• Pediatric Gastroenterology, Hepatology & Nutrition
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• 제8권2호
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• pp.213-221
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• 2005

목 적: 혈구탐식 증후군은 지속적인 고열, 간비종대, 혈구감소증, 고 페리틴혈증, 간과 비장 또는 임파절 등의 망상내피계 전반에 걸쳐 적혈구탐식을 보이는 양성 대식세포의 활성화와 증식을 특징으로 하는 질환으로, 심한 급성간염 또는 전격성 간염으로 발현할 수 있어 소아소화기분과로 처음 의뢰되는 경우가 많은데, 혈구탐식증후군은 조기에 etoposide를 포함하는 항암치료 요법을 시행한 후 필요시 골수이식을 시행함으로써 완치가 가능한 질환이나, 다른 원인의 전격성 간염의 경우에는 간이식이 필요하다는 점에서 정확한 감별이 요구된다. 방 법: 1994년 2월부터 2005년 3월까지 서울아산병원 소아과에서 혈구탐식증후군으로 진단받은 환아 23명 중 중증 급성 간염의 소견으로 발현한 11명의 의무기록을 토대로 후향적으로 인구학적 특징, 임상 양상, 검사 결과 등을 분석하였다. 결 과: 전체 혈구탐식 증후군 환아들 23명 중 중증 급성 간염 소견으로 발현한 예는 모두 11예로 48%였고, 이 중 소아소화기 분과로 처음 의뢰된 환아가 7명(64%)으로 반 이상을 차지하였다. 평균 나이는 50개월이었다. 원인으로 가족력은 없었고 바이러스 감염이 4예(36%)에서 증명되었는데, 골수에서 EBV PCR 양성이었으며, 이 중 1예는 HSV PCR이 동시에 양성이었다. 임상 증상으로는 발열이 10예(91%), 간비종대가 모든 환아(100%)에서 있었고, 황달 10예(91%), 점상출혈 3예(27%), 임파절 비대가 3예(27%), 호흡기 증상은 3예(25%)에서 관찰되었다. 혈액학적 소견으로 빈혈 91%, 혈소판 감소증 91%, 백혈구 감소증이 72%에서 관찰되었다. 고 중성지방혈증은 81%, 저 피브리노겐 혈증은 72%에서, 고 페리틴혈증은 64%에서 있었다. 총 9명의 환아가 etoposide를 포함하는 항암요법을 받았고 사망률은 11명 중 8명으로 72%였는데, 발병시부터 4주 이내에 항암요법을 시작한 경우의 사망률은 50%, 4주 이후에 시작한 경우의 사망률은 80%였다. 2세 미만의 환아의 사망률은 100%였다. 결 론: 상당수의 소아 혈구탐식증후군 환아들이 심한 급성 간염 및 간부전, 전격성 간염 등으로 발현할 수 있으며, 특히 지속적인 고열과 혈구감소증 등이 동반된 경우 혈구탐식증후군을 의심하여 조기에 진단하고 4주 이내에 etoposide를 포함한 항암요법과 필요시 골수이식을 실시하여 완치의 가능성을 추구하여야 하며, 다른 원인에 의한 전격성 간염으로 오진하여 불필요한 간이식을 시행하지 않도록 해야할 것이다.

• Journal of Veterinary Science
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• 제23권1호
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• pp.2.1-2.18
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• 2022

Background: Co-infections of the porcine reproductive and respiratory syndrome virus (PRRSV) and the Haemophilus parasuis (HPS) are severe in Chinese pigs, but the immune response genes against co-infected with 2 pathogens in the lungs have not been reported. Objectives: To understand the effect of PRRSV and/or HPS infection on the genes expression associated with lung immune function. Methods: The expression of the immune-related genes was analyzed using RNA-sequencing and bioinformatics. Differentially expressed genes (DEGs) were detected and identified by quantitative real-time polymerase chain reaction (qRT-PCR), immunohistochemistry (IHC) and western blotting assays. Results: All experimental pigs showed clinical symptoms and lung lesions. RNA-seq analysis showed that 922 DEGs in co-challenged pigs were more than in the HPS group (709 DEGs) and the PRRSV group (676 DEGs). Eleven DEGs validated by qRT-PCR were consistent with the RNA sequencing results. Eleven common Kyoto Encyclopedia of Genes and Genomes pathways related to infection and immune were found in single-infected and co-challenged pigs, including autophagy, cytokine-cytokine receptor interaction, and antigen processing and presentation, involving different DEGs. A model of immune response to infection with PRRSV and HPS was predicted among the DEGs in the co-challenged pigs. Dual oxidase 1 (DUOX1) and interleukin-21 (IL21) were detected by IHC and western blot and showed significant differences between the co-challenged pigs and the controls. Conclusions: These findings elucidated the transcriptome changes in the lungs after PRRSV and/or HPS infections, providing ideas for further study to inhibit ROS production and promote pulmonary fibrosis caused by co-challenging with PRRSV and HPS.

