• Journal of the Society of Cosmetic Scientists of Korea
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• v.46 no.2
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• pp.89-103
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• 2020

A frizz hair is referred to the fly-away hairs that have become bulky or deviated from the regular hair and the cause of that is not clear known. The internal lipids are related to the physical properties of hair such as elasticity and tensile strength and interracial studies have previously conducted to relate the lipid mass and Afrikaan hair, which has a lot of frizzy hair. Although washing hair is the only way to control the hair loss without damage of hair surface, the number of washing and lipid loss are not linearly correlated. In this study, the amount of lipid hair was analyzed by washing the hair with a few different types of shampoos containing various conditioning polymers and oils of different polarities. The results confirmed that the higher the polarity of the oil, the higher the lipid content. This method was applied to Indian frizzy hair to evaluate the degree of frizziness and found that the frizzy volume was more severe for a hair with less lipids. On the other hand, the frizzy hair volume of fly-away hairs was observed more broadly for the hairs with higher lipid contents. In addition, the friction on the surface of the hair did not differ due to the oil treatment. Taken together, it was concluded that hair frizzing was affected by the amount of lipids in the hair rather than by the adhesion between the oils. Thus, this study suggests that controlling the lipid contents in hair may be an important solution in the development of hair anti-frizzy technology.

• Journal of the Society of Cosmetic Scientists of Korea
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• v.46 no.3
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• pp.295-305
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• 2020

Treatment for beauty using oxidizing agents damages hair with inducing structural alteration in cuticle layer, degradation of protein, and loss of lipid. This study connects a frictional coefficient upon the damaged hair by an instrumental test to the texture test by human being, and considered a moisture as a factor of the damage. A friction coefficient has been measured upon the hair with successive treatment of dye, perm, and bleach. The friction coefficient from the hair dye-treated three times was defined with 0.60, where 58% of answerer indicated an initial damage point as the hairs of iteration of dye-treatment increased. Even bleach treated three times results in 0.84 of friction coefficient corresponding to 88% of answerer attributed the hair to an initially damaged hair. In order to figure out a lipid loss in hair for human being to respond damage, a friction coefficient of the hair was controlled by removing 18-methyleicosanoic acid (18-MEA). The initial damage has been recognized by 0.60 of the friction coefficient for the 68% of answerer. Since moisture is the largest portion of the components in hair, moisture analysis has been performed to study a relationship between texture of damage and the friction coefficient from an instrumental evaluation. As an iteration of dye increases, the hair became hydrophilic with smaller contact angle. It is found that a damaged hair by dyeing possessed more than 0.42% of moisture compared to a healthy hair. Finally, it is elucidated that an increase of moisture in hair induced higher adhesive force corresponding to the friction coefficient, and the friction coefficient above 0.6 is attributed to the preception of hair damage.

• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• v.4 no.1
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• pp.43-58
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• 1991

In order to verify the effect of Sineungyangjin-Dan on alopecia, I experimented the hair regrowth of the normal mice and of the high butter diet-pretreated mice by feeding each group of mice a certain amount of ethanol extract of Sineungyangjin-Dan and water extract and thus obtained the results as follow; 1. The ethanol extract of Sineungyangjin-Dan was proved to promote the hair regrowth of the hair-removed normal mice. 2. 360mg/kg ethanol extract of Sineungyangjin-Dan was proved to have the effect of promoting hair regrowth by restraining the increase of free cholesterol and triglyceride but by helping the increase of free fatty acid in skin. As a result of the above study Sineungyangjin-Dan was proved to have the effect of promoting hair regrowth.

