• 제목/요약/키워드: Gypsum fibrosum

검색결과 26건 처리시간 0.031초

석고(石膏)가 만성 신부전 Rat의 신기능 보호 및 조직학적 변화에 미치는 영향 (The Effects of Gypsum Fibrosum on Renal Functional and Histopathological Disorder in Chronic Renal Failure Rat Model)

  • 변상혁
    • 대한한방내과학회지
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    • 제29권4호
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    • pp.871-886
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    • 2008
  • Objective : Gypsum fibrosum has been traditionally used in treatment of febrile diseases and recently been shown to have anti-inflammatory effect. Chronic renal failure has a serious clinical symptoms including proteinuria, azotemia, anemia, and hyperlipidemia and has characteristic histopathological changes, glomerular hypertrophy, infiltration of inflammatory cells, and crescentic sclerosis, We investigated the effects of gypsum fibrosum on renal functional and histopathological disorder in chronic renal failure rat model induced 5/6 nephrectomy. Methods : Using Sprague-Dawley rats, CRF was induced by 5/6 nephrectomy. The rats were divided into 3 groups, normal, conrol, and gypsum administered orally with gypsum fibrosum 500mg/kg/day. Body weight, 24 hr proteinuria, hematologic analysis, and histological morphologic changes were followed up after 8 weeks. The glomerular macrophage/monocyte infiltration, $TGF-{\beta}_1$, type IV collagen, and angiotensin II type1 receptor($AT_1$) were evaluated by immunohistochemistry. Resuls : In the CRF control group, functional parameters and histopathologic changes clearly indicated the development of CRF. 24 hr proteinuria significantly increased in the CRF control group over the normal group, and serum creatinine level was lower in the gypsum group than in the control group, LDL-cholesterol was significantly lower in the gypsum group than in the control group. Morphological investigations showed a variety of characteristic features of CRF, glomerular hypertrophy, increasing cellular density of glomerulus, deposition of extra-cellular matrix, fibrotic change, and glomerular sclerosis in the control group, but in the gypsum group, these features diminished significantly. In observation of renal type IV collagen and $AT_1$ expression, positive area significantly increased in the control group over the normal group, and it significantly decreased in the gypsum group compared to the control group. Conclusions : Our findings suggest that gypsum fibrosum inhibits $AT_1$ and type IV collagen expression in renal tissues and attenuates progression of glomerulosclerosis and interstitial fibrosis in chronic renal failure rats, which lead to amelioration of renal function. From these results, we suggest that gypsum fibrosum may have renoprotective effects and could be a useful remedy agent for treating chronic renal failure.

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동의수세보원(東醫壽世保元)에서의 석고(石膏)의 약리(藥理)에 대한 문헌적(文獻的) 고찰(考察) (The Bibiographical investigation of effect of GYPSUM FIBROSUM in Dongyi Soose Bowon)

