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Cytotoxic Activity of 13(E)-Labd-13-ene-8$\alpha$, 15-diol  

Lim Jin A (Department of Herbal Resources, Professional Graduate School of Oriental Medicine and Institute of Basic Natural Science)
Kwang Jung Sook (Department of Dental Hygiene, Mokpo Science College)
Yu Byung Soo (Division of Bionano Chemistry, Wonkwang University)
Baek Seung Hwa (Department of Herbal Resources, Professional Graduate School of Oriental Medicine and Institute of Basic Natural Science)
Publication Information
Journal of Physiology & Pathology in Korean Medicine / v.18, no.4, 2004 , pp. 1169-1172 More about this Journal
Abstract
The cytotoxic activity of 13(E)-labd-13-ene-8α, 15-diol (1) was evaluated against tumor cell lines. A comparison of IC/sub 50/ values of this compound in cancer cell lines showed that their susceptibility to this compound decreased in the following order: P388>B16{F10>MDA-MB-231>A549>KB>SNU-C4 by the MTT method. 13(E}-Labd-13-ene-8α, 15-diol (1) was the most effective growth inhibitor of P388 murine leukaemia cell lines, producing approximately 8.3㎍/mL of IC/sub 50/ in the MTT method.
Keywords
Cytotoxicity; 13(E}-labd-13-ene-8; 15-diol (1); P388 murine leukaemia cell lines; MTT method.;
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