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http://dx.doi.org/10.7314/APJCP.2015.16.2.613

Predictive Value of Serum Insulin-like Growth Factor-1 in Hepatocellular Carcinoma  

Elmashad, Nehal (Clinical Oncology, University of Tanta)
Ibrahim, Wesam Salah (Clinical Pathology, University of Tanta)
Mayah, Wael Wahid (Tropical Medicine and Infectious Disease, University of Tanta)
Farouk, Mohamed (Alexandria Clinical Oncology Department, Faculty of Medicine, University of Alexandria, King Abdulaziz University)
AboAli, Lobna (Tropical Medicine and Infectious Disease, University of Tanta)
Taha, Atef (Internal Medicine, University of Tanta)
Elmashad, Wael (Physiology Department, University of Tanta)
Publication Information
Asian Pacific Journal of Cancer Prevention / v.16, no.2, 2015 , pp. 613-619 More about this Journal
Abstract
Background: Hepatocellular carcinoma (HCC) is the commonest primary malignant cancer of the liver in the world. Insulin-like growth factor-1 (IGF-1) levels reflect hepatic function and are inversely correlated with the severity of background chronic liver disease. Objective: This study evaluated whether basal serum IGF-1 levels can predict prognosis of HCC patients according to different risks of disease progression. Materials and Methods: A total of 89 patients with hepatocellular carcinoma (HCC) were recruited in 3 groups: Group I, 30 HCC patients receiving sorafinib; Group II, 30 HCC patients with best supportive care; and Group III include 29 patients undergoing transcatheter arterial chemoembolization (TACE). All patients were investigated for serum levels of AST, ALP, Bb, Cr, BUN, AFP and IGF-I. Results: Patients with disease control had significantly higher baseline IGF-1 levels 210 (185-232.5) ng/mL (p value<0.01) than did patients without disease control. Low basal IGF-1 levels were associated with advanced HCC, such as multiple tumors and advanced stage, and low IGF-1 levels predicted shorter TTP and overall survival in patients treated with TACE. Conclusions: The levels of serum IGF-1, expressed as continuous values, may be helpful for accurately assessing hepatic function and the prognostic stratification of patients with HCC.
Keywords
Hepatocellular carcinoma; IGF-1; prognosis; serum factors;
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