  • 정광희;고병희;송일병
    • 사상체질의학회지
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    • 제12권1호
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    • pp.110-119
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    • 2000
  • 1. 연구목적(硏究目的) 이제마(李濟馬) 선생께서 함흥에서 의업(醫業)을 열어 사상의학(四象醫學)을 제창한 지 100여 년이 지났으나 이제마(李濟馬) 선생께서 쓰신 약물(藥物)에 대한 연구(硏究)가 아직 정립(定立)이 되지 않아 기존(旣存)의 음양오행론적(陰陽五行論的) 관점(觀點)에서 사상(四象) 처방(處方)을 쓰고 있는 것이 현실이다. 이 론고(論考)는 소양인(少陽人)의 대표적 약물인 석고(石膏)를 "동의수세보원(東醫壽世保元)"에서 이병증약(裏病證藥)이라고 규정하면서도 비수한표한병증(脾受寒表寒病證) 처방(處方)에도 사용되는 예가 있어 표이병증(表裏病症)에서 쓰이는 용례(用例)와 올바를 수치법(修治法), 귀경(歸經), 소양인(少陽人)의 한열병증(寒熱病症)에서의 역할을 살펴보아 소양인(少陽人) 비수한표한병(脾受寒表寒病)에서 사용된 석고(石膏)의 운용(運用) 정신(精神)을 살펴보고자 하였다. 2. 연구방법(硏究方法) 역대(歷代) 본초(本草) 의서(醫書)와 동의보감(東醫寶鑑)에 나타남 기존(旣存) 음양오행론적(陰陽五行論的) 관점(觀點)에서 석고(石膏)의 본초론적(本草論的) 의미를 살펴보고 동의수세보원(東醫壽世保元)의 소양인(少陽人) 비수한표한병(脾受寒表寒病)의 망음증(亡陰證) 처방(處方)에서 석고(石膏)가 포함된 처방(處方)인 형방사백산(荊防瀉白散)과 저령동전자탕(猪笭東前子湯)과 같은 망음증(亡陰證) 처방(處方)이면서 석고(石膏)가 들어가지 않은 골석고삼탕(滑石苦參湯)과 형방지황탕(荊防地黃湯)의 두 처방군(處方群)을 비교하여 석고(石膏)가 소양인(少陽人) 비수한표한병(碑受寒表寒病)에 쓰이게 된 운용(運用) 정신(精神)을 살펴보고 소양인(少陽人) 이병증(裏病證)에서 석고(石膏)의 효능(效能)과 작용(作用) 부위(部位)를 살펴보아 소양인(少陽人) 한열병증(寒熱病證)에서의 석고(石膏)의 효용(效用)에 대해 알아보았다. 3. 고찰(考察) 및 결과(結果) 이상의 과정을 통하여 다음과 같은 결론(結論)을 얻을 수 있었다. 1. 석고(石膏)의 수치법(修治法)은 감초수비(甘草水飛), 화가(火假)의 방법이 있으나 소양인약(少陽人藥)은 포, 자(炙), 초(炒), 법(法)을 사용하지 않고 소양인(少陽人) 병증(病症)에서의 석고(石膏)의 효용이 청열사화(淸熱瀉火)하는 기능이 강하므로 생석고(生石膏)를 감초수비(甘草水飛)하여 연세(硏細)하여 사용하는 것이 적절하다. 2. 석고(石膏)가 표병증약(表病證藥)인 형방사백산(荊防瀉白散)과 저령동전자탕(猪笭東前子湯)에 사용되는 양병(養病)이 같이 겸하여 표양겸병(表養兼病)에 청양열이강표음(淸養熱而降表陰)하는 치법(治法)에 사용되는 것이다. 3. 소양인(少陽人) 비수한표한병(脾受寒表寒病) 중에 망음증(亡陰證)은 신열두통설사(身熱頭痛泄瀉)의 망음(亡陰)과 신한복통설사(身寒腹痛泄瀉)의 망음증(亡陰證)으로 구별되며 신열두통설사(身熱頭痛泄瀉)의 망음증(亡陰證)에만 석고(石膏)가 쓰이게 되며 설사(泄瀉)의 유무(有無)와는 관계없이 신열두통(身熱頭痛)의 증장(證狀)으로 망음증(亡陰證)으로 전변(轉變)되는 증상(證狀)이 있을 때는 석고(石膏)를 사용하게 된다. 4. 석고(石膏)는 화열병증(火熱病證)으로 양화(陽化)되기 쉬운 소양인(少陽人)의 체질적(體質的) 특징(特徵)을 청열사화(淸熱瀉火)의 작용으로 소양인(少陽人) 보명지주(保命之主)인 음청지기(陰淸之氣)를 도와주는 대표적인 약물이다. 5. 석고(石膏)의 작용(作用) 부위(部位)는 중상초(中上焦) 부위(部位)인 위국(胃局)으로 위국(胃局)의 모양(耗陽)을 청열사화(淸熱瀉火)하여 소양인(少陽人) 이병증(裏病證)의 대전제(大前提)인 대변폐(大便閉)의 증상을 해소하여 청양(淸陽)을 상달(上達)시키는 작용을 한다.

