• Journal of Microbiology and Biotechnology
• /
• v.29 no.11
• /
• pp.1830-1840
• /
• 2019

Loliolide is one of the most ubiquitous monoterpenoid compounds found in algae, and its potential therapeutic effect on various dermatological conditions via agent-induced biological functions, including anti-oxidative and anti-apoptotic properties, was demonstrated. Here, we investigated the effects of loliolide on hair growth in dermal papilla (DP) cells, the main components regulating hair growth and loss conditions. For this purpose, we used a three-dimensional (3D) DP spheroid model that mimics the in vivo hair follicle system. Biochemical assays showed that low doses of loliolide increased the viability and size of 3D DP spheroids in a dose-dependent manner. This result correlated with increases in expression levels of hair growth-related autocrine factors including VEGF, IGF-1, and KGF. Immunoblotting and luciferase-reporter assays further revealed that loliolide induced AKT phosphorylation, and this effect led to stabilization of β-catenin, which plays a crucial role in the hair-inductive properties of DP cells. Further experiments showed that loliolide increased the expression levels of the DP signature genes, ALP, BMP2, VCAN, and HEY1. Furthermore, conditioned media from loliolide-treated DP spheroids significantly enhanced proliferation and the expression of hair growth regulatory genes in keratinocytes. These results suggested that loliolide could function in the hair growth inductivity of DP cells via the AKT/β-catenin signaling pathway.

• Biomolecules & Therapeutics
• /
• v.9 no.1
• /
• pp.15-19
• /
• 2001

The derivative of chrysin 7-O-cyclopropanecarboxylate was synthesized by condensing cyclopropanecarboxylic acid with chrysin in organic solvent, and its structure was identified by NMR, MS, UV IR etc. We also investigated the physico-chemical properties, anti-diabetic effect and set up the quantitative analytical method of this compound. The correlation coefficient of calibration curve on this compound was approximately 0.9985 by absorption spectrophotometry. And, this study was carried out to investigate the hair-growth effect of chrysin derivative to the black mouse (C57BL/6). When this derivative in ethanol solution was administered to the back of mouse by method of skin paste, this derivative promoted the hair growth of mouse.

• Journal of the Semiconductor & Display Technology
• /
• v.14 no.4
• /
• pp.1-7
• /
• 2015

People are always pursuing the aesthetic feeling relentlessly. But some people have such problems with their hairs like alopecia, cancer chemotherapy, burns, and scalp injury. So the synthetic hair has played a very important role to make up for these deficiencies. But long term use can lead to adverse reactions or uncomfortable feeling. This is primarily caused by its properties differ with human hair. In particular, nanotribological characterizations (roughness, friction force and adhesive force) of synthetic hair surface are dissatisfy with the needs of normal hairs. This paper presents the experiments on nanotribological characterizations measurements of human hairs (coloring hair, permed hair and common hair) in shampooing condition or without shampooing condition. Using atomic force microscopy (AFM) to find out a range of synthetic hair nanotribological characterizations which can correspond with natural hair. The measurements of nanotribological characterizations focus on surface roughness, friction force and adhesive force, and a new design of AFM probe was used for measuring the nanotribological characterizations.

• Journal of Digital Convergence
• /
• v.18 no.8
• /
• pp.479-484
• /
• 2020

In the social atmosphere where the importance of appearance is increasing day by day, efforts and desires of modern people are becoming more active and diversified, and the beauty beauty industry is gradually becoming more specialized and specialized due to these effects. Hair damage is inevitable due to the excessive permanent wave or hair coloring of modern people. However, as the hair is damaged, the cuticle peels off and falls off, and the tensile force decreases and the satisfaction after hair styling or perm decreases relatively. Therefore, it is necessary to manage damaged hair, but since artificial synthetic products occupy most of hair treatment agents on the market, it is necessary to develop a hair treatment product containing antioxidants useful for the human body. In this study, the effect of maple leaf extract on the mechanical change of colored hair was analyzed to investigate the potential of maple leaf extract as a hair treatment agent to improve damaged hair and improve hair health. It is considered that this study will be used as basic data for the development of hair beauty products using natural products in the future.

• Journal of the Society of Cosmetic Scientists of Korea
• /
• v.49 no.3
• /
• pp.225-230
• /
• 2023

In this study, the porous structure inside the hair were observed using an optical microscope without damaging the hair, and the porosity inside the hair was quantitatively expressed using the results. Experiments were conducted on the effect of the decrease in density inside the hair on the bending and tensile properties of the hair, and experiments on endogenous and extrinsic factors were conducted to find out the causes of the decrease in density inside the hair. As for the endogenous factor, the porosity of gray hair, one of the representative symptoms of aging, was compared with normal hair. As for extrinsic factors, it was observed that the internal density of hair decreased by surfactant and heat, which are factors that can cause hair damage in daily life. In addition, we confirmed whether it is possible to increase the internal density and luster of the hair by using an amino acids and material that can prevent hair lipid predisposition.

