• Title/Summary/Keyword: Group practice

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Improvement Effect of Non-alcoholic Fatty Liver Disease by Curcuma longa L. Extract (강황 추출물의 비알코올성 지방간 질환 개선 효과)

  • Lee, Young Seob;Lee, Dae Young;Kwon, Dong Yeul;Kang, Ok Hwa
    • Korean Journal of Medicinal Crop Science
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    • v.28 no.4
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    • pp.276-286
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    • 2020
  • Background: Non-alcoholic fatty liver disease (NAFLD) is a chronic liver disease associated with multiple metabolic disorders. The medicinal plant Curcuma longa L. is widely distributed in Asia and has been used to treat a spectrum diseases in clinical practice. To date, there are inadequate reports of the effects of C. longa 50% EtOH extract (CE) on NAFLD. Therefore, in this study, we evaluate the CE on an NAFLD animal and elucidate the mechanism of action. Methods and Results: C57BL/6J mice fed a methionine-choline deficient diet (MCD) were treated with CE or milk thistle, and changes in inflammation and stetosis were assessed. Experimental animals were divided into six group (n = 10); Normal, MCD, MCD + CE 50 mg/kg/day (CE 50), MCD + CE 100 mg/kg/day (CE 100), MCD + CE 150 mg/kg/day (CE 150), and the Control, MCD + Milk thistle 150 mg/kg/day (MT 150). Body weight, liver weight, liver function, and histological changes were assessed in experimental animals. Quantitative real-time polymerase chain reaction and western blot analyses were performed on samples collected after 4 weeks of treatment. We observed that CE administration improved MCD-diet-induced lipid accumulation, and triglyceride (TG) and total cholesterol (TC) levels in serum. Treatment with CE also decreased hepatic lipogenesis through modulation of the sterol regulatory element binding protein-1 (SREBP-1), CCAAT-enhancer binding protein α (C/EBPα), fatty acid synthase (FAS), and peroxisome proliferator-activated receptor γ (PPARγ) expresion. In addition, the use of CE increased adenosine monophosphate-activated protein kinase (AMPK) phosphorylation and inhibited the up-regulation of toll-like receptor (TLR)-2 and TLR-4 signaling and the production of inflammatory mediators. Conclusions: In this report, we observed that CE regulated lipid accumulation in an MCD dietinduced NAFLD model by decreasing lipogenesis. These data suggeste that CE could effectively protect mice against MCD-induced NAFLD, by inhibiting the TLR-2 and TLR-4 signaling cascades.

Development and Evaluation of Korean Diagnosis Related Groups: Medical service utilization of inpatients (한국형 진단명기준환자군의 개발과 평가: 입원환자의 의료서비스 이용을 중심으로)

  • Shin, Young-Soo;Lee, Young-Seong;Park, Ha-Young;Yeom, Yong-Kwon
    • Journal of Preventive Medicine and Public Health
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    • v.26 no.2 s.42
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    • pp.293-309
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    • 1993
  • With expanded and extended coverage of the national medical insurance and fast growing health care expenditures, appropriateness of health service utilization and quality of care are concerns of both health care providers and insurers as well as patients. An accurate patient classification system is a basic tool for effective health care policies and efficient health services management. A classification system applicable to Korean medical information-Korean Diagnosis Related Groups (K-DRGs)-was developed based on the U.S. Refined DRGs, and the performance of the developed system was assessed in this study. In the process of the development, first the Korean coding systems for diagnoses and procedures were converted to the systems used in the definition of the U.S. Refined DRGs using the mapping tables formulated by physician panels. Then physician panels reviewed the group definition, and identified medical practice patterns different in two countries. The definition was modified for the differences in K-DRGs. The process resulted in 1,199 groups in the system. Several groups in Refined DRGs could not be differentiated in K-DRGs due to insufficient medical information, and several groups could not be defined due to procedures which were not practiced in Korea. However, the classification structure of Refined DRGs was retained in K-DRGs. The developed system was evaluated fur its performance in explaining variations in resource use as measured by charges and length of stay(LOS), for both all and non-extreme discharges. The data base used in this evaluation included 373,322 discharges which was a random sample of discharges reviewed and payed by the medical insurance during the five-month period from September 1990. The proportion of variance in resource use which was reduced by classifying patients into K-DRGs-r-square-was comparable to the performance of the U.S. Refined DRGs: .39 for charges and .25 for LOS for all discharges, and .53 for charges and .31 for LOS for non-extreme discharges. Another measure analyzed to assess the performance was the coefficient of variation of charges within individual K-DRGs. A total of 966 K-DRGs (87.7%) showed a coefficient below 100%, and the highest coefficient among K-DRGs with more than 30 discharges was 159%.

