• 사상체질의학회지
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• 제15권2호
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• pp.166-179
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• 2003

In order to evaluate the antiallergic effects of CSYJT, studies were done. We measured the cytotoxic activity for cytokines transcript expression, production of IL-4, IgE, $IFN-{\gamma}$, proliferation of B cell in HRF plus anti-CD40mAb plus rIL-4 stimulated murine splenic B cells. and cytokines transcript expression of IgE in Mast cell The results were obtained as follows: 1. CSYJT decreased the expression of IL-4 in mast cell significantly. 2. CSYJT decreased the production of IL-4 significantly. 3. CSYJT decreased the expression of IgE in mast cell significantly. 4. CSYJT decreased the production of IgE significantly. 5. CSYJT increased the appearance of $IFN-{\gamma}$. The facts above prove that CSYJT is effective against the allergy. Thus, I think that we should study on this continuously.

• 한국전기전자재료학회:학술대회논문집
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• 한국전기전자재료학회 2002년도 춘계학술대회 논문집 디스플레이 광소자 분야
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• pp.42-44
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• 2002

The experimental model of the 8-view stereoscopic display system using the photopolymer-based VHOE is proposed. At first, the VHOE is implemented by angle-multiplexed recording of 8-view's diffraction gratings using the optimized exposure-time scheduling scheme in the photopolymer (HRF-150-100) and then. the VHOE-based 8-view stereoscopic display system is implemented by sequentially synchronizing the incident angles of the reference beam of the VHOE with the 8-view stereo images on the LCD pannel. Accordingly, from some experimental results using 8-view images generated by the toed-in stereo camera system, it is found that 8-view stereo images can be diffracted to eight different directions time-sequentially and there is some disparity between the stereo images.

• 전자공학회논문지C
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• 제36C권9호
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• pp.66-75
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• 1999

영상분할은 입력된 영상을 처리하여 유사한 화소들의 집합인 영역들로 화소들을 구분하는 작업이다. 영상분할의 결과는 영상인식의 정확성에 큰 영향을 미친다. 본 논문에서는 유전자 알고리즘을 이용하여 마르코프 랜덤 필드(Markov random field)에 기반한 영상분할 방법을 제안한다. 제안한 방법에서는 잡음과 흔들림(blurring)에 강한 MRF를 이용하여 영상을 모델링 한다. HRF기반 영상분할 방법은 왜곡에 강한 반면, 정확한 파라미터의 추정이 요구된다. 그래서 , 추정방법으로 많은 파라미터를 포함하는 문제를 다루는데 효율적인 유전자 알고리즘을 사용한다. 실 영상을 가지고 수행된 실험 결과와 자동 차량 추출 시스템에의 응용결과는 제안된 방법의 효율성을 보여준다.

• International Journal of Computer Science & Network Security
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• 제22권9호
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• pp.23-30
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• 2022

Glaucoma is a chronic neuropathy that affects the optic nerve which can lead to blindness. The detection and prediction of glaucoma become possible using deep neural networks. However, the detection performance relies on the availability of a large number of data. Therefore, we propose different frameworks, including a hybrid of a generative adversarial network and a convolutional neural network to automate and increase the performance of glaucoma detection. The proposed frameworks are evaluated using five public glaucoma datasets. The framework which uses a Deconvolutional Generative Adversarial Network (DCGAN) and a DenseNet pre-trained model achieves 99.6%, 99.08%, 99.4%, 98.69%, and 92.95% of classification accuracy on RIMONE, Drishti-GS, ACRIMA, ORIGA-light, and HRF datasets respectively. Based on the experimental results and evaluation, the proposed framework closely competes with the state-of-the-art methods using the five public glaucoma datasets without requiring any manually preprocessing step.

• 한국전자통신학회논문지
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• 제14권6호
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• pp.1257-1264
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• 2019

기존의 Cuff 기반의 혈압(Blood Pressure)측정 방법은 연속적인 실시간 혈압측정에는 한계를 갖는다. 이러한 이유로 ECG와 PPG 센서 신호를 상호융합한 다양한 혈압추정이 이루어졌다. 그러나 PPG 중심에 측정기법은 AC 노이즈, 작은 맥동, 비박동 등의 많은 문제를 지니고 있다. 본 논문은 ECG와 PPG 관계에 발생하는 맥파전달시간(PTT)과 맥파속도(PWV)를 이용하여 혈압을 추론기법이다. 신호 피크를 이용하는 HRF(Height Ratio Features)에 비해, 본 제안방식은 ECG, PPG의 최고점 혹은 최저점을 사용한 시차를 이용해 추정하기 때문에 PPG 센싱 시그널의 오류에도 안정적인 추출이 가능한 장점이 있다. 본 논문에서 제안 방법을 이용하여 25만 회의 혈압측정의 결과 ±28.5%의 정확도를 갖는 혈압 추정기법을 제시할 수 있었다.

