• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• v.20 no.1 s.32
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• pp.27-37
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• 2007

Background and Objective : Psoriasis is a chronic skin disease characterized by angiogenesis. It has been reported that growth factor as vascular endothelial growth factor (VEGF) and insulin-like growth factor (IGF)-II are overexpressed in psoriatic epidermis. This stydy was carried out for whether SB extracts have an anti-angiogenic effect for angiogenic factor. Method : To investigate the inhibitory effect of VEGF expression by the SB extracts, we performed MTS assay, western blots using HaCaT cells. HaCaT cells were pretreated with SB extracts for 1 hour followed by treatment with IGF-II. Result : SB extracts significantly reduced IGF-II induced HIF-1 ${\alpha}$ protein level via p53 and MAPK pathway in HaCaT cells. Also, SB extracts inhibited IGF-II induced VEGF mRNA and protein expression levels in the HaCaT keratinocytes. Conclusion : These results suggest that inhibition of HIF-1 ${\alpha}$ and VEGF expressions by SB extracts contributes to the anti-angiogenic effects.

• Journal of the Architectural Institute of Korea Planning & Design
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• v.34 no.10
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• pp.95-106
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• 2018

Currently, the way of providing housing in Korea has been regarded as public rental housing through large-scale development by the government. However, there is an increasing need for qualitative growth not only in quantitative growth but also in policies, systems, and sustainable design. The purpose of this study is to explore the applicable methods for domestic social housing through the policy and design guideline study of UK social housing which has achieved qualitative growth through diversification of development subject. First, the concept of social housing in the UK and sustainable housing design elements will be examined. Second, the characteristics and policy direction, project background, management and sustainability of five social housing projects over the last 10 years in the UK will be analyzed. In conclusion, in order to achieve the sustainable design of social housing, the construction of the social housing in terms of policy and environment must include safe and eco-friendly design adaptability that can secure local identity and respond flexibly to social change. In addition, the social housing in the UK, which forms a sustainable complex through cooperation between the public and the private sector based on its place and history, can be a guideline for establishing policies and design guidelines in terms of urban regeneration.

• The Journal of Asian Finance, Economics and Business
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• v.9 no.8
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• pp.81-88
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• 2022

For each country, the growth of the country is significantly associated with the growth of the manufacturing industry. Especially in the early stages of development, the manufacturing industry has greatly played a great role in creating great added value for society and economic development in that country. Starting from a country with a weak manufacturing background, Vietnam is gradually opening up and integrating into the global economy, which has brought many opportunities for manufacturing enterprises in particular and the enterprise community in general, making Vietnam one of the countries with large production activities in Southeast Asia and Asia. The study evaluates the factors affecting the financial performance of manufacturing enterprises through a case study in Hanoi, Vietnam. Using a survey sample of 235 enterprises operating in production and using quantitative analysis methods, the research results show that: Enterprises with high governance quality are enterprises with high economic efficiency or enterprises with low management capacity have low business efficiency. Moreover, large-scale enterprises often have many advantages in seeking profits and improving business efficiency. Finally, the study has some recommendations to improve corporate governance and growth, create a stronger business community and contribute more to Vietnam's economic development.

• Journal of The Korean Association of Information Education
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• v.19 no.1
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• pp.127-138
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• 2015

Finland is referred to the country which is conducting the most advanced education in the world with the excellent education policy and the outstanding education system. Historical background and geographical environment of between Finland and Korea is similar in many ways, since the lack of resources, Finland has focused on the fostering the human resources for the growth of the country like Korea. However, because of the recent PISA in 2012 indicated a sharp declined result than before, pointed out the lack of computer related education and national level implementation strategies for a software education of neighboring countries, the discussion on software education in Finland is increased. Thus, the coming 2016 year become a significant year to bring up the opportunity for national growth through software education, Finland government prepared the software education curriculum as a national common required curriculum which will be implemented from elementary school. In this study, we will look through the background of Finland's software education and curriculum, we are going to suggest which might be helpful to set the direction of software education curriculum.