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Effects of Dietary Green Tea on Egg Storage in Laying Hens Under Stress (녹차의 급여가 스트레스하의 산란계가 생산한 계란의 저장성에 미치는 영향)

  • Kim, Jimin;Yoon, Hyung-Sook;Choi, Yang-Ho
    • Korean Journal of Organic Agriculture
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    • v.22 no.4
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    • pp.815-823
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    • 2014
  • Green tea has been known to show beneficial effects on alleviating stress. The present study was conducted to determine the effects of dietary green tea on quality of eggs, during storage, laid by laying hens treated with corticosterone in order to mimic the current practice of the egg market. Hens were fed for 2 weeks one of three diets containing green tea at 0.0, 0.4 or 1.0%. Each dietary group was divided into two subgroups receiving corticosterone at 0 or 30 mg/kg for 1 week. Eggs, laid at 5-7 days following the initiation of corticosterone treatment, were stored at $10^{\circ}C$ for 1 or 5 weeks and then analyzed for egg quality. After 1 week of storage, egg weight was significantly increased by green tea (p<0.025) but decreased by corticosterone (p<0.0001), but no interaction was observed between both. Corticosterone decreased shell color (p<0.0001) but green tea significantly decreased shell strength (p<0.006). Yolk color, albumen height and Haugh unit were not affected by both treatments. After 5 weeks of storage, corticosterone resulted in reduced egg weight (p<0.01) and eggshell color (p<0.001) and increased shell strength, which were not attenuated by green tea. Taken together, the results of the current study show that dietary corticosterone reduces egg quality during storage, which are attenuated in part by dietary green tea.

Anti-fibrotic effects of Orostachys japonicus A. Berger (Crassulaceae) on hepatic stellate cells and thioacetamide-induced fibrosis in rats

  • Koppula, Sushruta;Yum, Mun-Jeong;Kim, Jin-Seoub;Shin, Gwang-Mo;Chae, Yun-Jin;Yoon, Tony;Chun, Chi-Su;Lee, Jae-Dong;Song, MinDong
    • Nutrition Research and Practice
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    • v.11 no.6
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    • pp.470-478
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    • 2017
  • BACKGROUND/OBJECTIVE: Orostachys japonicus A. Berger (Crassulaceae) has been used in traditional herbal medicines in Korea and other Asian countries to treat various diseases, including liver disorders. In the present study, the anti-fibrotic effects of O. japonicus extract (OJE) in cellular and experimental hepatofibrotic rat models were investigated. MATERIALS/METHODS: An in vitro hepatic stellate cells (HSCs) system was used to estimate cell viability, cell cycle and apoptosis by MTT assay, flow cytometry, and Annexin V-FITC/PI staining techniques, respectively. In addition, thioacetamide (TAA)-induced liver fibrosis was established in Sprague Dawley rats. Briefly, animals were divided into five groups (n = 8): Control, TAA, OJE 10 (TAA with OJE 10 mg/kg), OJE 100 (TAA with OJE 100 mg/kg) and silymarin (TAA with Silymarin 50 mg/kg). Fibrosis was induced by treatment with TAA (200 mg/kg, i.p.) twice per week for 13 weeks, while OJE and silymarin were administered orally two times per week from week 7 to 13. The fibrotic related gene expression serum biomarkers glutathione and hydroxyproline were estimated by RT-PCR and spectrophotometry, respectively, using commercial kits. RESULTS: OJE (0.5 and 0.1 mg/ mL) and silymarin (0.05 mg/mL) treatment significantly (P < 0.01 and P < 0.001) induced apoptosis (16.95% and 27.48% for OJE and 25.87% for silymarin, respectively) in HSC-T6 cells when compared with the control group (9.09%). Further, rat primary HSCs showed changes in morphology in response to OJE 0.1 mg/mL treatment. In in vivo studies, OJE (10 and 100 mg/kg) treatment significantly ameliorated TAA-induced alterations in levels of serum biomarkers, fibrotic related gene expression, glutathione, and hydroxyproline (P < 0.05-P < 0.001) and rescued the histopathological changes. CONCLUSIONS: OJE can be developed as a potential agent for the treatment of hepatofibrosis.

