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http://dx.doi.org/10.3746/jkfn.2007.36.1.043

Effects of Mulberry Leaf Extract Feeding on Lipid Status of Rats Fed High Cholesterol Diets  

Park, Surk-Hoon (Dept. of Food Science and Nutrition, Catholic University of Daegu)
Jang, Mi-Jin (Dept. of Food Science and Nutrition, Catholic University of Daegu)
Hong, Jung-Hee (Dept. of Food Science and Nutrition, Catholic University of Daegu)
Rhee, Soon-Jae (Dept. of Food Science and Nutrition, Catholic University of Daegu)
Choi, Kyung-Ho (Dept. of Food Science and Nutrition, Catholic University of Daegu)
Park, Mo-Ra (Dept. of Food Science and Nutrition, Sanju National University)
Publication Information
Journal of the Korean Society of Food Science and Nutrition / v.36, no.1, 2007 , pp. 43-50 More about this Journal
Abstract
This study was to investigate the effect of mulberry leaf water extract on lipid metabolism of rats fed high cholesterol diets. Sprague-Dawley male rats were randomly assigned to two normal groups; mulberry extract-free (N), 0.16% mulberry leaf extract (NM) groups and high cholesterol groups with four different levels of mulberry leaf extract; 0% (HC), 0.08% (HCL), 0.16% (HCM), and 0.32% mulberry leaf extract (HCH) groups. Serum levels of triglyceride, cholesterol, LDL-cholesterol and AI index in mulberry leaf extract supplemented groups were significantly lower than the HC group (p<0.05). The level of HDL-cholesterol in the HC group was significantly (p<0.05) reduced, compared with N group, but it was increased by mulberry leaf extract supplementation. Mulberry leaf extract had no effect on the UDP-glucuronyl transferase activity. Also, there was no significant difference in the level of liver cholesterol between the HC and mulberry leaf extract supplemented groups, while there was significant difference in the levels of liver total lipid and triglyceride. The HCM and HCH groups had more significant reduction in the activity of lipoprotein lipase in epididymal fat tissue than the HC group. The levels of total lipid, triglyceride and total cholesterol in epididymal fat tissue of HCL, HCM and HCH groups were decreased compared to HC group. The levels of total lipid, triglyceride and total cholesterol in feces from HCL, HCM and HCH groups were higher than those of HC group.
Keywords
mulberry leaf water extract; lipid metabolism; high cholesterol diet; lipoprotein lipase; UDP-glucuronyl transferase;
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Times Cited By KSCI : 7  (Citation Analysis)
Times Cited By SCOPUS : 2
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