• Archives of design research
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• v.14 no.4
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• pp.57-64
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• 2001

The Korea's automotive industry has been changed since 1990's for the global reform of the automotive industry even though the rapid growth of domestic market from the late 1980's to early 1990's The cultural understanding for an automobile in the Korea society has been relatively lacked by the political reason, which focused on the economic growth through the industrialization. This works as a limit which caused by the point of view which is concentrated into the automotive industry as an economy developing tool. As much as being observed in the advanced nations which have the long history and huge scale of the automotive industry, an automobile is not only a single product, but also a way of life which has a cultural background. It is possible to develop a competitive quality and design with an understanding the cultural background. And the most important thing to the Korean automotive industry is a uniqueness with the cultural character which is gained by the cultural understanding of automobile as in the public Therefore the contribution of infrastructure of Korean automotive industry and culture would become more important in the future.

• Asian Pacific Journal of Cancer Prevention
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• v.16 no.2
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• pp.613-619
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• 2015

Background: Hepatocellular carcinoma (HCC) is the commonest primary malignant cancer of the liver in the world. Insulin-like growth factor-1 (IGF-1) levels reflect hepatic function and are inversely correlated with the severity of background chronic liver disease. Objective: This study evaluated whether basal serum IGF-1 levels can predict prognosis of HCC patients according to different risks of disease progression. Materials and Methods: A total of 89 patients with hepatocellular carcinoma (HCC) were recruited in 3 groups: Group I, 30 HCC patients receiving sorafinib; Group II, 30 HCC patients with best supportive care; and Group III include 29 patients undergoing transcatheter arterial chemoembolization (TACE). All patients were investigated for serum levels of AST, ALP, Bb, Cr, BUN, AFP and IGF-I. Results: Patients with disease control had significantly higher baseline IGF-1 levels 210 (185-232.5) ng/mL (p value<0.01) than did patients without disease control. Low basal IGF-1 levels were associated with advanced HCC, such as multiple tumors and advanced stage, and low IGF-1 levels predicted shorter TTP and overall survival in patients treated with TACE. Conclusions: The levels of serum IGF-1, expressed as continuous values, may be helpful for accurately assessing hepatic function and the prognostic stratification of patients with HCC.

• Journal of Korean Society of Industrial and Systems Engineering
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• v.45 no.4
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• pp.210-216
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• 2022

The army is concerned about the decrease in enlistment resources due to the low birth rate and the weakening of military combat power due to the shortening of the military service period. Now, the military's quantitative growth is no longer limited and it is a time for qualitative growth. To this end, the Army has been applying the Israeli learning method Havruta to recruit training to improve the quality of training since 2019. After applying Havruta, several scholars have studied the effect of recruit training applying Havruta. As a result, it was verified that recruit training applying Havruta improves the inner motive, creativity, and military service value of trainees. This study investigated how trainees' inner motive, creativity, and military service value affect their satisfaction and achievement. In addition, it was studied whether the effect of recruit training applied with Havruta on achievement differs according to the educational background (high school graduate or higher) and military family (professional soldiers within 4th degree) of the trainees. To this end, a survey was conducted on 472 recruits, and the structural relationship between each variable and the moderating effect were analyzed using the structural equation model. As a result of the study, military service value did not affect training satisfaction. Also, there was a difference in the effect of creativity on training satisfaction according to the educational background of new recruits, and there was a difference in the effect of military service value on training satisfaction and training achievement according to military family members. The purpose of this study is to contribute to the improvement of the army's recruit training development plan and effective training system.

