• Journal of the Korea Institute of Information and Communication Engineering
• /
• v.13 no.9
• /
• pp.1905-1912
• /
• 2009

Clustering results based on the FCM algorithm sometimes produces undesirable clustering result through data distribution in the clustered space because data is classified by comparison with membership degree which is calculated by the Euclidean distance between input vectors and clusters. Symmetrical measurement of clusters and fuzzy theory are applied to the classification to tackle this problem. The enhanced FCM algorithm has a low impact with the variation of changing distance about each cluster, middle of cluster and cluster formation. Improved hybrid network of applying FCM algorithm is proposed to classify patterns effectively. The proposed enhanced FCM algorithm is applied to the learning structure between input and middle layers, and normalized delta learning rule is applied in learning stage between middle and output layers in the hybrid network. The proposed algorithms compared with FCM-based RBF network using Max_Min neural network, FMC-based RBF network and HCM-based RBF network to evaluate learning and recognition performances in the two-dimensional coordinated data.

• Journal of Pharmaceutical Investigation
• /
• v.7 no.1_4
• /
• pp.38-50
• /
• 1977

A study on the mechanism of biliary and urinary excretion of chloramphenicol has been performed in the dog. 1) Chloramphenicol administered intravenously to dogs with ligated renal pedicle, readily appeared in bile greater than in plasma. 6.9% of a 50mg /kg i. v. dose of chloramphenicol were excreted into bile within 100 minutes. During the same periods of above experiment, the bile/plasma concentration ratios(B/P ratios) were 46 to 87. 2) Chloramphenicol injected into the vein of dog was rapidly excreted into urine. 18% of the administered dose were excreted into urine within 70 minutes. In the same periods of this experiment, Ccm/Ccr ratios were greater than 1.0 in most cases. 3) In experiment of simultaneous measurement of biliary and urinary excretion of chloramphenicol, Ccm/Ccr ratios were less than 1.0 and B/P ratios were 50 to 52. 4) In experiment measured simultaneously biliary and urinary excretion both Ccm/Ccr and $C^Hcm$(hepatic clearance) were significantly declined by probenecid, but not affected by 2,4-DNP and aminophylline although 2,4-DNP increased only bile flow and aminophylline both bile and urine volume. 5) Ccm/Ccr and $C^Hcm$ were increased in proportion to increment of plasma concentration ranging from 3.3 to 30 mg% of chloramphenicol. But when plasma concentration were increased to 70mg %, Ccm/Ccr were not increased and $C_Hcm$ were reduced about 30% in comparison with values obtajned at 30mg% of chloramphenicol. 6) Free/Bound(free to bouid from) ratios ranging from 1.0 to 90.0mg% of chloramphenicol were 76.2+3.72% $(mean{\pm}S.E.)$ Above results suggest that chloramphenicol is excreted into bile by a process of active trasport, that excretion of chloramphenicol into urine was made up with dual process, reabsorption and secretion, and that renal secretion was attained by active trasport process although renal reabsorption process could not understand.

• KSCE Journal of Civil and Environmental Engineering Research
• /
• v.14 no.3
• /
• pp.379-390
• /
• 1994

The recent study of the delay models have assumed random arrival which has a constant average flow rate throughout the cycle. However, where signals are spaced closely together or form part of progressive system, platoon flows are common and more closely represent reality. In such cases, those results are quite different pattern of estimated delay from that of observed one. In order to solve this problem, the 1985 HCM takes Progression Adjustment Factor (PAF) into account. In the 1985 HCM, however, it has deficiencies in defining and applying it, such as platoon ratio ($R_p$) and platoon arrival type. The Purpose of this study is to investigate theoretically the predictive ability of the individual models concerned through comparing the estimated delay and PAF suggested by NCHRP Report 339, KHCM or USHCM (1985) with the observed obtained by field survey at a signalized intersection.

