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Hair Growth Promoting Effect of Thuja orientalis Ethanol Extracts on Hair Loss-induced DBA1J Mice  

Kim Young Jun (Immtec Research Laboratory)
Chung Heon Chul (Immtec Research Laboratory)
Chung Hun Taeg (Immtec Research Laboratory)
Choi Kyu Yoon (Department of Chemistry, Wonkwang University)
Yun Yong Gab (Department of Oriental medical prescription, Wonkwang University)
Jang Seon Il (Department of Skin & Beauty, Seojeong College)
Publication Information
Journal of Physiology & Pathology in Korean Medicine / v.18, no.5, 2004 , pp. 1471-1475 More about this Journal
Abstract
Thuja orientalis extract (TOS) has been used on the hemostatic roborant, sedatives and stressless in oriental countries. We investigate the inhibitory effects on the productions of pro-inflammatory cytokines such as interleukin-1beta (IL-1β), IL-6, tumour necrosis factor alpha (TNF-α), and nitric oxide (NO) and the hair promotiont of TOS in the macrophage celline RAW264.7 or hair loss-induced DBA1J mice. T08 (50-500 ㎍/㎖) per se had no cytotoxic effect non-stimulated cells, but this extracts concentration-dependently reduced the release of NO, (IL-1β), IL-6, and TNF-α in the stimulate RAW264.7 cells with lipopolysaccharide (LPS). Moreover, when applied TOS (500 ㎍/㎖) to DBA 1J/mice, hair growth was promoted remarkably. These data suggest that T08 promotes hair growth on hair loss induced model mice and these properties may contribute to the anti- hair loss activity of the Thuja orientalis.
Keywords
huja orientalis; hair growth; RAW264.7 cells; pro-inflammatory cytokines; nitric oxide;
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