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Mechanism for Antioxidant Activity of Nardostachys chinensis root Extract

  • Heo, Jee-In;Kim, Jeong-Hyeon;Lee, Jeong-Min;Kim, Sung Chan;Park, Jae-Bong;Kim, Jaebong;Lee, Jae-Yong
    • Journal of Applied Biological Chemistry
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    • v.57 no.1
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    • pp.17-22
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    • 2014
  • Nardostachys chinensis (N. chinensis) has been used in traditional medicine as a sedative and analgesic. It has been reported that N. chinensis extract has an antioxidant activity. However, the mechanism has not been elucidated. In this study, we showed that FOXO3a was activated by N. chinensis extract. FOXO3a is a transcriptional factor that involved in cell cycle arrest, DNA repair, apoptosis, and detoxification of reactive oxygen spices (ROS). Protein level of FOXO3a was increased by N. chinensis extract whereas phospho-FOXO3a (Thr 32) was not changed. Promoter activities of target genes of FOXO3a such as MnSOD, p27, and GADD45 were increased by N. chinensis extract. Among target genes, protein level of MnSOD was increased by N. chinensis extract, and this leads to removal of ROS level in human embryonic fibroblast (HEF) cells. These results suggested that N. chinensis extract has an antioxidant activity by upregulation of MnSOD through FOXO3a activation.

A Study on the Synthesis and Refining of Isothiazoline Derivatives (Isothiazoline 유도체의 합성 및 정제에 관한 연구)

  • Sung, Ki-Chun;Kim, Ki-Jun
    • Journal of the Korean Applied Science and Technology
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    • v.14 no.2
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    • pp.93-102
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    • 1997
  • Isothiazoline derivatives is widely used to food, medical drug and industrial goods, cosmetics etcs, and it makes to restrain and to sterilize a breeding of microbe as a preservative and a sterilizing agent. It differs with the raw material of paraoxybenzoic acid derivatives or imidazolydinyl urea to be in use at present, on the efficacy and effect, and has various characteristics. This synthesis makes 3,3'-dithiodipropionic chloride to add a thionyl chloride in 3,3'-dithiodipropionic acid, and 3,3'-dithiodipropionic methyl amide makes to synthesize in a reflux reaction the mono methyl amine to 3,3'-dithiodipropionic chloride. And last synthesis becomes to make chlorination-cyclization molecule doing a reflux reaction in the temperature of $90{\sim}100^{\circ}C$ to mix excessively thionyl chloride and ethylene dichloride to 3,3'-dithiodipropionic methyl amide. The last synthesis material has got in the mixture of 5-chloro-2-methyl-4-isothiazoline-3-one and 2-methyl-4-isothiazoline-3-one, and it is so-called isothiazoline derivatives. The purification of isothiazoline derivatives makes to fuse in ethyl acetate, and makes to decolorize and to deodorize in recrystallization. This experiment has been in synthesis and purification of isothiazoline derivatives, and has tried to measure on the antisepsis and sterilization function of microbe according to pH or content change.

Ultra Miniature Eddy Current Sensor with 3 Axes for On-Machine-Measurement (기상측정용 3축 구조의 초소형 와전류 센서 개발 및 평가)

  • Kim, Sun-Ho
    • Journal of the Korean Society for Precision Engineering
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    • v.27 no.3
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    • pp.27-32
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    • 2010
  • The OMM(On-Machine-Measurement) system has many advantages compare to conventional measurement in the way the time and cost. But, the sensor suitable to OMM system is restrictive use. Touch trigger probe sensor has long time for measurement and non-contact sensor has directional demerit. Because the long mechanical parts such as gear and lead screw for pump, injector and machine tools has big and heavy, unclamp and transferring for measurement in machining process is very difficult. This paper presents a development of ultra miniature eddy current displacement sensor with 3 axes for On-Machine-Measurement system. The accuracy of the sensor is experimentally proved in the grinding machine. In experimental results, the accuracy has under ${\pm}5\;{\mu}m$.

Dielectric and Strain Properties of PMN-PT Ceramics Doped with $\textrm{SrTiO}^3$ and excess MgO ($\textrm{SrTiO}^3$ 와 과잉 MgO가 첨가된 $\textrm{Pb(Mg_{1/3}Nb_{2/3})O}_3$ - $\textrm{PbTiO}^3$ 계 세라믹스의 유전 및 변위 특성)

  • 이상훈
    • Journal of the Korean Institute of Telematics and Electronics T
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    • v.36T no.3
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    • pp.7-12
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    • 1999
  • In this paper, dielectric and strain properties of (1-f-y)PMN-yPT-xST ceramics investigated with the amount of $\textrm{SrTiO}^3$(ST). The $\textrm{SrTiO}^3$ content is ranged within 1~6㏖%. Another compositions with excess MgO also investigated. As the amount of ST is increased, dielectric constant has a maximum value at 5㏖% composition. The Curie temperature is decreased linearly with increasing the amount of ST. Coercive field and ramnant polarization has a maximum value at l㏖% composition. As for the effects of excess MgO, the dielectric constant has been increased by the addition of excess MgO up to 3㏖% to a 0.8PMN-0.12PT-0.04ST specimen. But the strain has been decreased by the addition of excess MgO.