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전광증(癲狂症) 환자(患者) 치험(治驗) 1례(例) (A case with schizophrenia)

  • 김태헌;김근우;송지형
    • 동의신경정신과학회지
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    • 제12권2호
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    • pp.223-230
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    • 2001
  • We experienced one case of schizophrenia. A patient who has hypertetyion & c.v.a as a past history was suffer from conspitation, headache, nausea, sweating, insomnia, & etc. This study is peformed to find out gypsum fibrosum enema theraphy has a clinical effect on constipation with schizophrenia. Gypsum fibrosum enema theraphy has a sufficient effect. Altought, the most important thing is that schizophrenia is almost due to seven feelings. So maybe more and more studies are need in the schizophrenia & seven feelings.

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마황(麻黃)과 석고(石膏) 혼합물이 지방전구세포 분화와 흰쥐의 비만에 미치는 영향 (Effect of Mixed Extract of Ephedrae Sinica and Fibrosum Gypsum on Differentiation of Preadipocytes and Obesity of Rats)

  • 기영범;김대훈;양미성;강대희;김선종;최진봉
    • 한방재활의학과학회지
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    • 제24권3호
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    • pp.11-27
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    • 2014
  • Objectives This study was designed to evaluate the effects of Ephedra Sinica and Fibrosum Gypsum extract on obesity by using 3T3-L1 cells and high fat diet rats. Methods In vitro, Ephedra Sinica and Fibrosum Gypsum extract (50, 100, 200, $500{\mu}g/ml$) were added in 3T3-L1 cells. Cytotoxicity was measured by MTT assasy. Adipocyte differentiation was measured by Oil Red O staining, GPDH activity and $C/EBP{\alpha}$ protein expression. In vivo, Sprague-Dawley rats were divided into 5 groups : Normal diet group (Normal group), taken high fat diet and no treatment group (Control group), taken high fat diet and orally administered Ephedra Sinica and Fibrosum Gypsum extract daily (Group I: 50 mg/kg, Group II: 100 mg/kg, Group III : 200 mg/kg, oral). For 6 weeks of administration, body weight and the amount of food intake were measured once a week. After administration, blood analysis (AST, ALT, T-Bilirubin, BUN, RBC, Hb, HCT), serum lipid level (triglyceride, Total cholesterol, HDL, LDL), serum leptin level, epididymal adipose tissue weight and histological finding of liver were estimated. Results In vitro, The cytotoxicity was not significant. 3T3-L1 cell's differentiation was significantly decreased in Oil Red O staining, GPDH activity and $C/EBP{\alpha}$ protein expression. In vivo, Body weight and the amount of food intake, AST, ALT, Total cholesterol, TG, LDL, serum leptin, epididymal adipose tissue weight showed significant decrease in group I, group II and group III. There were no significant difference in T-bilirubin, BUN, RBC, Hb and HCT between all groups. HDL showed significant increase in group I, group II and group III. In histological finding of liver tissue, there were decreased adiposity and cytopathic effect in group I, group II and group III. Conclusions It is suggested that Ephedra Sinica and Fibrosum Gypsum extract can be used in the treatment of obesity.

소문선명논방(素問宣明論方)과 난실비장(蘭室秘藏)의 본초구성 비교 분석 (Analysis of Prescriptions from Somunsunmyungronbang and Nansilbijang)