• Korean Journal of Pharmacognosy
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• v.48 no.3
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• pp.195-201
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• 2017

To develop new therapy for prevention and treatment of hair loss is very important according to increase of the number of hair loss people. The aim of this study was to investigate the hair growth promoting effects of pectin lyase-modified red ginseng extract (GS-E3D). We examined antioxidant and anti-inflammatory effects, human hair dermal papilla cells (HHDPC) proliferation, and testoterone-induced $5{\alpha}$-reductase inhibitory effects. GS-E3D show not only 1,1-diphenyl-2-picryhydrazyl (DPPH) radical scavenging activity and xanthine oxidase inhibitory effects as an anti-oxidant property, but also lip-oxygenase and hyaluronidase inhibitory effects as an anti-inflammatory property. Human hair dermal papilla cells proliferation by GS-E3D was higher than those of minoxidil or finasteride, using the positive controls. Moreover, GS-E3D exhibited $5{\alpha}$-reductase inhibitory activities after stimulating by testoterone. The present results indicate that GS-E3D has a potential to be as an hair growth promoting agent for cosmetic materials.

• Journal of Fashion Business
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• v.17 no.2
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• pp.151-163
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• 2013

In this research, with a goal of lessening the damage to hair by adding rose hip extract to permanent wave 1 solution and performing permanent wave procedure prior to acid dyeing and maximizing the effect of the procedure, rose hip extract 15%, 20% was added to each thioglycolate 1 solution and cysteine 1 solution and the procedure was performed. As a result, when performing the procedure by adding rose hip extract to permanent wave 1 solution thioglycolate and cysteine permanent wave 1 solution, the effect of wave effectiveness is increased and the damage to hair was confirmed to be low. Depending on the rose hip additive status in thioglycolate, the treatment effect of hair was shown to be beneficial. However, the limit of this research is that the thickness of hair strands for each person differs as well as the location of the hair contributing to the difference and therefore exact judgement regarding the shape of waves as well as the level of damage cannot be fully measured. In the following clinical tests, we will test the procedure on variety of hair types.

• Archives of Plastic Surgery
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• v.46 no.2
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• pp.167-170
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• 2019

Full-thickness scalp burns secondary to hair coloring are rare; however, such defects can be large and complex reconstruction of hair-bearing tissue may be necessary. Many skin-stretching devices that use gradual traction have been applied to take advantage of the viscoelastic properties of the skin. A 21-year-old female patient was seen with a burn defect on her occipital scalp leading to exposed subcutaneous tissue after chemical application of hair coloring in a salon. The dimensions of the wound were $10cm{\times}5cm$, and a skin graft or flap would have been necessary to close the defect. Two long transfixing K-wires (1.4 mm) and paired 3-wire threads (23 gauge), which are readily available in most hospitals, were applied over a period of 12 days for trichophytic closure of the defect. The remaining scalp scars after primary trichophytic closure with this skin-stretching method were refined with hair follicle transplantation. This skin-stretching method is simple to apply and valuable for helping to close problematic areas of skin shortage that would otherwise require more complicated procedures. This case shows a relatively unknown complication of hair coloring and its treatment.

• Journal of Microbiology and Biotechnology
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• v.25 no.3
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• pp.407-412
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• 2015

We investigated the effect of ultra-high molecular weight poly-γ-glutamic acid (UHMW γ-PGA) on hair loss in vitro and in vivo. 5-Alpha reductase is an enzyme that metabolizes the male hormone testosterone into dihydrotestosterone. By performing an in vitro experiment to analyze the inhibitory effects of UHMW γ-PGA on 5-alpha reductase activity, we determined that UHMW γ-PGA did in fact inhibit 5-alpha reductase activity, indicating the use of UHMW γ-PGA as a potential 5-alpha reductase inhibitor in the treatment of men with androgenetic alopecia. To evaluate the promotion of hair growth in vivo, we topically applied UHMW γ-PGA and minoxidil on the shaved dorsal skin of telogenic C57BL/6 mice for 4 weeks. At 4 weeks, the groups treated with UHMW γ-PGA showed hair growth on more than 50% of the shaved skin, whereas the control group showed less hair growth. To investigate the progression of hair follicles in the hair cycle, hematoxylin and eosin staining was performed. Histological observations revealed that the appearance of hair follicles was earlier in the UHMW γ-PGA-treated group than in the control group. The number of hair follicles on the relative area of shaved skin in the UHMW γ-PGA-treated group was higher than that observed on the shaved skin in the control group. These results indicate that UHMW γ-PGA can promote hair growth by effectively inducing the anagen phase in telogenic C57BL/6 mice.

