• Genomics & Informatics
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• 제9권1호
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• pp.19-27
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• 2011

Gene Expression Omnibus (GEO) has kept the largest amount of gene-expression microarray data that have grown exponentially. Microarray data in GEO have been generated in many different formats and often lack standardized annotation and documentation. It is hard to know if preprocessing has been applied to a dataset or not and in what way. Standard-based integration of heterogeneous data formats and metadata is necessary for comprehensive data query, analysis and mining. We attempted to integrate the heterogeneous microarray data in GEO based on Minimum Information About a Microarray Experiment (MIAME) standard. We unified the data fields of GEO Data table and mapped the attributes of GEO metadata into MIAME elements. We also discriminated non-preprocessed raw datasets from others and processed ones by using a two-step classification method. Most of the procedures were developed as semi-automated algorithms with some degree of text mining techniques. We localized 2,967 Platforms, 4,867 Series and 103,590 Samples with covering 279 organisms, integrated them into a standard-based relational schema and developed a comprehensive query interface to extract. Our tool, GEOQuest is available at http://www.snubi.org/software/GEOQuest/.

• 생물정신의학
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• 제16권2호
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• pp.121-126
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• 2009

Objectives : The serotonin transporter gene(SLC6A4) is one of the most widely studied candidate genes in autism spectrum disorder(ASD), but there have been conflicting results from studies into the association between SLC6A4 and ASD. The aim of this study was to evaluate the association between single nucleotide polymorphisms(SNPs) in the SLC6A4 gene and ASD in the Korean population. Methods : We selected 12 SNPs in SLC6A4 and observed the genotype of 151 Korean ASD trios. We tested the family-based association for each individual polymorphism and haplotype by using the standard TDT method in Haploview(http://www.broad.mit.edu/mpg/haploview/). Results : Through transmission-disequilibrium testing and haplotype analysis, we could not find any statistically significant transmitted allele or haplotype. In addition, a case-control association test with Korean HapMap data did not reveal any statistical significance. Conclusion : Although serotonin-related genes must be considered candidate genes for ASD, we suggest that common SNPs of SLC6A4 are not important markers for associations with Korean ASD.

• 한국간호교육학회지
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• 제13권1호
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• pp.82-89
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• 2007

Purpose: The purpose of this study was to develop and evaluate an e-Learning Program designed to enhance novice nurses's performance ability Method: The e-Learning program was designed for novice nurses before beginning to work in a hospital using a KMS(Knowledge Management System). This study was carried out from February 2006 to April 2007. The program had progressive steps including design, pilot test & modification, contents development, program application and evaluation. After the program design and pilot testing, the learner's satisfaction was analyzed. Result: The program site is http://kms.emc.ac.kr titled, 'Cyber Education Center'. The sixteen part course has been developed as follows: blood sugar test, skin test, insulin test 1, insulin test 2, blood culture, blood sampling, heat therapy, cold therapy, glycerin enema, preparation of operation, oxygen therapy, suction technique, transfusion, foley catheterization and aseptic technique. The overall learner's satisfaction score was 4.08 out of 5 points. Conclusion: E-Learning could be useful for education and nursing work. This method may be effective for clinical nurses.

• Child Health Nursing Research
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• 제16권1호
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• pp.73-83
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• 2010

Purpose: This study was designed to analyze recent trends in pediatric oncology research in Korea and suggest future research directions in this area. Methods: Studies (105) selected from http://www.riss4u.net for last 15 yr were used. They were analyzed by publication type, field and design of the study, study participants, main theme, and outcome variables used in intervention studies. Results: 1. Of the 105 studies, 67 were master and doctoral dissertations and 49.5% of studies were conducted in nursing. 2. There were 73 (69.5%) quantitative studies and 20 (19.1%) qualitative research studies and the most frequently used study design was that of a descriptive study. 3. Children with cancer undergoing treatment and their parents, mostly mothers, were the participants most frequently studied. 4. Most themes were psychological/spiritual problems, coping, and family function. 5. Most frequently measured outcome variables were nausea/vomiting, fear/anxiety and adjustment. Conclusion: The results indicate that future research should include more well-designed intervention studies to develop new intervention protocols and to confirm the effect of previous study findings. It is also necessary to use an interdisciplinary approach to deal with physical and psychosocial needs of these children and their families including siblings and fathers of children with cancer.