  • 박우용;백진웅;이병욱
    • 한국의사학회지
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    • 제24권2호
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    • pp.117-123
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    • 2011
  • Objectives : To quantitatively analyze the academic characteristics of Yuhagan and Idongwon and compare it to existing qualitative analysis. Methods : The prescriptions listed in Somunsunmyungronbang and Nansilbijang were entered into a database. Commonly used combination of medical herbs were researched throughout the literature. Results : In Nansilbijang, among the combinations of 8 medical herbs, Glycyrrhizae Radix, Cimicifugae Rhizoma, Bupleuri Radix, Ginseng Radix, Citri Pericarpium, Atractyodis Rhizoma, Astragali Radix, Phellodendri Cortex combination was used 11 times out of the 277 prescriptions. In Somunsunmyungronbang, combinations of 7 medical herbs: (Glycyrrhizae Radix, Platycodi Radix, Rhei Radix et Rhizoma, Menthae Herba, Atractylodis Rhizoma Alba, Gypsum Fibrosum, Forsythiae Fructus), (Glycyrrhizae Radix, Angelicae gigantis Radix, Paeniae Radix Alba, Atractylodis Rhizoma Alba, Gypsum Fibrosum, Cnidii Rhizoma, Scutellariae Radix), (Glycyrrhizae Radix, Platycodi Radix, Angelicae gigantis Radix, Rhei Radix et Rhizoma, Atractylodis Rhizoma Alba, Gypsum Fibrosum, Schizonepete Herba) were each used 7 times out of the 350 prescriptions. Conclusions : Nansilbijang shows more prescriptions applying Cimicifugae Rhizoma, Bupleuri Radix, Ginseng Radix, Citri Pericarpium, Atractyodis Rhizoma, Astragali Radix, Phellodendri Cortex. Prescriptions aimed to tonify ql with Ginseng Radix and Astragali Radix, to upraise the middle qi with Bupleuri Radix and Cimicifugae Rhizoma, and to regulate qi with Citri Pericarpium and Atractyodis Rhizoma were common. Somunsunmyungronbang preferred the use of Angelicae gigantis Radix, Platycodi Radix, Rhel Radix et Rhizoma, Gypsum Fibrosum, Schizonepete Herba, Forsythiae Fructus and Menthae Herba so its focus was on the aggressive management of febrile diseases.

"상한론(傷寒論)"의 마행감석탕(麻杏甘石湯)에 대한 연구(硏究) (The Study on the "Sanghanron(傷寒論)"'s Mahanggamsuktang(麻杏甘石湯))

  • 방정균
    • 대한한의학원전학회지
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    • 제25권1호
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    • pp.163-171
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    • 2012
  • Objective : There are lots of wrong treatment cases in the "Sanghanron". Therefore, search the symptoms that before performed the wrong treatment is important, and that can be a another way to study "Sanghanron". Method : I'll have to figure out "Sanghanron" related publications. Result : The symptoms of Mahanggamsuktang already had the symptoms of Mahwantang(麻黃湯) and the fever of Lung before performed the wrong treatment. Because pathogenic heat is blockaged in the Lung, so we use the Mahanggamsuktang. Conclusion : The efficacies of this drug are disseminating Lung Gi(肺氣) and clearing heat. However, as the rise and fall of fever, the amount of HERBA EPHEDRAE(麻黃) and GYPSUM FIBROSUM(石膏) can be adjusted.

정신질환(精神疾患)에 사용된 광물성(鑛物性) 약재(藥材)에 대한 고찰(考察) (A Study on the mineral of substance used in mental disease.)

  • 허성;구병수
    • 동의신경정신과학회지
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    • 제10권1호
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    • pp.159-177
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    • 1999
  • In the study on the mineral substance used in Dong Eu Bo Gam(range of 'Sin') and the recent prescription of china, the results were as follows. 1. According to Dong Eu Bo Gam, Realgar was used for Sa-Su most often and Gold-leaf, Succinum, especially Cinnabaris were used for amnesia, epilepsy, a general term of manic-depressive psychosis too. The most kinds of mineral substance used for epilepsy. 2. According to recent prescription of china, Fossilia Ossis Mastodi got the most, and Succinum, Cinnabaris, Lapis Chloriti, Haematitum, Magnetitum, Gypsum Fibrosum, Fossilia Dentis Mastodi, iron powder were used frequently. For external application, Sulfur was too. And most kinds of mineral substance were used for epilepsy and schizophrenia. 3. Realgar, Gold-leaf, Succinum, Cinnabaris, Lapis Chloriti, Haematitum, Magnetitum, Gypsum Fibrosum, Fossilia Dentis Mastodi, iron powder have drug effect for mental disease, especially for epilepsy induced by terror. 4. For Application of mineral substance, it should be considered that the chemical elements of mineral substance act on human body. 5. For drug effect, it is important to make clear of original prescription.

