• Molecules and Cells
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• 제42권12호
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• pp.893-905
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• 2019

Mitochondria are highly dynamic organelles that constantly undergo fission and fusion processes that closely related to their function. Disruption of mitochondrial dynamics has been demonstrated in acute kidney injury (AKI), which could eventually result in cell injury and death. Previously, we reported that augmenter of liver regeneration (ALR) alleviates renal tubular epithelial cell injury. Here, we gained further insights into whether the renoprotective roles of ALR are associated with mitochondrial dynamics. Changes in mitochondrial dynamics were examined in experimental models of renal ischemia-reperfusion (IR). In a model of hypoxia-reoxygenation (HR) injury in vitro, dynamin-related protein 1 (Drp1) and mitochondrial fission process protein 1 (MTFP1), two key proteins of mitochondrial fission, were downregulated in the Lv-ALR + HR group. ALR overexpression additionally had an impact on phosphorylation of Drp1 Ser637 during AKI. The inner membrane fusion protein, Optic Atrophy 1 (OPA1), was significantly increased whereas levels of outer membrane fusion proteins Mitofusin-1 and -2 (Mfn1, Mfn2) were not affected in the Lv-ALR + HR group, compared with the control group. Furthermore, the mTOR/4E-BP1 signaling pathway was highly activated in the Lv-ALR + HR group. ALR overexpression led to suppression of HR-induced apoptosis. Our collective findings indicate that ALR gene transfection alleviates mitochondrial injury, possibly through inhibiting fission and promoting fusion of the mitochondrial inner membrane, both of which contribute to reduction of HK-2 cell apoptosis. Additionally, fission processes are potentially mediated by promoting tubular cell survival through activating the mTOR/4E-BP1 signaling pathway.

• 한국정보시스템학회:학술대회논문집
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• 한국정보시스템학회 2003년도 춘계학술대회
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• pp.241-251
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• 2003

The rapidly changing environment have forced organizations to improve systems thinking capability to coordinate diverse activities across cross-functional business areas necessarily involving group decision-making processes. Although many approaches have been introduced to enable the collaborative processes of group decision-making, they often lack features supporting the dynamic complexity issues. The study proposes system dynamics modeling based on simulation techniques to improve systems thinking capability in group decision-making context.

• 한국수소및신에너지학회논문집
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• 제17권4호
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• pp.403-408
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• 2006

The plate reformer consisting of combustion chamber and reforming chamber for 25 kW MCFC stack has been operated and computational fluid dynamics was applied to estimate reactions and thermal fluid behavior in the reformer. The methane air 2-stage reaction was assumed in the combustion chamber, and three step steam reforming reactions were included in the calculation. Flow uniformity, reaction rate and species distribution, and temperature distribution were analyzed. In particular, temperature distribution was compared with the measurements to show good agreement in the combustion chamber, however, inappropriate agreement in the reformer chamber.

• Design & Manufacturing
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• 제13권3호
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• pp.41-47
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• 2019

In conventional machining, the use of cutting fluid is essential to reduce cutting heat and to improve machining quality. However, to increase the performance of cutting fluids, various chemical components have been added. However, these chemical components during machining have a negative impact on the health of workers and cutting environment. In current machining, environment-friendly machining is conducted using MQL (minimum quantity lubrication) or cryogenic air spraying to minimize the harmful effects. In this study, the injection nozzle that can combined injecting minimum quantity lubrication(MQL) and cryogenic gas was designed and the shape optimization was performed by using computational fluid dynamics(CFD) and design of experiment(DOE). Performance verification was performed for the designed nozzle. The diameter of the sprayed fluid at a distance of 30 mm from the nozzle was analyzed to be 21 mm. It was also analyzed to lower the aerosol temperature to about 260~270K.

