• Title/Summary/Keyword: Glycyrrhizae Radix

Search Result 294, Processing Time 0.034 seconds

Comparison of Herbs in Prescription Composition of Consumptive Disease and Internal Injury in Donguibogam Through Network Analysis (네트워크 분석을 통한 동의보감(東醫寶鑑) 내상(內傷)문과 허로(虛勞)문의 처방 구성 본초 비교)

  • Chien-hsin Kuo;Heung Ko;Seon-mi Shin
    • The Journal of Internal Korean Medicine
    • /
    • v.44 no.1
    • /
    • pp.35-52
    • /
    • 2023
  • Objective: Internal injuries and consumptive disease have different causes, yet they can affect each other. The relationship and combination of prescription drugs in the clinical practice of internal injuries and consumptive disease were analyzed for various diseases of "Donguibogam" through network analysis. Methods: The prescriptions used in consumptive disease and internal injury were established by conducting a full survey on the papers extracted from Donguibogam. The R version 4.0.3 (2020-10-10) and the igraph and arules package were used to perform network analysis and association rule relationship mining analysis in the first and second prescription compositions. Results: The herb frequently used for internal injury was Glycyrrhizae Radix, while the herb combination frequently used was Citri Pericarpium-Glycyrrhizae Radix. For centrality, the main factor was generally Glycyrrhizae Radix. In the case of consumptive disease, the herb most frequently used was Angelicae Gigantis Radix, and the combination most frequently used was Rehmanniae Radix Preparata-Angelicae Gigantis Radix. In terms of centrality, it was Angelicae Gigantis Radix. As a result of the network analysis of herbal prescription frequency, each group was divided into three. Conclusion: The interrelationship between internal injury and consumptive disease prescription drugs may reveal the differences and similarities between internal injury and consumptive disease and may serve as a basis for the development of new drugs or materials that can enhance mutual effectiveness in the treatment of internal injury and consumptive diseases.

A literature study on the treatments of the Decubitus ulcer (褥瘡의 治療에 關한 文獻的 考察)

  • Kim, Hong-jin;Choi, Jung-hwa
    • The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
    • /
    • v.12 no.2
    • /
    • pp.104-121
    • /
    • 1999
  • The results were as follows ; 1. The treatment method is most used reinforcing the spleen and strengthening of Ki(氣) detoxication and draining of pus on each stage. In first stage, the method of actirating blood and aeration of Lag(絡) nourishing blood and moisturizing skin is used. In ulcer stage, the method of expelling blood stasis and detoxication, promoting pus and drainage is used. In chronic stage, strengthening of Ki(氣) and blood, invigiration and dispersion is used. 2. In the frequency of prescription, the most numerous prescription is Paljintang(八珍湯) and the next are Insamyangyoungtang(人蔘養榮湯). Taglisodongum(托裏消耗飮) ect. In the frequency of medicine the most numerous medicine is Angelicae Gigantis Radix(當歸) and the next are Glycyrrhizae Radix (甘草), Astragali Radix(황기) etc. 3. In the frequency of prescription of exteral therapy. the most numerous prescription is Saengioghongo(生肌玉紅膏), Saengisan(生肌散) and the next are hongsungdan(紅升丹), guildan(九一丹) etc. In the frequency of medicine of exteral therapy, the most numerous medicine is Glycyrrhizae Radix (甘草) and the next are Calomelas(輕粉), Draconis Resina(血竭) etc.

  • PDF

Literatural Study on the cause of a disease and prescription in migraine (편두통(偏頭痛)의 원인(原因)과 처방(處方)에 대한 문헌적(文獻的) 고찰(考察))

