• 제목/요약/키워드: Half Life

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구아니딘화 폴리에틸렌이민이 처리된 폴리프로필렌 부직포의 군사용 화학 작용제 제독 특성 (Detoxification Properties of Guanidinylated Polyethyleneimine Treated Polypropylene Non-woven Fabric Against Chemical Warfare Agents)

  • 김지윤;권웅;김창규;정의경
    • 한국염색가공학회지
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    • 제33권1호
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    • pp.1-9
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    • 2021
  • This study aims to prepare the fabric with detoxification properties against chemical warfare agent by the simple treatment. For this purpose, polypropylene non-woven fabric(PP) was treated with polyethyleneimine(PEI) and guanidinylated PEI and detoxification properties of the guanidinylated PEI treated PP were evaluated using diisopropylfluorophosphate(DFP), as a chemical warfare agent simulant, and compared with the untreated and PEI treated PP. The half-lives of DFP on guanidinylated PEI treated PP and untreated PP were 334 min and 714 min, respectively. The half-life of DFP with guanidinylated PEI treated PP was 53.22% shorter than with untreated PP. This result shows that guanidine group in guanidinylated PEI treated PP was acted as a base catalyst for hydrolysis of DFP and decreased half-life of DFP. Therefore, it is expected that guanidinylated PEI treatment can be an simple pathway to prepare the detoxification fabric material for protective clothing against chemical warfare agents.

갑상선암 환자에서 고용량 방사성요오드 치료 후 유효반감기에 대한 연구 (A Study on the Effective Half-life after the High Dose Radioactive Iodine (131I) Therapy for Thyroid Cancer Patients)

  • 김성철;권다영;김용민
    • 한국방사선학회논문지
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    • 제11권7호
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    • pp.597-603
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    • 2017
  • 고용량 $^{131}I$ 치료는 분화갑상선암으로 인한 갑상선전절제술을 받은 환자에게 보편적으로 시행되어 왔다. 고용량 $^{131}I$ 치료를 하는 경우 환자로부터 일반인이 받게 되는 피폭선량을 선량한도 이내로 제한하기 위해 환자를 일정 기간 동안 격리하여야 한다. 유효반감기는 환자로부터 가족들이 얼마나 피폭되는지 계산하거나 격리기간을 결정하는데 중요한 값이다. 이에 본 연구에서는 NM670 SPECT/CT를 이용해 고용량 $^{131}I$ 치료환자의 유효붕괴상수, 유효반감기, 격리기간을 도출하였다. 본 연구를 통해 고용량 $^{131}I$ 치료환자의 유효반감기를 도출하였고, 체내에 잔류 방사능량이 퇴원기준인 1.2 GBq 에 도달하는 시간을 확인하였다. 또한 치료선량별 유효반감기를 비교하였을 때 유의한 차이가 없었으나, 격리기간은 치료선량이 커질수록 격리기간이 길어지는 것을 확인할 수 있었다. 전처치 유형별 유효반감기를 비교하였을 때 rhTSH 환자군과 THW 환자군의 유효반감기가 유의한 차이를 보이지 않았으나, 격리기간은 rhTSH 환자군이 THW 환자군 보다 짧게 나타났다. 이는 치료선량의 차이로 인해 격리기간이 짧아진 것으로 판단된다. 따라서 현행 의료보험체계(rhTSH 사용 시 3.7 GBq 이하에서 보험적용)가 유지된다면, 전처치 유형별로 구분하여 현행 격리기간(2박 3일)보다 더 이른 시간에 환자를 퇴원시킬 수 있을 것이다.

유료시설 거주노인의 생활만족도 영향요인 (A Study on Influential Factors Related to the Level of life Satisfaction of the Elderly Residents at Paid Facilities)