• 한국CDE학회논문집
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• 제7권2호
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• pp.110-120
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• 2002

This paper presents the method that allows easy and rapid integration of legacy resources within the company and between departments. The proposed system can easily construct a distributed environment for collaborative design between departments in the companies. It supports knowledge-based integration system, which allows designers to develop product with deep knowledge about product design. For the purpose, DOME (Distributed Object-based Modeling Environment)-which has been developed through various studies-was used in this paper. To overcome its problems and insufficiency, the Web-Integrator is proposed. The Web-Integrator is very suitable for an Internet environment because it uses HTTP (Hyper Text Transfer Protocol) and XML (extensible Markup Language) as its main communication method. By supporting the remote object access via URL (Uniform Resource Locator), the implementation of the integrated system makes the Web-Integrator systematic and intuitive. All the functions and resources provided by DOME could be used with the interface that enables bi-directional communication with the DOME system. Web-Integrator provides full web-based environments for the general designers, who do not have a full design knowledge and experience, and the proposed system allows design operations to happen at any place and anytime. Also it provides XML-RPC(Remote Procedure Call) based web service framework, which allows other systems to use easily the service that the DOME system supplies regardless the location and the platform.

• 한국의상디자인학회지
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• 제10권2호
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• pp.163-178
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• 2008

The purpose of this study is to search the characteristics and strategy of sales promotion in on-line fashion SOHO (Small Office Home Office) shopping malls. 87 of these shopping malls have been selected through a ranking service called 100HOT (http://www.100hot.co.kr), and 906 cases of sales promotion activities have been executed on web-sites of these shopping malls. The cases have been analyzed by descriptive statistics and chi-square analysis. The results are as follows: First, on-line fashion SOHO shopping malls have frequently used sales promotion tactics such as demonstration, display, viral marketing, sale, event, customer compensation, community marketing, experimental marketing, coupon, premium, reserve fund and delivery service. Second, there are significant differences between shopping malls for men and women in sales promotion tactics such as demonstration, viral marketing, sale, and community marketing, but there is no significant difference in tactics such as demonstration, event, and customer compensation. Third, the shopping malls have used various sales promotion strategies such as maximizing the sales, characterizing product features, procuring new customers, preserving existing customers, enhancing customer loyalty, improving customer relationship and controlling returns.

• 정보통신설비학회논문지
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• 제1권2호
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• pp.70-81
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• 2002

1990년대 후반부터 다양한 디지털 통신망을 이용하여 멀티미디어 컨텐츠 서비스가 가능하게 되었다. 하지만 멀티미디어 컨텐츠의 전달 및 이용을 위한 기반 구조들의 독자적 발전 및 다양한 통합 관리 시스템 때문에 멀티미디어 컨텐츠 표현 방식의 호환성, 네트워크 방식과 단말기 등의 잠재적인 문제점이 발생한다. 이를 위해서 현재 존재하는 기술 및 기반 구조들 사이의 연동을 통한 큰 멀티미디어 프레임워크인 MPEG-21이 진행 중이다. 본 논문에서는 현재 표준화 작업이 진행 중인 MPEG-21을 기반으로 하는 웹 (Web) 기반 테스트베드를 제안한다. 기본적으로 테스트베드는 서버(server), 클라이언트(client), DIA(Digital Item Adaptation)의 세 모듈로 구성된다. 서버의 역할은 멀티미디어 컨텐츠를 Digital Item(DI)의 형태로 생성하고, 클라이언트가 DI를 요구할 경우 DIA 모듈을 통해서 변환된 DI를 클라이언트에게 제공한다. DIA 모듈은 서버에서 동작되며 클라이언트로부터 요청된 DI를 분석하고 클라이언트로부터 전송된 환경 정보를 이용하여 클라이언트 환경에 적합하게 변환된 (adapted) DI를 생성하는 것이 주 기능이다. 클라이언트는 서버에 저장되어 있는 DI를 선택하고 사용자 선호도(user preferences), 터미널 능력(terminal capabilities) 등의 필요한 정보를 서버로 전송한다. 테스트베드에서는 스포츠 경기의 동영상, 정지 영상, 경기 내용, 역사를 기록한 파일 등의 DI를 이용한다. 표현 언어는 XML이며, HTTP 기반의 웹 환경에서 구동되도록 설계된다.

