• Proceedings of the Korean Institute of Navigation and Port Research Conference
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• 2011.06a
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• pp.227-228
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• 2011

이 연구는 기름 유출 사고 시 해상에서 실시되는 방제활동을 보다 신속하고 효과적으로 실시하기 위해 사고초기부터 오일붐의 필요량을 신속하고 간단하게 제시해주는 프로그램의 개발에 대하여 알아보려고 한다. 유출유의 기계적회수를 위해 유회수기, 임시저장탱크의 필요수량은 제시되었으나, 오일붐은 제시되지 못하고 있다. 본 연구에서는 해양선진국 및 국제해사기구(IMO)에서 제시한 오일붐의 필요수량에 대한 방법들을 활용해 프로그램에서 유출규모, 유막특징의 입력을 통해 오일붐의 최소 및 권고량이 제시되도록 NI(National Instuments)사(社)의 LabVIEW 2010버전으로 프로그래밍 되었다. 기름유출 시 OBM Program을 이용해 누구나 쉽게 오일붐 필요량을 파악할 수 있고, 신속하게 오일붐의 필요량이 파악되어 방제활동 대응시간을 단축시켜주며, 단축된 대응시간만큼 피해규모의 축소를 기대할 수 있다.

• BMB Reports
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• v.47 no.7
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• pp.361-368
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• 2014

Lipid components in biological membranes are essential for maintaining cellular function. Phosphoinositides, the phosphorylated derivatives of phosphatidylinositol (PI), regulate many critical cell processes involving membrane signaling, trafficking, and reorganization. Multiple metabolic pathways including phosphoinositide kinases and phosphatases and phospholipases tightly control spatio-temporal concentration of membrane phosphoinositides. Metabolizing enzymes responsible for PI 4,5-bisphosphate (PI(4,5)P2) production or degradation play a regulatory role in Toll-like receptor (TLR) signaling and trafficking. These enzymes include PI 4-phosphate 5-kinase, phosphatase and tensin homolog, PI 3-kinase, and phospholipase C. PI(4,5)P2 mediates the interaction with target cytosolic proteins to induce their membrane translocation, regulate vesicular trafficking, and serve as a precursor for other signaling lipids. TLR activation is important for the innate immune response and is implicated in diverse pathophysiological disorders. TLR signaling is controlled by specific interactions with distinct signaling and sorting adaptors. Importantly, TLR signaling machinery is differentially formed depending on a specific membrane compartment during signaling cascades. Although detailed mechanisms remain to be fully clarified, phosphoinositide metabolism is promising for a better understanding of such spatio-temporal regulation of TLR signaling and trafficking.

• International Journal of Naval Architecture and Ocean Engineering
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• v.6 no.1
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• pp.27-38
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• 2014

Flow mixing and pressure drop characteristics for marine selective catalytic reduction applications were investigated numerically to develop an efficient static mixer. Two different mixers, line- and swirl-type, were considered. The effect of vane angles on the relative intensity, uniformity index, and pressure drop was investigated in a swirl-type mixer; these parameters are dramatically affected by the mixer geometry. The presence of a mixer, regardless of the mixer type, led to an improvement of approximately 20% in the mixing performance behind the mixer in comparison to not having a mixer. In particular, there was a tradeoff relationship between the uniformity and the pressure drop. Considering the mixing performance and the pressure drop, the swirl-type mixer was more suitable than the line-type mixer in this study.

• Journal of Korea Game Society
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• v.19 no.3
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• pp.87-100
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• 2019

Serious games based on VR(Virtual Reality) and motion recognition technologies have been studied in physical therapy and have shown significant positive effects. These existing systems have focused on measuring performance for the general public rather than patients which need rehabilitation. In the paper, We propose a serious game of self-rehabilitation that measures the patient's current physical state to generate appropriate difficulty levels to aid patients with shoulder injury.

• The Journal of Asian Finance, Economics and Business
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• v.9 no.4
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• pp.325-332
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• 2022

This research aims to examine and assess how management methods, financial conditions, and corporate governance strategies affect stock returns. This study employs a quantitative approach with a population of 1968 firms with stock returns (return) and a sample of 225 companies with corporate governance practices in the manufacturing industry in Indonesia from 2013 to 2018. The findings of this study show that strategic management has a significant impact on stock return, financial condition, and corporate governance strategy. The findings of this study on debt strategy as a proxy for management strategy, debt default as a proxy for economic conditions, corporate governance strategy as a proxy for centralized ownership, and independent commissioners function as a mechanism of internal and external control in increasing stock return for investors all support increasing stock return for investors. The cost reduction strategy includes reducing operating costs unless the audit committee has not yet functioned as an internal control or requirement for a company to be listed with the Financial Services Authority on the Indonesia Stock Exchange.

