• 환경위생공학
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• 제22권2호
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• pp.75-84
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• 2007

A lysine determination method for low quantity of rice was modified from the original Dye-Binding Lysine (DBL) method used in the national standard in China [GB 4801-84, 1984]. By making use of the property that lysine does not bind to the crocein orange G dye after treated with propionic anhydride, the amount of lysine in rice samples could be determined directly by calculating the difference between the absorbances of the treated and the untreated samples. Various commercial rice samples were purchased from market and evaluated. Several methods were tested by varying both the sizes of the samples and the concentrations of the dye solutions. Results showed that when using 1.284 mM of crocein orange G dye solution and 15.5 mg of sample, the results were most reproducible. The corresponding lysine content in sample were $3.36\;{\pm}\;0.09\;mg/g$ and $3.35\;{\pm}\;0.19\;mg/g$ by traditional method and modified method, respectively. Statistically, there was no significant difference between the results (p>0.05).

• Tribology and Lubricants
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• 제33권3호
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• pp.92-97
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• 2017

The understanding of the friction characteristics of micro-textured surface is of great importance to enhance the tribological properties of nano- and micro-devices. We fabricate rectangular patterns with submicron-scale structures on a Si wafer surface with various pitches and heights by using a focused ion beam (FIB). In addition, we fabricate tilted rectangular patterns to identify the influence of the tilt angle ($45^{\circ}$ and $135^{\circ}$) on friction behaviour. We perform the friction test using lateral force microscopy (LFM) employing a colloidal probe. We fabricate the colloidal probe by attaching a $10{\pm}1-{\mu}m$-diameter borosilicate glass sphere to a tipless silicon cantilever by using a ultraviolet cure adhesive. The applied normal loads range between 200 nN and 1100 nN and the sliding speed was set to $12{\mu}m/s$. The test results show that the friction behavior varied depending on the pitch, height, and tilt angle of the microstructure. The friction forces were relatively lower for narrower and deeper pitches. The comparison of friction force between the sub-micro-structured surfaces and the original Si surface indicate an improvement of the friction property at a low load range. The current study provides a better understanding of the influence of pitch, height, and tilt angle of the microstructure on their tribological properties, enabling the design of sub-micro- and micro-structured Si surfaces to improve their mechanical durability.

• 환경영향평가
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• 제16권2호
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• pp.107-120
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• 2007

The introduction of strategic environmental assessment (SEA) has strengthened and extended the value of environmental impact assessment (EIA) as a foundational tool for sustainable development. In particular, SEA helps to overcome the limitation of project EIA as a 'stand alone' approach, applied relatively late in the decision making cycle. SEA is applied to policy, plan and programme (3P) proposals, when major alternatives are open and systematic consideration can be given to their environmental effects. This process also corresponds to options appraisal of development proposal to find the best practical outcome having regard to all potential impacts. There are imperatives for sustainable development (SD) that are shaping future directions for EIA and SEA internationally, regionally and locally. There is a shift toward more integrative approaches of using EIA and SEA as sustainability tools in cooperated environmental management system (EMS). Korea has established and applied EIA for over twenty years for various projects. Given its coverage, the current EIA system is SEA exclusive. The Prior Environmental Review System (PERS), which is a SEA-type of system, was applied in the late 1990s, mainly for various developing planning programs. The current PERS has been modified as a SEA type system, but in general, policy is not going to be covered.

