• Proceedings of the KIEE Conference
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• 1995.11a
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• pp.242-245
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• 1995

In this paper the multiple three rectifiers for the power factor correction are proposed, analyzed and designed. The multiple three phase rectifiers draw sinusoidal ac currents from the ac voltage sources with nearly unity input power factor and operate with PWM making the control circuit simple and system cost low. Outstandingly it reduces the rated power capacity of devices and the input filter size by reducing input current ripples. Moreover design rules can be obtained from input and output current equations. With the proposed rules, input power factor and output power capacity are determined approximately. Finally these design rules are verified with computer simulations.

• Proceedings of the Korean Institute of Electrical and Electronic Material Engineers Conference
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• 2002.05a
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• pp.62-67
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• 2002

A single-phase power factor corrected converter for switched reluctance motor driving is presented to achieve sinusoidal, near unity power factor input currents. Because it combines a power factor corrected converter and a conventional asymmetric SRM driver into one power stage, the configuration has a simple structure resulted in low cost. A prototype to drive 6/6 poles SRM employing a parking magnet is designed to evaluate the proposed topology. The characteristics and operational mode will be discussed in depth, and the validity of proposed driver will be verified through the experimental results.

• Proceedings of the KIEE Conference
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• 1996.07b
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• pp.902-904
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• 1996

In this paper, we proposed the reasonable design standard and countermeasures of Demand Factor for large office buildings, that was made by the statistical way considering actual conditions, such as investicated electric equipment capacity, electric power consumption, etc. So as to save electric equipment investment, the decrease of power loss, the improvement of facilities utilization and the decrease of electric rates, we can be contributed by the application of the design standard. The result of saving effect is showed to confirm the practical use of the proposed Demand Factor, and also, it is believed that this proposed Demand Factor will be useful in electric equipment operation and planning.

• Biotechnology and Bioprocess Engineering:BBE
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• v.9 no.1
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• pp.12-16
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• 2004

Partitioning of human granulocyte-macrophage colony stimulating factor (hGM-CSF) was achieved in the aqueous two-phase systems (ATPSs) using a crude extract of transgenic tobacco cell suspension culture. This study examined the effects of polyethylene glycol (PEG) molecular weight and concentration and the effects of sodium phosphate concentration in different PEG/sodium phosphate systems on the partition coefficient, K. The best ATPS system was 5% PEG 8,000/1.6 M sodium phosphate after 2 h of incubation at room temperature. In this system, hGM-CSF was partitioned in the PEG-rich phase with a yield of 57.99% and K$\_$hGM-CSF/ of 8.12. In another system, 3% PEG 10,000/1.6 M sodium phosphate, hGM-CSF was also partitioned primarily in the top phase with a yield of 45.66% and K$\_$hGM-CSF/ of 7.64 after 2 h of incubation at room temperature.

• Journal of Animal Science and Technology
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• v.61 no.2
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• pp.61-68
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• 2019

The hG-CSF (human Granulocyte Colony-Stimulating Factor) is a growth and stimulation factor capable of inducing the proliferation of bone marrow cells, several types of leukocytes, among other hematopoietic tissue cells. hG-CSF is used in used to treat anomalies that reder a small number of circulating white blood cells, which may compromise the immune defenses of the affected person. For these reasons, the production of hG-CSF in a bioreactor system using the mammary gland of genetic modified animals is a possibility of adding value to the bovine genetic material and reducing the costs of hG-CSF production in pharmaceutical industry. In this study, we aimed the production of transgenic hG-CSF bovine through the lipofection of bovine primary fibroblasts with an hG-CSF expression cassette and cloning these fibroblasts by the somatic cell nuclear transfer (SCNT) technique. The bovine fibroblasts transfected with the hG-CSF cassette presented a stable insertion of this construct into their genome and were efficiently synchronized to G0/G1 cell cycle stage. The transgenic fibroblasts were cloned by SCNT and produced 103 transferred embryos and 2 pregnancies, one of which reached 7 months of gestation.

• Journal of Acupuncture Research
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• v.33 no.1
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• pp.47-56
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• 2016

