• 대한두개안면성형외과학회지
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• 제21권5호
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• pp.288-293
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• 2020

Background: Pilomatrixoma is a benign tumor that originates from the hair follicle matrix. It usually presents as a hard, slow growing, solitary mass that can be easily misdiagnosed as other skin masses. The aim of this study was to clinically analyze a case series of pilomatrixoma in pediatric patients from Korea. Methods: A total of 165 pediatric patients from 2011 to 2018 with a histological diagnosis of pilomatrixoma were included. A retrospective review was performed using the electronic medical records, including patient demographics, number and location of the mass, clinical and imaging presentation, and postoperative outcomes. Results: There were 61 male and 104 female patients with 152 solitary and 13 multiple pilomatrixomas. Among solitary pilomatrixomas, the lesion commonly occurred in the head and neck (84.2%), followed by upper limbs (11.2%), lower limbs (3.3%), and trunk (1.3%). The pilomatrixoma lesion presented as the following types based on our clinical classification: mass (56.02%), pigmentation (25.31%), mixed (12.65%), ulceration (4.82%), and keloid-like (1.2%). Ultrasonography showed a high positive predictive value (95.56%). There were no specific complications observed except for two cases of recurrence. Conclusion: Pilomatrixoma has various clinical feature presentations and commonly occurs in the head and neck. Ultrasonography is a helpful diagnostic tool. Surgical removal of the lesion is the main treatment method with a low recurrence rate.

• 수산해양기술연구
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• 제30권3호
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• pp.161-171
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• 1994

Mesh selection analysis for the trawl net were carried out at the Southern Korean Sea and the East China Sea during the 1992-1994 years by the training ship Seabada of the National Fisheries University of Pusan, using A type (51.2mm), B type (70.2mm), C type (77.6mm), D type (88.0mm) square mesh cod-ends. The fishing trials were made using bottom trawl of the trouser type cod-end with cover net. Selection curves and selection parameters were calculated by a logistic model for Sphyraena pinguis, Pampus argenteus, Trachurus japonicus, Pagrus major, Callanthias japonicus, Trichiurus lepturus. The results obtained are summarized as follows: 1. Red barracuda : Selection range and fifty percent selection length in the A type was 115.8mm, 292.8mm, respectively. 2. Harvest fish : Each selection range and fifty percent selection length in the B. C. and D type was 37.7mm, 113.8mm : 40.1mm, 131.7mm and 64.8mm, 148.6mm, respectively. Selection parameters of master curve were : slope, 3.81 : intercept, -6.4. Optimum mesh size was 89.3mm. 3. Horse mackerel : Each selection range and fifty percent selection length in the A, B, C and D type was 43.0mm, 148.3mm : 60.7mm, 183.2mm, 214.5mm and 91.4mm, 254.9mm, respectively. Selection parameters of master curve were : slope 2.30 : intercept, -6.4. Optimum mesh size was 66.8mm. 4. Red seabrem : Selection range and fifty percent selection length in the D type was 42.7mm, 203.4mm, respectively. 5. Yellowsail red bass : Selection range and fifty percent selection length in the A type was 84.0mm, 110.6mm, respectively. 6. Hair tail : Each selection range and fifty percent selection length in the A, B and C type was 59.7mm, 176.0mm : 100.9mm, 250.7mm and 178.6mm, 307.0mm, respectively. Selection parameters of master curve were : slope, 1.54 : intercept, -5.4. Optimum mesh size was 57.5mm.

• The Journal of Korean Physical Therapy
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• 제12권1호
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• pp.1-7
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• 2000

전기자극이 흰쥐 창상 표피세포의 핵소체형성부위에 미치는 영향을 규명할 목적으로 Sprague-Dawley계 수컷 흰쥐 24마리의 등애 15mm의 절개창을 만들고 봉합한 후 각각 4일 7일 대조군 및 전기자극에 각각 6마리씩 무작위로 배치하고 전기자극군 흰쥐의 에 전극을 부착한 후 맥동빈도 0.5pps, 전류량 $500{\mu}A$로 60분간 전기자극하였으며 대조군은 전극만 부착하고 전류를 통전시키지 않았다. 전자자극 후 등의 피부를 적출하여 포르말린에 고정한 후 파라핀 포매 절편을 제작하여 silver colliod염색을 하였다. 이 표본을 400배율 현미경하에서 관찰하여 핵당 AgNOR으 수를 계측한 후 핵당 AgNOR의 분포와 핵당 평균 AgNOR수를 산출하여 통계분석한 결과 창상유발 4일과 7일째의 전기자극군의 평균 AgNOR수가 대조군보다 통계학적으로 유의하게 높게 나타났다. 이러한 결과는 전기자극이 흰쥐 피부 창상연 표피세포에서 AgNOR 발현을 증가시켰음을 확인할 수 있었으며 이는 미세맥동전류자극이 창상연의 표피세포를 증식시키고 있음을 시사하고 있다.

