• The Journal of Information Systems
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• v.24 no.4
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• pp.21-42
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• 2015

Purpose The high-technology market shows characteristics of a highly interdependent network market in both supply-side and demand-side, compared to other markets. Particularly, for convergence products, connectivity with related elements, as well as characteristics of innovation itself, is relatively important to the extent that they combine functions provided by several devices into a single device. Therefore, this study aims to identify whether network externality exists in value and adoption of a convergence product and discover a source of network externality, if any. Design/methodology/approach: Through a preceding research analysis and a literature review, 'social influence' and 'network size' have been drawn as direct network elements. On the other hand, general (comprehensive) concept compatibilities including 'intra-technology compatibility', 'inter-technology compatibility' and 'complementary-technology compatibility' are regarded as indirect network elements. Findings: Major findings are as followed;- First, it is shown that the factors influencing on perceived value of a convergence products are 'social influence' and 'network size' as the direct network elements and 'complementary-compatibility' among indirect network elements. Second, it is also found that 'intra-technology compatibility', 'inter-technology compatibility', 'complementary-compatibility' and 'perceived value' have significant effects on adoption of a convergence product. Particularly, it is known that 'complementary-compatibility' is an important source of network externality as it plays a decisive role in value judgment and has significant effects on perceived value. It is worthwhile to notice that this study comprehensively explains effects of network on high-tech products by structuring comparability as a multi-dimensional concept, as well as direct network elements.

• Journal of Korean Library and Information Science Society
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• v.6
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• pp.53-103
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• 1979

Kyujang-gak was an institution established by the King Jungjo's order to enshrine and edit the royal writings and autographs, and to help the revival of learning with more active services in collection, control, and use of the important materials. Furthermore, it was aimed in its establishment to promote the settlement of an innovative and ideal Royal Regime. In this paper, the Outer Kyujang-gak(外奎章閣) of Kangwha Magistracy(江華府), which was one of the lower branches of the Kyujanggak(奎章閣), will be treated, especially about its details of establishment, location, functions, the characteristics and value of its collection. After the Japanese invasion of Korea in 1592, the Historical Deposit Library(史庫) was established at the Kangwha Magistracy to take custody of the royal writings and autographs. An Annex(別庫) was built near by the Historical Deposit Library to enlarge the space in the reign of the King Hyojong. These spaces, however, become insufficient as the amount of materials deposited expanded, and custody for them was also not successful. Therefore, at the April of the 6th year of the King Jungjo's rule, the Outer Kyujang-gak was built at the east of the Temporary Palace(行宮) within Kangwha Magistracy, where the royal materials were deposited. This Outer Kynjang-gak was also called 'Kangdo Oe-gak(江都外閣)', 'Kyujang Oe-gak(奎章外閣)' or 'Simdo Oe-gak(心都外閣)', and its major function was to take custody of the materials and to hand them down to the next generations forever. The Kandwha Magistrate(江華留守) was responsible for the management of the Outer Kyujang-gak. Regular events for the book keeping were enshrinement, inventory and airing. In the 6th year in the reign of the King Jungjo, 4,892 volumes consisting of 762 titles were moved here from the Bon-gmodang(奉謨堂), the Seoseo(西序) in Main Palace, the Annex(別庫), the Deposit Library(史庫) mentioned above, the Kaegsa(客舍) and Chaeg-go(冊庫) within Kangwha Magistracy. By the end of the Joseon Dynasty, through fourteen times of addition altogether, the number of collection enshrined here reached 6,400 volumes consisting of 1,212 titles. The significance of this Outer Kyujang-gak established at the Kangwha Magistracy is in the point that this was one of the most important deopsit libraries of the Joseon Dynasty.

• BMB Reports
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• v.39 no.6
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• pp.722-729
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• 2006

Recently, we have reported that 3-hydrogenkwadaphnin (3-HK), a diterpene ester isolated from Dendrostellera lessertii (Thymealeaceae), is very effective against leukemia cell lines without any detectable effects on normal cells (Moosavi et al., 2005b). In this study, we report that 3-HK induces $G_1$ cell-cycle arrest, differentiation and apoptosis in APL NB4 cell line. Indeed, the drug between 24 to 96 h induced 7-65% growth inhibition of NB4 cells. Cell viability was also decreased by 2-55% between 24 to 96 h treatments with the drug, respectively. These effects of the drug were also dose-dependent. According to flow cytomtry results, 3-HK (15 nM) induced a significant G1-arrest up to 24 h which was consequently followed with appearance of sub-$G_1$ peak at 72 to 96 h. Hoechst 33258 staining and DNA fragmentation assays confirmed the occurrence of apoptosis among the treated cells. On the other hand, NBT reducing assay, Wright-Giemsa staining, phagocytic activity and expression of cell surface markers (CD11b and CD14) confirmed that the inhibition of proliferation is associated with differentiation especially toward macrophage-like morphology. Interestingly, 3-HK at 5 and 10 nM enhanced the effects of all-trans retinoic acid (ATRA) in NB4 cells. Based on these results, 3-HK might become an ideal candidate for treatment of APL patients pending full exploration of its biological functions.

