• 셀메드
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• 제4권1호
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• pp.4.1-4.4
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• 2014

Gynura segetum, family Asteraceae is a cultivated species and can be found growing in the tropical regions of Indonesia and Malaysia. The plant is known for its use for the treatment of cancer, inflammation, diabetes, hypertension and skin afflictions. In the current study, anti-inflammatory effect of Gynura segetum leaf has been investigated. The present study investigated the in vivo anti-inflammatory effect of Gynura segetum leaf by using hen's egg test-chorioallantoic membrane (HET-CAM) assay. Different solvent extract of Gynura segetum leaf were tested, the most active methanol extract was further fractionated and tested. Among the extracts tested, the methanol extract showed a significant good anti-inflammatory effect (76.8% inhibition at 50 ${\mu}g/disc$) on the HET-CAM assay as compared with the anti-inflammatory drug indomethacin (82.1% inhibition). However, the fractionated sample exhibited a significantly lower activity in comparison to crude methanol extract. The results demonstrated that Gynura segetum leaf displayed remarkable anti-inflammatory effects, which support the folkloric uses of this plant for treatment of inflammation.

• Journal of Communications and Networks
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• 제18권2호
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• pp.150-161
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• 2016

Coordinated multi-point transmission (CoMP) techniques are being touted as enabling technologies for interference mitigation in next generation heterogeneous wireless networks (HetNets). In this paper, we present a comparative performance study of uplink (UL) CoMP algorithms for the 3GPP LTE HetNets. Focusing on a distributed and functionally-split architecture, we consider six distinct UL-CoMP algorithms: 1. Joint reception in the frequency-domain (JRFD) 2. Two-stage equalization (TSEQ) 3. Log-likelihood ratio exchange (LLR-E) 4. Symmetric TSEQ (S-TSEQ) 5. Transport block selection diversity (TBSD) 6. Coordinated scheduling with adaptive interference mitigation (CS-AIM) where JRFD, TSEQ, S-TSEQ, TBSD and CS-AIM are our main contributions in this paper, and quantify their relative performances via the post-processing signal-to-interference-plus-noise ratio distributions.We also compare the CoMP-specific front-haul rate requirements for all the schemes considered in this paper. Our results indicate that, with a linear minimum mean-square error receiver, the JRFD and TSEQ have identical performances, whereas S-TSEQ relaxes the front-haul latency requirements while approaching the performance of TSEQ. Furthermore, in a HetNet environment, we find that CS-AIM provides an attractive alternative to TBSD and LLR-E with a significantly reduced CoMP-specific front-haul rate requirement.

• 전자공학회논문지
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• 제53권1호
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• pp.3-8
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• 2016

무선망에서 소모 전력, 전송률, 통신 반경 등 서비스 요구 사항에 따라 상호 다른 망의 발전이 진행되어 왔다. 최근 차세대 무선망 환경에서는 초고속, 초저지연, 저전력 등 서비스 요구 사항이 보다 다양해지고 높은 수준으로 설정되고 있으며, 이를 만족하기 위한 방안으로 이기종간 효과적인 연동에 대한 연구에 관심이 높아지고 있다. 본 논문에서는 이기종 무선망 환경에서 망간 연동을 통해 데이터 서비스가 이루어지는 상황에서 에너지 효율성을 반영하는 스케쥴링 기법을 제안한다. 특히 이기종 무선망 환경에서 사용자 형평성을 고려하면서 데이터 수율을 개선하는 비례균등 스케쥴링 방식을 기반으로 에너지 효율에 관한 요소를 반영하는 문제를 고려하고 에너지 효율을 개선함과 동시에 사용자 형평성, 데이터 수율을 모두 감안하는 에너지 효율적인 비례균등 스케쥴링 방식을 제안한다. 또한 모의실험을 통해 제안된 방식으로 비례균등 달성도를 유지하면서 에너지 효율이 개선됨을 보인다.

