• Journal of Nutrition and Health
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• 제29권9호
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• pp.1035-1041
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• 1996

The study was undertaken to examine the levels of serum lipids and the correlations between serum lipid levels and other factors(nutrient intakes, anthrometric measurement, blood pressure, drinking, smoking). The participants in this study were healthy volunteers over the age of 40 residing in Whachon area, Kang-Wan Do. The level of serum TG was higher in males than in females, particularly in age of 40(209.8mg/dl$\pm$154.9, p<0.05). The HDL-c/total cholesterol ratio(HTR) in males was the lowest(0.23$\pm$0.07, p<0.05) in age of 40 and in females was the lowest(0.25$\pm$0.1) in age of 60 and over. LDL-c/HDL-c ratio(LHR) was the highest (males 3.64$\pm$6.29, females 3.28$\pm$3.03) in age of 40 in both sexes. In the age of 40-59, serum TG, total cholesterol and LDL-cholesterol and HDL-cholesterol tended to increase with BMI. Serum TG showed positive correlation with drinking (r=0.026, p<0.001) and BMI (r=0.2096, p<0.01). BMI was negatively correlated with HTR(r=-0.2242, p<0.01) and HDL-cholesterol (r=-0.2054, p<0.01).

• Nuclear Engineering and Technology
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• 제53권8호
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• pp.2753-2760
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• 2021

This paper proposes using sodium-cooled fast reactor technologies for use in hydrogen vapor methane (SMR) modification. Using three independent energy rings in the Russian BN-600 fast reactor, steam is generated in one of the steam-generating cycles with a pressure of 13.1 MPa and a temperature of 505 ℃. The reactor's second energy cycles can increase the gas-steam mixture's temperature to the required amount for efficient correction. The 620 ton/hr 540 ℃ steam generated in this cycle is sufficient to supply a high-temperature synthesis current source (700 ℃), which raises the steam-gas mixture's temperature in the reactor. The proposed technology provides a high rate of hydrogen production (approximately 144.5 ton/hr of standard H₂), also up to 25% of the original natural gas, in line with existing SMR technology for preparing and heating steam and gas mixtures will be saved. Also, exergy analysis results show that the plant's efficiency reaches 78.5% using HTR heat for combined hydrogen and power generation.

• 한국식품영양과학회지
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• 제46권3호
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• pp.289-297
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• 2017

본 연구는 고지방식이로 유도된 제2형 당뇨 동물모델에서 잠상산물의 항당뇨 및 지질개선 효과를 규명하기 위하여 C57BL/6N 마우스에 14주간 잠상산물 분말(ML, SK, MF, CT)을 급여한 후 제2형 당뇨의 임상적 지표 및 인슐린 신호 전달체계에 미치는 영향을 분석하였다. HFD군보다 잠상산물을 급여한 군들의 체중증가량이 감소하는 경향이었으며, 혈장 포도당 및 인슐린 농도는 HFD군보다 ML분말을 급여한 군에서 특히 감소하였다. 혈장 T-C 농도는 HFD군에 비하여 ML과 SK 분말 급여 군에서 유의적으로 감소하였으며, 혈장 HDL-C 농도 및 HTR은 HFD군보다 ML군과 SK군에서 현저히 증가하였다. 간 조직 지질 농도는 HFD군보다 잠상산물을 급여한 네 군 모두에서 TG와 T-C 농도의 유의적인 감소가 나타났다. 이상의 결과 잠상산물 중 ML분말이 혈장 포도당, 인슐린, T-C 및 TG 농도를 가장 효과적으로 감소시켰으며, 혈장 HDL-C 농도 및 HTR은 증가시켰다. 또한, 내장지방 조직의 AKT, S6K, 그리고 AMPK의 활성도 증가시킨 것으로 보아 고지방식이에 의한 인슐린 저항성 및 지질 대사를 개선한 것으로 생각된다. 향후 ML의 인슐린 저항성 개선 효과에 대해 더 깊이 있는 기전연구가 수행된다면 제2형 당뇨환자를 위한 건강기능성 식품으로 개발될 수 있을 것으로 생각한다.