• Journal of the Korean Institute of Landscape Architecture
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• v.30 no.5
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• pp.16-30
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• 2002

This study tried to understand an ambiguous urban landscape through a relational context. Gongpyeong district, an urban renewal area in Seoul, was selected as the site of the case study because traditional and modern styles coexist in this district. The research method and processes are summarized as follows. First, the district, which has both a redeveloped environment and an inherent environment, was divided into Yin & Yang structures. Next, an effort was made to grasp the fundamental relational characteristics(external relationships) of each type through three aspects: physical environment, activities, and meaning. As a result, Yin characteristics were found in the redeveloped environment which has predominantly Yang characteristics. In many cases, advertising, which is a Yang element, was missing in the redeveloped area. On the other hand, in the inherent environment which has Yin characteristics in general, shabby appearances were evident in aspects beyond advertising, and Yang elements, were found from the viewpoint of the theory of place. On the basis of these results, new dualistic frameworks with respect to the functions were re-structured, and complementary characteristics (internal relationship) based on topological aspects were analyzed. Unlike the monotonous appearances found in large scale environments, a variety of spatial characteristics were found in the various small scale environments. This explains that the dualistic coexistence has made a contribution to the complementary attributes of urban landscape. This study has the following ramifications. Much research of urban landscapes that has used western methodology which employs analytic aspects. As a methodology of urban landscape research this study introduced Iching, which tries to understand phenomena in a relational context. In addition, this study expects that the profound understanding of urban environments and the detailed relationship through this framework will suggest a new approach to urban planning, design and management related to future urban environments.

• Preventive Nutrition and Food Science
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• v.20 no.4
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• pp.266-275
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• 2015

Exposure to cadmium (Cd) has harmful effects on the liver and kidney. Resveratrol (RES) is an herbal substance that functions as a protective mediator. This study aimed to investigate the effects of RES on the histology of liver and kidney in Cd-exposed mice. Male mice were divided into 4 groups daily receiving normal saline (1 mL normal saline/d), Cd (1 mg/kg/d), RES (20 mg/kg/d), and Cd plus RES, respectively. After 4 weeks, the liver and kidney components were evaluated using stereological methods. The total volume and number of hepatocytes, and volume of fibrous tissue were respectively increased by 34%, 58%, and a 3-fold in the Cd-exposed mice in comparison to the control animals (P<0.03). On the other hand, the volume of the main vasculature (sinusoids and central veins) was decreased by 36% in the Cd group compared to the control mice (P<0.03). Considering the kidney, the results showed a 3-fold increase in the total glomeruli volume and a 7-fold increase in fibrous tissue in the Cd-treated group compared to the control mice (P<0.03). After Cd treatment, a 32% reduction was observed in the volume and length of the proximal and distal convoluted tubules. RES-treatment alone did not induce any structural changes. In comparison to the Cd group, an increase in the normal components of the liver and kidney and a decrease in the formation of the fibrous and degenerated tissues were observed in the Cd+RES-treated mice (P<0.03).

• Journal of the Korea Academia-Industrial cooperation Society
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• v.21 no.4
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• pp.49-55
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• 2020

Recently, companies are growing by introducing rational and optimized technology for all processes, including design. In particular, the emergence of ICT-based cloud platforms has given rise to solutions that are equipped with all the necessary business services in corporations and schools, affecting technical education and corporate growth that have not been experienced thus far. The virtual reality technology and convergence of HMD devices utilizing this platform is a new turning point in corporate development. Therefore, this study tested the VR functions used in design based on 3DEXP and HMD VR devices. Second, design utilization and this issue were examined through a survey based on the experimental data. The results showed that 3DEXP and HMD VR technologies are closely related in terms of design utilization and have demonstrated their mediated effects through statistical analysis. Nevertheless, it is not enough to generalize some engineering students as a result of the study. On the other hand, the introduction of HMD VR technology is one of the pillars of education and the implementation of virtual reality technology.

• Preventive Nutrition and Food Science
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• v.4 no.1
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• pp.52-56
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• 1999