• 인터넷정보학회논문지
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• 제24권5호
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• pp.1-7
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• 2023

본 논문은 매크로 기지국 (Macro base station, MBS) 커버리지 내 스몰셀 기지국 (Small-cell base station, SBS)이 중첩된 5G 이기종 네트워크 (Heterogeneous network, HetNet)환경에서 머신 타입 통신 장치 (Machine-Type Communications Devices, MTCD)들에게 미치는 간섭을 해결하고 성능향상을 위한 스몰셀 자원 분리 할당 방법을 제안한다. 5G HetNet에서는 다양한 타입의 MTCD들이 데이터 트래픽을 생성하므로 기지국에 대한 부하가 심해진다. 따라서 이 부하를 해결하기 위해 SBS의 수신세기에 bias값을 더해 조건에 만족하는 MTCD들을 SBS에 연결하는 셀 범위 확장 (Cell range expansion, CRE)방법이 적용된다. CRE를 통해 SBS에 연결되는 MTCD들의 수가 증가하여 MBS의 부하는 줄어들지만 간섭의 영향을 받아 성능이 저하되므로 이를 해결하는 방법이 필요하다. 제안하는 스몰셀 자원 분리 할당 방법은 CRE로 SBS 내 새롭게 추가된 MTCD의 간섭 완화를 위해 기존 MBS로부터의 간섭이 적은 자원을 할당하고 기존 MTCD들의 성능에 따라 자원을 분리하여 할당하므로 전체 MTCD들의 성능을 향상시킨다. 시뮬레이션 결과를 통해 제안하는 스몰셀 자원 분리 할당 방법은 기존의 자원 할당 방법보다 MBS와 SBS에 연결된 MTCD들의 시스템 용량에서 21%와 126%의 성능향상을 보인다.

• 대한본초학회지
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• 제39권1호
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• pp.39-47
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• 2024

Objectives : This study evaluates how various traditional Korean herbal medicines assess MUC5AC expression for esophageal mucosal defense and analyzes the associated mechanisms involved in inflammation. Methods : Forty types of traditional Korean herbal medicines were assessed for in vitro antioxidant activities, and the real-time PCR method was employed to analyze MUC5AC expression under pH 4.5 conditions in human esophageal epithelial cells (HET-1A). Eight types of Korean herbal medicines were evaluated for in vitro antioxidant activities, and Reactive oxygen specise (ROS) expression was analyzed under bile salt (480 𝜇M) and pH 5.5 conditions in human esophageal epithelial cells (HET-1A). Simulation experiments involving bile salts and acidity were conducted for one hour to assess the efficacy of four drugs, and the activities of Mitogen-activated Protein Kinase (MEK), Nuclear Factor Kappa B (NF-𝜅B), and Cyclooxygenase-2 (COX-2) were detected through Western blot analysis. Results : Compared to the Normal group, the Control group exhibited higher ROS generation. Such increased ROS levels were significantly reduced by four extracts: Citrus Unshius Pericarpium (CUP), Cnidium officinale Rhizoma (CR), Ginseng Radix (GR), and Linderae Radix (LR). The protein expression of COX-2 decreased with the treatment of LR, CUP, and CR. Particularly, CUP and CR exhibited superior effects compared to other groups in inhibiting the phosphorylation of NF-𝜅B. Conclusion : Based on the results obtained, we have identified drugs that inhibit oxidative stress and inflammation caused by bile acid in esophageal epithelial cells. Our future plans involve comparing and analyzing the efficacy of these herbal medicines through animal experiments.

• 한국전기전자재료학회:학술대회논문집
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• 한국전기전자재료학회 2010년도 하계학술대회 논문집
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• pp.232-232
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• 2010

Simulation Program (AFORS-HET 2.4.1) was used, include the basic structure of crystalline silicon thin film as above, under the intrinsic a-Si:H films bonded symmetrical structure (Symmetrical structure) were used. The structure of ITO, a-Si p-type, intrinsic a-Si, c-Si, intrinsic a-Si, a-Si n-type, metal (Al) layer has one of the seven. When thickness for each layer was given the change, the changes of a-Si p-type layer and the intrinsic a-Si layer on top had an impact on efficiency. Efficiency ratio of p-type a-Si:H layer thickness was sensitive to, especially a-Si: H layer thickness is increased in a rapid decrease in Jsc and FF, and efficiency was also decreased.

• BMB Reports
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• 제55권12호
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• pp.633-638
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• 2022