• BMB Reports
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• v.54 no.5
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• pp.278-283
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• 2021

Our understanding of the differential effects between specific omega-3 fatty acids is incomplete. Here, we aimed to evaluate the effects of docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) on T-helper type 1 (Th1) cell responses and identify the pathways associated with these responses. Naïve CD4⁺ T cells were co-cultured with bone marrow-derived dendritic cells (DCs) in the presence or absence of palmitate (PA), DHA, or EPA. DHA or EPA treatment lowered the number of differentiated IFN-γ-positive cells and inhibited the secretion of IFN-γ, whereas only DHA increased IL-2 and reduced TNF-α secretion. There was reduced expression of MHC II on DCs after DHA or EPA treatment. In the DC-independent model, DHA and EPA reduced Th1 cell differentiation and lowered the cell number. DHA and EPA markedly inhibited IFN-γ secretion, while only EPA reduced TNF-α secretion. Microarray analysis identified pathways involved in inflammation, immunity, metabolism, and cell proliferation. Moreover, DHA and EPA inhibited Th1 cells through the regulation of diverse pathways and genes, including Igf1 and Cpt1a. Our results showed that DHA and EPA had largely comparable inhibitory effects on Th1 cell differentiation. However, each of the fatty acids also had distinct effects on specific cytokine secretion, particularly according to the presence of DCs.

• Journal of Technologic Dentistry
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• v.39 no.3
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• pp.137-143
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• 2017

Purpose: The purpose of this study is to analyze the fitness of heat - pressed ceramic laminate veneers fabricated using the additive manufacturing. Methods: Impression was replicated by using light body silicone and heavy body silicone on the custom tray, and it was fabricated using Type IV Stone. The test specimens were prepared by using a dental scanner, a laminating veneer using a dental design program, and a specimen with a 3D printer. The control specimens were prepared by the lost wax technique and heat - pressed to fabricate the specimens. The data of the specimens were measured by the RMS value of the internal fitness a using a 3-dimensional measurement program. Results: The Stereolithography laminate veneer group was measured at $78.10(4.09){\mu}m$ and the LWV group was measured at $31.50(5.10){\mu}m$. There is a significant difference between the two groups (p<0.001) Conclusion : Evaluation of fitness laminate veneers was fabricated by additive manufacturing showed the difference statistically significantly and clinically acceptable result.

• Journal of Biomedical Engineering Research
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• v.30 no.3
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• pp.221-225
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• 2009

The purpose of this study was to investigate the biomechanical effects of an application of whole body vibration during strengthening exercise. Every participant performed four weeks exercise program using general leg-press versus vibrating leg-press. Participants did legpress exercise three sets of 25 repetitions with the load of 25 percent of 1RM during first week, three sets of 20 repetitions with 40 percent of 1RM during second week, three sets of 15 repetitions with 60 percents of 1RM during third week, and three sets of 15 repetitions with 80 percent of 1RM during last fourth week. The vibration(25Hz, 5mm) was applied only to the vibration exercise group. A three dimensional virtual lower extremity model for one of subject and virtual leg-press model were generated. The knee extensor muscle forces were analyzed using the virtual model and the knee joint torque(maximum extension torque) was measured using an isokinetic device. Calculated muscle forces were smaller in vibrating leg-press exercise than in general leg-press exercise. An increase of the maximum knee extension joint torque was 2.14 times larger approximately after the four week vibration leg-press exercise program was performed.

• Safety and Health at Work
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• v.8 no.1
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• pp.94-98
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• 2017

Background: Physical activity (PA) is ranked as a leading health indicator and the workplace is a key setting to promote PA. The purpose of this study was to examine how goal-setting and exercise self-efficacy (SE) during a health promotion program influenced PA level among Japanese workers. Methods: Using a cross-sectional study design, we surveyed 281 employees. The short version of the International Physical Activity Questionnaire was used to assess PA level. Exercise SE was assessed using a partially modified version of Oka's exercise SE scale. Personal goals were assessed as the total numbers of "yes" responses to five items regarding "details of personal goals to perform PA". A mediational model was used to examine whether exercise SE mediates between the number of personal goals and PA level. Results: The mean age of the participants was 46.3 years, 76.2% were men, and the most common occupational category was software engineer (30.6%). The average PA level per week exceeded the recommended level in 127 participants (45.2%). One hundred and eighty-four participants (65.5%) set some form of concrete personal goal to perform PA. The relationship between the number of personal goals and PA level was mediated by exercise SE. Conclusion: Our study showed that exercise SE mediates goal-setting and increases PA. The results suggest that the components of PA promotion programs should be tailored to enhance participants' confidence in performing PA.

• International Journal of Stem Cells
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• v.16 no.2
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• pp.156-167
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• 2023

Background and Objectives: Cellular reprogramming in regenerative medicine holds great promise for treating patients with neurological disorders. In this regard, small molecule-mediated cellular conversion has attracted special attention because of its ease of reproducibility, applicability, and fewer safety concerns. However, currently available protocols for the direct conversion of somatic cells to neurons are limited in clinical application due of their complex nature, lengthy process, and low conversion efficiency. Methods and Results: Here, we report a new protocol involving chemical-based direct conversion of human fibroblasts (HF) to matured neuron-like cells with a short duration and high conversion efficiency using temporal and strategic dual epigenetic regulation. In this protocol, epigenetic modulation by inhibition of histone deacetylase and bromodomain enabled to overcome "recalcitrant" nature of adult fibroblasts and shorten the duration of neuronal reprogramming. We further observed that an extended epigenetic regulation is necessary to maintain the induced neuronal program to generate a homogenous population of neuron-like cells. Conclusions: Therefore, our study provides a new protocol to produce neurons-like cells and highlights the need of proper epigenetic resetting to establish and maintain neuronal program in HF.