• 한국식품과학회지
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• 제32권1호
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• pp.206-211
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• 2000

본 실험은 발아메밀을 식이에 50%(w/w) 혼합하여 6주간 섭취시켰을 때 발아메밀이 고혈압쥐의 혈압, 혈당 및 혈중 지질농도에 어떠한 영향을 미치는지를 파악하므로써 발아메밀의 기능성 식품으로서의 이용성을 확인하고자 하였다. 실험기간 중 실험쥐의 체중증가는 숫컷의 경우 대조군에 비하여 발아메밀군에서 유의적으로 증가하였다. 장기무게는 숫컷의 경우 간, 신장, 심장이 대조군에 비하여 발아메밀군에서 유의하게 무거웠으나 체중에 대한 장기 무게비로 볼 때 모든 장기에서 유의적인 차이가 없었으며 암컷의 경우 심장의 경우에만 대조군에 비하여 발아메밀군에서 유의적으로 증가하였다. 실험기간 6주 후 수축기혈압은 숫컷의 대조군에 비하여 발아메밀군에서 유의적으로 3% 감소하였으며, 혈당은 숫컷과 암컷 모두에서 대조군에 비하여 발아메밀군에서 감소하는 경향을 나타내었으며, 혈중 HDL-콜레스테롤 농도 및 HTR은 대조군에 비하여 암컷의 발아메밀군에서 유의하게 증가하였다. 동맥경화지수는 대조군에 비하여 암컷의 발아메밀군에서 유의하게 감소하였다. 본 실험의 결과에서 발아메밀은 숫컷 고혈압쥐의 혈압상승을 뚜렷하게 억제하였으며, 암컷의 경우 혈중 HDL-콜레스테롤 및 HTR을 증가시켰으며 동맥경화지수를 유의적으로 감소시켰다. 따라서 본 실험 조건하에서 제조된 발아메밀은 혈압 상승을 억제시키고 혈당 및 혈중 지질대사를 개선시킬 수 있는 항고혈압 기능성식품으로의 이용 가능성이 기대된다.

• Journal of Animal Science and Technology
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• 제64권5호
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• pp.922-936
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• 2022

5-Hydroxytryptamine (5-HT), a monoamine, as a local regulator in the mammary gland is a chemical signal produced by the mammary epithelium cell. In cows, studies have shown that 5-HT is associated with epithelial cell apoptosis during the degenerative phase of the mammary gland. However, studies in other tissues have shown that 5-HT can effectively promote cell viability. Whether 5-HT could have an effect on mammary cell viability in dairy cows is still unknown. The purpose of this study was to determine: (1) effect of 5-HT on the viability of bovine mammary epithelial cells and its related signaling pathways, (2) interaction between prolactin (PRL) and 5-HT on the cell viability. The bovine mammary alveolar cell-T (MAC-T) were cultured with different concentrations of 5-HT for 12, 24, 48 or 72 hours, and then were assayed using cell counting kit-8, polymerase chain reaction (PCR) and immunobloting. The results suggested that 20 μM 5-HT treatment for 12 or 24 h promote cell viability, which was mainly induced by the activation of 5-HT receptor (5-HTR) 1B and 4, because the increase caused by 5-HT vanished when 5-HTR 1B and 4 was blocked by SB224289 and SB204070. And protein expression of mammalian target of rapamycin (mTOR), eukaryotic translation elongation factor 2 (eEF2), janus kinase 2 (JAK2) and signal transducer and activator of transcription 5 (STAT5) were decreased after blocking 5-HT 1B and 4 receptors. When MAC-T cells were treated with 5-HT and PRL simultaneously for 24 h, both the cell viability and the level of mTOR protein were significantly higher than that cultured with 5-HT or PRL alone. In conclusion, our study suggested that 5-HT promotes the viability of MAC-T cells by 5-HTR 1B and/or 4. Furthermore, there is a reciprocal relationship between PRL and 5-HT.