This study has examined the effects of Aralia elata Seemann ethanol extract on antioxidant enzyme systems inrats along with benzo($\alpha$) pyrene(B(a)P) administration . The ethanol extract of Aralia elata Seemann (50mg/kg body wt.) was fed to rats for 4 weeks by stomach tubing. The extract administration increased antioxidant activities of glutathione sulfur transferase(GST) comparing to the control. also total superoxide dismutase(SOD) and Cu, Zn-SOD activities were stimulated. Catalase activities were increased by 50% with the extract feeding compared to the control . Combined administration of B($\alpha$)P and the extract increased GST activity in B($\alpha$) P group. Although total SOD acitivity was decreased , Cu, Zn-SOD was greately increased from 0.10unit to 0.18 unit and catalase activity also was increased compared to the group of B($\alpha$) P. GST activity in CLE group was 1.32 unit, increased by 33% comparing to the group CL of 0.99unit. Cu, Zn-SOD and catalase activities in thegroup fed high fat and ethanol extracts were increased by 25% and 39%, respectivley comparing to the group of high fat. In addition , total SOD was decreased but, Cu, Zn-SOD acitivity was increased from 0.09 unit to 0.18unit. Catalase activity was 76.05 unit in the group of B($\alpha$) P and extract comparing to 65.26 units in B($\alpha$)P group. Serum $\alpha$-tocopherol of rat was markedly increased by theextract. Administration of B9$\alpha$)P reduced $\alpha$-tocopherol levels in the serum, on the other hand, lard in the diet increased $\alpha$-tocopherol levels in the serum. The above results indicate that Aralia bud exerts antioxidant functions in vivo against B($\alpha$)P. Further research may be necessary for the identification fo the biologically active material.

• Archives of Plastic Surgery
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• v.37 no.1
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• pp.46-51
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• 2010

Purpose: The loss of web space is caused by congenital syndactyly or acquired burn injury, trauma or surgery. Numerous surgical procedures have been described for restoration of the web space. Local flaps are usually preferred because of the easiness to perform and tolerable postoperative outcome. Among the various local flaps, the authors introduce V-M plasty for correction of web space contracture and syndactyly. Method: From March 2007 to Jun 2008, 4 patients underwent V-M plasty for correction of web space contracture and syndactyly. V-M plasty consists of 3 distinct triangular flaps. One triangular flap is designed next to the web region on the dorsal site of the hand, whereas the remaining 2 triangular flaps are placed on the volar site. The dorsal triangular flap is then placed between the volar adjacent triangular flaps. At the end of the operation, the involved fingers or toes are positioned in abduction to avoid kinking of the triangular flaps. Result: All the patients gained web functions with good esthetic appearance without any recurrence or complications. Mean follow-up was 8 months. Conclusion: V-M plasty is a safe, easy and rapid procedure to design and apply by using local tissues without the needs for a skin graft or risk of linear scarring and recurrence. The authors advise this versatile technique both in primary and recurrent cases of web space contracture and syndactyly.

• Journal of the Korean Society of Physical Medicine
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• v.15 no.3
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• pp.127-133
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• 2020

PURPOSE: The study examined the relationship between the knee function score and knee strength and muscular endurance of an elite female handball athletes according to their position in the team. METHODS: Thirty handball athletes participated on the study: 12 front positions, 12 back positions, and five goalkeepers. The knee function score consisted of symptoms, pain, daily activity, sports and recreation, and quality of life. In addition, CSMI (Cybex, USA) was used to measure the strength and muscular endurance of the knee. The muscular strength and muscular endurance were measured at an angular velocity of 60°/s and 180°/s, respectively. RESULTS: The overall items of the knee function score showed a significant difference (p = .017), and goalkeepers had significantly higher scores than the back positions. In addition, significant differences were observed in all five items depending on the position (p ≤ .05). On the other hand, both the flexor and extensor muscles of the knee strength and muscular endurance were not significant. Moreover, there was no correlation between the knee function score and the knee strength and muscle endurance. CONCLUSION: Elite female handball athletes have different knee functions score depending on their position in the team, but the, strength and muscular endurance of the knee were similar for each position. Furthermore, the knee function score showed no correlateion with the strength and muscular endurance of the knee.

• Biomolecules & Therapeutics
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• v.20 no.6
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• pp.499-505
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• 2012

Chemoprevention represents a strategy designed to protect cells or tissues against various carcinogens and carcinogenic metabolites derived from exogenous or endogenous sources. Recent studies indicate that plant-derived triterpenoids, like oleanolic acid, may exert cytoprotective functions via regulation of the activity of different transcription factors. The chemopreventive effects may be mediated through induction of the nuclear factor erythroid 2-related factor 2 (Nrf2) transcription factor. Activation of Nrf2 by triterpenoids induces the expression of phase 2 detoxifying and antioxidant enzymes such as NAD(P)H quinone oxidoreductase 1 (NQO1) and heme oxygenase-1 (HO-1) - proteins which can protect cells or tissues against various toxic metabolites. On the other hand, inhibition of other transcription factors, like NF-${\kappa}B$ leads to the decrease in the pro-inflammatory gene expression. Moreover, the modulation of microRNAs activity may constitute a new mechanism responsible for valuable effects of triterpenoids. Recently, based on the structure of naturally occurring triterpenoids and with involvement of bioinformatics and computational chemistry, many synthetic analogs with improved biological properties have been obtained. Data from in vitro and in vivo experiments strongly suggest synthetic derivatives as promising candidates in the chemopreventive and chemotherapeutic strategies.