Objectives : This study examined the effects of Bee venom on apoptosis in NCI-H157 human lung cancer cells and for promoting the apoptosis effects of Natural killer cell. Methods : Bee venom and Natural killer-92 cells were cultured either separately from or together with NCI-H157 cells for 24 hours. To figure out whether Bee venom enhances the cytotoxic effect of Natural Killer-92 cells, a cell viability assay was conducted. To observe the changes in Death receptors, apoptotic regulatory proteins and Nuclear $Factor-{\kappa}B$, western blot analysis was conducted. To observe the effect of Bee venom through an extrinsic mechanism, a transfection assay was conducted. Results : 1. Natural killer-92 cells and Bee venom significantly inhibited the growth of NCI-H157 cells and co-culture had more inhibitory effect than the separate culture. 2. Expressions of Fas, DR3, DR6, Bax, caspase-3, caspase-8, cleaved caspase-3, cleaved caspase-8 were increased, and expressions of Bcl-2 and cIAP were decreased. More efficacy was observed in co-culture than in separate culture. 3. Nuclear $Factor-{\kappa}B$ activation was clearly decreased. And co-culture showed much less activation than separate culture. 4. As a result of treatment for DR-siRNA, the reduced cell viability of NCI-H157 cells and the activity of Nuclear $Factor-{\kappa}B$ were increased. With this, it can be seen that Bee venom and Natural killer-92 cells have an effect on the cancer cells through the extrinsic mechanism. Conclusion : Bee venom is effective in inhibiting the growth of human lung cancer cells. Furthermore Bee venom effectively enhances the functions of Natural killer cells.

• Fisheries and Aquatic Sciences
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• v.26 no.1
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• pp.35-47
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• 2023

Myelophycus caespitosus, a brown alga belonging to genus Myelophycus, has been traditionally used as a food and medicinal resource in Northeastern Asia. However, few studies have been conducted on its pharmacological activity. In this study, we evaluated whether methanol extract of M. caespitosus (MEMC) could protect against oxidative damage caused by hydrogen peroxide (H₂O₂) in C2C12 murine myoblasts. Our results revealed that MEMC could suppress H₂O₂-induced growth inhibition and DNA damage while blocking the production of reactive oxygen species. In H₂O₂-treated cells, cell cycle progression was halted at the G2/M phase, accompanied by changes in expression of key cell cycle regulators. However, these effects were attenuated by MEMC. In addition, we found that MEMC protected cells from induction of apoptosis associated with mitochondrial impairment caused by H₂O₂ treatment. Furthermore, MEMC enhanced the phosphorylation of nuclear factor-erythroid-2 related factor 2 (Nrf2) and expression and activity of heme oxygenase-1 (HO-1) in H₂O₂-treaetd C2C12 myoblasts. However, such anti-apoptotic and cytoprotective effects of MEMC were greatly abolished by HO-1 inhibitor, suggesting that MEMC could increase Nrf2-mediated activity of HO-1 to protect C2C12 myoblasts from oxidative stress.

• Journal of the Institute of Electronics Engineers of Korea SD
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• v.45 no.2
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• pp.125-129
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• 2008

A low-voltage active CMOS inductor approach, which can improve the quality-factor(Q), is proposed in this paper. A low-voltage active inductor circuit topology with a feedback resistance is proposed, which can substantially improve its equivalent inductance and quality-factor(Q). This proposed low-voltage active inductor with a feedback resistance was simulated by ADS(Agilent) using 0.18um standard CMOS technology. Simulation showed that the designed active inductor had a maximum quality-factor(Q) of 3000 with a 1.5nH inductance at 4GHz

• Journal of Welding and Joining
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• v.1 no.1
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• pp.37-46
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• 1983

This paper describes a study of fillet welded joint stressed perpendicular to the weld line. The finite element method was used to determine the stress intensity factor for cruciform joint at weld toe and root cracks according to variation of H/Tp, weld angle and main plate thickness. But, in this study, weld angle was fixed at 45.deg., since the variation of weld angle affect the stress intensity factor little, also main plate thickness was fixed. Pulsating tension fatigue test was done at the second phase of experiment. The work using the concepts of the fracture mechanics on the stable crack growth, was in the correlation of the experimental fatigue stress-life behavior because the fatigue behaviors of various joint geometries are related to the stress intensity factors calculated by F.E.M. analysis. Main results obtained are summarized as follows. 1) According to the propagation of toe crack, the variation of the stress intensity factor at root crack is obvious as H/Tp is smaller. 2) According to the propagation of root cracks, the change of the stress intensity factor of the toe is very large with propagation of root crack. 3) The calculation formula of the stress intensity factor of crack propagation at the root crack was obtained. 4) The calculation formula of the stress intensity factor at the toe cracks was obtained in similar manner. 5) From the results of experiment, the velocity of fatigue crack propagation at the weld toe and root was estimated.

• Clinical and Experimental Reproductive Medicine
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• v.17 no.2
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• pp.197-202
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• 1990

Early studies demonstrated that seminal plasma has a factor which inhibits fertilizing ability in a reversible manner. The factor can be precipitated by centrifugation at 104000g for 18 hr. The precipitate was applied to a CM cellulose column and eluted with high salt concentration. This fraction possessed antifertilizing activity was applied to a Sephacryl S-200 column according to a modification of the method of Reddy et al. Using such inhibition of in vitro fertilization ability as an assay, we have carried our experiments to purified the factor. When the factor was added to IVF medium, 70-80% of fertilization was inhibited.