• Proceedings of the Korean Society of Crop Science Conference
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• 2022.10a
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• pp.272-272
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• 2022

Water and phosphorus (P) fertilizer are two of the most critical inputs in rice cultivation. Under climate change scenarios and urbanization, irrigation and fertilizer are becoming limiting factors often leading to significant decrease in yield whenever supplied scarcely. It has been shown that the Pup1 QTL confers tolerance to P starvation and improved early-stage root vigor in indica rice grown in the tropics. However, whether the QTL works in japonica rice genetic background grown in temperate regions remains to be elucidated. Here, we have introgressed the Pup1 QTL into three temperate rice varieties MS11, TR22183, and Dasan using marker-assisted backcrossing and next generation sequencing. The selected lines all harbored the full Pup1 QTL with recurrent parent genome recovery rates ranging from 66.5% to 99.8%. Evaluation of the introgression rice lines grown in South Korea under low inputs of P and water revealed early vegetative growth advantage relative to that of the recurrent parents. Under rainfed condition, Pup1 introgression lines had yield advantage ranging from 7.2 to 19.9% and 24 to 26% in P non-supplied soil and P-supplied soil, respectively compared to that of the recurrent parents suggesting that Pup1 confers enhanced yield under low P and water inputs in temperate rice genetic background grown in temperate climate. In terms of early vegetative growth, temperate Pup1 introgression lines showed a similar trend on the extent to which Pup1 promotes yield advantage in temperate rice in comparison with indica control Pup1 introgression line IR64-Pup1.

• Journal of Korean Society of Occupational and Environmental Hygiene
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• v.20 no.3
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• pp.184-191
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• 2010

Although the usage of nanomaterials including carbon nanotubes (CNTs) has increased in various fields, scientific researches on workers' exposures and controls of these materials are very limited. The purpose of this study was to compare the airborne nanoparticles concentrations from two university laboratories conducting experiments of CNTs growth based on containment of thermal chemical vapor deposition (CVD). Airborne nanoparticle concentrations in three metrics (surface area concentration, particle number concentration, and mass concentrations) were measured by task using three direct reading instruments. In a laboratory where CVD was not contained, the surface area concentration, number concentration and mass(PM$_1$) concentration of airborne nanoparticles were 1.5 to 3.5 times higher than those in the other laboratory where CVD was confined. The ratio of PM$_1$ concentration to total suspended particles(TSP) in the laboratory where CVD was not confined was about 4 times higher than that in the other laboratory. This indicates that CVD is a major source of airbone nanoparticles in the CNTs growth laboratories. In conclusion, researchers performing CNTs growth experiments in these laboratories were exposed to airborne nanoparticles levels higher than background levels, and their exposures in a laboratory with the unconfined CVD were higher than those in the other laboratory with the confined CVD. It is recommended that in the CNTs growth laboratories adequate controls including containment of CVD be implemented for minimizing researchers' exposures to airborne nanoparticles.

• Korean Journal of Medicinal Crop Science
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• v.27 no.6
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• pp.383-389
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• 2019

Background: Ginseng has been used as a medicine and functional food since ancient times. It is a perennial crop, and its whose commercial valuse increases with growing period and is affected by the atmosphere and soil environment. Methods and Results: In a selected field, we measured air temperature under a shade structure and soil physicochemical properties, and determied plant and root growth as well as ginsenoside and total polyphenol content of one- to five-year-old ginsengs plants. Although air temperature above 30℃ was recored for more than 37 days, no marked growth inhibition of ginseng was detected. Among all soil physicochemical properties, except for pH, were within the allowable range the shortage increases with ginseng years. In five-year-old ginseng, the quantity is about 9.7% higher than the average weight by standard, indicating that is not affected by temperature when grown under a shade structure. Three-year-old ginseng contained the highest total ginsenoside and total polyphenol levels and exhibited the greatest DPPH radical scavenging activity. Conclusions: The total ginsenoside and protopanaxadiol/protopanaxatriol ratio were both low at five-year-old ginseng plants, which was attributed to rapid growth of the root system in five-year-oid plants. There were no significant differences in total polyphenol content and antioxidant activity between.