Successful Marriage Adaptation of Korean Husbands Who are Multicultural Families (다문화가정 한국인 남편의 성공적인 결혼적응)

  • Jeong, Hye-Won
    • The Journal of the Korea Contents Association
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    • v.17 no.5
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    • pp.337-356
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    • 2017
  • The purpose of the research is to explore the main cause and effect of successful marriage that Korean husbands, who are multicultural families had. To do the research, the experiment has been done with 7 husbands for 2 months. The 7 husbands took depths interview and analyzed the result by grounded theory approach. As a result, the husband experienced 'repentance of marriage' because of 'unready marriage', but 'Raising children', 'Helping housework' and 'recognition from friends and colleague' have affected the husbands to have a successful marriage adaptation. Based on the result, a political and practical proposal has been proposed to the Korean husbands who are multi-cultural family. Here are the examples of the proposal. As a social welfare policy, 'obligation of information offering for prospective spouse', 'following the Labor Standards and parental leave', 'expansion of visiting supervise system' and 'making guidance for husbands and distribute map of Immigration Office, Multicultural Family Support Center and Community Center' have proposed. And as an alternative plan for a practical social welfare policy and continuous social awareness improvement, 'various education program', 'a program with domestic married couple', 'a program with parents-in-law', 'a specific program to increase the housework participation for husbands' and necessity of development and practice of group program for husband have been emphasized.

The association of PBX1 polymorphisms with overweight/obesity and metabolic alterations in the Korean population

  • Ban, Ju-Yeon;Kang, Soon-Ah;Jung, Kyung-Hee;Kim, Hak-Jae;Uhm, Yoon-Kyung;Kim, Su-Kang;Yim, Sung-Vin;Choe, Bong-Keun;Hong, Seung-Jae;Seong, Yeon-Hee;Koh, In-Song;Chung, Joo-Ho
    • Nutrition Research and Practice
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    • v.2 no.4
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    • pp.289-294
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    • 2008
  • Pre-B-cell leukemia transcription factor 1 (PBX1), which is located on chromosome 1q23, was recently reported to be associated with type 2 diabetes mellitus. We examined whether single nucleotide polymorphisms (SNPs) of the PBX1 gene are associated with overweight/obesity in a Korean population. We genotyped 66 SNPs in the PBX1 gene and investigated their association with clinical phenotypes found in 214 overweight/obese subjects and 160 control subjects using the Affymetrix Targeted Genotyping chip array. Seven SNPs (g.+75l86C>T, g.+78350C>A, g.+80646C>T, g.+138004C>T, g.+185219G>A, g.+191272A>C, and g.+265317T>A) were associated with the risk of obesity in three models (codominant, dominant, and recessive) (P=0.007-0.05). Haplotype 1 (CAC) and 3 (TAC) of block 3 and haplotype 2 (GGAAT) of block 10 were also strongly associated with the risk of obesity. In the control group, subjects that had homozygote for the major allele for both g.+185219G>A and g.+191272A>C showed lower high density lipoprotein-cholesterol (HDL-C) level compared to those possessing the minor allele, suggesting that the association between the homozygote for the major allele for both g.+185219G>A and g.+191272A>C and HDL-C is attributable to the increased risk of obesity. This study suggests that the PBX1 gene is a possible risk factor in overweight/obese patients.

