• Genomics & Informatics
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• v.19 no.1
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• pp.3.1-3.12
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• 2021

Functional interpretation of noncoding genetic variants associated with complex human diseases and traits remains a challenge. In an effort to enhance our understanding of common germline variants associated with lung cancer, we categorize regulatory elements based on eight major cell types of human lung tissue. Our results show that 21.68% of lung cancer-associated risk variants are linked to noncoding regulatory elements, nearly half of which are cell type-specific. Integrative analysis of high-resolution long-range chromatin interactome maps and single-cell RNA-sequencing data of lung tumors uncovers number of putative target genes of these variants and functionally relevant cell types, which display a potential biological link to cancer susceptibility. The present study greatly expands the scope of functional annotation of lung cancer-associated genetic risk factors and dictates probable cell types involved in lung carcinogenesis.

• Safety and Health at Work
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• v.12 no.4
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• pp.544-545
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• 2021

The article by Tae-Gu Kim et al. conducted elastic FE modeling, which was inappropriate for fracture of elastic-plastic chain material (11.3% of elongation). FE analysis results and the findings in the fracto-graphic analysis did not tally but contradicted each other. The article identified "incorrect installation"/bending forces as the root cause while FE results of the chain under bending forces showed very low stresses at fracture locations but the highest stress in the middle of shank of the chain. The article's "step-like topographies indicating the fracture due to bending moment rather than uniaxial tension" lacked scientific support. The load value carried by each chain section under bending/incorrect installation was only half of that under tension, thus the article using same load value in FE simulation comparison for bending and tension was incorrect. The real cause of the chain fracture was likely improper checking the lifted load or/and using the wrong chain with much lower safety working load.

• The Journal of The Korea Institute of Intelligent Transport Systems
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• v.7 no.4
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• pp.61-70
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• 2008

This paper designed the antenna for collecting and servicing the traffic information that apply to freeway Traffic Management System, as using DSRC (Dedicated Short Range Communication). Active DSRC is the technology that is using 5.8GHz Radio Frequency to a mean Sequency and there are a lot of the case occurring a physical electric wave shadowing because of the traveling straight of a electric wave. In such inferior communication environment, it constructed the stabilized communication link that can do collecting and servicing the correct traffic information and designed the beam pattern considering the establishment position of the antenna that can apply to various road environments and a communication area. By considering the communication link environment, this paper designed and manufacture the mean frequency of 5.8GHz, the input loss of -17dB in 75MHz bandwidth, the Axial ratio of 1.5:1, and $2{\times}4$ array microstrip antenna which beam pattern have the characteristic of $55^{\circ}$ horizontal half power beam width and $26^{\circ}$elevation half power beam width and the minimum establishment height of the antenna was designed as 14m for avoiding electric wave shadowing on a physical condition between vehicles

• Journal of the Korean Institute of Illuminating and Electrical Installation Engineers
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• v.16 no.2
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• pp.9-17
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• 2002

A high-efficiency electronic ballast for HID lamps is presented. The ballast consists of a PFC and a resonant inverter. To reduce losses of the ballast, DC link voltage should be determined by taking into account the peak voltage of lamp and the maximum flux density should be kept 0.2[T] on all of inductors. AR inductor at bridge diode is employed in order to remove currant harmonics from PFC. An inductor is connected in series with an electrolytic capacitor at DC link to reject high-frequency current. The acoustic resonance is eliminated using the stead spectrum technique. The electronic ballast for 250[W] metal-halide discharge lamp is implemented and 96[%] efficiency, no acoustic resonance and low conducted EMI level are accomplished.

• Journal of Institute of Control, Robotics and Systems
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• v.17 no.10
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• pp.1021-1028
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• 2011

The objective of this paper is to optimize the design parameters of a novel mechanism for a robotic knee orthosis. The feature of the proposed knee othosis is to drive a knee joint with independent actuation during swing and stance phases, which can allow an actuator with fast rotation to control swing motions and an actuator with high torque to control stance motions, respectively. The quadriceps device operates in five-bar links with 2-DOF motions during swing phase and is changed to six-bar links during stance phase by the contact motion to the patella device. The hamstring device operates in a slider-crank mechanism for entire gait cycle. The suggested kinematic model will allow a robotic knee orthosis to use compact and light actuators with full support during walking. However, the proposed orthosis must use additional linkages than a simple four-bar mechanism. To maximize the benefit of reducing the actuators power by using the developed kinematic design, it is necessary to minimize total weight of the device, while keeping necessary actuator performances of torques and angular velocities for support. In this paper, we use a SGA (Simple Genetic Algorithm) to minimize sum of total link lengths and motor power by reducing the weight of the novel knee orthosis. To find feasible parameters, kinematic constraints of the hamstring and quadriceps mechanisms have been applied to the algorithm. The proposed optimization scheme could reduce sum of total link lengths to half of the initial value. The proposed optimization scheme can be applied to reduce total weight of general multi-linkages while keeping necessary actuator specifications.