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A Study of Effects on Secretion of Gastric Juice, Movement of Intestine and Pulse Rate with Coptidis Rhizoma and Zingiberis Rhizoma (황연(黃連) 및 건강(乾薑)이 위액분비(胃液分泌).장관운동(腸管運動) 심장박동(心臟搏動)에 미치는 영향(影響)에 관(關)한 연구(硏究))

  • Yu, Gi-Won;Park, Dong-Won;Ryu, Bong-Ha;Gwak, Gi-Hwan
    • The Journal of Internal Korean Medicine
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    • v.3 no.1
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    • pp.23-32
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    • 1986
  • As a result of administration of Coptidis Rhizoma extract and Zingiberis Rhizoma extract to Rat and Rabbit, its effect to the Gastric Juice Volume, Acidity, Pepsin out put of Rat and the movement of Intestine, Pulse Rate of Rabbit was as follows; 1. In the secretion of Gastric Juice, the Juice Volume in Coptidis Rhizoma administered group in contrast to Control Group, has increased in 30mg the increasing rate 21.4%, and has decreased in 300mg the decreasing rate 113.9%. But the Juice Volume in Zingiberis Rhizoma administered group has all decreased in 12, 30, 60, 120mg, and has remarkably decreased in 60mg the decreasing rate 62.9%. 2. The Gastric Acidity in Coptidis Rhizome administered group, in contrast to Control Group, has increased in 30, and 75mg, but no significant value, and has decreased in 300mg the decreasing rate 104.7%. But the Gastric Acidity in Zingiberis Rhizoma administered group has all decreased in 12, 30, 60 120mg, and has remarkably decreased in 60mg the decreasing rate 105.6%. 3. The Pepsin out-put in Coptids Rhizoma administered group, in contrast to Control group, has increased in 30mg the increasing rate 30.3%, and has decreased in 150, 300mg, no significant value. But the Pepsin out-put in Zingiberis Rhizoma administered group has all decreased in 12, 30, 60, 120mg, and has remarkably decreased in 60mg the decreasing rate 86.4%. 4. In the movement of Intestine, the contraction Coptidis Rhizoma administered group, in contrast before the administration, has increased in 12mg, but has begun to decrease in 30mg, and has remarkably decreased in 70mg. The contraction in Zingiberis Rhizoma administered group, in contrast before the administration, has all increased in 30, 60, 120mg. 5. In Pulse Rate, the pulsation, in contrast to Control group after 60, 120 180, 240min. has decreased in Coptidis Rhizoma administered group, and has increased in Zingiberis Rhizoma administered group, but no significant value.

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Reinforced concrete beams under drop-weight impact loads

  • May, Ian M.;Chen, Yi;Owen, D. Roger J.;Feng, Y.T.;Thiele, Philip J.
    • Computers and Concrete
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    • v.3 no.2_3
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    • pp.79-90
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    • 2006
  • This paper describes the results of an investigation into high mass-low velocity impact behaviour of reinforced concrete beams. Tests have been conducted on fifteen 2.7 m or 1.5 m span beams under drop-weight loads. A high-speed video camera has been used at rates of up to 4,500 frames per second in order to record the crack formation, propagation, particle spallation and scabbing. In some tests the strain in the reinforcement has been recorded using "Durham" strain gauged bars, a technique developed by Scott and Marchand (2000) in which the strain gauges are embedded in the bars, so that the strains in the reinforcement can be recorded without affecting the bond between the concrete and the reinforcement. The impact force acting on the beams has been measured using a load cell placed within the impactor. A high-speed data logging system has been used to record the impact load, strains, accelerations, etc., so that time histories can be obtained. This research has led to the development of computational techniques based on combined continuum/discontinuum methods (finite/discrete element methods) to permit the simulation of impact loaded reinforced concrete beams. The implementation has been within the software package ELFEN (2004). Beams, similar to those tested, have been analysed using ELFEN a good agreement has been obtained for both the load-time histories and the crack patterns.

Comparison of the kinematic analysis of grand battement Jeté á la seconde in center between skilled and unskilled ballet majors (발레 숙련도에 따른 센터에서 Grand Battement Jeté á la seconde 동작의 운동학적 비교 분석)

