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http://dx.doi.org/10.14400/JDC.2015.13.5.337

In vitro Anti-Cancer Effect of Wellness-Compound (Ochnaflavone)  

Lee, Jae-Sook (Dep. of Beauty Science, Gwangju Women's University)
Choi, Hwa-Jung (Dep. of Beauty Science, Gwangju Women's University)
Kim, Myung-Ju (Dep. of Hair stylist, Skin, Gwangju Health University)
Park, Jang-Soon (Dep. of Beauty Art, Songwon University)
Publication Information
Journal of Digital Convergence / v.13, no.5, 2015 , pp. 337-344 More about this Journal
Abstract
Medicinal plants containing wellness-fusion-complex compound are increasingly being pursued as suitable alternative sources of various biological properties. In this study, inhibitory effect of Quintinia acutifolia, which is a New Zealand plant, on P388 murine lymphocytic leukemia cells using MTT [3-(4,5-dimethylthiazol-2-yl)- 2,5-diphenyl-tetrazolium bromide] assay. Based on $^1H-NMR$, $^{13}C-NMR$ spectral data and other spectral analysis, 2,3,2'',3''-tetrahydroochanaflavone (1) and 2'',3''-dihydroochana-flavone (3) inhibited the leukemia cells were purified from the plants. 2,3,2'',3''-tetrahydroochanaflavone (1) and 2'',3''-dihydroochana-flavone (3) are biflavonoids possessing two basic flavonoids and actively inhibited growth of P388 murine lymphocytic leukemia cells with a 50% inhibitory concentration ($IC_{50}$) of $8.2{\mu}g/mL$ and $3.1{\mu}g/mL$, respectively. Specially, 2'',3''-dihydroochana-flavone (3) possessed unconjugated flavonone system, which isn't consist of a pair with B ring of 2,3,2'',3''-tetrahydroochanaflavone (1). Therefore, the two compounds could be considered as a candidate for development of anticancer drugs and need to much studies in the future.
Keywords
Wellness-fusion-complex; Anti-cancer; Funtional materials; Biflavonoid; New Zealand plant; P388 murine lymphocytic leukemia cells;
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