• 동의생리병리학회지
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• 제20권5호
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• pp.1211-1216
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• 2006

The effect of a chronic programme of either low- or moderate-to-high-intensity treadmill running on the activation of the Extracellular-signal regulated protein kinase (ERK1/2), Phosphorylated ERK 1/2(pERK1/2) and the Phosphorylated c-Jun N-terminal kinase(pJNK) pathways was determined in rat Back skin Hair follicle. Sprague-Dawley rats were assigned to one of three groups: (i) sedentary group(NE; n=10); (ii) low-intensity exercise group (Bm/min; LIE; n=10); and (iii) moderate-high-intensity exercise group(28m1min; HIE; n=10). The training regimens were planned so that animals covered the same distance and had similar utilization for both LIE and HIE exercise sessions. The report runs as follows; A single bout of LIE or HIE following 4 weeks of exercise led to a twofold increase in the phosphorylation of ERK2, pERK2 and a threefold increase in pJNKl, pERKl. ERKI phosphorylation in LIE Back skin sampled and pJNK2 in HIE Back skin sampled 48h after the last exercise bout was similar to sedentary values, while pJNK2 phosphorylation in LIE Back skin sampled was 70-80% lower than sedentary. 48h after the last exercise bout of LIE or HIE increased ERK2, pERKl and pJNKl expression, with the magnitude of this increase being independent of prior exercise intensity or duration. PERK1/2, pJNKl expression was increased Three- to fourfold in Back skin Hair follicle sampled 48h after the last exercise bout irrespective of the prior exercise programme, but ERKI expression in HIE Back skin sampled was approximately 90% lower than sedentary values. In conclusion, exercise-training of different jntensities/durations results in selective postexercise activation of intracellular signal pathways, which may be one mechanism regulating specific adaptations induced by diverse training programmes.

• 대한물리의학회지
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• 제6권1호
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• pp.81-92
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• 2011

Purpose : The purpose of this study was to compare combined exercise program group to conventional physiotherapy for patients with chronic neck pain. Methods : Participants were randomly allocated to two groups by experimental(n=17) and control(n=17). Combined exercise program group involved stretching, stability, strengthening and endurance, proprioceptive exercises along with an educational programme. Patient attended for 60min, three times a weeks. Control group was treated as conventional physiotherapy on 40 min, three times a weeks. Outcome variables included pain, disability, range of motion, fatigability at 0 and 6 weeks. Results : Pain, Disability Index, Fatigability significantly decreased(p<.05) and Range of motion improved significantly after active exercise program(p<.05). In conclusion. Combined exercise program improves pain and disability, range of motion, fatigability. Conclusion : These results suggest that combined exercise program is suitable for chronic neck pain.

• Communications for Statistical Applications and Methods
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• 제31권5호
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• pp.467-485
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• 2024

Policymakers and educational researchers have grown increasingly interested in the extent to which study results generalize across different groups of students. Current generalization research in education has largely focused on the compositional similarity among students based on a set of observable characteristics. However, generalization is defined differently across various disciplines. While the concept of compositional similarity is prominent in causal research, generalization among the statistical learning community refers to the extent to which a model produces accurate predictions across samples and populations. The purpose of this study is to assess the extent to which concepts related to contextual generalization (based on compositional similarity) are associated with the ideas related to model generalization (based on accuracy of prediction). We use observational data from the Programme for International Student Assessment (PISA) 2015 wave as a case study to examine the conditions under which contextual and model generalization are aligned. We assess the correlations between statistical measures that quantify compositional similarity and prediction accuracy and discuss the implications for generalization research.

• 한국생산제조학회지
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• 제26권3호
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• pp.272-277
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• 2017

CCTV image processing techniques have been developed for safety management in manufacturing sites. However, CCTV growth has become a social problem for video surveillance with regard to privacy. This study aims to manage the safety system efficiently and protect privacy simultaneously. In this study, the CCTV monitoring system is composed of five steps (accident monitoring, detection, notification, management, restoration). De-identified image is observed when we are in a normal situation. De-identified image changes to identified image when it detects an accident. As soon as it detects an accident, the accident information is sent to the safety administrator. Then the administrator could conduct safety measures. Afterward, accumulated accident data could be used for statistical data that could be utilized as analyzing expecting accident.