  • 서병숙
    • 가정과삶의질연구
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    • 제14권4호
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    • pp.129-144
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    • 1996
  • The purpose of this study was to illuminate the ways to im-prove the level of life satisfaction of the elderly who chose or happened to live at paid facilities by examining some of factors such as individual family social support and facility related el-ements that would influence their life satisfaction. The interview outcomes came out in three main discussions. First the general characteristics of the participating elderly appeared to be that most of them were ver7y elderly relatively highly educated females and religions and the rate of being ill was high. And a half of them considered themselves as heal- thy people and the other half as unhealthy. Secondly in view of statisticsal results the level of their life satisfaction was influnced by their individual family and facillity related factors. As far as their individual related factor are concerned the level of one party's life satisfaction was relative-ely higher than that of other's when the person is female had religio presumed oneself as in healthy and good physical condition. And when participating member keeps good relation-ship with his or her own children the level of the person's life satisfaction was only slightly higher than other elderly group who did not have good relationship with their children. There were no other significant statistical differences on the level of their life satisfaction related to the social support factors between those two group. Thirdly the level of the elderly's life satisfaction was influe- nced in the order of folldwing factors: (1) the quality of facility living condition 2) the commitment of ownership of the organization (3) the elderly residents' own education level (4) the elderly's own subjectivel health condition and (5) the sex of the individuals.

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Foreign and Domestic Influence of the First Half of the Twentieth-Century American Furniture

  • Kim, Seong-Ah
    • 한국가구학회지
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    • 제18권4호
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    • pp.324-336
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    • 2007
  • Throughout the twentieth century, American furniture was subject to a number of influences-both domestic and foreign. Especially, in the first half of the twentieth century, there were strong foreign influences compare to the later half of the century. Therefore, this study aimed for discussing foreign influences and for addressing issues such as attitudes toward materials, ornamentation, and technology. As a result, this study suggests how American furniture becomes instinctive moving away from strong foreign influences from the second half of the century. The twentieth century was a period of rapid and dynamic change for American furniture design. In many ways, the designs throughout the century were reflective of the social, political, and economic culture of the time. With the birth of the modern movement in Europe and a strong influx of foreign immigrants, American design in the first half of the century was characterized by a reliance on European and foreign influences. However, after the two world wars, strong domestic influences came into play. The two world wars provided the essential catalysts for change: new materials, developing technology, and changes in life style and consumer values. A historical examination of design trends and individual designers illustrates how American furniture design evolved during this period.

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전북지역 영양교사의 식생활교육 실태와 연수 요구도 분석 (Operation and Training Demand on Dietary Life Education of Nutrition Teachers in Jeonbuk Province)

  • 박은숙
    • 한국생활과학회지
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    • 제23권1호
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    • pp.149-161
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    • 2014
  • The purpose of this study was to investigate the nutrition teachers' operation and demand of dietary life education in Jeonbuk Province. The study was carried out using a self administered questionnaire and the subjects were 190 nutrition teachers. The questions were general characteristics of the subjects, operating status as frequency, place, the main use time, and training demand on dietary life education by elementary school and middle & high school, teaching career, and training hours. The results are as follows. Most of the subjects were female(98.9%), more than half were 40's(52.1%) in their age, school work career was 13.2 years. Frequency of the dietary life education operation was once per month(56.8%), 2~3 times per month(27.9%), and place of education were dinning room (49.7%), classroom(25.9%). Almost of the subjects(90.4%) recognized the facilities for education was lack, 89.3% of them did the education materials was lack, also. The desirable frequency of dietary life education was once per month(48.9%), and once per week(35.3%.) The half of the subjects recognized the objects of the dietary life education was not only students but also their parents and teachers. The proper education time was dietary life education tim (34.2%), discretion activity time(31.1%). Most of the subjects(95.7%) had willing to get training, the proper training program was 30 hours, and they prefer summer vacation(61.0%) than winter vacation(30.5%) and semester(8.6%). Proper experimental practice ratio of environment : health : thanks were 30% : 43% : 27%. It is concluded that the demand of nutrition teachers is necessary for their education program in elementary and middle & high school.

Prediction of Continuous Reactors Performance Based on Batch Reactor Deactivation Kinetics Data of Immobilized Lipase

  • Murty, V.Ramachandra;Bhat, Jayadev;Muniswaran, P.K.A.
    • Biotechnology and Bioprocess Engineering:BBE
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    • 제7권4호
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    • pp.225-230
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    • 2002
  • Experiments on deactivation kinetics of immobilized lipase enzyme from Candida cyl-indracea were performed in stirred bath reactor using rice bran oil as the substrate and temperature as the deactivation parameter. The data were fitted In first order deactivation model. The effect of temperature on deactivation rate was represented by Arrhenius equation. Theoretical equations were developed based on pseudo-steady state approximation and Michaelis -Menten rate expression to predict the time course of conversion due to enzyme deactivation and apparent half-life of the immobilized enzyme activity in PFR and CSTH under constant feed rate polity for no diffusion limitation and diffusion limitation of first order. Stability of enzyme in these continuous reactors was predicted and factors affecting the stability were analyzed.