"Poor Theatre, Poor Art" - Jerzy Grotowsky's Play and Arte Povera ('가난한 연극, 가난한 미술' - 그로토프스키 연극이론과 아르테 포베라)

  • Kang, Young-Joo
    • The Journal of Art Theory & Practice
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    • no.5
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    • pp.109-133
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    • 2007
  • What a concept of theatricality in modern art became more controversial is through a review "art and object-hood" on Michael Fried's minimal art, as having been already known broadly. As he had been concerned, the art following the minimalism is accepting as the very important elements such as the introduction of temporality, the stage in the exhibition space, and the audience's positive participation, enough to be no exaggeration to say that it was involved in almost all the theatricality. Particularly even in the installation art and the environment art, which have substantially positioned since the 1970s, the space is staged, and the audience's participation is greatly highlighted due to the temporal character and the site-specific in works. In such way, the theatricality in art work is today regarded as one of the most important elements. In this context, it is thought to have significance to examine theatricality, which is shown in the works of Arte Povera artists, who had been active energetically between 1967-1971. That is because the name of this group itself is what was borrowed from "Poor Theatre" in Jerzy Grotowski, who is a play director and theorist coming from Poland, and because of having many common points in the aspect of content and form. It reveals that the art called Arte Povera is sharing many critical minds in the face of commanding the field called a play and other media. Grotowski's theatre theory is very close to the theory and substance in Arte Povera in a sense that liberates a play, which was locked in literature, above all, renews the relationship between stage and seat and between actor and audience, and pursues a human being's change in consciousness through this. That is because Arte Povera also emphasizes the communication with the audience through appealing to a human being's perception and through the direct and living method, not the objective art concept of centering on the work. In addition, the poor play or poor art all has tendency that denies a system, which relies upon economic and cultural system, and seeks for what is anti-cultural, elemental, and fundamental. It is very similar even in a sense that focuses on the exploration process itself rather than the result, excludes the transcendental concept, and attaches importance to empiricism. However, Arte Povera accepts contradictoriness and complexity, and suggests eclecticism and tolerance, thereby being basically the nomadic art and the art difficult to be captured constitutively. On the other hand, there is difference in a sense that the poor play is characterized by purity, asceticism, seriousness, and solemnity. If so, which significance does this theatricality, which was introduced to art, ultimately have? As all the arts desire to be revealed with invisible things beyond the visual thing, theatricality comes to play a very important role at this time. If all the artists and audiences today came to acquire actual or virtual freedom much more, that can be said to be a point attributable to that art relied upon diverse conditions in a play.

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A Study on the Oral Health and Status in Diabetic Patients - Based on Data of 2006 National Oral Health Survey - (일부 당뇨병환자의 구강건강 및 관련실태 - 2006국민구강실태조사 자료를 바탕으로 -)

  • Jung, Mee-Hee;Gwon, Mi-Young;Kim, Yoon-Shin
    • Journal of dental hygiene science
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    • v.9 no.5
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    • pp.571-577
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    • 2009
  • This research basically work on oral health condition of the diabetes patients with data from 2006 National oral Health Survey. Based on this data, this research will provide basic materials about developing program with necessity of Recognition and education of the oral health condition. Analysis with using SPSSWIN 12.0 makes some results on the below. First, Existence and nonexistence based on age division shows result that over 70 years old gets 39.8%, which is highest percentage(p<0.05). Second, In existence and nonexistence based on sex distinction and age division, Women gets higher percentage (60.8%) than percentage of the men (39.2%). Third. Both diabetes patient and control group answered 'unhealthy' about subjective recognition of the oral health condition. Forth, percentage of caries on permanent tooth 12 92.0% for diabetes patient (p<0.05). Fifth, Answer about periodontal structure of diabetes patient is 88.9% of blooding periodontal structure(p<0.05). Sixth, Result of the demand of caries and periodontal structure treatment from diabetes patients show that diabetes patient does not feel necessity about treatment although they gets hardship of chewing. Also, it does not show any statistical difference. Seventh, Results of the oral health practice based on demographic characteristics are eating snack(highest answer). Latest visiting dental hospital before 1 year ago, or long before this. Frequencies of brushing tooth are less than 3 times. Also, il does not show any statistical difference.

