• Nutrition Research and Practice
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• 제9권4호
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• pp.379-384
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• 2015

BACKGROUND/OBJECTIVE: Apolipoprotein A5 gene promoter region T-1131C polymorphism (APOA5 T-1131C) is known to be associated with elevated plasma TG levels, although little is known of the influence of the interaction between APOA5 T-1131C and lifestyle modification on TG levels. To investigate this matter, we studied APOA5 T-1131C and plasma TG levels of subjects participating in a three-month lifestyle modification program. SUBJECTS/METHODS: A three-month lifestyle modification program was conducted with 297 participants (Age: $57{\pm}8years$) in Izumo City, Japan, from 2001-2007. Changes in energy balance (the difference between energy intake and energy expenditure) and BMI were used to evaluate the participants' responses to the lifestyle modification. RESULTS: Even after adjusting for confounding factors, plasma TG levels were significantly different at baseline among three genotype subgroups: TT, $126{\pm}68mg/dl$; TC, $134{\pm}74mg/dl$; and CC, $172{\pm}101mg/dl$. Lifestyle modification resulted in significant reductions in plasma TG levels in the TT, TC, and CC genotype subgroups: $-21.9{\pm}61.0mg/dl$, $-20.9{\pm}51.0mg/dl$, and $-42.6{\pm}78.5mg/dl$, respectively, with no significant differences between them. In a stepwise regression analysis, age, APOA5 T-1131C, body mass index (BMI), homeostasis model assessment-insulin resistance (HOMA-IR), and the 18:1/18:0 ratio showed independent association with plasma TG levels at baseline. In a general linear model analysis, APOA5 T-1131C C-allele carriers showed significantly greater TG reduction with decreased energy balance than wild type carriers after adjustment for age, gender, and baseline plasma TG levels. CONCLUSIONS: The genetic effects of APOA5 T-1131C independently affected plasma TG levels. However, lifestyle modification was effective in significantly reducing plasma TG levels despite the APOA5 T-1131C genotype background.

• Journal of Nutrition and Health
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• 제44권4호
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• pp.292-302
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• 2011

본 연구는 직장인 남성 근로자를 대상으로 12주 심혈관질환예방 중재프로그램이 신체계측, 혈중지질 및 아디포사이토카인, 영양소 섭취상태에 어떠한 영향을 미치는지 파악하고자 성인 남성 157명을 대상으로 실시되었다. 중재프로그램 전과 후를 비교 분석한 결과, 체중감량, 혈중지질 농도 및 인슐린 저항성 개선과 아디포사이토카인의 농도가 개선 되는 등 심혈관질환 위험 인자에 바람직한 영향을 미치는 것으로 나타났다. 아디포넥틴은 HDL-콜레스테롤, HOMA-IR과 연관성을 보였고, 렙틴은 허리둘레, 레지스틴은 HDL-콜레스테롤, HbA1c, 열량섭취와 연관성이 있는 것을 확인하였다. 이상의 연구에서처럼 12주 심혈관질환 예방 중재프로그램 수행 후에, 신체계측, 혈중 지질 농도 및 아디포사이토카인 농도가 효과적으로 개선됨을 알 수 있었고, 심혈관질환 위험 인자와 아디포사이토카인과의 연관성을 파악할 수 있었다. 향후에는 직장인 남성 근로자를 대상으로 심혈관질환 예방을 위한 전향적 연구가 이루어져야 할 것이다.

• Journal of Nutrition and Health
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• 제42권8호
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• pp.714-722
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• 2009

