• Asian Pacific Journal of Cancer Prevention
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• v.14 no.2
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• pp.695-700
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• 2013

Background: Mutations affecting the epidermal growth factor receptor (EGFR) are good predictors of clinical efficacy of EGFR tyrosine kinase inhibitors (TKI) in patients with non-small cell lung cancer. Serum carcinoembryonic antigen (CEA) levels are also regarded as predictive for the efficacy of EGFR-TKI and EGFR gene mutations. This study analyzed the association between EGFR gene mutations and clinical features, including serum tumor marker levels in lung adenocarcinomas patients. Patients and Methods: A total of 70 lung adenocarcinoma patients with complete clinical data and pathological specimens were investigated. EGFR gene mutations at exons 19 and 21 were assessed. Serum tumor markers were detected by protein chip-chemiluminescence at the corresponding time, and correlations were analyzed. Results: Mutations of the EGFR gene were detected in 27 of the 70 patients and the serum CEA and CA242 concentrations were found to be significantly associated with the incidence of EGFR gene mutations (P<0.05). The AUCs for CEA and CA242 were 0.724 (95% CI: 0.598~0.850, P<0.05) and 0.769 (95% CI: 0.523~0.800, P<0.05) respectively. Conclusions: Serum CEA and CA242 levels are associated with mutations of the EGFR gene in patients with lung adenocarcinomas.

• Asian Pacific Journal of Cancer Prevention
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• v.14 no.9
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• pp.5243-5248
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• 2013

Background: Triptolide, extracted from the herb Tripteryglum wilfordii Hook.f that has long been used as a natural medicine in China, has attracted much interest for its anti-cancer effects against some kinds of tumours in recent years. Artesunate, extracted from the Chinese herb Artemisia annua, has proven to be effective and safe as an anti-malarial drug that possesses anticancer potential. The present study attempted to clarify if triptolide enhances artesunate-induced cytotoxicity in pancreatic cancer cell lines in vitro and in vivo. Methods: In vitro, to test synergic actions, cell viability and apoptosis were analyzed after treatment of pancreatic cancer cell lines with the two agents singly or in combination. The molecular mechanisms of apoptotic effects were also explored using qRT-PCR and Western blotting. In vivo, a tumor xenograft model was established in nude mice, for assessment of inhibitory effects of triptolide and artesunate. Results: We could show that the combination of triptolide and artesunate could inhibit pancreatic cancer cell line growth, and induce apoptosis, accompanied by expression of HSP 20 and HSP 27, indicating important roles in the synergic effects. Moreover, tumor growth was decreased with triptolide and artesunate synergy. Conclusion: Our result indicated that triptolide and artesunate in combination at low concentrations can exert synergistic anti-tumor effects in pancreatic cancer cells with potential clinical applications.

• The Research Journal of the Costume Culture
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• v.22 no.5
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• pp.862-872
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• 2014

Global luxury jewelry brands had begun to launch their direct businesses in Korea since the 1990s, and have attained fast growth by holding events reflecting their philosophies. The purpose of this study was to analyze the background of their growth by examining the types and roles of events in Korea held by luxury jewelry brands. For the research method, the quantitative and qualitative analysis were performed about domestic events of Tiffany & Co., Cartier, Bvlgari, Chaumet, and Van Cleef & Arples during the period from 1990 to 2013. Also, theoretical study was reviewed. The results are as follows. The events are largely classified into jewelry exhibitions, jewelry shows, wedding fairs, and hybrids. The roles of such events were, first, the artification of products and, second, the contemporization of traditions. According to the findings of this study, luxury jewelry brands transmitted new emotions and values to their customers through their events in Korea, and extended their influence continuously over the Korean high-end jewelry market.

• Journal of the Korean Society of Costume
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• v.27
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• pp.207-217
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• 1996

The purpose of this study were to find ethnic fashion's background in the late period of 20th century to compare the World ethnic with the Korean ethnic through content analysis and to identify Korean ethnic of the world fashion Eth-nic fashion started at orientalism by Poiret in the 1910s advancing to African ethnic & Hippy fe-ver in 1960s-70-s have emerged variously with ecology in 1980s-90s' fashion trend. The next the present research analyzed the world ethnic and the Korean ethnnic. The identified 517 fashion photograph from fashion magazines were categorized into two areas: the trend of ex-ternal growth and ethnic fashion's origins/designers wearable situation colors fabrics/pattern. The result were as follows :First eth-nic fashion's external growth of both the World ethnic and the Korean ethnic were incresed. Sec-ond in the ethnic fasions' origins/designers while the World ethnic were almost the same rate between Asian and European ethnic by many designers the Korean ethnic were limited to Asian ethnic Third in the ethnic fashion's wearable situation while the World ethnic were variously wearing the Korean ethnic were lim-ited to work of collection. Forth in the ethnic fashion's colors the Korean ethnic were limited to white color. Last in the ethnic fashions' fabrics/patterns If the Korean ethnic would become a world of ethnic would become a world of ethnic fashion it should be deviced practival abrics and modernized patterns.

• Proceedings of the Korean Institute of Electrical and Electronic Material Engineers Conference
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• 2001.11b
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• pp.270-273
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• 2001

Electrical tree is studied widely by manufacture state of insulating material fare and blazing fire diagnosis system of use in phenomenon of part discharge that happen for main cause of dielectric breakdown of equipment for electric power. Use process that draw tree pattern here measuring above zero to study special quality of this electricity tree, real-time processing by image processing is proposed because reproduction of tree blazing fire process drops and pattern of tree is difficult correct quantification of tree growth by existent visual observation by involution. This research presents general process that need in image processing of tree blazing fire, and that remove various noises that happen in above zero by measuring electrical tree dividing background and complete view in measured above zero taking advantage of specially proposed complete view object abstraction techniques effectively and quantification of tree becomes easy naturally, can apply to dielectric breakdown estimate because can chase growth process of tree.