• Journal of Physiology & Pathology in Korean Medicine
• /
• v.18 no.5
• /
• pp.1471-1475
• /
• 2004

Thuja orientalis extract (TOS) has been used on the hemostatic roborant, sedatives and stressless in oriental countries. We investigate the inhibitory effects on the productions of pro-inflammatory cytokines such as interleukin-1beta (IL-1β), IL-6, tumour necrosis factor alpha (TNF-α), and nitric oxide (NO) and the hair promotiont of TOS in the macrophage celline RAW264.7 or hair loss-induced DBA1J mice. T08 (50-500 ㎍/㎖) per se had no cytotoxic effect non-stimulated cells, but this extracts concentration-dependently reduced the release of NO, (IL-1β), IL-6, and TNF-α in the stimulate RAW264.7 cells with lipopolysaccharide (LPS). Moreover, when applied TOS (500 ㎍/㎖) to DBA 1J/mice, hair growth was promoted remarkably. These data suggest that T08 promotes hair growth on hair loss induced model mice and these properties may contribute to the anti- hair loss activity of the Thuja orientalis.

• Preventive Nutrition and Food Science
• /
• v.13 no.4
• /
• pp.299-305
• /
• 2008

This study compared the physicochemical properties of root hair of white ginseng (WG), root hair of tissue cultured mountain ginseng (MG), root hair of red ginseng (RG) and extruded ginseng samples. The comparison of crude ash and total sugar resulted insignificant differences between extruded and raw samples. MG had a higher content of crude ash, crude protein, amino acids and polyphenolic compound than WG and RG; the total sugar and reducing sugar were highest in RG. Crude fat and acidic polysaccharide in RG and WG were similar to and higher than MG. Crude saponin of treated samples WG1 (moisture content 25%, barrel temperature $110^{\circ}C$) and WG3 (moisture content 35%, barrel temperature $110^{\circ}C$) were 9.80% and 9.73%, respectively, which were the highest among ginseng samples. In conclusion, the extrusion process can be applied to red ginseng manufacturing, and some characteristics of MG were higher than in RG and WG.

• Applied Microscopy
• /
• v.39 no.1
• /
• pp.49-56
• /
• 2009

In this study, we investigated tensile properties and ultrastructural changes of straight permed hair using the rheometer and the scanning electron microscopy. First, we compared the morphological characteristic between the virgin hair and the straight permed hair after testing tensile strength. Cuticle cells were heavily lifted off in straight permed hair than in the virgin hair. Cuticle cells were separated by the destruction of intercellular membrane complex and no destruction or damage were found in cytoplasm. In the comparative test for tensile characteristic between the virgin hair and the straight permed hair, tensile distance of the straight permed hair was decreased by 24.5% or 3.05 mm than the virgin hair. The tensile strength was decreased by 34.63% or $5.62\;g/cm^2$ and the maximum stress by 34.59% or 56.12 g. As a result, the tensile property dropped to the lowest level with the straight permed hair than with the bleached hair or the permanent dyed hair of previous studies.

• Proceedings of the Korean Society of Dyers and Finishers Conference
• /
• 2008.04a
• /
• pp.105-107
• /
• 2008

Dyeing properties of the colorants extracted from pomegranate hull on hair were investigated to study its efficay of natural hair coloring dye. Effect of dyeing condition and mordanting on dye uptake, color change and colorfastness were explored. In addition, tensile strength retention is measured and the surface of the hair was observed by SEM. The water extracted pomegranate hull was concentrated and freeze-dried for preparing colorant powders. It was considered that ionic bonding was involved in the adsorption of pomegranate colorants to hair. Pomegranate hull colorants produced greyish brown colors on hair and the hair mordanted with Fe showed dark brown color. Mordant except Fe did not significantly increased dye uptake. Mordant except Cu increased light fastness, mordant except Cr increased washing fastness. SEM to observe the hair is damaged by ultraviolet light and cleaning. This is consistent with the results of tensile strength retention. From the results of colorfastness th washing and light, it was concluded that colorants from pomegranate hull can be need as a semi-permanent natural hair coloring dye.

• Journal of Fashion Business
• /
• v.10 no.1
• /
• pp.94-105
• /
• 2006

Hair bleaching is a treatment process in which the melanic pigment is oxidized by hydrogen peroxide. With the increase of the number of treatments, $1{\sim}10$ levels of various colors develop, the hair luster diminishes, and the appearance becomes very rough. In this study, by changing the number of hair bleaching and bleaching conditions, the changes in the degree of hair damage and its process were observed through the use of scanning electron microscopy. The color changes were also compared through the use of spectrophotometer. In order to study the physical changes of the bleached hairs and to search for the optimum conditions to keep the hair damages minimum during bleaching, tensile properties were measured and reviewed. By increasing the number of hair bleaching and by the severe conditions, the scales became eroded and the protection layers were decreased, and the oxidation reached the inner sectors resulting in rough surface and fibrillation. The surface of the hairs became bright yellowish and transparent by the bleaching of melanic pigments or by the destruction of pigments. With the increase of bleaching degree, in terms of physical changes, the breaking strength decreased while the elongation increased a little.