipal sewage. Noryangjin site showed the more distinct 12-hour periodicity than Dook-do site did, and tidal effect might be responsible for the difference. The water quality, as measured by DO and turbidity, was better in the afternoon compared with the quality in the morning. This change can be explained by the periodic variation of DO, temperature and the amount of municipal wewage discharge. It was also observed that the water temperature at Noryangjin was higher than the temperature at Dook-do. This difference might have been caused by the pollutants that were added to the section between two sites. The correlation coefficients between some of the variables were fairly high. For example, the coefficient was -0.88 between DO and water temperature, 0.75 between turbidity and river flow, and 0.957 between water temperature and air temperature. The lag time of heat transfer from the air to the water was estimated as 24 days. The first order auto-regressive model was appropriate for explaning standardized hourly DO time series. The ARIMA model of (1, 0, 0) type provided relatively satisfactory results for daily DO time series after the removal of significant harmonic value.

• 대한기계학회논문집
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• 제16권12호
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• pp.2328-2339
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• 1992

본 연구에서는 일방향(unidirectional)으로 섬유가 강화된 복합재료를 다루게 되는데, 섬유는 직경이 모두 같고, 길이가 무한이며, 서로 평행하게 정렬되엉 불규칙 하게 분포된 원형실린더로 가정한다. 먼저, 임의의 한 기준 산란체에 의한 압축파 및 SV파의 산란을 수식화하고, 기준 산란체에 대한 나머지 산란체들이 존재할 확률을 이용하여 산란계수의 통계적 기대값을 구함으로써 그 매질내에 존재하는 파동의 전파 특성을 지배하는 분산 관계식의 해를 수치적으로 구함으로써 매질의 평균전파속도, 유 효 동탄성계수 및 감쇠계수를 주파수와 체적비의 함수로 구한다. 또 구하여진 동탄 성계수의 저주파 극한값과 정적하중상태에서 구한 Hashin-Rosen의 값들과 비교하여 봄 으로써 본 연구의 타당성을 입증한다.

• 대한조선학회지
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• 제22권3호
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• pp.9-18
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• 1985

The numerical calculation for solving boundary-value problem related to potential flows with a free surface is carried out by application of the localized finite element method. Only forced motion of 2-D body in infinitely deep fluid is considered, although this schemes is equally applicable to any first order time-harmonic problems of similar nature. The infinite domain of the fluid is separated into the inner flow field and the outer flow field with common inter-surface boundary. The finite element method is applied to obtain the solution in the inner flow field and the Green functions are utilized to represent the solution in the outer flow field. At the inter-surface boundary, the continuity of the value of potential and the normal derivative of the potential(i.e. matching condition) is conserved. The present method has better computational efficiency than the previous LFEM and the integral equation method of Frank. This enhanced computational efficiency is presumably due to the fact that the present method gives a symmetric coefficient matrix and requires less computational time in calculating the influence coefficient matrix of Green function than the integral equation method. And the irregular frequency desen't exist because the uniqueness of the solution is assured by the such that the exact free surface condition is satisfied on the boundary of the localized finite element region(i.e. inner region). As an example of the above method, the hydrodynamic forces for the circular cylinder and the rectangular cylinders are calculated. In the computed results, the small number of singularity distribution segments($3{\sim}6$) give good result relative to Ursell's and Vugts'.

• Wind and Structures
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• 제20권2호
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• pp.349-361
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• 2015

Higher-mode vertical vortex-induced vibrations (VIV) have been observed on several steel box-girder suspension bridges where different vertical modes are selectively excited in turn with wind velocity in accordance with the Strouhal law. Understanding the relationship of VIV amplitudes for different modes of vibration is very important for wind-resistant design of long-span box-girder suspension bridges. In this study, the basic rectangular cross-section with side ratio of B/D=6 is used to investigate the effect of different modes on VIV amplitudes by section model tests. The section model is flexibly mounted in wind tunnel with a variety of spring constants for simulating different modes of vibration and the non-dimensional vertical amplitudes are determined as a function of reduced velocity U/fD. Two 'lock-in' ranges are observed at the same onset reduced velocities of approximately 4.8 and 9.4 for all cases. The second 'lock-in' range, which is induced by the conventional vortex shedding, consistently gives larger responses than the first one and the Sc-normalized maximum non-dimensional responses are almost the same for different spring constants. The first 'lock-in' range where the vibration frequency is approximately two times the vortex shedding frequency is probably a result of super-harmonic resonance or the "frequency demultiplication". The main conclusion drawn from the section model study, central to the higher-mode VIV of suspension bridges, is that the VIV amplitude for different modes is the same provided that the Sc number for these modes is identical.

