• Journal of the Korean Ceramic Society
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• v.51 no.5
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• pp.442-446
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• 2014

Influences of Co and inhibitors from nano-sized WC materials were observed in the sintering process. VC and $Cr_3C_2$ were used as inhibitors. The crystal structure and surface images of sintered nano-sized WC materials, as functions of Co and inhibitors, were evaluated by XRD and FE-SEM analyses. The relative densities of sintered nano-sized WC materials did not change even with increased quantity of Co and increased temperature. The density of sintered nano-sized WC materials with inhibitors was lower than that of sintered nano-sized WC materials without inhibitors. No difference in hardness due to change of inhibitors was found.

• Biomedical Science Letters
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• v.17 no.4
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• pp.291-295
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• 2011

PD98059 is the specific inhibitor of extracellular signaling-regulated kinase (ERK) kinase (MEK). ERK is involved in a mitogen-activated protein kinase (MAPK) cascade controlling cell growth and differentiation. Although the inhibition of ERK is known to induce cell death in various cell lines, this effect is still controversial and the role of PD98059 on the death of HeLa $S_3$ cells, a subclone of the cervical cancer cell line, is not well understood. The apoptosis of HeLa $S_3$ cells increased after the treatment of 50 ${\mu}M$ PD98059. The induction of apoptosis by PD98059 was occurred in a time- and a dose-dependent manners. The expression of Bcl-2 was reduced in accordance with decrease of ERK2 expression. Taken together, these results indicate that PD98059 has a cytotoxicity in HeLa $S_3$ cells and it may be used as a potential target for the treatment of cervical cancer.

• Journal of Physiology & Pathology in Korean Medicine
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• v.18 no.4
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• pp.1169-1172
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• 2004

The cytotoxic activity of 13(E)-labd-13-ene-8α, 15-diol (1) was evaluated against tumor cell lines. A comparison of IC/sub 50/ values of this compound in cancer cell lines showed that their susceptibility to this compound decreased in the following order: P388>B16{F10>MDA-MB-231>A549>KB>SNU-C4 by the MTT method. 13(E}-Labd-13-ene-8α, 15-diol (1) was the most effective growth inhibitor of P388 murine leukaemia cell lines, producing approximately 8.3㎍/mL of IC/sub 50/ in the MTT method.

• Proceedings of the Korea Concrete Institute Conference
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• 1998.10c
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• pp.217-222
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• 1998

In these days, mostof marine structures are constructed by reinforcement concrete due to economic reason. Theoretically, it is widely recognized that rebar in sound concrete is safe against corrosion because of the high alkalinity of concrete. However, corrosion for reinforcement concrete made by marine aggregate and exposed to ocean enviroments has become serious social problem. Especially in Korea, with the rapid economic growth construction activities have been accelerated and needed more natural aggregate. Therefore, inevitably marine aggregate had to be used due to limitation of good quality aggregate. In this study, as a part of efforts to establish the fundamental counterplan on corrosion problems related to marine aggregate, concrete specimens with chloride containing material and inhibitor have been studied. And, in order to analyze corrosion characteristics several electrochemical techniques including half-cell potential survery, linear and cyclic polarization tests were carried out.

• Journal of Microbiology and Biotechnology
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• v.19 no.9
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• pp.918-921
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• 2009

In the present study, we examined the inhibitory effects of protein tyrosine phosphatase (PTPase) inhibitors, including sodium orthovanadate (SOV), ammonium molybdate (AM), and iodoacetamide (IA), on cell growth, accumulation of astaxanthin, and PTPase activity in the photosynthetic algae Haematococcus lacustris. PTPase activity was assayed spectrophotometrically and was found to be inhibited 60% to 90% after treatment with the inhibitors. SOY markedly abolished PTPase activity, significantly activating the accumulation of astaxanthin. These data suggest that the accumulation of astaxanthin in H. lacustris results from the concerted actions of several PTPases.