  • Kim, Jong-In;Hwang, Chi-Won
    • Journal of Haehwa Medicine
    • /
    • v.8 no.2
    • /
    • pp.171-189
    • /
    • 2000
  • By Literatural studying on migraine, The results were obtained as fallow : 1. A different name on migraine were called hemicrania(頭偏痛, 邊頭痛, 偏頭風). 2. In the cause of a disease in migraine, the cases were clasified into the fallowing kind : internal cause were a decline in energy and blood(氣血具虛), external cause were outside evil(外邪) in wind cold heat wetness(風寒暑濕), non internal, external cause were exhaustion. The right side migraine were concerned phlegm heat, the right side migraine were concerned wind decline in blood. 3. Migraine is appeared on the side, For the reason, liver function in excess of normal limits(肝陽上亢), a sudden of liver fire(肝火) is becomeed of invasion upon soyangkuong(少陽經) in internal external cause 4. Usage method of medicines is appeared that order underclothes theraphy(內服法), to pump out in nose theraphy, to join head theraphy(頭點法), heating smoke theraphy(熏煙法) 5. CNIDII RHIZOMA(川芎) is in mostly general use for migraine, in that order LEDEBOURIELLAE RADIX(防風) ANGELICAE DAHURICAE RADIX(白芷) ASARI HERBA CUM RADICE(細辛) NOTOPTERYGII RHIZOMA(羌活) GLYCYRRHIZAE RADIX(甘草) CHRYSANTHEMI FLOS(菊花) BUPLEURI RADIX(柴胡) SCUTELLARIAE RADIX(黃芩) ANGELICAE GIGANTIS RADIX(當歸) GYPSUM FIBROSUM(石膏) MENTHAE HERBA(薄荷) GLYCYRRHIZAE RADIX(炙甘草) VITICIS FRUCTUS(蔓荊子), nature is in mostly general hot warm(辛溫), bitter cold(苦寒), guikuong(歸經) is in mostly general liver gall kuong(肝膽經), efficacy is in mostly general to remove wind pain (祛風止痛) and to down fire(瀉火).

  • PDF

Study on Application of the Herbal Medicines Mentioned in ${\ulcorner}$Sanghanron${\lrcorner}$, ${\ulcorner}$GeumGweyoryak${\lrcorner}$ with Regards to the abdominal Diagnoses Impressions of Epigastric Fullness and Rigidity (심하부 복진 소견과 연관된 상한론, 금궤요략 수재 약물, 처방의 응용에 관한 연구)

  • Choi, Myong-Hee;Kim, June-Ki
    • Journal of Physiology & Pathology in Korean Medicine
    • /
    • v.20 no.6
    • /
    • pp.1375-1387
    • /
    • 2006
  • Through abdominal diagnoses, deficiency and excess, and cold and heat of the eight principles for differentiating syndromes can be determined, pathogens such as fluid retention, dry stool, retention of undigested food, abdominal mass, blood stagnation, stagnation of Gi, deficiency of Kidney Yang, and, spermatorrhea can be identified, nature and stages of the symptoms can be understood and then pathogenesis analyzed. Abdominal diagnosis can be one of primary factors in deciding treatment, expecting prognosis and treatment effect, and choosing herbal prescriptions. Representative herbs for epigastric stuffiness/fullness are Radix Ginseng, Pericarpium Citri, etc; for fullness of epigastrium, Rhizoma Pinelliae, Pericarpium Citri, Rhizoma Rhei, etc.; for severely rigid epigastrium, Radix Glycyrrhizae, Radix Ginseng, etc.; for epigastric pain, Rhizoma Pinelliae, Pericarpium Citri, etc.; for epigastric fullness and rigidity, Rhizoma Coptidis, Radix Ginseng, etc.; for feeling of obstruction in the epigastirum, Radix Bupleuri, Radix Ginseng, etc.; for palpitation in the epigastrium, Radix Glycyrrhizae, Ramulus Cinnamomi, etc. It is essential to rightly diagnose through comprehensive analysis of the data gained by the four methods of diagnosis, and in doing this, further studies on how to utilize abdomen diagnosis for clinical practice.

Antitumor and Immunomodulatory Effects of Glycyrrhizae Radix Aqua-acupuncture Solution (감초 약침액의 항암 및 면역활성에 미치는 영향)

  • Park, Gyung-Mi;Cho, Kyoung-Hee;Shon, Yun-Hee;Lim, Jong-Kook;Nam, Kyung-Soo
    • Korean Journal of Pharmacognosy
    • /
    • v.31 no.1
    • /
    • pp.7-15
    • /
    • 2000
  • Glycyrrhizae Radix aqua-acupuncture solution (GRAS) and Glycyrrhizae Radix water-extracted solution (GRWS) were prepared and tested for organ toxicities, antitumor activities, and immunomodulatory effects. The organ-toxicity of GRAS to male ICR mice was studied by the measurements of glutamic oxaloacetic transaminase (GOT), glutamic pyruvate transaminase (GPT), lactate dehydrogenase (LDH), and alkaline phosphatase (ALP-s) activities after injection of GRAS for 7 days. The activities of GOT, GPT, LDH, ALP-s were decreased with GRAS. It was shown to possess considerable toxicity toward various tumor cell lines. Concentration of GRAS at 1.5g/ml and 3g/ml resulted in more than 80% inhibition of growth in Ehrlich ascites tumor cells (EATC), Hepa1c1c7, and HeLa cells. Toxicity of GRAS to A549 revealed that 68% inhibition of growth. GRWS at the concentration of 3g/ml showed more than 80% inhibition of growth with EATC, Hepalclc7, A549 and HeLa. In morphological study, the number of cells were decreased, and the shape of cells was round-form in EATC, Hepalclc7, A549 and HeLa cells with GRAS. Administration of GRAS inhibited the growth of EATC in vivo. Mice given EATC at 1.5g/ml or 0.3g/ml GRAS had 16.7% to 50% survival after 21 days. GRAS increased the proliferation of T and B cells and the cytolytic activity of purified T cell. The biosyntheses of nucleic acid and protein of EATC, Hepalclc7, A549 and HeLa cells were inhibited by GRAS.