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齒牙 및 齒周疾患에 使用되는 藥物에 관한 文獻的 考察 (A Literature Studies on the use of apply the drug to the Dental and Paradental disease)

  • 이준성;유현신;서형식;노석선
    • 한방안이비인후피부과학회지
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    • 제14권2호
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    • pp.44-83
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    • 2001
  • The result were as follows: 1. Apply the drug to the Dental and Paradental digease is used to be very busy on the Gypsum Fibrosum( 石膏) and Asari herba cum Radice(細辛). 2. Apply the drug to the Dental and Paradental digease is clearing away heat and helping sweat 3. Apply the drug to the Dental and Paradental digease is cold and hot. 4. Apply the drug to the Dental and Paradental digease is pungent, bitter and sweet. 5. Apply the drug to the Dental and Paradental digease is non-toxic. 6. Apply the drug to the Dental and Paradental digease is used to be very busy on the chanel of liver and stomach.

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현곡(玄谷) 사비탕(瀉脾湯)의 구성한약과 그 기미배오(氣味配伍) 분석 (Hyeongok's Sabeetang Was Combined According to the Theory for Properties and Tastes of Herbal Medicines)

  • 박태열;김경철;신순식
    • 대한한의학방제학회지
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    • 제15권1호
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    • pp.137-144
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    • 2007
  • Background and Objectives : There are three kinds of formulas for purging the spleen to cure its sthenic syndrome based on the types of preparation formulas : Sabeetang, Sabeehwan, Sabeesan and Sabeeeum. Another formulas called Sahwangtang, Sahwangsan. Sahwangeum is to purge the yellow colour of spleen. There are 8 kinds of Sabeetang, 3 kinds of Sabeehwan, 3 kinds of Sabeesan, 1 kind of Sabeeeum, 4 kinds of Sahwangtang, 7 kinds of Sahwangsan, and 1 kind of Sahwangeum. Combination of herbal medicines, carried out in formulas for purging the spleen, consists of various kinds depending on medical scientists' personal experience in medical treatment without any general principles, which makes it difficult to apply it to clinical use. The objectives of this study lie in theoretical establishment of Sabeetang for curing the sthenic syndrome of spleen through analyzing the component medicines and combination principles of Hyeongok's Sabeetang, and furthermore, maximizing the clinical use of Sabeetang. Methods : This study analyzed the component medicines and combination principles of Hyeongok's Sabeetang based on the theory for properties and tastes of herbal medicines from the ${\ulcorner}$Yellow Emperor's Canon of Internal Medicine${\lrcorner}$ , the theory for principal herbal medicine, assistant herbal medicine, adjuvant herbal medicine, dispatcher herbal medicine, and the five elements doctrine. Hyeongok's Sabeetang is an odd prescription, composed of 7 kinds of ingredients : No.1 Rhizoma Coptidis (2don;7.5g), No.2 Fructus Gardeniae (1don;3.75g), No.3 Ramulus Cinnamomi (1don), No.4 Gypsum Fibrosum (1don), No.5 Fructus Aurantii Immaturus (1don), No.6 Cortex Magnoliae Omcinalis (1don), and No.7 Radix Et Rhizoma Rhei (1don) Results : There are three methods for curing the sthenic syndrome of spleen according to the five elements doctrine : purging the spleen, purging the lung and invigorating the liver. First, if you suffer from the sthenic syndrome of the spleen, you need to purge your spleen. There are two available methods, including taste and property purgation according to the theory for properties and tastes of herbal medicines. They each imply the bitter taste and the cool property purge the spleen. In the case of taste purgation, two herbal medicines with bitter taste. Rhizoma Coptidis and Fructus Gardeniae, are combined into the principal and assistant herbal medicine, respectively. For property purgation, three herbal medicines with the cool property, Gypsum Fibrosum, Fructus Aurantii Immaturus and Radix Et Rhizoma Rhei, are combined into adjuvant herbal medicines. Secondly, if you suffer from the sthenic syndrome of the spleen, you need to purge your lung which is child in the mother-child relationship in inter-promotion among the five elements. There are two methods to purge the lung, including taste and property purgation according to the theory for properties and tastes of herbal medicines. They each mean the pungent taste and the warm property purge the lung. Therefore, it is important to use pungent herbal medicines for taste purgation and warm ones for property purgation. Both pungent and warm herb and property invigoration to invigorate the liver with warm property. Therefore, it is important to use pungent herbal medicines for taste invigoration and warm ones for property invigoration. Both pungent and warm herbal medicines, Ramulus Cinnamomi and Cortex Magnoliae Officinalis, were combined to invigorate the liver and purge the lung. In addition, Gypsum Fibrosum are combined as dispatcher herbal medicine, leading all the herbal medicines composing the formula to the spleen. Conclusions : First, to cure the sthenic syndrome of the spleen, the methods of purging the spleen and the lung, and invigorating the liver should be used according to the five elements doctrine. Secondly, herbal medicines appropriate for those treatment methods should be chosen according to the theory for properties and tastes of herbal medicine and thirdly, the combination of those herbal medicines should be carried out according to the theory for principal herbal medicine, assistant herbal medicine, adjuvant herbal medicine, dispatcher herbal medicine. As a good example, Hyeongok's Sabeetang is combined according to the above theories. In conclusion, this formula was created by applying to the theory for properties and tastes of herbal medicines.