• 한국정보처리학회:학술대회논문집
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• 한국정보처리학회 2003년도 춘계학술발표논문집 (중)
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• pp.911-914
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• 2003

HPSS는 수 백만 개의 파일들을 동시에 처리하며 수 petabyte의 용량과 초당 수 gigabyte의 전송률을 보여주는 고성능 소프트웨어이며 고성능 컴퓨팅 환경에서 사용되는 대용량 데이터 스토리지를 위하여 개발되었다. 본 고에서는 HPSS의 대용량 테이프 저장장치 서비스를 시작하면서 사용자별로 용량 제한을 두기 위해서 사용량 제한 시스템을 구현하였다.

• Tribology and Lubricants
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• 제20권3호
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• pp.163-167
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• 2004

Reducing friction torque of the oil hydraulic vane pump used as the power source of power steering system should consider friction torque including viscous and mechanical friction torque according to the changes of rpm and pressure. This paper analyzes the forces acting on the vane to reduce the friction torque of the vane of the hydraulic vane pump used for Hydraulic Power Steering(HPS) system, and futhermore, the forces according to the shapes of cam profiles are analyzed.

• Pediatric Gastroenterology, Hepatology & Nutrition
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• 제1권1호
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• pp.120-124
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• 1998

미숙아에서 유문협착증은 매우 드문 질환으로 증상이 비전형적이고 한번의 복부 초음파 검사로 진단이 어렵다. 저자들은 구토와 수유 곤란이 발생한 미숙아에서 계속적인 복부 초음파 검사와 위장관 조영술로 유문협착증으로 진단하였고 수술 후 증세 호전되어 퇴원한 2례를 보고하는 바이다.

• Journal of Veterinary Science
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• 제22권5호
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• pp.59.1-59.13
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• 2021

Background: Antimicrobial peptides (AMPs) have been identified as promising compounds for consideration as novel antimicrobial agents. Objectives: This study analyzed the efficacy of cecropin B against Haemophilus parasuis isolates through scanning electron microscopy (SEM) and atomic force microscopy (AFM) experiments. Results: Cecropin B exhibited broad inhibition activity against 15 standard Haemophilus parasuis (HPS) strains and 5 of the clinical isolates had minimum inhibition concentrations (MICs) ranging from 2 to 16 ㎍/mL. Microelectrophoresis and hexadecane adsorption assays indicated that the more hydrophobic and the higher the isoelectric point (IEP) of the strain, the more sensitive it was to cecropin B. Through SEM, multiple blisters of various shapes and dents on the cell surface were observed. Protrusions and leakage were detected by AFM. Conclusions: Based on the results, cecropin B could inhibit HPS via a pore-forming mechanism by interacting with the cytoplasmic membrane of bacteria. Moreover, as cecropin B concentration increased, the bacteria membrane was more seriously damaged. Thus, cecropin B could be developed as an effective anti-HPS agent for use in clinical applications.

• Horticulture, Environment, and Biotechnology : HEB
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• 제59권6호
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• pp.827-833
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• 2018

Plasma lighting systems have been engineered to simulate sunlight. The objective of this study was to determine the effects of plasma lighting on tomato plant growth, photosynthetic characteristics, flowering rate, and physiological disorders. Tomato plants were grown in growth chambers at air temperatures of $25/23^{\circ}C$ (light/dark period), in a $16h\;day^{-1}$ light period provided by four different light sources: 1 kW and 700 W sulfur plasma lights (1 SPL and 0.7 SPL), 1 kW indium bromide plasma light, and 700 W high pressure sodium lamp (0.7 HPS) as a control. The totaldry weight and leaf area at 0.7 SPL were approximately 1.2 and 1.3 times greater, respectively, than that of 0.7 HPS at the 62 days after sowing (DAS). The maximum light assimilation rate was observed at 1 SPL at the 73 DAS. In addition, the light compensation and saturation points of the plants treated with plasma lighting were 98.5% higher compared with HPS. Those differences appeared to be related to more efficient light interception, provided by the SPL spectrum. The percentage of flowering at 0.7 SPL was 30.5%, which was higher than that at 0.7 HPS; however, there were some instances of severe blossom end rot. Results indicate that plasma lighting promotes tomato growth, flowering, and photosynthesis. Therefore, a plasma lighting system may be a valuable supplemental light source in a greenhouse or plant factory.