• Nutrition Research and Practice
• /
• v.3 no.2
• /
• pp.128-133
• /
• 2009

Few studies have examined short tenn responses to the different contents of carbohydrate or fat in the meal, although long tenn effects of the high fat meal have been considered as compound risk factor for metabolic disorders. The aim of this study was to investigate the postprandial changes of plasma glucose, insulin and lipids upon intakes of high carbohydrate or high fat meal in young healthy women. Subjects were randomly assigned to either the high carbohydrate meal (HCM, 75% carbohydrate, n=13) or the high fat meal (HFM, 60% fat, n=12) groups. The meals were prepared as isocaloric typical Korean menu. Blood samples were obtained prior to and 30, 60, 90, 120, 180 and 240 minute after the meal. There were no significant differences on fasting blood parameters including glucose, insulin, lipids concentrations between the groups prior to the test. The HCM had higher blood glucose and insulin concentrations, reached the peak at 30 min and maintained for 240 min compared to the HFM (P<0.05). The HFM had higher plasma triglyceride (TG) and free fatty acid (FFA) concentrations, reached the peak at 120 min and maintained for 240 min compared to the HCM (P<0.05). It is concluded that macronutrients content in the meal may be an important determinant of postprandial substrate utilization in healthy women.

• Journal of the Korean Institute of Intelligent Systems
• /
• v.15 no.1
• /
• pp.81-86
• /
• 2005

In this study, we introduce a new category of fuzzy inference systems based on information granulation to carry out the model identification of complex and nonlinear systems. Informally speaking, information granules are viewed as linked collections of objects (data, in particular) drawn together by the criteria of proximity, similarity, or functionality Granulation of information with the aid of Hard C-Means (HCM) clustering help determine the initial parameters of fuzzy model such as the initial apexes of the membership functions and the initial values of polynomial functions being used in the premise and consequence part of the fuzzy rules. And the initial parameters are tuned effectively with the aid of the genetic algorithms(GAs) and the least square method (LSM). An aggregate objective function with a weighting factor is also used in order to achieve a balance between performance of the fuzzy model. The proposed model is evaluated with using a numerical example and is contrasted with the performance of conventional fuzzy models in the literature.

• Journal of the Korean Institute of Intelligent Systems
• /
• v.24 no.5
• /
• pp.536-541
• /
• 2014

Data through meteorological radar includes ground echo, sea-clutter echo, anomalous propagation echo, clear echo and so on. Each echo is a kind of non-precipitation echoes and the characteristic of individual echoes is analyzed in order to identify with non-precipitation. Meteorological radar data is analyzed through pre-processing procedure because the data is given as big data. In this study, echo pattern classifier is designed to distinguish non-precipitation echoes from precipitation echo in meteorological radar data using RBFNNs and echo judgement module. Output performance is compared and analyzed by using both HCM clustering-based RBFNNs and FCM clustering-based RBFNNs.

• Nutrition Research and Practice
• /
• v.3 no.1
• /
• pp.31-37
• /
• 2009

Recently, Korean people are consuming seaweeds almost 3.5 times more now than three decades ago. It is well known that seaweeds contain lots of soluble dietary fiber in addition to micronutrients such as ${\beta}$-carotene, iodine and some bioactive components. Seaweeds are considered to be effective for preventing chronic diseases including obesity, diabetes mellitus, atherosclerosis, cancer or constipation. This study was conducted to investigate the effect of seamustard intake on body weight gain, blood glucose level and lipid profiles in rats fed diets with different energy nutrient composition. Male Sprague-Dawley rats (average initial weight 103.7g) were divided into groups for two experiments as follows; Control, M2.5 & M5 groups (Exp. I) and M5, M10, HCM5, HCM10, HFM5 & HFM10 groups (Exp. II). The rats were fed diet and water ad libitum for 4 weeks. In general, there was no significant difference in blood glucose and triglyceride concentration among groups. In Exp. I, serum LDL-cholesterol level of rats fed diet with 5% seamustard powder (M5) was significantly lower than that of control group, while HDL-cholesterol level, TC/LDL ratio and weight of adrenal gland were higher. In Exp. II, food intake, body weight gain and EER of high fat diet with 10% seamustard group (HFM10) were the lowest among groups. Except gastrocnemius muscle, all organ weights of HFM10 group were the lowest. Fecal cholesterol excretion and serum LDL-cholesterol concentration of HFM10 group were the highest, while serum HDL-cholesterol level was the lowest among groups. Interestingly, HDL-cholesterol concentration was the highest in HCM5 group among groups. From these results, it was suggested that seamustard intake might be more effective for body weight control, but not for improving blood lipid profiles in high fat diet than in high carbohydrate diet.