The principal objective of this study was to determine the effects of leucine on body weight reduction in high fat diet-induced overweight rats. To induce overweight, six-month-old male Sprague-Dawley rats (n = 80) were divided into 8 groups; one group of 10 rats was fed on a normal fat diet and the remaining 70 rats were fed on a high-fat diet (40% of energy as fat) for 14 weeks. Then, 10 rats fed on the normal fat diet and another 10 rats fed on the high fat diet were sacrificed to identify overweight induction. The remaining 60 rats were divided randomly into 6 groups according to body weight and fed on one of the diets with different dietary fat levels (9.6% or 40% of energy as fat) and leucine levels (0, 0.6 or 1.2 g/kg BW) for the following 5 weeks of experiments. The body weight loss in the Leu-administered groups (0.6 g, 1.2 g/kg BW) was significantly higher than those of Leu non-administered groups. The perirenal fat pad weights in the Leu-administered groups were significantly lower than those of the Leu non-administered groups. Of the hepatic enzymes, glucose-6-phosphate dehydrogenase (G6PDH) activities were reduced significantly in the Leu-administered groups than in the Leu non-administered groups. With the oral glucose tolerance test (OGTT), the incremental areas under the curve of the glucose response (IAUC) of the Leu-administered groups were significantly lower than those of the Leu non-administered groups. The fasting glucose concentration and HOMA-IR of the Leu-administered groups were significantly lower than those of the Leu non-administered groups. In conclusion, the results of this study suggest that one of the possible mechanisms of leucine in the observed body weight reduction might involve the inhibition of lipogenic enzyme activities such as glucose-6-phosphate dehydrogenase, rather than the activation of lipolysis enzymes. Additionally, leucine adminstration resulted in improved glucose metabolism.

• 한국식품영양과학회지
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• 제43권5호
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• pp.763-771
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• 2014

본 연구는 국민건강영양조사 2010년 자료를 이용하여 우리나라 만 30세 이상 성인을 대상으로 공복혈당에 따라 정상군, 전당뇨병군, 당뇨병군으로 나누어 각 군에서 나트륨 섭취량과 복부비만과의 상관성을 분석하고자 하였다. 분석 결과, 전당뇨병군에서 나트륨 섭취와 복부비만 관련 지표인 허리둘레가 유의적인 양의 상관관계를 보였으며, 특히 전당뇨병 고나트륨군의 경우 당뇨병 관련 임상지표인 공복혈당, 공복인슐린, HOMA-IR 수치가 높아질수록 복부비만 발병위험 또한 유의적으로 증가하였다. 본 연구는 당뇨병과 여러 관련 합병증으로 이행될 위험이 높은 전당뇨병 대상자에서 나트륨 섭취와 복부비만 간 상관성을 밝혔다는 점에 의의가 있다. 우리나라 전당뇨병 성인의 경우 나트륨 섭취 수준이 높다고 분석되었으므로 추후 연구에서는 전당뇨병 대상자를 위한 지속적인 나트륨 섭취량 모니터링과 함께 나트륨 섭취가 복부비만과 당뇨병에 미치는 인과관계와 그 기전을 밝힐 수 있는 연구가 필요하며, 이를 통해 당뇨병과 여러 관련 합병증의 예방 및 관리를 위한 적절한 식사지침과 효과적인 영양교육을 제시할 수 있을 것으로 사료된다.

• 한국식품영양학회지
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• 제31권3호
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• pp.425-434
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• 2018

Metabolic syndrome is a risk factor for cardiovascular and type 2 diabetes. This study was conducted to examine the relevance between nutrition intake, meal quality, and high-sensitivity C-reactive protein in Koreans with metabolic syndrome. The 2,536 subjects, aged 19~64, who participated in 2015 National Nutrition Survey were included in this study. The 24-hour recall method was employed to analyze nutrition intake and dietary quality. Subjects were grouped into either the non-metabolic syndrome group (n=1,938) or the metabolic syndrome group (n=598). Total males and females were divided into 3 groups according to the high-sensitivity C-reactive protein (hs-CRP) level to study its relationship to metabolic syndrome and its components, including odds ratio (OR) and confidence interval (CI). Results showed the homeostasis model assessment of insulin resistance (HOMA-IR) value was higher in the metabolic syndrome group (3.37) than non-metabolic syndrome group (1.57) (p<0.001). In the Index of Nutrition Quality, males in the non-metabolic syndrome group showed higher niacin (p<0.05) than males in metabolic syndrome group. Females in the non-metabolic syndrome group had higher vitamin $B_1$ (p<0.01), vitamin $B_2$ (p<0.001), niacin (p<0.05), calcium (p<0.001), and phosphate (p<0.01). Female in the high hs-CRP group showed high OR in blood glucose component (OR 2.488, 95% CI: 1.269~4.879) and metabolic syndrome risk (OR 2.856, 95% CI: 1.292~6.314). Females in the middle hs-CRP group had high triglycerides component (OR 2.956, 95% CI: 1.920~4.551), compared to the low hs-CRP group. The study showed females with higher hs-CRP had a higher risk of metabolic syndrome.