• Archives of Pharmacal Research
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• 제29권1호
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• pp.50-58
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• 2006

Translationally controlled tumor protein (TCTP), also known as histamine releasing factor (HRF), is found abundantly in different eukaryotic cell types. The sequence homology of TCTP between different species is very high, belonging to the MSS4/DSS4 superfamily of proteins. TCTP is involved in both cell growth and human late allergy reaction, as well as having a calcium binding property; however, its primary biological functions remain to be clearly elucidated. In regard to many possible functions, the TCTP of Plasmodium falciparum (Pf) is known to bind with an antimalarial agent, artemisinin, which is activated by heme. It is assumed that the endoperoxide-bridge of artemisinin is opened up by heme to form a free radical, which then eventually alkylates, probably to the Cys14 of PfTCTP. Study of the docking of artemisinin with heme, and subsequently with PfTCTP, was carried out to verify the above hypothesis on the basis of structural interactions. The three dimensional (3D) structure of PfTCTP was built by homology modeling, using the NMR structure of the TCTP of Schizosaccharomyces pombe as a template. The quality of the model was examined based on its secondary structure and biological function, as well as with the use of structure evaluating programs. The interactions between artemisinin, heme and PfTCTP were then studied using the docking program, FlexiDock. The center of the peroxide bond of artemisinin and the Fe of heme were docked within a short distance of $2.6{\AA}$, implying the strong possibility of an interaction between the two molecules, as proposed. When the activated form of artemisinin was docked on the PfTCTP, the C4-radical of the drug faced towards the sulfur of Cys14 within a distance of $2.48{\AA}$, again suggesting the possibility of alkylation having occurred. These results confirm the proposed mechanism of the antimalarial effect of artemisinin, which will provide a reliable method for establishing the mechanism of its biological activity using a molecular modeling study.

• 혜화의학회지
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• 제13권2호
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• pp.131-146
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• 2004

In the present study, we exarnined anti-allergic effect of SGBHB in cultured B cells. B cells were prepared from isolated murine splenocytes and activated by co-treatment of anti-CD40 monoclonal antibody and recombinant IL-4 allergens. Anti-allergic effects of SGBHB in activated B cells were determined by measuring B cell surface activated molecules (CD23+ and CD11a+), and expression levels of IL-$1{\beta}$, IL-6, IL-10, TNF-$\alpha$, IgE, and HRF. The major findings are summarized as follows. 1. SGBHB treatment did not produce significant cytotoxic effects on mouse lung fibroblast cells. 2. SGBHB produced significant inhibitory effect on the expression of B cell surface activated molecules (CD23+ and CD11a) in activated B cells. 3. SGBHB treatment significantly inhibited expression levels of IL-$1{\beta}$, IL-6, and TNF-$\alpha$ mRNAs in activated B cells.IL-6 protein levels were significantly decreased by $100{\mu}g/m{\ell}$ of SGBHB treatrrient, and TNF-$\alpha$ protein levels were decreased compared to the control group, but statistically insignificant. 4. SGBHB treatment significantly increased IL-10 at both mRNA and protein levels in activated B cells. 5. SGBHB treatment significantly inhibited levels of IgE production. Thus, the present data suggest that SGBHB has an anti-allergic effect on activated B cells by controlling irnmune responses, and further implicates the possibility on clinical application as a therapeutic agent.

• 한국어병학회지
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• 제11권2호
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• pp.129-136
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• 1998

1997년 3월 전라남도 및 경상남도의 해산어 육상 및 가두리 양식장에서 양성 중이던 넙치가 HRV(hirame rhabdovirus, Rhabdovirus olivaceus) 감염증과 유사한 증상을 나타내어 그 원인을 조사한 결과 새로운 rhabdovirus가 분리 되었다. 분리 바이러스(DF-9708)는 RTG-2 및 EPC 세포주에서 $15^{\circ}C$로 배양하였을 때 랩도바이러스 특유의 세포변성효과(CPE)를 나타내었으나 CHSE-214에서는 증식되지 않았다. 투과전자현미경으로 감염 세포내의 바이러스 입자 형태를 관찰해본 결과 bullet-shape의 크기 $70nm{\times}100\sim150nm$으로 인벨롭을 가진 바이러스였다. 분리바이러스는 pH 3 및 diethyl ether의 처리 조건에서는 감염성을 상실하였고, 열($50^{\circ}C$ 5 min, $60^{\circ}C$ 1 min)에도 약한 성상을 나타내었다. DNA 저해제인 IUdR $10^{-4}$M 처리에 의해서는 바이러스 감염가에 영향을 받지 않았다. 분리 바이러스는 Anti-HRV(8401-H) rabbit serum에 의해서만 중화 되었고, 전염성 조혈기 괴사증 바이러스(IHNV), 연어과 레오바이러스(CSV), 바이러스성 선회병 바이러스(RVS) 및 전염성 췌장괴사증 바이러스(IPNV) 등의 국내에서 분리되어지는 바이러스 항체로는 중화되지 않았다. 초원심법으로 정제한 분리 바이러스를 전기영동 한 결과 polymerase(L), glycoprotein(G), nucleoprotein(N) 및 2개의 matrix proteins(M1 및 M2)으로 구성되어져 있었으며, 각 단백질의 분자량은 L, 160 kDa; G, 55 kDa; N, 45 kDa; M1, 26 kDa; M2, 22 kDa의 크기로 계산되었다. 새롭게 분리된 바이러스는 외부증상으로는 기존의 HRV 감염과 유사한 점을 나타내었으나 그 바이러스학적 특성에 있어 약간의 차이점이 있어 본 분리바이러스를 우선 Nubchi rhabdovirus(NRV)(HRV-like)로 부르기로 한다.