• 한방비만학회지
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• 제11권2호
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• pp.41-68
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• 2011

Objectives: After organizing segmentations related to obesity from classics and each studies, we would like to examine the value of wild ginseng, bovis calculus, ursi fel and moschus as a obesity medicine. Methods: We found out 4 drugs which are wild ginseng, bovis calculus, ursi fel and moschus from the classics, such as "Shin-Nong-Bon-Cho-Kyung", "Myoung-Eui-Byul-Lok", "Bon-Cho-Gang-Mok", "Bon-Cho-Jong-Shin", "Bon-Cho-Bi-Yo", "Bon-Cho-Gu-Jin" and "Deuk-Bae-Bon-Cho", we searched websites such as RISS, Korean traditional knowledge portal, the society of Korean medicine for obesity research, Korean pharmacopuncture institute, the Korean academy of oriental rehabilitation medicine and Korean acupuncture & moxibustion society as well. Results: 1. We couldn't find the contents related to the efficacy of improving obesity through wild ginseng, bovis calculus, ursi fel and moschus from the classics. 2. Wild ginseng had a study dealing with the efficacy of anticancer, obesity, toxicity, immunity, sulfation, diabetes, plasma proteins, depression, hypertension, endometriosis and hair loss. Especially among 6 studies related to obesity, apart from the study that treated extract of wild ginseng directly to the cell or oral administration to the animals, also have studies that had an efficacy of improving obesity through injecting pharmacopuncture to acupuncture point and vein, etc. 3. Bovis calculus had a study about efficacy related to arthritis, liver, inflammation of cornea, obesity, anticancer, immunity, antacid, heart, lumbar pain, hypertension, toxicity, a digestive organ and sasang constitution, especially in case of obesity, had each studies about oral administration of complex prescription and about cell unit experiment of pharmacopuncture. 4. Ursi fel had a study about efficacy related to liver, arthritis, inflammation of cornea, immunity, obesity, anticancer, antacid, lumbar pain, digestive organ, toxicity, cell protection, skin ailment, etc. Especially in case of obesity, had each studies about oral administration of animal experiment and about cell unit experiment of pharmacopuncture. 5. Moschus had a study about efficacy related to liver, the central nervous system, arthritis, inflammation of cornea, immunity, obesity, anticancer, hypertension, heart, lumbar pain, etc. Especially in case of obesity, had one study about oral administration of complex prescription. Conclusion: Through the result of probability as a obesity medicine of wild ginseng, bovis calculus, ursi fel and moschus, we could identify the possibility of each drug as a obesity medicine. Also in the future, it is considered that studies about one or complex prescription and pharmacopuncture as a obesity medicine will be needed.

• 동아시아식생활학회지
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• 제26권4호
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• pp.325-333
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• 2016

네 품종의 장려품종 나물콩(녹채콩, 다원콩, 서남콩, 풍산나물콩)으로 재배한 콩나물의 일반성분 함량과 관능적 특성을 분석하였다. 일반성분은 생콩나물과 데친 콩나물을 비교, 분석하였으며, 콩나물을 자엽(머리 부분)과 배축(줄기 부분)으로 나누어 각 부분의 일반성분 함량도 측정하였다. 생콩나물과 데친 콩나물의 탄수화물, 지방질, 단백질, 회분 함량은 자엽이 더 높았으며, 수분 함량은 배축이 더 많았다. 콩나물의 일반성분은 나물콩 품종에 따라 차이를 보였으며, 데친 후 성분 함량이 변화하였다. 생콩나물은 콩비린 맛과 풀맛이 약하고 고소한 맛과 단맛이 강할수록, 데친 콩나물은 콩비린 맛과 풀맛이 약하고, 고소한 냄새, 고소한 맛, 단맛이 강할수록, 콩나물무침은 고소한 맛과 단맛이 강할수록 높은 기호도를 보였다. 생콩나물에서 기호도가 가장 좋았던 서남콩 콩나물과 풍산나물콩 콩나물은 데친 콩나물과 콩나물무침에서도 가장 높은 기호도를 나타내었으므로, 서남콩과 풍산나물콩이 데친 콩나물 및 콩나물 무침용 콩나물 생산에 적합한 나물콩으로 생각되었다.