• 생명과학회지
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• 제27권7호
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• pp.817-825
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• 2017

본 연구는 체지방률 30% 이상인 비만 중년여성을 대상으로 복합운동 영양교육군(n=7), 복합운동군(n=7), 대조군(n=7) 총21명을 대상으로 연구한 결과 다음과 같은 결론을 얻었다. 12주간 복합운동과 영양교육의 실시는 비만 중년 여성의 체지방률, 제지방량, GOT, TC, TG, HDL-C, 인슐린 저항성을 개선시키는 효과를 나타냈다. 이러한 결과는 복합운동과 영양교육이 비만중년여성의 신체조성, 간기능, 혈중지질, 및 인슐린 저항성에 긍정적인 영향을 미쳐 중년여성의 비만을 개선하는데 효과적인 프로그램 사료되며, 추후에도 비만중년여성의 운동방법, 운동빈도, 식이방법 등을 고려한 다양한 연구가 필요할 것으로 사료된다.

• 대한본초학회지
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• 제32권1호
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• pp.15-23
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• 2017

Objectives : It is well known that Sibjotang (Shizaotang), traditional herbal medicine formula, regulates the body fluid blood pressure homeostasis. This study is to investigate whether Sibjotang improves diabetic renal dysfunction in type II diabetes mellitus animal model, db/db mice. Methods : The animals model were divided into three groups at the age of 8 weeks; control group (C57BLKS/J-db/m mice), diabetic group [(C57BLKS/J+Lepr)-db/db mice], and Sibjotang group [(C57BLKS/J+Lepr)-db/db mice + Sibjotang 100 mg/kg/day]. During 8 weeks of treatment, blood glucose and urinary albumin excretion were checked in metabolic chamber at 8, 12, and 16 weeks of age, respectively. Results : Body weight and food intake of diabetic group were significantly higher than control group after 8 weeks administration. However, there were not significant different between the diabetic group and Sibjotang group. Urinary albumin excretion was significantly decreased in the Sibjotang group than the diabetic group. In addition, supplementation with Sibjotang significantly lowered levels of blood glucose, insulin, and homeostatic model assessment-insulin resistance (HOMA-IR), suggesting reduced insulin resistance. The ratio of mesangial matrix/glomerular area was markedly larger in diabetic group than control group, whereas Sibjotang significantly reduced this expansion. Moreover, immunohistological study revealed that Sibjotang attenuated the increase of transforming growth $factor(TGF)-{\beta}$ expression in kidney. Conclusion : Sibjotang ameliorates diabetes-associated renal injury through the improvement of the blood glucose and insulin sensitivity, and inhibiting the $TGF-{\beta}1$ expression. Therefore, Sibjotang may be a new therapeutic formula for the treatment of diabetic-associated renal dysfunction.

• 디지털융복합연구
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• 제13권5호
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• pp.393-400
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• 2015