  • PDF

Antigastritic Effect of Carbenoxolone Disodium from Glycyrrhizae Radix (감초성분 Carbenoxolone Disodium의 항위염 효과)

  • Cho, So-Yean;Lee, Seung-Ho;Choi, Ji-Young;Myoung, Shin-Eun;Kang, Sam-Sik;Jeong, Jeong-Suk;Jeong, Choon-Sik
    • Toxicological Research
    • /
    • v.23 no.2
    • /
    • pp.165-172
    • /
    • 2007
  • Glycyrrhizae Radix, the dried roots of Glycyrrhiza glabra or Glycyrrhiza uralensis Fischer(Legumino-sae), has been used as a medicine for treatment of imflammation, arthritis, respiratory ailment, skin diseases and liver problems. The purpose of this study was to examine the effect of 70% ethanol extract, 18-${\beta}$-glycyrrhetinic acid, glycyrol and carbenoxolone disodium from Glycyrrhizae Radix on gastritis and gastric cancer. Using these materials, we tested antibacterial activity against Helicobacter pylori, antigastritic activity for HCI-ethanol-induced gastric lesion and the pylorus ligated gastric secretion with rats, and cell viability in gastric cancer cell. 18-${\beta}$-glycyrrhetinic acid and carbenoxolone disodium decreased the volume of gastric secretion and acid output in pylorus ligated rats. Also, carbenoxolone disodium had a strong effect of antibacterial activity on H. pylori. In addition 18-${\beta}$-glycyrrhetinic acid and glycyrol reduced cell viability in human gastric cancer cells(AGS and SNU638 cell) in dose-dependent manner. The reduction of total acid output and gastric secretion as well as the anti-bacterial activity against H. pylori might account for the antigastritic effects of carbenoxolone disodium.

Changes of Microorganisms and Active Compounds in Glycyrrhizae Radix as Affected by Drying Method and Gamma Ray Treatments (건조 방법 및 감마선 조사에 따른 감초의 미생물 저감효과 및 유효성분 변화)

  • Kim, Joon-Hee;Kang, Byoung-Man;Kim, Jun Yong;Kim, Ryu-Dam;Hwang, Hyun Chul;Lee, Jae-Woong
    • Korean Journal of Plant Resources
    • /
    • v.35 no.4
    • /
    • pp.428-434
    • /
    • 2022
  • Glycyrrhizae Radix is an herbal medicine vulnerable to fungi. So there are regulations on mycotoxins. Therefore, in this study, the affect of various drying methods and additional gamma irradiation (10 kGy) was studied to suppress the microbial generation of Glycyrrhizae Radix. As a result of detecting and comparing microorganisms using the dry film method for samples prepared by each of natural, hot air, freezing, microwave drying and gamma irradiation, the affect of reducing microorganisms by microwave drying and gamma irradiation was confirmed. There was no statistically significant change in the content of the active compounds between the treatment groups.

Effect of Qi Tonifying herbs, Ginseng, Astragali, Atractylodis, Glycyrrhizae on Mouse Cytokine Secretion (보기약물(補氣藥物)인 인삼(人參), 황기(黃?), 백출(白朮), 감초(甘草)의 물 추출액이 생쥐 면역세포의 Cytokine분비에 미치는 영향)