• International Journal of Oral Biology
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• 제32권4호
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• pp.119-125
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• 2007

Dlx3 is a homeodomain protein and is known to play a role in development and differentiation of many tissues. Deletion of four base pairs in DLX3 (NT3198) is causally related to tricho-dento-osseous (TDO) syndrome (OMIM #190320), a genetic disorder manifested by taurodontism, hair abnormalities, and increased bone density in the cranium. The molecular mechanisms that explain the phenotypic characteristics of TDO syndrome have not been clearly determined. In this study, we examined phenotypic characteristics of wild type DLX3(wtDlx3) and 4-BP DEL DLX3 (TDO mtDlx3) in C2C12 cells. To investigate how wtDlx3 and TDO mtDlx3 differentially regulate osteoblastic differentiation, reporter assays were performed by using luciferase reporters containing the promoters of alkaline phosphatase, bone sialoprotein or osteocalcin. Both wtDlx3 and TDO mtDlx3 enhanced significantly all the reporter activities but the effect of mtDlx3 was much weaker than that of wtDlx3. In spite of these differences in reporter activity, electrophoretic mobility shift assay showed that both wtDlx3 and TDO mtDlx3 formed similar amounts of DNA binding complexes with Dlx3 binding consensus sequence or with ALP promoter oligonucleotide bearing the Dlx3 binding core sequence. TDO mtDlx3 exhibits a longer half-life than wtDlx3 and it corresponds to PESTfind analysis result showing that potential PEST sequence was missed in carboxy terminal of TDO mtDlx3. In addition, co-immunoprecipitation demonstrated that TDO mtDlx3 binds to Msx2 more strongly than wtDlx3. Taken together, though TDO mtDlx3 acted as a weaker transcriptional activator than wtDlx3 in osteoblastic cells, there is possibility that during in vivo osteoblast differentiation TDO mtDlx3 may antagonize transcriptional repressor activity of Msx2 more effectively and for longer period than wtDlx3, resulting in enhancement of osteoblast differentiation.

• 디지털융복합연구
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• 제13권5호
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• pp.337-344
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• 2015

많은 식물들은 부작용이 적고, 가격이 저렴하며, 다양한 웰니스 융복합 화합물들을 함유하고 있기 때문에 다양한 제재에 이용되고 있다. 이 연구에서 뉴질랜드 식물인 Quintinia acutifolia (Q. acutifolia)로부터 쥐 백혈병 세포(P388 murine lymphocytic leukemia cells)의 성장을 저해하는 활성을 MTT [3-(4,5-dimethylthiazol-2-yl)- 2,5-diphenyl-tetrazolium bromide] assay에 의해 평가하였다. P388 murine lymphocytic leukemia 세포의 성장을 저해하는 2,3,2'',3''-tetrahydroochanaflavone (1)과 2'',3''-dihydroochana-flavone (3)을 1D/2D-NMR와 다른 분광학적 분석법에 의해 분리하였고, 구조를 규명하였다. 이 두 화합물은 두 개의 플라보노이드 기본구조를 갖는 바이플라보노이드 (biflavonoid)로써 2,3,2'',3''-Tetrahydroochnaflavone (1)과 2'',3''-dihydroochana-flavone (3) 화합물은 P388 murine lymphocytic leukemia세포에 대해 50%의 성장저해를 나타내는 농도가 각각 $8.2{\mu}g/mL$와 $3.1{\mu}g/mL$로 나타났다. 특히 2'',3''-dihydroochana-flavone (3) 화합물은 2,3,2'',3''-tetrahydroochanaflavone (1)의 B 링(ring)에 쌍으로 결합되지 않은 플라본 구조 (unconjugated flavonone system)를 갖는 것으로 나타났다. 그럼으로 두 화합물은 향후 항암 치료제 개발에 이용될 수 있으며, 더 많은 연구가 요구된다.