본 연구는 중년여성을 대상으로 12주간의 간헐적 단식과 저항운동이 성호르몬과 당대사 변인에 어떤 영향을 주는지 알아보고자 하였다. 이에 두 그룹을 선정하여 EG에는 간헐적 단식과 저항운동을 적용하였으며, CG는 통제군으로서 EG의 효과를 검증할 수 있는 군으로 설정하였다. EG에 적용된 간헐적 단식은 주당 1회 24시간의 단식을 실시하였으며, 저항운동은 주 당 3회 60분간 1RM을 기준으로 60% 강도로 실시하였다. 각 측정변인은 12주간의 처치전후 측정하여 처치효과를 검증하였다. 이와 같은 절차를 통해 다음과 같은 결론을 얻었다. 첫째, 간헐적 단식과 저항운동을 적용한 그룹에서 성호르몬(에스트라디올, 테스토스테론)의 변화에 유의한 상호작용효과를 나타냈다. 둘째, 간헐적 단식과 저항운동을 적용한 그룹에서 당대사변인(글루코스, 인슐린, HOMA-IR)의 변화에 유의한 상호작용효과를 나타냈다. 본 연구는 간헐적 단식과 저항운동을 동시에 적용하여 진행하여 긍정적인 결과를 얻었다. 하지만 간헐적 단식과 저항운동 각각의 효과를 검증하는 데는 한계가 있는 것으로 판단된다.

• Journal of Preventive Medicine and Public Health
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• 제43권3호
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• pp.213-221
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• 2010

Objectives: Plasma lipid profiles and Apolipoprotein E (ApoE) are established risk factors for cardiovascular disease (CVD). The knowledge of lipid profile may estimate the potential victims of cardiovascular disease before its initiation and progression and offers the opportunity for primary prevention. The most common ApoE polymorphism has been found to influence plasma lipid concentrations and its correlation with CVD has been extensively investigated in the last decade. Methods: The ApoE polymorphism and its influence on plasma lipid were investigated in healthy woman workers. The information on confounding factors was obtained through a self-administered questionnaire and ApoE polymorphism was investigated using PCR. Results: The relative frequencies of alleles E2, E3 and E4 for the study population (n = 305) were 0.127, 0.750 and 0.121, respectively. ApoE polymorphism was associated with variations in plasma HDL-cholesterol lipid profile. In order to estimate the independent effects of alleles E2 and E4, as compared with E3, on lipid profile, multiple regression was performed after adjustment for confounding variables such as age, BMI, blood pressure, education status, insulin, fasting glucose, HOMA-IR, menopause. ApoE2 had a negative association with HDL cholesterol and ApoE4 had a positive association with LDL cholesterol. Conclusions: This study identified that the ApoE and CVD risk factors contribute to the lipid profiles, similar to other studies. The analysis including dietary intake and other gene in further studies may help to identify clear effects on lipid profiles as risk factor for CVD.

• 한국응용과학기술학회지
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• 제36권3호
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• pp.804-812
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• 2019

The purpose of this study was to investigate the effects of different types of exercise training on neurodegeneration and cognitive function in mice with impaired glucose tolerance (IGT). Thirty-six male C57BL/6 mice were randomly assigned to the control (CO, n = 9) and impaired glucose tolerance (IGT, n = 27) groups. The IGT group consumed 45% high fat diet for 4 weeks and received 40 mg/kg of streptozotocin twice in the lower abdomen to induce IGT. After the IGT induction period, the IGT group was subdivided into IGT + sedentary (IGT, n = 9), IGT + endurance exercise (IGTE, n = 9), and IGT + resistance exercise (IGTR, n = 9). The IGTE and IGTR groups performed treadmill and ladder climbing exercises 5 times per week for 8 weeks, respectively. Fasting glucose and glycated hemoglobin (HbA1c) levels were significantly higher in IGT group than in CO, IGTE, and IGTR groups (p < 0.05). HOMA-IR was significantly higher in IGT group than CO group (p < 0.05). Hippocampal catalase (CAT) was significantly lower in IGT group than in CO group (p < 0.05), while beta-amyloid ($A{\beta}$) was significantly higher in IGT group than in CO group (p < 0.05). Hippocampal tau was significantly higher in IGT group than in CO, IGTE, and IGTR groups (p < 0.05). The Y-maze test performance for cognitive function was significantly lower in IGT group than in CO, IGTE, and IGTR groups (p <0.05). These results suggest that IGT induces neurodegeneration and negatively affects cognitive function, while regular exercise may be effective in alleviating neurodegeneration and cognitive decline regardless of exercise type.