• Journal of the Institute of Electronics Engineers of Korea TC
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• v.44 no.5
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• pp.7-15
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• 2007

In wireless communication networks, single-radio single-channel architecture degrades throughput and end-to-end delay due to half-duplex transmission of wireless node and route intra interference. Also, In contention-based MAC (Medium Access Control) architecture, channel contention reduces throughput and packet collision enlarges end-to-end delay. In this paper, we use multi-radio multi-channel architecture which will make wireless node to operate in full duplex mode, and exclude route intra interference. Based on this architecture, we propose a new link metric, ccf which reflects the characteristics of a contention-based wireless link, and propose a routing path metric MCCR considering channel switching delay and route intra interference. MCCR is compared with MCR by simulation, the performance of a route established by MCCR outperforms the performance of a route by MCR in terms of throughput and end-to-end delay.

• The Journal of Advanced Prosthodontics
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• v.10 no.6
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• pp.408-414
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• 2018

PURPOSE. This study aimed to assess the effect of non-thermal plasma on the shear bond strength of resin cements to polyetherketoneketone (PEKK) in comparison to other surface treatment methods. MATERIALS AND METHODS. Eighty PEKK discs were subjected to different surface treatments: (1) Untreated (UT); (2) Non-thermal plasma (NTP); (3) Sandblasting with $50{\mu}m$ $Al_2O_3$ particles (SB); and (4) Sandblasting + Non-thermal plasma (SB+NTP). After each surface treatment, the contact angle was measured. Surface conditioning with Visio.Link was applied in all groups after pre-treatment. RelyX Unicem resin cement was bonded onto the PEKK specimens. After fabrication of the specimens, half of each group (n=10) was initially tested, while the other half was subjected to thermocycling ($5^{\circ}C$ to $55^{\circ}C$ at 10,000 cycles). Shear bond strength (SBS) testing was performed using a universal testing machine, and failure modes were assessed using stereomicroscopy. The SBS results were analyzed statistically using one-way ANOVA followed by Tukey's post hoc test. Independent t-test was used to examine the effect of thermocycling (P<.05). RESULTS. The highest SBS values with or without thermocycling were observed with PEKK specimens that were treated with SB+NTP followed by the SB group. The lowest SBS results were observed in the UT groups. CONCLUSION. The shear bond strength between PEKK and resin cements was improved using non-thermal plasma treatment in combination with sandblasting.

• KIEE International Transaction on Electrical Machinery and Energy Conversion Systems
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• v.5B no.2
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• pp.181-188
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• 2005

In this paper, a DC smoothing filterless soft switching pulse modulated high frequency AC power conversion circuit connected to utility. frequency AC power source is proposed for consumer induction heating hot water producer, steamer and super heated steamer. The operating principle of DC link filterless utility frequency AC-high frequency AC (HF AC) power conversion circuit defined as high frequency cycloinverter is described, which can operate under a principle of ZVS/AVT and power regulation based on alternate asymmetrical PWM in synchronization with the utility frequency single phase AC positive or negative half wave voltage. The dual mode modulation control scheme based on high frequency PWM and commercial frequency AC voltage PDM for the proposed high frequency cycloinverter are discussed to enlarge its soft switching commutation operating range for wide HF AC power regulation. This high frequency cycloinverter is developed for high frequency IH Dual Packs Heater (DPH) type boiler used in consumer and industrial fluid pipeline systems. Based on the experiment and simulation results, this high frequency cycloinverter is proved to be suitable for the consumer use IH-DPH boiler and hot water producers. The cycloinverter power regulation and power conversion efficiency characteristics are evaluated and discussed.

• Journal of Institute of Control, Robotics and Systems
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• v.20 no.2
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• pp.143-148
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• 2014

Conventional wireless power transfer methods based on coupled magnetic fields need a complex winding structure on the surface of the energy transfer and shows poor efficiency near metal objects due to the eddy current effect. In this study, to mitigate these problems, we investigate an electric field-coupled power transmission system, which is less prone to metal object problems and EMI. Because of the fundamental physical limit in the size of link capacitances, a half-bridge converter with an impedance matching transformer is proposed and the design procedure is derived to provide a soft-switching scheme. Hardware implementation shows that the proposed scheme with a pair of 10cm by 10cm copper plate can power a 1.4W USB FAN in a separation of 0.2mm by using insulating paper when driven by 227 kHz gate pulse.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.29 no.2 s.233
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• pp.176-187
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• 2005

This paper presents an evaluation of joint configurations of a robotic finger based on kinematic analysis. The evaluation is based on an assumption that the current control methods for the fingers require that the contact state specified by the motion planner be maintained during manipulation. Various finger-joint configurations have been evaluated for different contact motions. In the kinematic analysis, the surface of the manipulated object was represented by B-spline surface and the surface of the finger was represented by cylinders and a half ellipsoid. Three types of contact motion, namely, 1) pure rolling, 2) twist-roiling, and 3) slide-twist-rolling are assumed in this analysis. The finger-joint configuration best suited for manipulative motion is determined by the dimension of manipulation workspace. The evaluation has shown that the human-like fingers are suitable for maintaining twist-rolling and slide-twist-rolling but not for pure rolling. A finger with roll joint at its fingertip link, which is different from human fingers, proved to be better for pure rolling motion because it can accommodate sideway motions of the object. Several kinds of useful finger-joint configurations suited for manipulating objects by fingertip surface are proposed.