• THE JOURNAL OF KOREAN ORIENTAL ONCOLOGY
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• v.5 no.1
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• pp.33-46
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• 1999

To evaluate the antitumor and antimetastatic effects of Samiyeongeontanggamibang(SYTG), We have examined whether SYTG can inhibit the growth of several tumor cell lines, tumor cell adhesion, experimental tumor metastasis and increase survival rate of tumor-bearing mice by inhibition of DNA topoisomrase activity. The results were obtained as follows: 1. SYTG extracts revealed an efficient cytotoxicity against A549, SK-OV-3, B16-F10, and SK-MEL-2 cell lines. 2. SYTG extracts inhibited DNA topo-isomerase I from calf thymus. 3. The T/C% in S-180 bearing ICR mice treated with SYTG was 115.8% 4. SYTG extracts significantly inhibited adhesion of A549 cell to complex extracellular matrix. 5. In pulmonary colonization assay, SYTG suppressed lung metastases in tumor cell-injected mice. 6. In CAM assay, SYTG extracts inhibited angiogenesis at $15{\mu}g/egg$ concentration as compared with control. These results suggested that SYTG extracts might be a potent inhibitor of cancer.

• Archives of Pharmacal Research
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• v.29 no.9
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• pp.762-767
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• 2006

Danshen is an herbal medication frequently used in oriental medicine to treat liver or kidney malfunction. In the course of our studies, we observed that compounds purified from Danshen exhibit an inhibitory activity against Discoidin Domain Receptor 2 (DDR2) tyrosine kinase. Through this inhibition, these compounds also inhibited the growth of HSC T6 cells and suppressed the expression of alpha-smooth muscle actin and MMP2, as well as collagen synthesis, all of which are increased in activated liver stellate cells. Given that activation of liver stellate cells is the hallmark of liver fibrosis and that DDR2 plays a critical role in this activation, these results suggest that one of the pharmacological activities of Danshen extract that protects the liver is the inhibition of key cell-signaling kinases, such as DDR2, in liver stellate cells.

• Proceedings of the PSK Conference
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• 2003.04a
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• pp.266.3-267
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• 2003

In order to induce production of methylnissolin, sterol biosyntheis inhibitor, in the adventitious root of Astragalus membranaceus the effect of methyl jasmonate(MeJ), a growth regulator of plant, was investigated. After treatment of MeJ (0$\mu\textrm{m}$, 10$\mu\textrm{m}$, 100$\mu\textrm{m}$) to the adventitious root which was harvested in the time interval of 0, 7, 14, 21, 28days and the fresh weight, dry weight and the contents methylnissolin was determined. (omitted)

• Archives of Craniofacial Surgery
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• v.18 no.1
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• pp.54-58
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• 2017

Lymphangioma is a congenital malformed lymphatic tumor that rarely involves the tongue. In our clinic, a 10-year-old female presented with lymphangioma circumscriptum involving the right two-thirds of the tongue. We administered an intralesional combination injection of triamcinolone, bleomycin, and bevacizumab as a treatment. Almost complete remission after combination therapy was achieved without complications such as edema, swallowing difficulties or recurrence. Bevacizumab, an inhibitor of vascular endothelial growth factor, was effective for the treatment of lymphangioma of the tongue in this case. No recurrence was noted at the 1-year follow up.

• Biomedical Science Letters
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• v.20 no.3
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• pp.103-110
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• 2014

Matrix metalloproteinases (MMPs), also called matrixins, function in the extracellular environment of cells and degrade both matrix and non-matrix proteins. They are multidomain proteins and their activities are regulated by tissue inhibitor of metalloproteinases (TIMPs). The uncontrolled regulation of MMPs is involved in various pathologic processes, such as tumor invasion, migration, host immune escape, extravasation, angiogenesis, and tumor growth. Especially, matrix metalloproteinase-9 (MMP-9) is one of the metastasis-accelerating genes involved in metastasis of various types of human cancers. Here, we review the member of MMP family and discusses their domain structure and function, enzyme activation, the mechanism of inhibition by TIMPs. In particular, we focus the role of MMP-9 in relation to cancer metastasis.