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편두통(偏頭痛)의 원인(原因)과 처방(處方)에 대한 문헌적(文獻的) 고찰(考察) (Literatural Study on the cause of a disease and prescription in migraine)

  • 김종인;황치원
    • 혜화의학회지
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    • 제8권2호
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    • pp.171-189
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    • 2000
  • By Literatural studying on migraine, The results were obtained as fallow : 1. A different name on migraine were called hemicrania(頭偏痛, 邊頭痛, 偏頭風). 2. In the cause of a disease in migraine, the cases were clasified into the fallowing kind : internal cause were a decline in energy and blood(氣血具虛), external cause were outside evil(外邪) in wind cold heat wetness(風寒暑濕), non internal, external cause were exhaustion. The right side migraine were concerned phlegm heat, the right side migraine were concerned wind decline in blood. 3. Migraine is appeared on the side, For the reason, liver function in excess of normal limits(肝陽上亢), a sudden of liver fire(肝火) is becomeed of invasion upon soyangkuong(少陽經) in internal external cause 4. Usage method of medicines is appeared that order underclothes theraphy(內服法), to pump out in nose theraphy, to join head theraphy(頭點法), heating smoke theraphy(熏煙法) 5. CNIDII RHIZOMA(川芎) is in mostly general use for migraine, in that order LEDEBOURIELLAE RADIX(防風) ANGELICAE DAHURICAE RADIX(白芷) ASARI HERBA CUM RADICE(細辛) NOTOPTERYGII RHIZOMA(羌活) GLYCYRRHIZAE RADIX(甘草) CHRYSANTHEMI FLOS(菊花) BUPLEURI RADIX(柴胡) SCUTELLARIAE RADIX(黃芩) ANGELICAE GIGANTIS RADIX(當歸) GYPSUM FIBROSUM(石膏) MENTHAE HERBA(薄荷) GLYCYRRHIZAE RADIX(炙甘草) VITICIS FRUCTUS(蔓荊子), nature is in mostly general hot warm(辛溫), bitter cold(苦寒), guikuong(歸經) is in mostly general liver gall kuong(肝膽經), efficacy is in mostly general to remove wind pain (祛風止痛) and to down fire(瀉火).

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