• The Pure and Applied Mathematics
• /
• v.11 no.2
• /
• pp.127-132
• /
• 2004

$H_v$-rings first were introduced by Vougiouklis in 1990. The largest class of algebraic systems satisfying ring-like axioms is the $H_v$-ring. Let R be an $H_v$-ring and ${\gamma}_R$ the smallest equivalence relation on R such that the quotient $R/{\gamma}_R$, the set of all equivalence classes, is a ring. In this case $R/{\gamma}_R$ is called the fundamental ring. In this short communication, we study the fundamental rings with respect to the product of two fuzzy subsets.

• Bulletin of the Korean Mathematical Society
• /
• v.56 no.4
• /
• pp.885-898
• /
• 2019

This paper gives a counterexample to show that the first order commutator $C_2$ is not bounded from $H^1({\mathbb{R}}){\times}H^1({\mathbb{R}})$ into $L^{1/2}({\mathbb{R}})$. Then we introduce the atomic definition of abstract weighted Hardy spaces $H^1_{ato,{\omega}}$$({\mathbb{R}})$ and study its properties. At last, we prove that $C_2$ maps $H^1_{ato,{\omega}}$$({\mathbb{R}}){\times}H^1_{ato,{\omega}}$$({\mathbb{R}})$ into $L^{1/2}_{\omega}$$({\mathbb{R}})$.

• 한국정보디스플레이학회:학술대회논문집
• /
• 2004.08a
• /
• pp.799-802
• /
• 2004

In this paper, the active backlight control technology with data processing algorithm was developed in order to improve image quality for IPS-mode LCD-TV applications. The image blinking problem caused by repeatedly abrupt change of the backlight luminance was solved by algorithms-Fba(Flexible Boundary algorithm) and Cfa(Cumulative Feedback algorithm)-and the optimized number and space of backlight dimming steps based on perception. In the IPS-mode 42" TFT-LCD panel, the dynamic contrast ratio can be more than twice the typical level by means of lower block luminance and higher white luminance. Additionally, Power consumption and LCD temperature was decreased.

• Bulletin of the Korean Mathematical Society
• /
• v.56 no.4
• /
• pp.1041-1057
• /
• 2019

Let ${\Gamma}$ be a nonzero commutative cancellative monoid (written additively), $R={\bigoplus}_{{\alpha}{\in}{\Gamma}}$ $R_{\alpha}$ be a ${\Gamma}$-graded integral domain with $R_{\alpha}{\neq}\{0\}$ for all ${\alpha}{\in}{\Gamma}$, and $S(H)=\{f{\in}R{\mid}C(f)=R\}$. In this paper, we study homogeneously divisorial domains which are graded integral domains whose nonzero homogeneous ideals are divisorial. Among other things, we show that if R is integrally closed, then R is a homogeneously divisorial domain if and only if $R_{S(H)}$ is an h-local $Pr{\ddot{u}}fer$ domain whose maximal ideals are invertible, if and only if R satisfies the following four conditions: (i) R is a graded-$Pr{\ddot{u}}fer$ domain, (ii) every homogeneous maximal ideal of R is invertible, (iii) each nonzero homogeneous prime ideal of R is contained in a unique homogeneous maximal ideal, and (iv) each homogeneous ideal of R has only finitely many minimal prime ideals. We also show that if R is a graded-Noetherian domain, then R is a homogeneously divisorial domain if and only if $R_{S(H)}$ is a divisorial domain of (Krull) dimension one.

• Genomics & Informatics
• /
• v.11 no.4
• /
• pp.245-253
• /
• 2013

A radioresistant cell line was established by fractionated ionizing radiation (IR) and assessed by a clonogenic assay, flow cytometry, and Western blot analysis, as well as zymography and a wound healing assay. Microarray was performed to profile global expression and to search for differentially expressed genes (DEGs) in response to IR. H460R cells demonstrated increased cell scattering and acidic vesicular organelles compared with parental cells. Concomitantly, H460R cells showed characteristics of increased migration and matrix metalloproteinase activity. In addition, H460R cells were resistant to IR, exhibiting reduced expression levels of ionizing responsive proteins (p-p53 and ${\gamma}$-H2AX); apoptosis-related molecules, such as cleaved poly(ADP ribose) polymerase; and endoplasmic reticulum stress-related molecules, such as glucose-regulated protein (GRP78) and C/EBP-homologous protein compared with parental cells, whereas the expression of anti-apoptotic X-linked inhibitor of apoptosis protein was increased. Among DEGs, syntrophin beta 2 (SNTB2) significantly increased in H460R cells in response to IR. Knockdown of SNTB2 by siRNA was more sensitive than the control after IR exposure in H460, H460R, and H1299 cells. Our study suggests that H460R cells have differential properties, including cell morphology, potential for metastasis, and resistance to IR, compared with parental cells. In addition, SNTB2 may play an important role in radioresistance. H460R cells could be helpful in in vitro systems for elucidating the molecular mechanisms of and discovering drugs to overcome radioresistance in lung cancer therapy.