• 한국식물병리학회:학술대회논문집
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• 한국식물병리학회 2003년도 정기총회 및 추계학술발표회
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• pp.135.2-136
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• 2003

To characterize plasmids in Xanthomonu axonopodis pv. glycines, we isolated plasmids pAG1 from the strain AG1 and pXAG81 and PXAG82 from the strain Bra, respectively, and sequenced three plasmids. The size of plasmids, pAG1, pXAG81, and pXAG82 was 15,149-base pairs (bp), 26,727-bp, and 1,496-bp, respectively Fifteen and twenty six possible open reading frames (ORFs) were present in pAG1 and pXAG81, respectively. Only one ORF homologous to a rep gene of Xylella fastidiosa was present in pXAG82. pAG1 contained genes homologous to avrBs3, tnpA, tnpR, repA, htrA, three parA genes, M.XmaI, R.XmaI, and six hypothetical proteins. pXAG81 contained genes homologous to avrBs3, tnpA, tnpR, repA, htrA, two parA genes, pemI, pemK, mobA, mobB, mobC, mobD, mobE, trwB, traF, traH, ISxac2, and eleven hypothetical proteins. Based on DNA sequence analysis, we presume that pXAG81 is a conjugal plasmid. Interestingly, we found 0.5-kb truncated avirulence gene similar to aurXacE3 on the right border of avrBs3 homolgs of pAG1 and pXAG81. Two hundred twenty five isolates were analyzed to find aurBS3 or tra gene homologs by Southern hybridization. The numbers of avrBs3 homolog varied from 3 in AG1 to 8 in AG166. Two hundred seventeen isolates appeared to can conjugative plasmids (pXAG81 type), and thirty eight isolates appeared to carry non-conjugative plamids (pAGl type). This indicated that aurBs3 gene homologs might be spread by conjugation in X. axonopodis pv. glycines.

• 에너지공학
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• 제14권4호
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• pp.232-240
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• 2005

경수 및 중수로 원자로계통에 대한 열수력 안전해석을 위해 개발된 MARS 코드가 고온가스로에 적용될 수 있을지 화인하기 위하여 IAEA TECDOC-1163에서 제시된 고온가스로 원자로공동냉각계통에 대한 Benchmark problem을 평가계산 하였다. HTR-10과 HTTR의 MARS 코드 계산결과는 기 보고된 THERMIX 코드와 THANPACST2 코드의 계산결과 그리고 가용한 실험결과와 비교한 바, 최대 오차범위 $4.5\%$ 정도로 전반적으로 일치하는 것으로 나타났다. 오차의 주요 원인은 복잡한 기하학적 구조를 단순하게 모델링한 부분과 MARS 코드에서 모사하기 어려운 냉각기 , 공기냉각기와 같은 고온가스로. Component에서 발생하였다. 경수형 원자로에서는 중요하게 고려하지 않았던 복사열전달이 고온가스로 원자로공동에서는 붕괴열 제거에 중요한 역할을 수행하는 것으로 나타났다. 결론적으로, 본 연구를 종합하여 볼 때 MARS 코드는 고온가스로 원자로공동냉각계통의 냉각능력을 잘 모사하고 있으며 향후 수소생산용 고온가스로 개발에 있어서 안전해석 코드로서의 역할을 충분히 수행할 수 있을 것으로 판단된다.

• 생물정신의학
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• 제23권4호
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• pp.166-172
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• 2016