  • Bae, Hang;Myung, Eu-Gene;Kang, Hee;Shim, Bum-Sang;Kim, Sung-Hoon;Choi, Seung-Hoon;Ahn, Kyoo-Seok
    • Journal of Physiology & Pathology in Korean Medicine
    • /
    • v.19 no.1
    • /
    • pp.69-74
    • /
    • 2005
  • In Oriental medicine the primordial Qi and the defensive Qi are considered as important for immunity. Therefore it is anticipated that the improvement of the primordial Qi and the defensive Qi can enhance the ability of immune cells. This experiment was conducted to investigate how Ginseng Radix, Astragali Radix, Atractylodis Rhizoma Alba, Glycyrrhizae Radix, representative of Qi tonifying herbs, affect the immune system in terms of controlling and balancing immune cells. Using the MTS assay, increased proliferations were observed from herbal treated cells, among which Gins-eng showed the highest proliferation. When splenocytes were activated with anti-CD3 plus herbal extracts, levels of IFN-g and IL-4 were increased but those of IL-2 showed little change compared with the control cells. Levels of IL-2, IFN-g and IL-4 were increased in purified CD4 T cells when activated with anti-CD3/anti-CD28 but at $100\;{\mu}g/ml$ of Astragali and Atractylodis, levels of IL-2 were decreased by 11% and 42%, respectively and those of IFN-g were decreased by 55% and 12%, respectively. Under Th1/Th2 polarizing conditions, levels of IFN-g in Th1 cells treated with herbal extracts were all decreased but when it comes to IL-4, its levels were increased in Ginseng and Glycyrrhizae treated cells but decreased in Astragali and Atractylodis treated cells. Taken together, the data show that compared with other qi tonifying herbs, Ginseng and Glycyrrhizae have a tendency to favor Th2 cell differentiation in vitro.

Inhibitory Effect of Respective Herbs in Cheonggugamrosu on Oral Malodor Using Malodor Modeling of the Salivary Sediment System (타액침전물모델을 이용한 청구감로수 구성약물의 구취억제작용)

  • Kim, Jin-Sung;Park, Jae-Woo;Yoon, Seong-Woo;Ryu, Bong-Ha
    • The Journal of Korean Medicine
    • /
    • v.30 no.2
    • /
    • pp.79-87
    • /
    • 2009
  • Objective: This study assessed five respective herbs in Cheonggugamrosu (CGGRS) for ability to inhibit malodor in vitro. Methods: We used malodor modeling of the salivary sediment system. Incubation mixtures were prepared with sediment at 16.7% (v/v), amino acids (cysteine and tryptophan) at 6mM and either herb extract at 1% (w/v) or water as control. Mixtures were incubated at $37^{\circ}C$ and odor was monitored organoleptically and for volatile sulfur compounds with the Halimeter. Indole/skatole was determined by Kovac's colorimetric method. Results: Two of the herbs, Caryophilli Flos and Glycyrrhizae Radix, had inhibitory effect on malodor generation. Both of them significantly reduced VSC, organoleptic odor and indole/skatole formation (p<0.05). Conclusions: We found Caryophilli Flos and Glycyrrhizae Radix played a main role in CGGRS. Both herbs have potential as effective anti-malodor agents and this suggests they are worthy of further exploration.

  • PDF

Effect of Glycyrrhizae Radix Pharmacopuncture on PCA and Secretion of ${\beta}$-Hexosaminidase and Cytokines in RBL-2H3 Cells (감초약침(藥鍼)이 PCA반응과 비만세포의 ${\beta}$-Hexosaminidase 및 Cytokine 분비에 미치는 영향)

  • Lee, Hang-Do;Song, Choon-Ho
    • Korean Journal of Acupuncture
    • /
    • v.28 no.3
    • /
    • pp.73-83
    • /
    • 2011
  • Objectives : The purpose of this study is to investigate anti-allergic effects of Glycyrrhizae Radix(GR) pharmacopuncture and GR extract. Methods : In vivo, animals were gotten GR pharmacopunctures at both sides of ST36s three times for 5 days. Then, we investigated anti-DNP IgE-induced passive cutaneous anaphylaxis of Sprague Dawley rats. In vitro, we measured cell viability, ${\beta}$-hexosaminidase release, and the secretion of interleukin-4(IL-4) and tumor necrosis factor-alpha(TNF-${\alpha}$) in RBL-2H3 cells after treatment of various concentrations of GR extract. Results : In vivo, we observed inhibition of passive cutaneous anaphylaxis after GR pharmacopuncture treatments at both sides of ST36s and optional points. In vitro, GR extract treatments did not affect cell viability, but inhibited ${\beta}$-hexosaminidase release and the secretion of IL-4 and TNF-${\alpha}$. Conclusions : These results suggest that GR pharmacopuncture and GR extract should be beneficial in the inhibition of allergic inflammatory response.