Liver regeneration is a well-known systemic homeostatic phenomenon. The N⁶-methyladenosine (m⁶A) modification pathway has been associated with liver regeneration and hepatocellular carcinoma. m⁶A methyltransferases, such as methyltransferase 3 (METTL3) and methyltransferase 14 (METTL14), are involved in the hepatocyte-specific-regenerative pathway. To illustrate the role of METTL14, secreted from non-parenchymal liver cells, in the initiation phase of liver regeneration, we performed 70% partial hepatectomy (PH) in Mettl14 heterozygous (HET) and wild-type (WT) mice. Next, we analyzed the ratio of liver weight to body weight and the expression of mitogenic stimulators derived from non-parenchymal liver cells. Furthermore, we evaluated the expression of cell cycle-related genes and the hepatocyte proliferation rate via MKI67-immunostaining. During regeneration after PH, the weight ratio was lower in Mettl14 HET mice compared to WT mice. The expressions of hepatocyte growth factor (HGF) and tumor necrosis factor (TNF)-α, mitogens derived from non-parenchymal liver cells that stimulate the cell cycle, as well as the expressions of cyclin B1 and D1, which regulate the cell cycle, and the number of MKI67-positive cells, which indicate proliferative hepatocyte in the late G1-M phase, were significantly reduced in Mettl14 HET mice 72 h after PH. Our findings demonstrate that global Mettl14 mutation may interrupt the homeostasis of liver regeneration after an acute injury like PH by restraining certain mitogens, such as HGF and TNF-α, derived from sinusoidal endothelial cells, stellate cells, and Kupffer cells. These results provide new insights into the role of METTL14 in the clinical treatment strategies of liver disease.

• Archives of Pharmacal Research
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• 제19권5호
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• pp.396-399
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• 1996

High-performance liquid chromatographic method with UV detecction was developed for the determination of theophylline and its metabolites in human urine using ${beta}$-hydroxyethyl theophylline$({beta} -HET)$ as an internal standard. For extraction of urine sample, quality control sample and xanthine-free blank urine were mixed with decylamine (ion-paring reagent) and ${beta}$-HET. After saturation with ammonium sulfate, the mixture was then extracted with organic solvent at pH values of 4.0-4.5. All separations were performed with ion-pair chromatography using decylamine as an ion-pairing reagent and 3mM sodium acetate buffered mobile phase (pH 4.0) containing 1% (v/v) acetonitrile and 0.75 mM decylamine. The detection limits of theophylline, 1, 3-DMU, 1-MU, 3-MX and 1-MX in human urine were 0.17, 0.17, 0.39, 0.19 and 0.19 ${\mu}g$/ml, based on a signal-to-noise ratios of 3.0. The mean intraday coefficients of variation (C.V.s) of each compound on nine replicates were lower than 2.0%, while mean interday C.V.s on three days were lower than 1.6%. All separations were finished within 40miutes.

• Journal of Communications and Networks
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• 제18권5호
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• pp.784-795
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• 2016

In this paper, we investigate the resource allocation problem in time-varying heterogeneous wireless networks (HetNet) with multi-homing user equipments (UE). The stochastic optimization model is employed to maximize the network utility, which is defined as the difference between the HetNet's throughput and the total energy consumption cost. In harmony with the hierarchical architecture of HetNet, the problem of stochastic optimization of resource allocation is decomposed into two subproblems by the Lyapunov optimization theory, associated with the flow control in transport layer and the power allocation in physical (PHY) layer, respectively. For avoiding the signaling overhead, outdated dynamic information, and scalability issues, the distributed resource allocation method is developed for solving the two subproblems based on the primal-dual decomposition theory. After that, the adaptive resource allocation algorithm is developed to accommodate the timevarying wireless network only according to the current network state information, i.e. the queue state information (QSI) at radio access networks (RAN) and the channel state information (CSI) of RANs-UE links. The tradeoff between network utility and delay is derived, where the increase of delay is approximately linear in V and the increase of network utility is at the speed of 1/V with a control parameter V. Extensive simulations are presented to show the effectiveness of our proposed scheme.

• KSII Transactions on Internet and Information Systems (TIIS)
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• 제8권1호
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• pp.35-57
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• 2014

Multi-criteria decision making (MCDM) algorithms play an important role in ensuring quality of service in an integrated HetNets (Heterogeneous Networks). The primary objective of this paper is to develop a multi-criteria vertical handoff decision algorithm (VHDA) for best access network selection in an integrated Wireless Local Area Network (WLAN)/Universal Mobile Telecommunications System (UMTS)/Worldwide Interoperability for Microwave Access (WiMAX) system. The proposed design consists of two parts, the first part is the evaluation of an Analytic Hierarchy Process (AHP) to decide the relative weights of handoff decision criteria and the second part computes the final score of the weights to rank network alternatives using Simple Additive Weighting (SAW). SAW ranks the network alternatives in a faster and simpler manner than AHP. The AHP-SAW mathematical model has been designed, evaluated and simulated for streaming video type of traffic. For other traffic type, such as conversational, background and interactive, only simulation results have been discussed and presented in brief. Simulation results reveal that the hierarchical modelling and computing provides optimum solution for access network selection in an integrated environment as obtained results prove to be an acceptable solution to what could be expected in real life scenarios.