• Journal of Korean Tunnelling and Underground Space Association
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• v.7 no.1
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• pp.63-72
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• 2005

The influence of internal water pressure under the Probable Maximum Flood (PMF) on tunnel spillway is analysed using 3D FDM analysis. HEC-RAS program including 1-D hydrologic numerical model was also implemented to estimate the maximum pressure on the lining under the PMF, thereafter determined rational internal water pressure. Tunnel spillway was designed as twin tunnel and excavation and supporting stage are fully considered. Analysis was classified into the 3 cases; pressure is applied only to the left tunnel, only to right tunnel, and to both tunnels. The maximum tensile stress and axial force in supporting materials induced by water flow were compared with the critical values to assess the stablilty of the tunnel and the locations of stress concentration parts were also examined.

• Journal of Ginseng Research
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• v.44 no.1
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• pp.96-104
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• 2020

Objectives: Oleanolic acid, a minor element of ginsenosides, and its derivatives have been shown to have cytotoxicity against some tumor cells. The impact of cytotoxic effect of oleanolic acid 3-acetate on ovarian cancer SKOV3 cells and endometrial cancer HEC-1A cells were examined both in vivo and in vitro to explore the underlying mechanisms. Methods: Cytotoxic effects of oleanolic acid 3-acetate were assessed by cell viability, phosphatidylserine exposure on the cell surface, mitochondrial release of cytochrome C, nuclear translocation of apoptosis-inducing factor, depolarization of mitochondrial transmembrane potential (∆Ψ_m), and generation of reactive oxygen species (ROS). In vivo inhibition of tumor growth was also assessed with xenografts in immunocompromised mice. Results: Oleanolic acid 3-acetate exhibited potent cytotoxicity toward SKOV3 and HEC-1A cells by decreasing cell viability in a concentration-dependent manner. Importantly, oleanolic acid 3-acetate effectively suppressed the growth of SKOV3 cell tumor xenografts in immunocompromised mice. Furthermore, oleanolic acid 3-acetate induced apoptotic cell death as revealed by loss of ∆Ψ_m, release of cytochrome c, and nuclear translocation of apoptosis-inducing factor with a concomitant activation of many proapoptotic cellular components including poly(ADP-ribose) polymerase, Bcl-2, and caspases-8, caspase-3, and caspase-7. Oleanolic acid 3-acetate, however, caused a decrease in ROS production, suggesting the involvement of an ROS-independent pathway in oleanolic acid 3-acetate-induced apoptosis in SKOV3 and HEC-1A cells. Conclusion: These findings support the notion that oleanolic acid 3-acetate could be used as a potent anticancer supplementary agent against ovarian and endometrial cancer. Oleanolic acid 3-acetate exerts its proapoptotic effects through a rather unique molecular mechanism that involves an unconventional ROS-independent but mitochondria-mediated pathway.

• Journal of the Korean Society of Hazard Mitigation
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• v.8 no.2
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• pp.119-127
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• 2008

The flow characteristics and the aspects of riverbed changes were analyzed for the upstream and downstream sections of Gongju Bridge. The upstream and downstream had complex topography, and the sections had the confluence of tributaries and several structures. In order to simulate the flow characteristics of the target sections, 1D HEC-RAS and 2D RMA2 were applied. As a result, the longitudinal water level of the target sections matched the results of simulated 1D and 2D samples. Also, 2D SED2D were applied to predict riverbed changes. As a result of the simulation, quantitative analysis was able to be performed for longitudinal riverbed changes from the sections of sudden change, bridges, the confluence of tributaries, and bends. Also, the distribution of riverbed changes on the main sections was in close relation to flow velocity. As a result of evaluating the sensitivity of SED2D, the concentration of suspended sediment, the thickness of sand beds, and the size of sand grains affected riverbed changes sensitively. These results will be used to apply the models of riverbed changes in the future.

• Journal of Korea Water Resources Association
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• v.33 no.S1
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• pp.89-94
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• 2000

• Nutrition Research and Practice
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• v.4 no.1
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• pp.11-15
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• 2010

The purpose of the present study was to investigate the effect of ethanol extracts from red pepper seeds on the antioxidative defense system and oxidative stress in rats fed a high fat high cholesterol diet. Rats were divided into four experimental groups which were composed of high fat high cholesterol diet group (HF), high fat high cholesterol diet with 0.1% ethanol extracts from red pepper seeds supplemented group (HEA), high fat high cholesterol diet with 0.2% ethanol extracts from red pepper seeds supplemented group (HEB) and high fat high cholesterol diet with 0.5% ethanol extracts from red pepper seeds supplemented group (HEC). Supplementation of ethanol extracts from red pepper seeds groups (HEA, HEB and HEC) resulted in significantly increased activities of hepatic glutathione peroxidase and catalase. Hepatic superoxide radical contents in microsome and mitochondria were significantly reduced in the groups supplemented with red pepper seeds ethanol extracts. Hepatic hydrogen peroxide content in the mitochondria was reduced in ethanol extracts from red pepper seeds supplemented groups. TBARS values in the liver were reduced in red pepper seeds ethanol extracts supplemented groups. Especially, HEB and HEC groups were significantly decreased compared to the HF group. Hepatic carbonyl values were significantly reduced in mitochondria in these supplemented groups. These results suggest that red pepper seeds ethanol extracts may reduce oxidative damage, by activation of antioxidative defense system in rats fed high fat high cholesterol diets.