• Imaging Science in Dentistry
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• 제52권1호
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• pp.33-41
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• 2022

Purpose: This study aimed to evaluate the structural complexity of craniofacial trabecular bone in multiple myeloma by fractal analysis of panoramic and lateral skull radiography, and to compare the fractal dimension values of healthy patients (HPs), pre-treatment patients (PTPs), and patients during bisphosphonate treatment (DTPs). Materials and Methods: Pairs of digital panoramic and lateral skull radiographs of 84 PTPs and 72 DTPs were selected. After application of exclusion criteria, 43 panoramic and 84 lateral skull radiographs of PTPs, 56 panoramic and 72 lateral skull radiographs of DTPs, and 99 panoramic radiographs of age- and sex-matched HPs were selected. The fractal dimension values from panoramic radiographs were compared among HPs, PTPs, and DTPs and between anatomical locations within patient groups using analysis of variance with the Tukey test. Fractal dimension values from lateral skull radiographs were compared between PTPs and DTPs using the Student t-test. Pearson correlation coefficients were used to assess the relationship between the mandible from panoramic radiographs and the skull from lateral skull radiographs. Intra-examiner agreement was assessed using intraclass correlation coefficients (α=0.05). Results: The fractal dimension values were not significantly different among HPs, PTPs, and DTPs on panoramic radiographs or between PTPs and DTPs on lateral skull radiographs (P>0.05). The mandibular body presented the highest fractal dimension values (P≤0.05). The fractal dimension values of the mandible and skull in PTPs and DTPs were not correlated. Conclusion: Fractal analysis was not sensitive for distinguishing craniofacial trabecular bone complexity in multiple myeloma patients using panoramic and lateral skull radiography.

• 한국환경농학회지
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• 제41권4호
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• pp.245-251
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• 2022

BACKGROUND: Selection an suitable light source is essential in the year-round production of horticultural crops in closed production systems such as plant factory with controlled environments. This study was investigated to confirm the effects of artificial light sources on growth of cherry tomato'CF Jelly'(Lycopersicon esculentum var.) under high-pressure sodium lamps (HPS), metal-halide lamps (MH), and LEDs. METHODS AND RESULTS: Light intensity of the light sources was controlled at 220±30 µmol/m²/s with 12 hrs of photoperiod for a day. Flower development was significantly faster in HPS and MH treatments compared to the LEDs. There was no significant difference between the leaf number and leaf shape under the HPS and MH treatments. Reproductive growth of cherry tomato was significantly promoted by the LEDs treatment of blue plus red lights. Fruit yield per plant also increased under the LEDs compared to the others. CONCLUSION(S): Growth, flowering, and fruit setting of the cherry tomato were accomplished by the artificial lights under plant factory conditions. The HPS treatment showed negative effect on fruit quality in terms of blossom-end rot incidence compared to the LEDs or MH treatment. Effect of the LEDs on promotion of fruit weight and yield was also proved. Additional research should be carried out for improving sugar metabolism or decreasing disease in the fruits under plant factory system using only artificial lights.

• Journal of Hospice and Palliative Care
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• 제27권2호
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• pp.64-76
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• 2024

Purpose: End-of-life (EOL) care is a vulnerable period in an individual's life. Healthcare professionals (HPs) strive to balance the preservation of human life with respect for the patient's wishes. The aims of our study were to assess HPs' knowledge and perceptions of EOL care and to propose areas of improvement to improve the quality of care. Methods: We conducted a single-center, cross-sectional study involving HPs from a university hospital who encountered EOL care situations. We used a questionnaire divided into four sections: knowledge, practice, perception, and training. We calculated the rate of correct answers and the collective competence index. Results: Eighty-six questionnaires were analyzed, with 82.5% (71/86) completed by medical respondents and 17.5% (15/86) by paramedical respondents. Most of the respondents, 71.8% (51/71), were interns and residents. The study focused on palliative care, medical assistance in dying, aggressive medical treatment, and euthanasia, finding adequate knowledge in the first three areas. Respondents assigned to the intensive care unit and those with more than 8 years of experience had significantly higher correct answer rates than their counterparts. Seventy-five percent of respondents (65/86) reported feeling that they had little or no mastery of EOL care, primarily attributing this to insufficient training and the unavailability of trainers. Conclusion: Based on the findings of our study, which we believe to be the first of its kind in Tunisia, we can conclude that HPs possess an acceptable level of knowledge regarding EOL care. However, they require more exposure and training to develop expertise in this area.