• 한국정보통신학회논문지
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• 제13권5호
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• pp.922-930
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• 2009

유도 전동기를 전압 제어하기 위한 최적 PWM 스위칭 방법을 제시하려한다. 전압 인버터의 공간 벡터 변조 방식은 DC-버스 이용을 향상시키고 정류 손실을 감소시키기 때문에 디지털 구현의 경우 특히 선호하는 PWM 방법이다. 유도 전동기 전압 제어를 위한 최적 PWM 스위칭 방법은 제시한 최적 PWM 알고리즘을 사용하여 두 개의 활성 전압 벡터(active voltage vector)와 하나의 영 전압 벡터(zero voltage vector)로 구성하였다. 선택된 스위칭 순차 열은 변조 지수(modulation index)와 운송파(carrier wave) 주기의 함수로 정의 된다. 순차 열은 인버터 스위칭 손실과 전류 리플 값을 기준으로 사용하여 선택된다. 실험 결과 중 저 전력용으로 사용할 경우 스위칭 주파수를 증가시킴에 따라 고조파 왜곡이 감소하고 동특성이 좋아짐을 확인할 수 있었다.

• 대한기계학회논문집A
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• 제20권10호
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• pp.3079-3094
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• 1996

Recently, the high-precision vibration attenuation technology becomes the essence fo the seccessful development of high-integrated and ultra-precision industries, and is expected to continue playing a key role in the enhancement of manufacturing technology. Vibration isolation system using an air-spring is widely employed owing to its excellent isolation characteristics in a wide frequency range. It has, however, some drawbacks such as low-stiffness and low-damping features and can be easily excited by exogenous disturbances, and then vibration of table is remained for a long time. Consequently, the need for active vibration control for an air-spring vibration isolation system becomes inevitable. Furthermore, for an air-spring isolation table to be successfully employed in a variety of manufacturing sites, it should have a guaranteed robust performance not only to exogenous disturbances but also to uncertainties due to various equipments which might be put on the table. In this study, an active vibration suppression control system using H.inf. theory is designed and experiments are performed to verify its robust performance. An air-spring vibration isolation table with voice-coil-motors as its actuators is designed and built. The table is modeled as 3 degree-of-freedom system. An active control system is designed based on $H_\infty$control theory using frequency-shaped weighting functions. Analysis on its performance and frequency responce properties are done through numerical simulations. Robust characteristics of$H_\infty$ control on disturbances and model uncertainties are experimentally verified through (i) the transient response to the impact excitation of the table, (ii) the steady-state response to the harmonic excitation, and (iii) the response to the mass change of the table itself. An LQG controller is also designed and its performance is compared with the $H_\infty$ controller.

• 대한기계학회논문집A
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• 제39권2호
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• pp.143-156
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• 2015

함수구배재료의 모드 III 균열이 물성치 구배방향과 다른 방향으로 비정상적으로 전파할 때 전파균열선단부근의 응력 및 변위장에 대하여 연구하였다. 함수구배재료는 밀도가 일정한 상태에서 전단탄성계수가 선형적으로 변화하는 경우와 밀도와 전단탄성계수가 지수형적으로 변화하는 경우로 가정했다. 조화함수의 해를 얻기 위하여 일반적인 편미분방정식의 동적평형방정식을 라플라스 방정식으로 변환하였다. 라플라스 방정식으로부터 균열속도 변화률, 응력확대계수의 변화률 등에 의존되는 응력장과 변위장을 근접해법으로 얻었다. 본 연구에서 얻어진 응력장과 변위장을 사용하여 재료의 비 균질성, 균열속도의 변화률, 응력확대계수의 변화률 등을 고려한 상태에서 균열이 임의의 방향으로 전파할 때 균열선단부근의 응력 및 변위 그리고 응력확대계수에 대하여 연구하였다.

• 대한전자공학회논문지TC
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• 제41권5호
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• pp.69-76
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• 2004

본 논문에서는 낮은 위상잡음을 갖는 X-band용 전압 제어 유전체 공진형 발진기를 설계ㆍ제작하였다. 위상잡음을 개선하기 위하여 저잡음 특성과 프리커 잡음이 낮은 MESFET과 높은 선택도와 Q값이 큰 유전체 공진기를 사용하였다. 또한 바렉터 다이오드는 부하의 영향을 줄이기 위해서 Q-factor가 매우 큰 것을 사용하여야 하며, 전압에 대한 주파수 변동이 선형이 되도록 하기 위해 다이오드의 Gamma가 큰 바렉터 다이오드를 사용하였다. 구현된 회로는 최적의 성능을 갖도록 회로 시뮬레이터인 ABS를 사용하였다. 제작된 전압제어 유전체 공진형 발진기의 특성을 측정한 결과, 중심 주파수 12.05 ㎓에서 5.8㏈m의 출력 파워와 -30 ㏈c의 고조파 억압과 100㎑ offest 주파수에서 -114 ㏈c의 위상잡음 특성을 얻을 수 있었으며, 바렉터 다이오드에 인가되는 전압의 변화에 따른 주파수 동조 범위는 15.2 ㎒를 얻었고 이때의 전력 평탄도는 -0.2㏈ 의 우수한 성능을 얻을 수 있었다. 제작된 발진기는 X-band에서 국부 박진기로 이용될 수 있음을 확인하였다.