• Journal of the Korean Society of Hazard Mitigation
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• v.10 no.5
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• pp.125-133
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• 2010

In general, curved bends raises a risk of overtopping due to floods and also threatens a bank safety due to a local flow concentration. This study aims to test the applicability of CCHE2D model for experimental flumes with two different types of bends and then investigate flow characteristics in the sharply-curved bend of a natural channel. The results demonstrated that the percent error of water level was within 4.9% for experimental flume applications and the simulated spatial distribution of velocity matched the observed results very closely. The calibrated model based on the experimental flumes was also applied to analyze the flow characteristics in natural channel bends of the Daeyu reach, located in a downstream of the Youngdam Dam. The results showed that in upstream, the simulated water level by the CCHED was observed at 1.5 m higher than the 1-D numerical model (HEC-RAS) result since the HEC-RAS could not represent the bend geometry effect on streamflow. However, the calculated results by several empirical formula support that the CCHE2D is suitable for the super elevation simulation as well as flood stage and velocity in a natural channel bend.

• Journal of Korea Water Resources Association
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• v.37 no.11
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• pp.929-938
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• 2004

In this study, Miho stream basin(Seokhwa water level gauging station) In Geum river, Flood control main station of Geum River Flood Control Office, is selected. Hydrologic topographical informations are calculated using WMS which is hydrologic analysis software coupled with GIS Method, and flood analysis is accomplished by HEC-1 included In WMS. To calculate the effective rainfall CN values of SCS are used. Clark, Snyder and SCS methods are selected respectively to derive unit hydrograph. This study shows the applicability of GIS techniques to runoff simulation in ungauged basin by comparing with actual measured flood hydrograph. As a results, Snyder(Tulsa) method and Clark (Herby) method is suitable to Miho stream basin. But Snyder(Tulsa) method is suitable more than Clark(Herby) method. And according to the degree of urbanization, the peak discharge has increased and the peak time has tended to decrease.

• Journal of Korean Society of Disaster and Security
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• v.14 no.4
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• pp.37-45
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• 2021

Flooding damage may occur due to an unexpected increase in rainfall in summer. Previously, the roughness coefficient, which is a major factor of conveyance, was calculated through on-site measurement, but in case of on-site measurement, there are many limits in accurately grasping changes in vegetation. In this study, the vegetation index (NDVI) was calculated using the Sentinel-2 optical images, and the modified roughness coefficient was calculated through the density and distribution area of the vegetation. Then the calculated roughness coefficient was applied to HEC-RAS 1D model and verified by comparing the results with the water level at the water level station directly downstream of the Soyang River dam. As a result, the error rate of the water level decreased about 14% compared to applying the previous roughness coefficient. Through this, it is expected that it will be possible to refine the flood level of rivers in consideration of seasonal flood characteristics and to efficiently maintain rivers in specific sections.

• Journal of Korea Water Resources Association
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• v.37 no.5
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• pp.407-424
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• 2004

Using geomorphoclimatic unit hydrograph(GCUH), we estimated the fitness to calculate the mountainous area discharge and flash flood trigger rainfall(FFTR). First, we compared the GCUH peak discharge with the existing report using the design storm at the Dukcheon basin. Second, we compared the HEC-HMS(Hydrologic Engineering Center-Hydrologic Modeling System) model and GCUH with the observed discharge using the real rainfall events at the Taesu stage gage. Third, GCUH and NRCS(Natural Resources Conservation Service) were used for calculating FFTR and proper calculation method was shown. At the Dukcheon basin, the comparison result of using design storm was shown in Table 11, and it was not in excess of 1.1, except for the 30 year return period. In case of real rainfall events, the result was shown in Table 12, and GCUH discharges were all larger than the HEC-HMS model discharges, and they were very similar to the observed data at the Taesu stage gage. In this study, we found that GCUH was a very proper method in the calculation of mountainous discharge. At the Dukcheon basin, FFTR was 12.96 mm in the first 10 minutes when the threshold discharge was 95.59 $m^3$/sec.

• Journal of The Institute of Information and Telecommunication Facilities Engineering
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• v.10 no.1
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• pp.14-26
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• 2011

In this paper, we've studied Optical Fiber Subscribe Transmit system. After receiving the ATM cell passing through the FIFO of the Asynchronous Transfer Method from the ATM Layer images to the VC4 signal payload passing through scrambling of the cell payload, HEC computation of the cell and inserting the Idle/Unassigned cell. At this time formed VC4 signal passing through the generating and inserting POH overhead at the same time indicating the start point of the cell by the H4 byte on the VC4 POH. This ATM cell transmits 155Mbps speed changing the optical signal after outputting the frame format at the STM-1 signal generation block through the AUG bus after generating J1 of the VC4 start point at the AU4 pointer generation block.