• 한국임상약학회지
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• 제22권1호
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• pp.21-29
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• 2012

Modern biologics are biotechnology-derived therapeutics, including recombinant therapeutic proteins like monoclonal antibodies, cytokines and tissue growth factors. Although the pharmacokinetics of therapeutic biologics should be evaluated based on the same general principles as small molecules, careful considerations should be given to bioanalytics and pharmacokinetics when designing pharmacokinetic studies of biologics during their drug development, due to their different physicochemical properties compared with small molecules. The aim of this study was to develop a draft guidance on pharmacokinetic studies of therapeutic biologics in clinical studies. All the elements outlined in the current Food and Drug Administration (FDA), European Medicinal Agency (EMEA), and International Conference on Harmonisation (ICH) guidelines and regulations, and the related literatures previously published were searched and evaluated. In this draft guidance, the specific problems related to the pharmacokinetics of therapeutic biologics that need special consideration during drug development process were addressed, and differences in pharmacokinetic characteristics between biologics and small molecules affecting the content of the development programme were presented.

• 한국엔터테인먼트산업학회논문지
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• 제13권1호
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• pp.199-206
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• 2019

연구목적은 동작관찰훈련이 뇌졸중 환자의 인지기능 향상에 영향을 미치는가를 알아보고자 하였다. 연구방법으로는 2018년 4월 23일부터 5월 18일까지 경인지역 병원에 입원 중인 재활환자 7명을 대상으로 MMSE-K와 LICA를 사용하여 평가를 진행하였고, 동작관찰프로그램으로는 상지 ROM 댄스, 풀 오버형 옷정리, 운동화 끈 묶기, 수건 개기, 양말 개기, 종이접기, 넥타이 매는 법 총 7가지 과제를 적용하였다. 통계프로그램으로는 SPSS version 20을 사용하였으며 기술통계, Wilcoxon signed ranks을 사용하여 값을 구하였다. 동작관찰훈련을 적용한 결과 MMSE-K 점수는 3.29±1.38의 변화량을 보여 p값 0.001로 유의한 값을 보였고, LICA 점수는 기억력에서 12.16±6.73으로 가장 유의한 값이 나왔다. 결론은 동작관찰훈련이 뇌졸중 환자의 인지기능 영역 중 기억력에서 가장 많은 영향을 미쳤으며, 다른 영역에서도 점수 향상은 있었으나 통계적으로 유의하지는 않았다. 앞으로 동작관찰훈련이 많이 사용되어 추후에는 뇌손상 부위별로 어느 영역에서 효과가 있는지에 대한 후속 연구가 이루어지길 바란다.

• Tribology and Lubricants
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• 제30권4호
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• pp.218-223
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• 2014

This paper presents a method of controlling the stiffness of a tungsten probe for an atomic force microscope (AFM) in order to provide high-quality phase contrast images in accordance with sample characteristics. While inducing sufficient deformation on sample surfaces with commercial Si or $Si_3N_4$ probes is difficult because of their low stiffness, a tungsten probe fabricated by electrochemical etching with appropriately high stiffness can generate relatively large elastic deformation without damaging sample surfaces. The fabrication of the tungsten probe involves two separate procedures. The first procedure involves immersing a tungsten wire with both ends bent parallel to the surface of an electrolyte and controlling the stiffness of the tungsten cantilever by decreasing its diameter using electrochemical etching in the direction of the central axis. The second procedure involves immersing the end of the etched tungsten cantilever in the direction perpendicular to the surface of the electrolyte and fabricating a tungsten tip with a tip radius of 20-50 nm via the necking phenomenon. The latter etching process applies pulse waves every 0.25 seconds to the manufactured tip to improve its yield. Finite element analysis (FEA) of the stiffness of the tungsten probe as a function of its diameter showed that the stiffness of the tungsten probes greatly varies from 56 N/m to 3501 N/m according to the cantilever diameters from $30{\mu}m$ to $100{\mu}m$, respectively. Thus, the proposed etching method is effective for producing a tungsten probe having specific stiffness for optimal use with an AFM and certain samples.