• Clinical and Experimental Pediatrics
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• v.54 no.1
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• pp.1-5
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• 2011

Asthma in childhood is a heterogeneous disease with different phenotypes and variable clinical manifestations, which depend on the age, gender, genetic background, and environmental influences of the patients. Several longitudinal studies have been conducted to classify the phenotypes of childhood asthma, on the basis of the symptoms, triggers of wheezing illness, or pathophysiological features of the disease. These studies have provided us with important information about the different wheezing phenotypes in young children and about potential mechanisms and risk factors for the development of chronic asthma. The goal of these studies was to provide a better insight into the causes and natural course of childhood asthma. It is well-known that complicated interactions between genes and environmental factors contribute to the development of asthma. Because childhood is a period of rapid growth in both the lungs and the immune system, developmental factors should be considered in the pathogenesis of childhood asthma. The pulmonary system continues to grow and develop until linear growth is completed. Longitudinal studies have reported significant age-related immune development during postnatal early life. These observations suggest that the phenotypes of childhood asthma vary among children and also in an individual child over time. Improved classification of heterogeneous conditions of the disease will help determine novel strategies for primary and secondary prevention and for the development of individualized treatment for childhood asthma.

• Health Policy and Management
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• v.23 no.4
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• pp.343-348
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• 2013

Background: Price control alone may not successfully restrain growth in health expenditures. This study aimed to propose fee adjustment model suitable for Korea reflecting health service volume and to clarify applicability of the model by comparing actual conversion factor with estimated conversion factor from simulation of this model. Methods: Fee adjustment model was developed based on Alberta's fee adjustment formula in Canada and 7 alternatives were assessed according to diversely applied parameters of the model. Results: Estimated conversion factors of the tertiary care hospital and the hospital were lower than actual conversion factors, since the utilization of heath service has been increased. However, there was no big difference between estimated conversion factors and actual conversion factors of the general hospital and the clinic. Eventually this fee adjustment model could estimate proper conversion factor reflecting health service volume. Conclusion: This model may be applicable to the mechanism as determining conversion factor between insurer and provider via negotiation and controling growth in health expenditures.

• Korean Journal of Medicinal Crop Science
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• v.28 no.2
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• pp.111-118
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• 2020

Background: Cnidium officinale is a medicinal crop sensitive to high temperature. It is necessary to develop environment control technology that can reduce environmental stresses such as high temperature. This study was conducted to develop technology for stable production of Cnidium officinale by reducing damage owing to high temperature by applying shading treatment of varying duration, and structure. Methods and Results: Black shading nets were used from May to September or November; shading structures such as pillar, flat roof, and tunnel type structures were installed. Environmental changes, rate of photosynthesis, and growth characteristics were investigated. The shading treatment reduced temperature by 3℃. The rate of photosynthesis and yield with shading treatment were higher by 134% and 127%, respectively, than those with full sunlight. The ratio of shading area ranged from 50% to 71% according to the type of shading structure. The effect of environmental control on growth varied depending on the type of shading structure. Conclusions: The shading treatment reduced damage owing to high temperature, shading rate of 55% - 75% was recorded between the period May - September, and the flat roof type shading structure was considered the most suitable among shading methods.

• Journal of Korean Society of Industrial and Systems Engineering
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• v.41 no.3
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• pp.170-175
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• 2018

While the term online shopping refers to all online transactions, cross-border online shopping means shopping activities purchasing products or services over the internet for the customers abroad. As Internet use for the international shopping activity increasing, cross border online shopping has grown substantially for last decade. This study is about the problem regarding the cross border online shopping for two different countries and the variables that influence their shopping behavior. The cross border online shopping has been increased by the growth of Internet access. However, the growth of the Internet use does not guarantee a successful development of cross border e-commerce for every country. To find out the perception for cross-border online shopping for two different cultures, shoppers from two countries with different cultural background were chosen, and the perception for cross-border online shopping from each culture is contrasted. For statistical Analysis, ANOVA is used to find the relationship between a single non-metric independent variable, and multiple metric dependent variables. Hofstede's cultural dimensions model is adopted for this study as a tool to find out the patterns of cross border online shopping. This study showed what the variables would affect the perception in cross border online shopping. The results of this study indicated that cross border online shoppers with different culture were notably different on two variables identified-timeliness and ease of use.

• Journal of Ginseng Research
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• v.42 no.3
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• pp.334-342
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• 2018

Background: Panax notoginseng is a highly valued medicine and functional food, whose quality is considered to be influenced by the size, botanical parts, and growth environments. Methods: In this study, a HPLC method integrating fingerprinting and determination of multiconstituents by single reference standard was established and adopted to investigate the chemical profiles and active constituent contents of 215 notoginseng samples with different sizes, from different botanical parts and geographical regions. Results: Chemical differences among main root, branch root, and rotten root were not distinct, while rhizome and fibrous root could be discriminated from other parts. The notoginseng samples from Wenshan Autonomous Prefecture and cities nearby were similar, whereas samples from cities far away were not. The contents of major active constituents in main root did not correlate with the market price. Conclusion: This study provided comprehensive chemical evidence for the rational usage of different parts, sizes, and growth regions of notoginseng in practice.