  • Youm, Chang-Hong;Park, Young-Hoon;Seo, Kook-Woong;Yang, Chung-Mo
    • Korean Journal of Applied Biomechanics
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    • v.14 no.2
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    • pp.153-166
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    • 2004
  • The purpose of this study was to investigate time of the phase, angle of the right ankle, knee, and hip joint, lateral angle of the trunk, mediolateral displacement of COM, and vertical displacement of COM between two groups while executing grand battement $jet{\acute{e}}$ $\acute{a}$ la seconde in a center exercise setting through 3D video analysis. The subjects participated in this study were skilled and unskilled 6 female ballet majors in Busan, respectively. The conclusions are as follows: 1. The time of the phase 2 was faster than P3. It shows a significant difference(p<.05) for P1 and P4 between skilled and unskilled groups 2. The angle of He right ankle joint has a significant difference(p<.05) at E4 between skilled and unskilled groups. The angle of the right knee joint has no significant difference at all events between skilled and unskilled groups. The angle of the right hip joint has a significant difference(p<.001) at E3 between skilled and unskilled groups. 3. The lateral angle of the trunk has a significant difference(p<.05) at E1 and at E5 between skilled and unskilled groups. The skilled group of the lateral angle of the trunk was lower than the unskilled group. However the skilled group's lateral angle of the trunk was bigger than the unskilled group at E3. It has significant difference(p<.001) at E3 between skilled and unskilled groups. 4. The mediolateral displacement of COM has no significant difference at all events between skilled and unskilled groups. The vertical displacement of COM has a significant difference(p<.01) at E3 between skilled and unskilled groups.

A Study of Supersonic Flow Around Lateral Jet Controlled Missile (측 추력 제어 미사일 주위의 초음속 유동현상 연구)

  • Min Byung-Young;Lee Jae-Woo;Byun Yung-Hwan;Hyun Jae-Soo
    • 한국전산유체공학회:학술대회논문집
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    • 2002.10a
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    • pp.28-34
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    • 2002
  • A computational study of supersonic flow around lateral jet controlled missile has been performed. For this study, three dimensional Navier-Stokes code(AADL3D) has been developed. Spalart-Allmaras one equation turbulence model has been implemented on the AADL3D code for relatively rapid computational time. For the validation of developed code, AADL3D, pressure distributions on an ogive-cylinder body has been compared with experimental data. Also, the shock structure of sonic jet on the flat plate in the supersonic flow field has been compared with experimental flow visualization result to see the analysis capability of freestream-jet interaction case. A case study has been performed through comparing the normal force coefficient and the moment coefficient of missile body for several jet flow conditions. Current results will be used to the optimum design of a lateral jet controlled missile.

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A Study on Quality Characteristics and Optimized recipe of Muffin with added Acai Berry powder (아사이베리 분말을 첨가한 머핀의 품질특성 및 레시피 최적화 연구)

  • Kim, Hyo Sun;Yoo, Seung-Seok
    • Journal of the Korean Society of Food Culture
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    • v.31 no.3
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    • pp.226-234
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    • 2016
  • In this study Muffins adding each 0, 1, 3, 5 7% of Acai Berry powder, which has very high anti-oxidant constituent, have been made, and its quality characteristics have been surveyed. From the volume and specific volume measurement, it has been decreased for MA1, 1% of Acai Berry powder added muffin, but the tendency thereafter has shown increasing (p<0.001). From texture characteristics gumminess and chewiness of MA0, reference group, was the highest by 885.86 g/ cm and 6645.71 g, and has shown decreasing tendency as per the adding rate of Acai Berry powder increased (0.001). The electronics scavenging activity of MA7, 7% added muffin, was the highest by 68.91%, and the ascending order was MA1 < Reference Group < MA3 < MA5 < MA7. From the preference test of Acai Berry powder added muffin, MA3, 3% added muffin, was the most preferable one from color, taste as well as total preference. As the added volume of Acai Berry powder is 5% or more, the typical taste and flavor of Acai Berry gives influence to the taste and flavor of muffin, so the preference level has been decreased. Thus the added volume of Acai Berry powder 5% or more is not recommendable.

First report of five free-living nematode species(Nematoda: Rhabditida) from Korea

  • Kang, Heonil;Seo, Jongmin;Kim, Donggeun;Bae, Changhwan;Kim, Yongchul;Choi, Insoo
    • Journal of Species Research
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    • v.8 no.3
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    • pp.259-267
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    • 2019
  • Five free-living nematode species belonging to the order of Rhabditida are described for the first time in Korea. Two unrecorded species of Rhabditidae, Cruznema tripartitum (Linston, 1906) Zullini, 1982, and Poikilolaimus oxycerca de Man, 1895, and one species of Peloderidae, Pelodera strongyloides Schneider, 1860, were collected in Korea. C. tripartitum has nine pairs of genital papillae arranged in 2+2+1+4 differently from similar species of C. scarabaeum which has ten genital papillae arranged in 2+1+4+3. Poikilolaimus oxycerca has shorter tail (shorter than anal body diameter) compared to similar species of P. regenfussi which has longer tail(longer than anal body diameter). Pelodera strongyloides has shorter tail(1-1.5 times anal body diameters long) than P. punctata (4 anal body diameters long). Two unrecorded species of Panagrolaimidae, Panagrolaimus apicatus Schuurmans Stekhoven & Teunissen, 1938 and Panagrolaimus rigidus (Schneider, 1866) Thorne, 1937 were collected in Korea. P. apicatus has rounded and lower lip compared to similar species, P. margaretae Massey, 1964 which has finely pointed lip. P. rigidus has slender tail and lips rounded and flat barely separated when compared to similar species, P. subelongatus(Cobb, 1914) Thorne, 1937 which has plumper tail and lips are well separated.