• Journal of Biosystems Engineering
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• 제38권1호
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• pp.25-32
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• 2013

Purpose: The objective of this study is to develop a data middleware for u-IT convergence in agricultural environment monitoring, which can support non-standard data interfaces and solve the compatibility problems of heterogenous sensor networks. Methods: Six factors with three different interfaces were chosen as target data among the environmental monitoring factors for crop cultivation. PostgresSQL and PostGIS were used for database and the data middleware was implemented by Python programming language. Based on hierarchical model design and key-value type table design, the data middleware was developed. For evaluation, 2,000 records of each data access interface were prepared. Results: Their execution times of File I/O interface, SQL interface and HTTP interface were 0.00951 s/record, 0.01967 s/record and 0.0401 s/record respectively. And there was no data loss. Conclusions: The data middleware integrated three heterogenous sensor networks with different data access interfaces.

• Mycobiology
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• 제48권5호
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• pp.373-382
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• 2020

Laccases (EC 1.10.3.2), a group of multi-copper oxidases (MCOs), play multiple biological functions and widely exist in many species. Fungal laccases have been extensively studied for their industrial applications, however, there was no database specially focused on fungal laccases. To provide a comparative genomics platform for fungal laccases, we have developed a comparative genomics platform for laccases and MCOs (http://laccase.riceblast.snu.ac. kr/). Based on protein domain profiles of characterized sequences, 3,571 laccases were predicted from 690 genomes including 253 fungi. The number of putative laccases and their properties exhibited dynamic distribution across the taxonomy. A total of 505 laccases from 68 genomes were selected and subjected to phylogenetic analysis. As a result, four clades comprised of nine subclades were phylogenetically grouped by their putative functions and analyzed at the sequence level. Our work would provide a workbench for putative laccases mainly focused on the fungal kingdom as well as a new perspective in the identification and classification of putative laccases and MCOs.

• 한국수자원학회:학술대회논문집
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• 한국수자원학회 2020년도 학술발표회
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• pp.186-186
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• 2020

본 연구에서는 IPCC (Intergovernmental Panel on Climate Change) 6차 평가보고서(6th Assessment Report, AR6)에서 제시한 새로운 온실가스 경로(SSP, Shared Socioeconomic Pathways)에 따라 산출된 전지구 기후변화 시나리오를 이용하여 제주도의 미래 강수량 변화를 살펴보고자 한다. 기상청에서 운영하는 기후정보포털(http://www.climate.go.kr/)에서는 6가지 기상요소(평균기온, 최고기온, 최저기온, 강수량, 상대습도, 풍속 등)에 대하여 SSP 시나리오 자료를 제공하고 있다. SSP 시나리오는 SSP1-2.6 저탄소 시나리오(사회 불균형의 감소와 친환경 기술의 빠른 발달로 기후변화 완화, 적응능력이 좋은 지속성장가능 사회경제 구조)와 SSP5-8.5 고탄소 시나리오(기후정책 부재, 화석연료 기반 성장과 높은 인적 투자로 기후변화 적응능력은 좋지만 완화능력이 낮은 사회경제 구조)로 구분되어 제공되고 있다. 또한, 현재의 기후 상태를 모의하는 historical period (1850-2014) 자료와 미래의 기후상태를 모의한 future period (2015-2100) 자료가 있으며, 월별(momthly), 연간(yearly) 자료의 형태로 제공된다. 본 연구를 통하여 새로운 SSP 시나리오를 이용한 제주도 강수량의 미래 변화를 정량적으로 분석하였고, 기후변화에 능동적인 대책을 수립하는데 도움이 될 것으로 판단된다.