• 한국식품과학회지
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• 제35권4호
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• pp.556-560
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• 2003

CP4 EPSPS에 대한 특이항체(다클론 및 단클론)을 이용하여 확립한 전보의 sandwich ELISA 분석법을 원료 콩의 GMO 분석에 적용가능한 가를 검토하였다. 원료 콩은 수입산 47점, 국산 20점을 분석하였다. 그 결과, 수입산 콩의 CP4 EPSPS 분석치는 크게 두 군으로 나뉘어 높은 군$(39.1{\pm}13.5{\mu}g/g,\;n=33)$과 낮은 군$(2.6{\pm}1.2{\mu}g/g,\;n=14)$으로 나타났다. 수입산 콩의 GMO 비율은 약 70.2%로 나타났다. 한편, 국산 콩의 CP4 EPSPS의 함량 $(0.9{\pm}0.5{\mu}g/g,\;n=20)$은 아주 낮은 것으로 나타났고 이는 non-GMO인 것으로 판단되었다. 콩나물의 경우에 GM과 non-GM 간 CP4 EPSPS의 차이를 보이고 있었고 GM 콩나물의 자엽부에서 뿌리보다 높은 CP4 EPSPS의 함량을 보여주고 있다. 국산 콩으로 만든 콩나물의 경우 CP4 EPSPS의 함량은 아주 낮은 것으로 나타나 GM과 non-GM 콩간의 구분이 가능하였다. 또한 PCR에 의해 sandwich ELISA가 정확하다는 것을 보여주었다. 이상과 같이 sandwich ELISA 방법은 신속, 간편하게 많은 콩 시료의 GMO 여부를 판단할 수 있음을 보여주었다.

• 한국의류학회지
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• 제40권6호
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• pp.1116-1133
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• 2016

This study examines the historical background of Goryeo and its relationship with Song and Yuan. In addition, it observes the shape of dress styles for the king, queen, officers, maids in waiting, and commoners after classifying them with a focus on the dress style of normal people appearing in Buddhist paintings. This study then investigates structures by tracing Goryeo's unique identity and its characteristic by a comparison and analysis of dressing style elements of Goryeo with Song and Yuan. The results shows that the Song's system was used exclusively for the dress style of the king and government officers of Goryeo after Goryeo's submission period by Yuan. There were no clear appearances of a Mongol style dress but only changes in head styles of cutting hair around the head and twisting the rest in a top down and long method. In addition, Song's style Bokgeon was shown by the king to his lower level officers. This was because the king and his officers of Yuan were in accordance with Song's system in officer's dress, hat and head style, armor, and horseback riding equipment. Second, there is doubt if they inherited a traditional form and style of the dress rather than followed the dress style of Yuan because the shape of Yuan's basic dress style Deel is very similar to the dress shape of early Buyeo people's Po in the $3^{rd}$ to $4^{th}$ centuries. Third, the shape of the Chaksu and Gung-go had been kept as it was in the dress style of ordinary men, and because the shape of the double collar had already appeared in the period of Samguk, which appeared in all classes of Yuan. There is no reason to adopt double collar shape that appeared. The general Pyeonbokpo of the country had to be influenced by Yuan. Forth, the dress style of queen and her maids in waiting were mentioned in documents; however, there was no shape of a dress like Boktag and Deel in the relics, which are the characteristic of Yuan's woman dress style. Fifth, the shape worn national style Yu and Sang had been kept in an ordinary woman's dress style; however, the two style system of high and lower class in Yuan's ordinary woman dress style appeared newly and is considered an influence of Goryeo.

• 한국임상수의학회지
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• 제30권2호
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• pp.95-99
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• 2013

본 연구는 정상개에서의 계절에 따른 안압의 변화를 평가하기 위해서 실시되었다. 총 474마리의 안질환이 없는 삽살개의 양안에 대해서 편평안압계(Tonopen$^{(R)}$ XL)를 이용해서 안압을 측정하였다. 측정된 결과를 바탕으로, 안압에 영향을 줄 것으로 예상되는 요소의 유의성과, 각 요소의 군내 차이를 통게적 방법을 통하여 검증을 실시 하였다. 전체 삽살개의 평균 안압 및 표준 편차는 $19.1{\pm}3.7$ mmHg (범위: 8 to 28 mmHg) 이었다. 계절적 요소에서만 안압 변화에 대한 유의성이 검증 되었고(P < 0.001), 그 외 나이, 성별, 모색과 관련된 유의성은 확인되지 않았다. 겨울에 측정된 평균 안압 수치($20.4{\pm}3.4$ mmHg)와 여름에 측정된 평균 안압 수치($17.1{\pm}3.6$ mmHg) 는 다른 계절의 평균 안압에 비하여서 신뢰구간 내로 각각 높게 그리고 낮게 측정 되었다. 이상의 결과를 바탕으로 계절적 변화는 정상 개의 안압에 영향을 줄 것으로 판단되며, 본 연구는 후속되는 수의 안과 연구와 수의 안과 임상에 유용한 자료가 될 것으로 사료된다.