Browse > Article
http://dx.doi.org/10.4333/KPS.2003.33.3.195

Pharmacokinetic Study of Decursinol Following Oral Administration in Rat  

Kim, Ji-Hae (Missi 2000 Bldg.)
Choi, Song-Am (Haechun Bldg.)
Kim, Dong-Chool (College of Pharmacy, Chungnam National University,Missi 2000 Bldg.)
Publication Information
Journal of Pharmaceutical Investigation / v.33, no.3, 2003 , pp. 195-199 More about this Journal
Abstract
The objective of this study is to investigate the pharamacokinetic parameters of decursinol following oral administration in Sprague-Dawley rats. The plasma concentration of decursinol was determined by LC/MS with APCI positive mode. The m/z value of decursinol was observed at 247. Following oral administration of decursinol extract, the apparent clearance was $5.3{\pm}2.7\;ml/hr/rat$, the absorption half life was $2.5{\pm}0.41\;hr$, the elimination half life was $3.05{\pm}1.57\;hr$, and the apparent volume of distribution was $21{\pm}12\;ml/rat$. The LC/MS method was successfully applied to the pharmacokinetic study of decursinol.
Keywords
Decursinol; Pharmacokinetics; LC/MS;
Citations & Related Records
연도 인용수 순위
  • Reference
1 D.J. Jung, A. Porzel, S. Huneck, Gigasol and other coumarins from Angelica gigas. Phytochemistry, 30, 710-712 (1991)   DOI   ScienceOn
2 S.Y. Kang, K.Y. Lee, S.H. Sung, M.J. Park and Y.C. Kim, Coumarins isolated from Angelica gigas inhibit acetylcholinesterase: structure-activity relationships. Journal of Natural Products 64, 683-685 (2001)   DOI   ScienceOn