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http://dx.doi.org/10.3746/pnf.2015.20.4.266

Mitigating Effect of Resveratrol on the Structural Changes of Mice Liver and Kidney Induced by Cadmium; A Stereological Study  

Rafati, Ali (Histomorphometry and Stereology Research Center)
Hoseini, Leila (Department of Traditional Medicine and History of Medicine, Shiraz University of Medical Sciences)
Babai, Ali (Histomorphometry and Stereology Research Center)
Noorafshan, Ali (Histomorphometry and Stereology Research Center)
Haghbin, Hossein (Histomorphometry and Stereology Research Center)
Karbalay-Doust, Saied (Histomorphometry and Stereology Research Center)
Publication Information
Preventive Nutrition and Food Science / v.20, no.4, 2015 , pp. 266-275 More about this Journal
Abstract
Exposure to cadmium (Cd) has harmful effects on the liver and kidney. Resveratrol (RES) is an herbal substance that functions as a protective mediator. This study aimed to investigate the effects of RES on the histology of liver and kidney in Cd-exposed mice. Male mice were divided into 4 groups daily receiving normal saline (1 mL normal saline/d), Cd (1 mg/kg/d), RES (20 mg/kg/d), and Cd plus RES, respectively. After 4 weeks, the liver and kidney components were evaluated using stereological methods. The total volume and number of hepatocytes, and volume of fibrous tissue were respectively increased by 34%, 58%, and a 3-fold in the Cd-exposed mice in comparison to the control animals (P<0.03). On the other hand, the volume of the main vasculature (sinusoids and central veins) was decreased by 36% in the Cd group compared to the control mice (P<0.03). Considering the kidney, the results showed a 3-fold increase in the total glomeruli volume and a 7-fold increase in fibrous tissue in the Cd-treated group compared to the control mice (P<0.03). After Cd treatment, a 32% reduction was observed in the volume and length of the proximal and distal convoluted tubules. RES-treatment alone did not induce any structural changes. In comparison to the Cd group, an increase in the normal components of the liver and kidney and a decrease in the formation of the fibrous and degenerated tissues were observed in the Cd+RES-treated mice (P<0.03).
Keywords
cadmium; resveratrol; liver; kidney; quantitative;
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