• Journal of Life Science
• /
• v.19 no.8
• /
• pp.1145-1151
• /
• 2009

This study was performed to investigate the effects of Sineui-Dae (Sasa coreana Nakai, a kind of bamboo) extracts on the improvement of serum lipid composition by using rats fed a hypercholesterol diet for 4 weeks. The experiment animals were administered with the following diets; high cholesterol diet group (HC diet) as a control and three supplemented groups with high cholesterol diets (HCW, HCM or HCH diet). Three kinds of extracts were prepared by orderly extraction with hexane, methanol, and water. We measured free cholesterol, cholesteryl ester, total cholesterol LDL- and HDL-cholesterol triglyceride and phospholipid in the serum of rats in three experimental and control groups. There were no significant differences in body weights and feed intakes between the HC control group and the extract supplemented groups. The levels of total cholesterol and LDL-cholesterol in the serum of extract supplemented groups were lower than that of the group fed with HC diet only. Serum HDL-cholesterol levet which is known as an antiatherosclerosis factor, was higher in all groups supplemented with bamboo extract by 17.2-21.9% compared to the HC control group. All groups supplemented with bamboo extracts showed the lowering effect of atherogenic index compared to the HC control group (HC group: 2.96${\pm}$0.08, HCM group: 1.48${\pm}$0.02, HCW group: 1.69${\pm}$0.04, HCH group: 1.84${\pm}$0.01). Furthermore, serum triglyceride and phospholipid decreased significantly in the HCM diet compared to the HC control diet. These results suggest that Sineui-Dae bamboo extract, especially methanol extract, has improving effects on hyperlipidemia of rats fed a high cholesterol diet.

• Journal of the Korean Society of Food Science and Nutrition
• /
• v.36 no.1
• /
• pp.43-50
• /
• 2007

This study was to investigate the effect of mulberry leaf water extract on lipid metabolism of rats fed high cholesterol diets. Sprague-Dawley male rats were randomly assigned to two normal groups; mulberry extract-free (N), 0.16% mulberry leaf extract (NM) groups and high cholesterol groups with four different levels of mulberry leaf extract; 0% (HC), 0.08% (HCL), 0.16% (HCM), and 0.32% mulberry leaf extract (HCH) groups. Serum levels of triglyceride, cholesterol, LDL-cholesterol and AI index in mulberry leaf extract supplemented groups were significantly lower than the HC group (p<0.05). The level of HDL-cholesterol in the HC group was significantly (p<0.05) reduced, compared with N group, but it was increased by mulberry leaf extract supplementation. Mulberry leaf extract had no effect on the UDP-glucuronyl transferase activity. Also, there was no significant difference in the level of liver cholesterol between the HC and mulberry leaf extract supplemented groups, while there was significant difference in the levels of liver total lipid and triglyceride. The HCM and HCH groups had more significant reduction in the activity of lipoprotein lipase in epididymal fat tissue than the HC group. The levels of total lipid, triglyceride and total cholesterol in epididymal fat tissue of HCL, HCM and HCH groups were decreased compared to HC group. The levels of total lipid, triglyceride and total cholesterol in feces from HCL, HCM and HCH groups were higher than those of HC group.

• Journal of Korean Society of Transportation
• /
• v.19 no.2
• /
• pp.89-98
• /
• 2001

The objective of this Paper is to derive an adjustment factor for the presence of heavy vehicles when estimating capacity at unsignalized intersections (and/or at modern roundabouts). According to the 1997 and 2000 Highway Capacity Manual (HCM), potential capacity in such cases is estimated by simply adjusting base critical gap and base follow-up time. However, the procedure suggested in the HCM may lead to some errors in the adjustment, hence resulting in poor evaluation and design for the intersections, because it determines the value of adjusting factors by only the number of lanes on main streets regardless of the types of heavy vehicles. This paper shows a simple formula for making the adjustment. This formula is much like the HCM formula used for heavy vehicles in estimating highway capacity by the adoption of passenger car units (PCU). In contrast to the traditional approaches seen in the HCM, the PCU value of this case is explicitly expressed by the flow rate in the major streams and the gap difference in critical gaps chosen by passenger cars and particular heavy vehicles. Computational results of the adjustment factor are graphically illustrated.