• 한국자기공명학회논문지
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• 제4권1호
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• pp.29-40
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• 2000

Coupled carbon-13 relaxation study of 1,1,1-trichloroethane dissolved in DMSO has been performed to gain some crucial insight into the dynamics of methyl group in this compound. For this purpose the relaxation behaviors of several observable magnetization modes for CH3 spin system generated by various perturbing pulse sequences have been carefully investigated and various dipolar spectral densities were estimated by nonlinear numerical fittings of the observed data with the relaxation curves, which were then employed to determine the three principal values for the diffusion tensor for end-over-end molecular rotation as well as internal rotational parameters of methyl group. In this process we could uniquely determine two correlation times $\tau$int(1) and $\tau$int(2) which give valuable information on internal rotor dynamics and thus obtained data were interpreted on the basis of various proposed models for internal rotation. compound undergoes three-fold jumps at 25$^{\circ}$. The fact that the ratio $\tau$int(1) / $\tau$int(2) is close to 1.0 may be interpreted as indicating that methyl group in this C.

• 한국정밀공학회:학술대회논문집
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• 한국정밀공학회 2005년도 춘계학술대회 논문집
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• pp.686-689
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• 2005

A numerical simulation method is developed to analyze the dynamic response of a cantilever switch, which is driven by electrostatic force and a basic component of electro-mechanical coupled system. First, point-charges model on conductor is proposed as a lumped parameter of electrical part. Then, this model is easily incorporated into a multi-body dynamics analysis algorithm, the generalized recursive dynamics formula previously developed by our research group. The resulting motion of a coupled overall system is formulated as a differential algebraic equation form including electrical and mechanical variables together. The equation is simultaneously solved in every time step. To implement this approach into the useful dynamics analysis tool, we used multibody dynamics software (RecurDyn) based on the generalized recursive formula using relative coordinate. The developed numerical simulation tool is evaluated by applying to many different driving condition and switch configuration. The final analysis model will be added to RecurDyn as a basic module for dynamics analysis of electro-mechanical coupled system.

• Journal of the Optical Society of Korea
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• 제1권1호
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• pp.15-18
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• 1997

Intensity dependent dynamics of photoinduced absorption in $CdS_{0.4}$/$Se_{0.6}$ semiconductor doped glasses below the band gap was investigated by using time-resolved differential transmittance spectroscopy. The carriers populated through ultrafast trapping at semiconductor-glass interfaces give rise to a broad photoinduced absorption below the band gap. The decay time of transient absorption depends strongly on the excitation intensity. Based on our results, the physical mechanism for photoinduced absorption processes was suggested.

• Asian Journal of Innovation and Policy
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• 제3권1호
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• pp.25-49
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• 2014

We wanted to show the different group dynamics of factors for success and failure cases for technology commercialization in small technology-based firms. Existing studies are based on product level, project level, division level or firm level. We deal with technology level, and at small-technology-based firms. This is a longitudinal case study based on 8 cases from Korea. Our study on technology level is a first trial in success and failure studies unlike all existing studies. As a first step, we introduced new categories and factors such as technology attributes and CEO reflecting data, and especially a new concept of launch readiness level. Finally, we adopted correspondence analysis to show the group dynamics. The results are as follows; Technology factors are the most important factors. Second, resource-based factors are more critical in failure cases than success cases and technology factors are more critical to success.

• Structural Engineering and Mechanics
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• 제8권3호
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• pp.257-272
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• 1999

In this paper a simple finite element is proposed for analyzing out of plane vibration of thin walled curved beams, with both open and closed sections, considering shear flexibility. The present element is obtained from a variational formulation governing the dynamics of a three-dimensional elastic body in which the stress tensor as well as the displacements are variationally independent. The element has two nodes with four degrees of freedom in each. Numerical examples for the first six frequencies are performed in order to assess the accuracy of the finite element formulation and to show the influence of the shear flexibility on the dynamics of the member.

• 한국정보통신학회:학술대회논문집
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• 한국정보통신학회 2021년도 추계학술대회
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• pp.586-589
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• 2021

본 논문에서는 RT(Robot Technology) 및 관련 산업을 중심으로 현대자동차그룹의 21세기를 이끌어갈 새로운 중추 산업 로봇기술의 보스턴 다이내믹스 M&A를 통해 모빌리티 분야에 현대자동차의 선진사례와 기술을 소개한다.