• 한국가스학회:학술대회논문집
• /
• 2003.05a
• /
• pp.153-158
• /
• 2003

• Journal of Ginseng Research
• /
• v.44 no.5
• /
• pp.690-696
• /
• 2020

Background: As the main metabolites of ginsenosides, 20(S, R)-protopanaxadiol [PPD(S, R)] and 20(S, R)-protopanaxatriol [PPT(S, R)] are the structural basis response to a series of pharmacological effects of their parent components. Although the estrogenicity of several ginsenosides has been confirmed, however, the underlying mechanisms of their estrogenic effects are still largely unclear. In this work, PPD(S, R) and PPT(S, R) were assessed for their ability to bind and activate human estrogen receptor α (hERα) by a combination of in vitro and in silico analysis. Methods: The recombinant hERα ligand-binding domain (hERα-LBD) was expressed in E. coli strain. The direct binding interactions of ginsenosides with hERα-LBD and their ERα agonistic potency were investigated by fluorescence polarization and reporter gene assays, respectively. Then, molecular dynamics simulations were carried out to simulate the binding modes between ginsenosides and hERα-LBD to reveal the structural basis for their agonist activities toward receptor. Results: Fluorescence polarization assay revealed that PPD(S, R) and PPT(S, R) could bind to hERα-LBD with moderate affinities. In the dual luciferase reporter assay using transiently transfected MCF-7 cells, PPD(S, R) and PPT(S, R) acted as agonists of hERα. Molecular docking results showed that these ginsenosides adopted an agonist conformation in the flexible hydrophobic ligand-binding pocket. The stereostructure of C-20 hydroxyl group and the presence of C-6 hydroxyl group exerted significant influence on the hydrogen bond network and steric hindrance, respectively. Conclusion: This work may provide insight into the chemical and pharmacological screening of novel therapeutic agents from ginsenosides.

• Korean Journal of Optics and Photonics
• /
• v.8 no.3
• /
• pp.183-188
• /
• 1997

Cut-off filters would reject all the radiation below and transmit all that above a certain wavelength or vice versa. In this paper, we study design and farbrication of dichroic mirror and broadband high reflective mirror for color separation of white laser beam source to R.G.B color beam source. In laser display system, color separation is very important. We fabricated below specific component for finite color separation of the Kr-Ar laser source. At 45$^{\circ}$ incidence s-polarized light , it is required that - H/R in blue region R>99%, H/T in green and red region T>90% - H/R in green and red region R>99%, H/T in blue region T>90% - H/R in green region R>99%, H/T in red region T>90% We composed the optical system and realize the full color image.

• Journal of the korean academy of Pediatric Dentistry
• /
• v.43 no.2
• /
• pp.137-144
• /
• 2016

The aim of this study was to evaluate the effect of a range of acidic pH values on the push-out bond strength and surface morphology of tricalcium silicate materials: Biodentine$^{(R)}$, Theracal$^{(R)}$ and ProRoot MTA$^{(R)}$. The standardized lumens of root slices prepared from extracted single-root human teeth were filled with Biodentine$^{(R)}$, Theracal$^{(R)}$ and ProRoot MTA$^{(R)}$ according to manufacturer's instructions. The specimens were randomly divided into 4 groups (n = 20) for each material and then incubated for 4 days at $37^{\circ}C$; 3 acidic groups (butyric acid buffered at pH 4.4, 5.4, 6.4) and 1 control group (phosphate buffered saline solution at pH 7.4). The push-out bond strengths were then measured by using a universal testing machine and the surface morphology of each experimental group was analyzed by a scanning electron microscope. Biodentine$^{(R)}$ and Theracal$^{(R)}$ showed higher push-out bond strength compared with ProRoot MTA$^{(R)}$ after exposure to acidic pH values. A substantial change in the surface morphology of each material occurred after exposure to different pH values. In conclusion, the push-out bond strengths of Biodentine$^{(R)}$ and Theracal$^{(R)}$ are higher than the ProRoot MTA$^{(R)}$. Further the acidic environment weakens the push-out bond strength and microstructure of tricalcium silicate materials.

• Pediatric Gastroenterology, Hepatology & Nutrition
• /
• v.5 no.1
• /
• pp.1-10
• /
• 2002

Purpose; Dysregulation of gastric epithelial cell proliferation and apoptosis are important in development of ulcer, atrophy and neoplasia in Helicobacter pylori (H. pylori) infection. The aim of this study was to investigate the effect of infection of H. pylori on gastric epithelial cell proliferation and apoptosis in children. Methods: Histological grading by updated Sydney system, PCNA immunostaining and TUNEL method were performed in H. pylori positive (N=58) and negative (N=40) gastric biopsy specimens. Results: In H. pylori positive children, there were significantly higher grade of polymorphonuclear neutrophil activity (P=0.000), chronic inflammation (P=0.000), epithelial damage (P=0.000) and lymphoid follicles (P=0.000) than in H. pylori negative children. Intestinal metaplasia was not seen in H. pylori positive children. PCNA index was significantly different between H. pylori positive children ($67.8{\pm}18.13$) and H. pylori negative children ($54.8{\pm}14.46$, P=0.000). There was positive correlation between PCNA index and H. pylori density (r=0.277, P=0.007), polymorphonuclear neutrophil activity (r=0.280, P=0.007) and chronic inflammation (r=0.284, P=0.006). Apoptosis index of H. pylori positive children ($0.44{\pm}0.447$) was significantly higher than of H. pylori negative children ($0.14{\pm}0.196$, P=0.000). There was positive correlation between apoptosis index and H. pylori density (r=0.472, P=0.000), polymorphonuclear neutrophil activity (r=0.370, P=0.001) and chronic inflammation (r=0.483, P=0.000). There was positive correlation between PCNA index and apoptosis index (r=0.353, P=0.003). Conclusion: The PCNA and apoptosis index in H. pylori positive children were significantly higher than in H. pylori negative children. This study suggested that gastric epithelial cell proliferation and apoptosis are important to pathogenesis of H. pylori infection in children.