Objectives We investigated whether the catechol-O-methyltransferase (COMT) and serotonin related gene polymorphisms may be associated with agoraphobia in patients with panic disorder in Korea. Methods The COMT gene (rs4680), 5-hydroxytryptamine (serotonin) transporter linked polymorphic region (5-HTTLPR) gene (rs25531), serotonin receptor 1A (HTR1A) gene (rs6295) genotypes were analyzed in 406 patients with panic disorder and age-sex matched 206 healthy controls. Patients with panic disorder were dichotomized by the presence of agoraphobia. The following instruments were applied : the Beck Depression Inventory, the Beck Anxiety Inventory, the Panic Disorder Severity Scale. Results There was a significant difference in the distribution of 5-HTTLPR genotype between panic patients with agoraphobia and without agoraphobia (p = 0.024). That is, the panic patients with agoraphobia had a significant excess of the less active 5-HTTLPR allele (S allele). (p = 0.039) Also, we replicated previous western reports which indicated a significant difference in the distribution of COMT genotype between the patients with panic disorder and the healthy controls (p = 0.040). However, no significant associations of agora-phobia or panic disorder with HTR1A gene polymorphisms were found. Conclusions This result supports that the COMT polymorphisms may be associated with panic disorder and suggests that the 5-HTTLPR polymorphisms may play a role in the pathogenesis of agoraphobia in the Korean patients with panic disorder.

• 한국응용약물학회:학술대회논문집
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• 한국응용약물학회 1996년도 제4회 추계심포지움
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• pp.65-73
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• 1996

LPS/LOS, the compound found only in gram-negative bacterial outer membrane, plays important roles in bacterial maintenance as well as its pathogenesis. We isolated and characterized several genes required for NTHi 2019 LOS biosynthesis, which encode enzymes required for sugar substrate synthesis or the transfer of substrates to receptor molecules. The htrB gene, however, appears to have more complex role. It has acryltransferase activity as well as various other activity, which may control regulation of LOS biosynthesis as well as its pathogenicity. Evidences supporting the latter come from the observations that the lipid A of the B29 induced significantly less TNF ${\alpha}$ from macrophages than that of the wild type LOS (unpublished data). H. influenzae A2-htrB mutant strain was also significantly less invasive than the wild type strain. The structural similarities of the enterobacterial LPS and the Haemophilus LOS enabled us to isolate the NTHi 2019 genes involved in LOS biosynthesis genes by using the S. typhimurium LPS deep core mutants. While a similar approach has been used for E. coli, this technique for selection of an LPS phenotype has not been applied to nonenterobacterial species. The difficulties inherent in the molecular manipulation of organism such as Neisseria and Haemophilus species make this approach particularly attractive in the identification and cloning LOS genes. Studies on genetic features of LPS/LOS biosynthesis would be useful for understanding bacterial pathogenesis as well as for developing vaccines for these gram-negative pathogenic bacteria.

• Korean Journal of Acupuncture
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• 제22권3호
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• pp.1-15
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• 2005

Objectives: This research was performed to investigate the effect of invasive low level laser acupuncture therapy(LLLAT) at Yolgyol(LU7), Yogu(LR5) and Yolgyol+Yogu(LU7+LR5) on weight gain, food intake, food efficiency, lipid metabolism, atherogenic index, HTR(HDL-cholesterol to total cholesterol ratio) and liver function in hyperlipidemia rats. Methods : Experimental groups were divided into high fat diet group(Control group), high fat diet and LLLAT at LU7(LU7 group), high fat diet and LLLAT at LR5(LR5 group), LLLAT at LU7 and LR5(LU7+LR5 group). Animals was treated by the LLLAT at 30mW-5min once a 2day during 5 weeks. Results: Body weight was decreased significantly in LU7+LR5 group when compared with control group. Food intake was increased significantly in LU7, LR5, LU7+LR5 group when compared with control group. Food efficiency was decreased significantly in LU7, LR5, LU7+LR5 group when compared with control group. In the lipid metabolism, total cholesterol and HDL-cholesterol was decreased significantly in LU7+LR5 group, LDL-cholesterol and phospholipids were decreased significantly in LR5, LU7+LR5 group, triglyceride and fee fatty acid were decreased significantly in LU7 group when compared with control group. Atherogenic index was decreased significantly in LU7, LR5, LU7+LR5 group when compared with control group. HTR was increased significantly in LU7 group when compared with conool group. In the liver function, the significance was not showed in AST and ALT, ALP was decreased significantly in LU7+LR5 group when compared with control group. Conclusions: LLLAT at LU7 and LR5 maybe can manage hyperlipidemia by controlling body weight, food intake, food efficiency ratio and lipid metabolism.