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Natural Compounds from Danshen Suppress the Activity of Hepatic Stellate Cells  

Oh, Seong-Hwan (Department of Family Medicine, Korea University, College of Medicine)
Cho, Kyung-Hwan (Department of Family Medicine, Korea University, College of Medicine)
Yang, Beom-Seok (Biomedical Research Center, KIST)
Roh, Yong-Kyun (Department of Family Medicine, Hallym University, College of Medicine)
Publication Information
Archives of Pharmacal Research / v.29, no.9, 2006 , pp. 762-767 More about this Journal
Abstract
Danshen is an herbal medication frequently used in oriental medicine to treat liver or kidney malfunction. In the course of our studies, we observed that compounds purified from Danshen exhibit an inhibitory activity against Discoidin Domain Receptor 2 (DDR2) tyrosine kinase. Through this inhibition, these compounds also inhibited the growth of HSC T6 cells and suppressed the expression of alpha-smooth muscle actin and MMP2, as well as collagen synthesis, all of which are increased in activated liver stellate cells. Given that activation of liver stellate cells is the hallmark of liver fibrosis and that DDR2 plays a critical role in this activation, these results suggest that one of the pharmacological activities of Danshen extract that protects the liver is the inhibition of key cell-signaling kinases, such as DDR2, in liver stellate cells.
Keywords
Danshen; Fibrosis; Liver stellate cell; Kinase inhibitor;
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Times Cited By Web Of Science : 3  (Related Records In Web of Science)
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