• Journal of the Korean Society of Fashion and Beauty
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• v.4 no.2 s.8
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• pp.15-21
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• 2006

In this research, I chose and studied colorless hair manicure, which is well known for its useful point and supplement damaged hair glossy, luster, elastic and soft one. Also I studied and found hair protection effect by the management time of colorless hair manicure products, as below. Both level 3 and level 6 hairs, when they get damaged after dyeing, both hairs' strength and enlargement are affected. Manicuring two weeks after dyeing is more effective way than manicuring right after dyeing. So, in case of making good hair quality in manicuring dyed hair, it's more effective to manicure right after dyeing to both level 3 and level 6 hair. To complement hair's damage, however, manicuring two weeks after dyeing is the best effective way.

• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• v.29 no.1
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• pp.47-64
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• 2016

Objective : This study was carried out to investigate the effect of Hwangryeonhaedoktang pharmacopuncture solution (HRHDT) and microneedle therapy system (MTS) on hair growth in an alopecia model of C57BL/6N mice.Methods : Six-week old mice were depilated and separated in 4 groups ; CON (saline), MXD (3% Minoxidil), MTS and HRHDT+MTS. The treatments were applied twice a week for 17 days. The hair growth was determined photographically. The hair density, thickness and length were identified by Folliscope and the weights of body and organs were measured. In dorsal skin tissue, the expression of hair growth-related gene and protein was analyzed by RT-PCR. In addition, the hair follicles in the dermis were observed by H&E staining.Results : The promotion of hair growth was observed in HRHDT+MTS and MTS compared to CON. The hair density, thickness and length were also improved in HRHDT+MTS and MTS compared to CON. The mRNA expression of IGF-1, PRL and PL and the protein expression of VEGF and IGF-1 were increased in HRHDT+MTS and MTS compared to CON. The hair follicles and hair root growth were improved in HRHDT+MTS and MTS compared to CON. In the above results, HRHDT+MTS were more effective than MTS.Conclusions : These results suggest that HRHDT and MTS have a hair growth activity and can be useful for the treatment of alopecia.

• The Journal of Pediatrics of Korean Medicine
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• v.28 no.2
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• pp.72-87
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• 2014

Objectives This study was carried out to investigate the effect of Ganoderma lucidum extract (GLE) and microneedle therapy system (MTS) on hair growth in an alopecia model of C57BL/6N mice. Methods Five-week old mice were depilated and separated in 4 groups ; CON (50% EtOH), MXD (5% Minoxidil), MTS and GLE + MTS. The treatments were applied twice a week for 3 weeks. The hair growth was determined photographically, the hair density, thickness and length were identified by Folliscope and the weights of body and organs were measured. In dorsal skin tissue, the expression of hair growth-related gene and protein was analyzed by RT - PCR or Western blot. In addition, the hair follicles in the dermis were observed by H&E staining. Results The promotion of hair growth was observed in GLE + MTS and MTS compared to CON. The hair density, thickness and length were also improved in GLE + MTS and MTS compared to CON. The mRNA expression of TGF-${\alpha}$, TGF-${\beta}1$, IGF-1, PRL and PL and the protein expression of VEGF and IGF-1 were increased in GLE + MTS and MTS compared to CON. The hair follicles and hair root growth were improved in GLE + MTS and MTS compared to CON. In the above results, GLE + MTS were more effective than MTS. Conclusions These results suggest that GLE and MTS has a hair growth activity and can be useful for the treatment of alopecia.