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Population Characteristics Influencing Treatment Service Use among Individuals with Drug Dependency (마약류 의존자 치료재활 서비스 이용에 영향을 미치는 개인적 특성에 관한 연구)

  • Kim, Nang-hee
    • Korean Journal of Social Welfare Studies
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    • no.39
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    • pp.395-423
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    • 2008
  • This study investigated population characteristics that influencing treatment service use of people who are voluntarily using drug dependency treatment services by using logistic and hierarchical regression analysis. The research model of the current study was driven by the framework of the 'the Behavioral Model of Health Services Use(the Andersen model)' that has been broadly applied to study on health behavior. This study used data from a sample group of 80 adults by using purposive sampling. This study found that some predisposing factors, enabling factors and need factors have direct effects on service use. In detail, individuals who graduated from high school use drug dependency treatment utilities more than those who did not. Further, individuals who were given more support from family, peers, or others, use the treatment utilities more frequently and were more willing to use the utilities continuously. Furthermore, the greater the perceived need felt by the dependent, the greater the tendency to enter hospitals or shelters. The important implications of this study for social work practice and social policy can be summarized as follows: first, this study supports the idea that intervention for drug dependents in Korea should be focused on environment resources rather than population characteristics; and government must support drug dependent treatment systems; the present study was the first to investigate Korean drug dependents through taking a more positive view, as well as the first to apply 'the Behavioral Model of Health Services Use', and as such represents an example of how studies could be productively conducted in the future. Despite these implications, there remain some limitations in this study. These include the following: limitation in generalizability of the results; the cross-sectional nature of the study design; survey research through the questionnaire method; using foreign scales; and the difficulty of classifying treatment settings.

A Longitudinal Study of Factors Associated with Happiness in Primary School Children (학령기 아동의 행복감에 영향을 미치는 요인에 대한 종단 연구)

  • Lee, Jae-Kyeong;Cho, Hye-Chung
    • Journal of the Korean Society of Child Welfare
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    • no.40
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    • pp.41-71
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    • 2012
  • The purpose of this study is to examine longitudinal impacts of various factors on happiness in primary school children. Specifically, attachment theory and ecosystems perspective were utilized for the purpose of this study. We used Korea Youth Panel Survey, which is a 5-year longitudinal data collected from fourth grade in elementary school to second grade in middle school Latent growth model was employed as the analytic method. The findings of this study are as follow: first, academic achievement, self-esteem, parent attachment, peer attachment, teacher attachment, and community attachment all decreased over the 5-year study period. Also, the intercept and the slope variance of variables were found to be statistically significant. This means that there are significant differences in the intercept and the slope of individuals. Second, self-esteem, parent attachment, and peer attachment were found to have cross-sectional influences on happiness. This means that self-esteem, parent attachment, and peer attachment are positively associated with happiness at the intercept. Also, self-esteem, parent attachment, teacher attachment, and community attachment were found to have longitudinal influences on happiness. This means that the higher levels of community attachment at the intercept is associated with slower the rate of decrease in happiness at the slope. In addition, faster rates of decrease in self-esteem, parent attachment, teacher attachment, and community attachment are associated with faster the rate of decrease in happiness. Third, this study conducted multiple group analysis with gender. The findings of this analysis revealed no significant differences in analytic models between males and females. Based on these findings, theoretical and practice implications with regard to happiness in primary school children are discussed.