데커시놀추출물의 경구투여후 흰쥐에 있어서의 약물속도론적 연구 (Pharmacokinetic Study of Decursinol Following Oral Administration in Rat)

  • 김지혜;최송암;김동출
    • Journal of Pharmaceutical Investigation
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    • 제33권3호
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    • pp.195-199
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    • 2003
  • The objective of this study is to investigate the pharamacokinetic parameters of decursinol following oral administration in Sprague-Dawley rats. The plasma concentration of decursinol was determined by LC/MS with APCI positive mode. The m/z value of decursinol was observed at 247. Following oral administration of decursinol extract, the apparent clearance was $5.3{\pm}2.7\;ml/hr/rat$, the absorption half life was $2.5{\pm}0.41\;hr$, the elimination half life was $3.05{\pm}1.57\;hr$, and the apparent volume of distribution was $21{\pm}12\;ml/rat$. The LC/MS method was successfully applied to the pharmacokinetic study of decursinol.

Inter-Region Relative Price Convergence in Korea

  • Moon, Seongman
    • East Asian Economic Review
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    • 제21권2호
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    • pp.123-146
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    • 2017
  • This paper examines the persistence of relative consumer price indices for 15 regions in Korea including 6 metropolitan cities and 9 provinces over the period of 1990-2016. In particular, we ask if relative regional price indices contain a common stochastic trend and find that they are not. We then investigate how quickly these relative prices converge to their long run value and find that a half-life of a deviation from the long run value is in the range of 13 to 22 months for the aggregate consumer price indices and in the range of 7 to 13 months for the tradable goods price indices, which is much quicker than the estimates of previous studies. These estimates suggest that existing monetary models with the realistic duration of price rigidities can generate the persistence in relative price indices.

오존화 기체를 이용한 오존수 제조에 관한 연구 (A Study about Ozonized Water Making that Use $O_3$)

  • 박현미;이창호;이상근;송현직;윤병한;임창호;이광식
    • 한국조명전기설비학회:학술대회논문집
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    • 한국조명전기설비학회 2004년도 학술대회 논문집
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    • pp.339-342
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    • 2004
  • It is research about special quality of ozone gas concentration and dissolved ozone concentration that show according to change of flow rate when liquefied ozone gas in water. If increase flow rate of ozone gas, ozone concentration increases being proportional and amount to fixed flow rate, dissolved ozone concentration was measured low. When ozone concentration How rate 1000 [ppm], dissolved ozone concentration smelted to flow rate 1.5[Q] for 28 [min] is $0.1740{\sim}0.8020[mg/l]$. Could know that half-life is most short by 3 minutes 8 seconds in flow rate 1.5 [Q]. And ozone smelted 20 minutes later after half-life measurement became disjointing all.

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N-end rule 기반 단백질 수명 예측 프로그램의 한계 (Limitation of Protein Half-life Prediction in Computational Approach Based on N-end Rule)

  • 류제운;김학용
    • 한국콘텐츠학회:학술대회논문집
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    • 한국콘텐츠학회 2011년도 춘계 종합학술대회 논문집
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    • pp.339-340
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    • 2011
  • 본 연구는 N말단 아미노산 종류에 따라 단백질의 수명(half-life)이 결정된다는 N-end rule을 기반으로 단백질 수명을 예측해주는 프로그램인 protparam의 결과와 bleach-chase를 이용한 실험 데이터를 비교 분석하였다. 단백질 수명을 결정하는 여러 요인들을 고려하지 않고 한 가지 요인만을 반영한 protparam의 결과는 실제 측정값과 현격한 차이를 나타낸다. 특히 실제 단백질은 NME(N-terminal Methionine Excision) 현상이 일어나는데 이를 고려하지 않고 유전체에서 번역한 그대로의 아미노산 서열을 가지고 단백질 수명을 계산하는 한계를 가지고 있다. 이에 본 연구에서 N말단 아미노산을 순차적으로 제거하여 N-end rule을 적용한 결과도 실험 데이터와 일치하지 않는 결과를 보여주고 있음을 확인하였다. 따라서 현재 사용되고 있는 단백질 수명 예측 프로그램은 이런 문제점을 가지고 있기 때문에 새로운 예측 알고리즘의 개발이 요구된다.

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